ライフサイエンスコーパス: tolerate

1 sensitization to foods that they clinically tolerate.

2 ls, such as conventional metal films, cannot tolerate.

3 e most effective therapy patients can safely tolerate.

4 PC786 was well tolerated.

5 b, PCV13, and PPV23 was immunogenic and well tolerated.

6 Both doses were well tolerated.

7 se and bone metastases and is generally well tolerated.

8 Islatravir was generally well tolerated.

9 e DAA era appears to be efficacious and well tolerated.

10 ith placebo and were safe and generally well tolerated.

11 meaningful proportion of patients but poorly tolerated.

12 Both dosages were equally effective and well tolerated.

13 360.RESULTSMIC infusions were extremely well tolerated.

14 c antiepileptics, and paracetamol were often tolerated.

15 d its combination with albendazole were well tolerated.

16 ned improvements in AD symptoms and was well tolerated.

17 vs. 79.7 +/- 7.4%, p = 0.932), but was well tolerated.

18 regardless of age or HIV status and was well tolerated.

19 ment, twice-daily DTG was effective and well tolerated.

20 In RSV-infected infants, JNJ-8678 was well tolerated.

21 TAK-003 was well tolerated.

22 d M6620 monotherapy, which was safe and well tolerated.

23 he triterpenoid scaffold at carbon-6 are not tolerated.

24 All vaccine regimens were well tolerated.

25 All injections were well tolerated.

26 CYP-001 was safe and well tolerated.

27 on of the H3.3K27M-specific vaccine was well tolerated.

28 tion of rhIL-15/anti-PD-L1 was safe and well tolerated.

29 Cilofexor was generally well-tolerated.

30 Nemolizumab was safe and well tolerated.

31 ve cancers in which oral medications are not tolerated.

32 intranasal corticosteroids, and it was well tolerated.

33 Treatment with S/V was well-tolerated.

34 Vaccines were generally safe and well tolerated.

35 Flurpiridaz PET was safe and well tolerated.

36 rTMS and tDCS were well tolerated.

37 wing and electron-donating substituents were tolerated.

38 lacking these three transporters was able to tolerate 100 mM serine whereas the wild type strain was

39 l therapy with concurrent ibrutinib was well tolerated; 13 patients (68%) received ibrutinib as plann

40 ns of chloroform led to culture GEO12CF that tolerated 83 muM (10 mg.L(-1)) chloroform.

41 utral reaction conditions are mild enough to tolerate a range of functionalities and cover a variety

42 apia (Oreochromis mossambicus) are fish that tolerate a wide salinity range from fresh water to > 3x

43 vity reaction to vancomycin who successfully tolerated a dalbavancin graded challenge.

44 Six subjects tolerated a total of 17 FUS treatments with no adverse e

45 The reaction tolerated a wide range of functional groups and heteroar

46 ew synthetic protocol is easy to perform and tolerates a broad range of functionalities and heterocyc

47 with both internal and terminal olefins and tolerates a diverse array of functional groups (ketone,

48 This protocol tolerates a great variety of functional groups and thus

49 Yeast tolerates a low pH and high solvent concentrations.

50 This reaction tolerates a range of acceptors and donors, including dis

51 ent shows that this reductive defluorination tolerates a range of functional groups and heterocycles

52 The scope of the process tolerates a range of nucleophiles to construct C-N, C-O,

53 This late-stage functionalization method tolerates a remarkably wide range of functional groups,

54 The methodology tolerates a variety of functional groups and furnishes t

55 The developed methodology tolerates a variety of functional groups.

56 dology avoids late-stage usage of azides and tolerates a wide range of functionalities.

57 te-bearing analogues display broad activity, tolerating a number of substitutions, and diphosphate an

58 ug-like properties for oral dosing, was well tolerated across preclinical species at pharmacologicall

59 The estimated maximum tolerated activity was about 1 MBq/kg.

60 The method tolerates all other known nucleophilic functional groups

61 Both TACTs were well tolerated, although early vomiting (within 1 h) was more

62 ctivities under mild reaction conditions and tolerate an array of functional groups.

63 tion of a learned floral-odor bumblebees can tolerate and identify which scent-pollutants are problem

64 to growth while increasing their ability to tolerate and metabolise reactive oxygen species (ROS).

65 The ability to tolerate and thrive in diverse environments is paramount

66 Both treatments were well tolerated and adherence during the study was high.

67 Regadenoson is well tolerated and can be safely used for cardiac MRI stress

68 clinically relevant dose of GS-9688 is well tolerated and can induce a sustained antiviral response

69 Enasidenib is generally well tolerated and can induce responses in patients with muta

70 Walnuts were well tolerated and compliance was good.

71 epatitis B virus (HBV) replication, was well tolerated and demonstrated dose-proportional pharmacokin

72 KAF156 was safe and well tolerated and demonstrated high levels of pre- and post-

73 mpared with vancomycin, fidaxomicin was well tolerated and demonstrated significantly higher rates of

74 and demonstrated that this compound is well tolerated and did not impair normal hematopoiesis in mic

75 STAR particles were well tolerated and effective at creating micropores when appl

76 vel findings indicate that zolpidem was well tolerated and effective in promoting sleep in people wit

77 Evolocumab was well tolerated and effectively reduced plasma LDL-C levels in

78 Posaconazole tablets are well tolerated and efficacious in the prophylaxis and treatme

79 us GP vaccine with Matrix-M adjuvant is well tolerated and elicits a robust and persistent immune res

80 Conclusion: Ledipasvir-sofosbuvir was well tolerated and highly effective in children 3 to <6 years

81 All regimens were well tolerated and immunogenic, with trends toward higher ant

82 Ivosidenib monotherapy was well-tolerated and induced durable remissions and transfusion

83 decompensated heart failure (ADHF) was well-tolerated and led to improved outcomes.

84 (PS1) mice, two selected compounds were well tolerated and led to positive trends, albeit statistical

85 5 patients studied, (99m)Tc-PHC-102 was well tolerated and no study drug-related adverse events were

86 Belapectin (2 mg/kg) was well tolerated and produced no safety signals.

87 lotherapy of the left gastric artery is well-tolerated and promotes clinically significant weight los

88 Single-agent EV was generally well tolerated and provided clinically meaningful and durable

89 Cilofexor for 24 weeks was well-tolerated and provided significant reductions in hepatic

90 d that self-sampling with foam swabs is well-tolerated and provides quantitative viral output concord

91 GB001 was well tolerated and rapidly absorbed with a 14.5-hour terminal

92 repeat dosing indicated that KB105 was well-tolerated and restricted to the dose site.

93 ab in combination with lenalidomide was well tolerated and resulted in a high proportion of patients

94 ccination using the HD-MAP was safe and well tolerated and resulted in immune responses that were sim

95 Oral dosing of PRCL-02 was well tolerated and resulted in suppressed T-cell proliferatio

96 iparum [Pf] sporozoites [SPZ]) has been well tolerated and safe in >1526 malaria-naive and experience

97 Pembrolizumab was well tolerated and showed encouraging antitumour activity in

98 mpared with aflibercept monotherapy, is well tolerated and shows modest anatomic benefit with potenti

99 R848 was well tolerated and significantly induced IFN-alpha2a, IFN-gam

100 Acalabrutinib was well tolerated and yielded an overall response rate (ORR) of

101 e, and tenofovir alafenamide as a safe, well tolerated, and durable treatment for people with HIV, wi

102 ent vaccine regimen was generally safe, well-tolerated, and found to elicit higher immune responses t

103 ster #7085), we report that ONM-100 was well tolerated, and four solid tumor types could be visualize

104 Novel OPV2 candidates were as safe, well tolerated, and immunogenic as monovalent OPV2 in previou

105 Treatment was well tolerated, and no events of hypoglycemia or hypotension

106 Both protocols were well tolerated, and no severe treatment-related adverse event

107 OPT-302 inhibition of VEGF-C and -D was well tolerated, and OPT-302 combination therapy may overcome

108 In addition, alkyl substituents are not tolerated, and the N-H proton of the aniline ring is res

109 Both treatments were well tolerated, and there were no serious adverse events.

110 e glucose conjugated compound was far better tolerated, and tumour growth delays for the parent compo

111 erium to manipulate the human immune system, tolerate antibiotic treatment and adapt to the variable

112 nidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF remains high.

113 HD-MAP vaccination was safe and well tolerated; any systemic or local adverse events (AEs) we

114 nd capecitabine, a prodrug of 5-FU, was well tolerated at biologically-active doses.

115 nce and cataplexy while generally being well tolerated at prescribed doses.

116 table environment for evolving mechanisms to tolerate B(12) limitation better.

117 opulations have rapidly evolved to resist or tolerate Bd infection.

118 s a safe and painless procedure that is well tolerated because it avoids rectal trauma and patients r

119 However, systemic delivery of R848 is poorly tolerated because of its poor solubility in water and sy

120 bability (TCP) of 99% and, second, a maximal tolerated biologically effective dose (BED(max)) for org

121 The vaccine was relatively well tolerated, but a high percentage developed a fever >=37.

122 AGS-004 and VOR were safe and well-tolerated, but no substantial impact on RCI was measured

123 er as well as more beneficial for and better tolerated by at-risk individuals.

124 troduced alleles (RAs) are more likely to be tolerated by modern humans than are introgressed Neander

125 Desmopressin is well tolerated by most patients, however adverse effects, suc

126 e anti-inflammatory properties, and are well tolerated by the brain, D-serine, an endogenous amino ac

127 Desiccation of plants is often lethal but is tolerated by the majority of seeds and by vegetative tis

128 , in which loss-of-function variants are not tolerated, can be highly successful as targets of inhibi

129 This phenomenon tolerates changes in hairpin order, linker lengths, and

130 at wild isolates of Saccharomyces cerevisiae tolerate chromosome amplification while laboratory strai

131 d CBF-independent cold signaling pathways to tolerate cold.

132 e infusions of ketamine were relatively well tolerated compared to active placebo, except for greater

133 ved progression-free survival and was better tolerated compared with sorafenib in patients with metas

134 The maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D,

135 At the maximum tolerated dose (MTD) of 400 mug/d, the response rate was

136 Once the maximum tolerated dose (MTD) was established, 21 patients were t

137 ty, dose-limiting toxicities (DLTs), maximum-tolerated dose (MTD), and preliminary antitumor activity

138 56.8 muM), and low in vivo toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with

139 ary objectives were to determine the maximum tolerated dose and dose limiting toxicities of brentuxim

140 The maximum tolerated dose and non-tolerated dose were not reached i

141 tor-initiated study was to determine maximum tolerated dose and safety.

142 wever, and whether escalation to the maximum tolerated dose confers clinical benefits that outweigh t

143 sion part, the starting dose was the maximum tolerated dose from the dose-escalation part).

144 Maximum tolerated dose of EV was not established; however, the r

145 n continuous 28-day cycles until the maximum tolerated dose or recommended phase 2 dose was determine

146 1:1 to liraglutide (1.8 mg daily or maximum tolerated dose up to 1.8 mg daily) or placebo plus stand

147 In phase 1, the established maximum tolerated dose was 40 mg of melflufen in combination wit

148 The maximum tolerated dose was 400 mg, and the recommended phase 2 d

149 Maximum tolerated dose was not reached; there were no dose-limit

150 The maximum tolerated dose and non-tolerated dose were not reached in the dose escalation p

151 olerability, the non-tolerated dose, maximum tolerated dose, and recommended phase 2 dose (RP2D).

152 the tolerability, systemic exposure, maximum tolerated dose, and the antitumour activity of nivolumab

153 termine the safety and tolerability, the non-tolerated dose, maximum tolerated dose, and recommended

154 Primary endpoints were maximum tolerated dose, recommended phase 2 dose, and safety in

155 pite receiving statin therapy at the maximum tolerated dose.

156 imary objective was to determine the maximum tolerated dose.

157 primary objective was estimating the maximum tolerated dose; the secondary objectives were to assess

158 esults of skin test and cellular assays, and tolerated drugs in subsequent pharmacological treatments

159 be enriched with traits that enable them to tolerate environmental stress, which may trade-off with

160 ation but also requires a loss function that tolerates errors in annotation.

161 referring lower local flows speeds, they can tolerate exposure to high-flow speeds of up to 114 cm s(

162 es, yet stiff materials that can resiliently tolerate extreme forces and deformation while being manu

163 sp. ICE-L thrives in polar sea ice, where it tolerates extreme low temperatures, high salinity, and b

164 n who remained symptomatic despite maximally tolerated GDMT, regardless of prior CRT implantation.

165 ucoma was defined as IOP >21 mmHg on maximum tolerated glaucoma medications or progressive visual fie

166 n who remained symptomatic despite maximally tolerated guideline-directed medical therapy (GDMT).

167 ly, patients with ARDS and class III obesity tolerate hemodynamically LRM with high airway pressure.

168 tive suppression of huntingtin was generally tolerated, however high dose AAV5-miHTT did induce astro

169 ed that a variant of AL002c is safe and well tolerated in a first-in-human phase I clinical trial and

170 resumed DR-TB infection is feasible and well tolerated in a high TB burden setting.

171 However, the switch to I438K expression is tolerated in adult mice, sparing normal cells but allowi

172 PCV20 was well tolerated in adults 60 to 64 years of age, with a safety

173 s kinase 1 inhibitor, was effective and well tolerated in adults with moderate-to-severe atopic derma

174 /- 28 MBq of the radiotracer, which was well tolerated in all patients over a follow-up period of 4 w

175 y demonstrates that (67)Cu-CuSarTATE is well tolerated in BALB/c nude mice and highly efficacious aga

176 DSR was well tolerated in both animals and human subjects and produce

177 ision with amplified centrioles, known to be tolerated in disease states, can occur as part of a norm

178 ous Ad26,MVA Ebola vaccine regimens are well tolerated in healthy adults, regardless of interval or d

179 ul, durable responses and was generally well tolerated in heavily pretreated patients with relapsed o

180 cate that these candidate compounds are well tolerated in mice without any significant side effects.

181 the analogue and established that 3 is well tolerated in mice, displays substantial PK improvements

182 yed excellent brain penetration and was well-tolerated in mice.

183 the presence of a certain level of rNMPs is tolerated in mitochondrial DNA (mtDNA) although aberrant

184 ophobic substitutions to levels that are not tolerated in monomers.

185 Treatment was well tolerated in most however serious AEs can occur in those

186 vacamten, a novel myosin inhibitor, was well tolerated in most subjects with symptomatic nHCM.

187 Although OGG1 depletion is well tolerated in non-transformed cells, we report here that

188 ChAdOx1 nCoV-19 appears to be better tolerated in older adults than in younger adults and has

189 treatment of migraine and was safe and well tolerated in patients for whom multiple previous standar

190 y cohort.CONCLUSIONOral NAC is safe and well tolerated in patients with moderately advanced RP and ma

191 In summary, daratumumab is well tolerated in patients with relapsed AL amyloidosis and l

192 of life measures, and it was generally well tolerated in patients with uncontrolled, persistent (pha

193 BAT product was well tolerated in patients.

194 ADx-001 was well tolerated in rats and monkeys and exhibited the slow cle

195 The regimen was also well tolerated in the majority of patients in this older popu

196 LAIV appears to be well tolerated in the vast majority of children with asthma o

197 as single or multiple doses is safe and well tolerated in very young infants and is suitable for furt

198 Debio-1452-NH3 is well tolerated in vivo, reduces bacterial burden in mice and

199 a bioactive anti-inflammatory compound well tolerated in vivo, that shows efficacy in reducing disea

200 ved in vitro profiles, but these were poorly tolerated in vivo.

201 A wide array of alkene substrates are tolerated, including complex drug-like molecules and a t

202 verattenuated, but the 106 PFU dose was well tolerated, infectious (RSV/DeltaNS2/Delta1313/I1314L rep

203 -BEYOND clinical trial (NCT01864798) is well tolerated, inhibits RANK pathway and increases tumor inf

204 Primarily, we consider age, fitness to tolerate intensive chemotherapy, remission duration, and

205 Although PI is generally well tolerated, it can be associated with significant ocular

206 e wood decay and nutrient cycling as well as tolerate latex and utilize resinous extractives.

207 ne in patients without rheumatic disease who tolerated LD-MTX during an active run-in period.

208 Although cells can tolerate loss of either protein, identifying their combi

209 At the same time, they tolerate many donor sites, including basic nitrogen and

210 and optic nerve head changes despite maximal tolerated medical therapy.

211 uncontrolled open-angle glaucoma on maximum tolerated medical therapy.

212 rticles provides a simple, low-cost and well-tolerated method for increasing drug and vaccine deliver

213 nted with spaced seeds, which are capable of tolerating mismatches.

214 ectable PDA is challenging; (2) Patients can tolerate modern systemic therapy and undergo successful

215 gregarious nonhuman primates, eye contact is tolerated more and may be used to communicate other emot

216 eaction, which yields amines and O(Bpin)(2), tolerates nitro, halide, and amino functional groups wel

217 Ripretinib is a well-tolerated, novel inhibitor of KIT and PDGFRA mutant kina

218 and electron-releasing substituents are well tolerated on the phthalide core as well as on the aromat

219 We also found that the ICA homo-trimer can tolerate one copy of Myrf-V679A or Myrf-R695H for its au

220 t a substantial number of mutations are well tolerated or even enhance ACE2 binding, including at ACE

221 Most tolerated oral miltefosine well, with mild gastrointesti

222 rring in the cell, and the cell's ability to tolerate packaging defects.

223 es inspire questions about how organisms can tolerate physiochemical stressors and whether the repeat

224 Thus, there is a need for well-tolerated presurgical therapies that could reduce the si

225 for patients who have not benefited from or tolerated previous standard-of-care treatments.

226 information about a gene and its ability to tolerate protein-altering variation can aid in clinical

227 Long-term PGDHi was well-tolerated, reduced the severity of pulmonary fibrotic le

228 stration as well as new, shorter, and better-tolerated regimens.

229 xicity generally demonstrate aquatic insects tolerate relatively high concentrations of metals in aqu

230 ted human airway organoid cultures, was well tolerated (selectivity index > 7,111) and orally bioavai

231 e protocol operates at low catalyst loading, tolerates several functional groups, and generates H(2)O

232 ganisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hiber

233 tion, all doses tested of JNJ-6379 were well tolerated, showed dose-dependent pharmacokinetics, and h

234 low LS BMD, 48 weeks of alendronate was well-tolerated, showed no safety concerns, and significantly

235 year leads to continued response from a well-tolerated, simple-to-use regimen.

236 nib, regorafenib for patients who previously tolerated sorafenib, or ramucirumab (for patients with a

237 ndrome and were on high-intensity or maximum-tolerated statin therapy, with a baseline low-density li

238 erolemia/mixed dyslipidemia taking maximally-tolerated statin therapy.

239 id levels in dyslipidemic PLHIV on maximally-tolerated statin therapy.

240 te coronary syndrome on intensive or maximum-tolerated statin treatment who were randomized to the PC

241 functional gene abundances toward those that tolerate stress but are weak decomposers.

242 nstrate that BRCA2 tumor suppressor function tolerates substantial reduction in full-length transcrip

243 but reveal inherent constraints restricting tolerated substitutions due to epistasis.

244 ast majority of the surface-exposed residues tolerated substitutions without loss of RD3's inhibitory

245 with HIV-1 infection and were generally well tolerated, supporting the further development of islatra

246 However, although being generally far better tolerated than classic cytotoxic chemotherapy, this trea

247 latory activity and that these RAs were more tolerated than NDAs.

248 fined pain populations of patients who could tolerate the drug.

249 designs that excluded patients who could not tolerate the drugs, had early adverse effects, or report

250 an immune-privileged organ, the placenta can tolerate the introduction of antigens without inducing a

251 required adaptations to conserve energy and tolerate the low oxygen (O(2)) and high carbon dioxide (

252 These layers must tolerate the resident microbiota while keeping homeostat

253 Suicide attempters tolerated the breath-hold and cold-pressor challenges fo

254 ompared with baseline; and 13.5% (19 of 141) tolerated the full double-blind, placebo-controlled food

255 The non-human primates tolerated the implant without gross pathology or microsc

256 All animals tolerated the procedure very well and gained weight with

257 d polyenyne cycloisomerization that not only tolerates the presence of all of the oxygen functionalit

258 oride donors and silyl ether acceptors while tolerating the Lewis basic environment found in carbohyd

259 opulations, whereas non-essential genes will tolerate their accumulation.

260 Highly effective, well-tolerated therapies are now available with markedly simp

261 ide to theranostics is that patients tend to tolerate these agents better than chemotherapy.

262 nal and clinical settings, yet how the brain tolerates these multi-stressor environments is unknown C

263 A broad range of substrates tolerate this facile transformation, in which the bridge

264 Six pediatric patients with glioma tolerated this combination without significant adverse e

265 ary analysis, and the PDS generally was well tolerated throughout the entire study period.

266 sms, we isolated suppressor mutants that can tolerate toxic serine concentrations by three targeted a

267 ents might affect the ability of patients to tolerate treatment over time.

268 ipenem/relebactam is an efficacious and well-tolerated treatment option for carbapenem-nonsusceptible

269 sease and nutritional status in patients who tolerated treatment.

270 Remarkably, this chemistry tolerates various electronic environments, providing acc

271 ion of the device from damage by effectively tolerating various external loads.

272 ocyanide insertion reaction is rather broad, tolerating various functionalized isocyanobenzoates and

273 tive transdermal testosterone, although well tolerated, was not more effective than placebo in improv

274 The procedure was tolerated well in over 100 SHR and normotensive rats tha

275 potent antitumor activity and was very well tolerated when compared to the initial BTC.

276 nt antitumor activity in vivo but was poorly tolerated, which was hypothesized to be the result of un

277 All treatment regimens were well tolerated with additional exposure.

278 IP RIT (131)I-omburtamab was well tolerated with minimal toxicities.

279 The treatment was well tolerated with minimal toxicities.

280 C1-INH was well tolerated with no new safety signals identified in this

281 Subcutaneous VRC01 was safe and well tolerated with only mild-to-moderate local reactions, pr

282 nstrate that a wide array of substituents is tolerated with this novel scaffold that increased cellul

283 Remdesivir was well tolerated, with a low incidence of serious adverse event

284 Ivosidenib plus azacitidine was well tolerated, with an expected safety profile consistent wi

285 The vaccine was tolerated, with induction of neutralizing antibodies and

286 ication of the lipid tail was generally well tolerated, with longer alkyl chains enhancing analogue c

287 Overall, BUP/SAM was generally well tolerated, with most adverse events (AEs) being mild or

288 All doses were generally safe and well tolerated, with no clinically relevant changes in any sa

289 Results: (89)Zr-IAB22M2C infusion was well tolerated, with no immediate or delayed side effects obs

290 Daratumumab-CyBorD was well tolerated, with no new safety concerns versus the intrav

291 f AFM13 and pembrolizumab was generally well tolerated, with similar safety profiles compared to the

292 M6620 was well tolerated, with target engagement and preliminary antitu

293 ative changes at positions 1 and 2 were well-tolerated, with Val(1)-Val(2), Ile(1)-Ala(2), and Leu(1)

294 Stress CMR was well tolerated without any adverse events.

295 itamin D concentrations were significant and tolerated without developing hypercalcemia.

296 The vaccine was well tolerated without safety concerns throughout the study.

297 Both doses were well tolerated without significant changes in BP, weight, or

298 Both regimens were generally well tolerated without unexpected toxicities.

299 y monitoring revealed that the drug was well tolerated, without an increase in plasma triglycerides.

300 Selatogrel was well tolerated, without major bleeding complications.