ライフサイエンスコーパス: tolerated

1 ith placebo and were safe and generally well tolerated.

2 meaningful proportion of patients but poorly tolerated.

3 ned improvements in AD symptoms and was well tolerated.

4 Both dosages were equally effective and well tolerated.

5 360.RESULTSMIC infusions were extremely well tolerated.

6 c antiepileptics, and paracetamol were often tolerated.

7 d its combination with albendazole were well tolerated.

8 vs. 79.7 +/- 7.4%, p = 0.932), but was well tolerated.

9 regardless of age or HIV status and was well tolerated.

10 ment, twice-daily DTG was effective and well tolerated.

11 In RSV-infected infants, JNJ-8678 was well tolerated.

12 TAK-003 was well tolerated.

13 d M6620 monotherapy, which was safe and well tolerated.

14 he triterpenoid scaffold at carbon-6 are not tolerated.

15 All vaccine regimens were well tolerated.

16 All injections were well tolerated.

17 CYP-001 was safe and well tolerated.

18 on of the H3.3K27M-specific vaccine was well tolerated.

19 tion of rhIL-15/anti-PD-L1 was safe and well tolerated.

20 Cilofexor was generally well-tolerated.

21 Nemolizumab was safe and well tolerated.

22 ve cancers in which oral medications are not tolerated.

23 onnaires indicated that both diets were well tolerated.

24 Results: (18)F-rhPSMA-7.3 was well tolerated.

25 All EBOV GP vaccine formulations were well tolerated.

26 Treatment was generally well tolerated.

27 virologic response and DAA therapy was well tolerated.

28 The drug was well tolerated.

29 IW-3718 was well tolerated.

30 mpared with placebo, and ivosidenib was well tolerated.

31 AV-101 was safe and well tolerated.

32 intranasal corticosteroids, and it was well tolerated.

33 Treatment with S/V was well-tolerated.

34 Vaccines were generally safe and well tolerated.

35 Flurpiridaz PET was safe and well tolerated.

36 rTMS and tDCS were well tolerated.

37 wing and electron-donating substituents were tolerated.

38 PC786 was well tolerated.

39 b, PCV13, and PPV23 was immunogenic and well tolerated.

40 Both doses were well tolerated.

41 se and bone metastases and is generally well tolerated.

42 Islatravir was generally well tolerated.

43 e DAA era appears to be efficacious and well tolerated.

44 l therapy with concurrent ibrutinib was well tolerated; 13 patients (68%) received ibrutinib as plann

45 ns of chloroform led to culture GEO12CF that tolerated 83 muM (10 mg.L(-1)) chloroform.

46 vity reaction to vancomycin who successfully tolerated a dalbavancin graded challenge.

47 Six subjects tolerated a total of 17 FUS treatments with no adverse e

48 The reaction tolerated a wide range of functional groups and heteroar

49 ug-like properties for oral dosing, was well tolerated across preclinical species at pharmacologicall

50 The estimated maximum tolerated activity was about 1 MBq/kg.

51 Cenegermin was well tolerated; adverse effects were mostly local, mild, and

52 The effects of the well-tolerated alkaloid Berberine (BRB), used for treating me

53 Both TACTs were well tolerated, although early vomiting (within 1 h) was more

54 Nilotinib was well-tolerated, although more adverse events, particularly mo

55 Both treatments were well tolerated and adherence during the study was high.

56 Regadenoson is well tolerated and can be safely used for cardiac MRI stress

57 clinically relevant dose of GS-9688 is well tolerated and can induce a sustained antiviral response

58 Enasidenib is generally well tolerated and can induce responses in patients with muta

59 Walnuts were well tolerated and compliance was good.

60 epatitis B virus (HBV) replication, was well tolerated and demonstrated dose-proportional pharmacokin

61 KAF156 was safe and well tolerated and demonstrated high levels of pre- and post-

62 mpared with vancomycin, fidaxomicin was well tolerated and demonstrated significantly higher rates of

63 and demonstrated that this compound is well tolerated and did not impair normal hematopoiesis in mic

64 STAR particles were well tolerated and effective at creating micropores when appl

65 vel findings indicate that zolpidem was well tolerated and effective in promoting sleep in people wit

66 Letermovir was well tolerated and effective in treating CMV-infections in lu

67 Evolocumab was well tolerated and effectively reduced plasma LDL-C levels in

68 Posaconazole tablets are well tolerated and efficacious in the prophylaxis and treatme

69 us GP vaccine with Matrix-M adjuvant is well tolerated and elicits a robust and persistent immune res

70 Initial data show AB680 is well tolerated and exhibits a pharmacokinetic profile suitabl

71 Conclusion: Ledipasvir-sofosbuvir was well tolerated and highly effective in children 3 to <6 years

72 All regimens were well tolerated and immunogenic, with trends toward higher ant

73 Ivosidenib monotherapy was well-tolerated and induced durable remissions and transfusion

74 decompensated heart failure (ADHF) was well-tolerated and led to improved outcomes.

75 (PS1) mice, two selected compounds were well tolerated and led to positive trends, albeit statistical

76 5 patients studied, (99m)Tc-PHC-102 was well tolerated and no study drug-related adverse events were

77 IL-2R signaling in Treg cells, but was well tolerated and only gradually impacted Treg cell function

78 Belapectin (2 mg/kg) was well tolerated and produced no safety signals.

79 lotherapy of the left gastric artery is well-tolerated and promotes clinically significant weight los

80 Single-agent EV was generally well tolerated and provided clinically meaningful and durable

81 Cilofexor for 24 weeks was well-tolerated and provided significant reductions in hepatic

82 d that self-sampling with foam swabs is well-tolerated and provides quantitative viral output concord

83 GB001 was well tolerated and rapidly absorbed with a 14.5-hour terminal

84 repeat dosing indicated that KB105 was well-tolerated and restricted to the dose site.

85 ab in combination with lenalidomide was well tolerated and resulted in a high proportion of patients

86 ccination using the HD-MAP was safe and well tolerated and resulted in immune responses that were sim

87 cted activities used for treatment were well tolerated and resulted in significant tumor growth inhib

88 Oral dosing of PRCL-02 was well tolerated and resulted in suppressed T-cell proliferatio

89 iparum [Pf] sporozoites [SPZ]) has been well tolerated and safe in >1526 malaria-naive and experience

90 antiretroviral regimens were generally well tolerated and showed a distinctive trend of increasing v

91 Pembrolizumab was well tolerated and showed encouraging antitumour activity in

92 mpared with aflibercept monotherapy, is well tolerated and shows modest anatomic benefit with potenti

93 R848 was well tolerated and significantly induced IFN-alpha2a, IFN-gam

94 bcutaneous and oral MSA-2 regimens were well tolerated and stimulated interferon-beta secretion in tu

95 range of aromatic aldehydes and ketones are tolerated and successfully converted into the correspond

96 Acalabrutinib was well tolerated and yielded an overall response rate (ORR) of

97 Extended treatment with VP250 was well tolerated, and desensitization observed at week 52 persi

98 e, and tenofovir alafenamide as a safe, well tolerated, and durable treatment for people with HIV, wi

99 ent vaccine regimen was generally safe, well-tolerated, and found to elicit higher immune responses t

100 ster #7085), we report that ONM-100 was well tolerated, and four solid tumor types could be visualize

101 Novel OPV2 candidates were as safe, well tolerated, and immunogenic as monovalent OPV2 in previou

102 Both novel OPV2 candidates were safe, well tolerated, and immunogenic in children and infants.

103 The C. difficile vaccine was safe, well tolerated, and immunogenic in healthy US adults aged 65-

104 LSPD was well tolerated, and no complement activation-related pseudoal

105 Treatment was well tolerated, and no events of hypoglycemia or hypotension

106 Both protocols were well tolerated, and no severe treatment-related adverse event

107 OPT-302 inhibition of VEGF-C and -D was well tolerated, and OPT-302 combination therapy may overcome

108 plus amodiaquine TACTs are efficacious, well tolerated, and safe treatments of uncomplicated P falcip

109 In addition, alkyl substituents are not tolerated, and the N-H proton of the aniline ring is res

110 Both treatments were well tolerated, and there were no serious adverse events.

111 Evolocumab was well tolerated, and treatment-emergent adverse events patient

112 e glucose conjugated compound was far better tolerated, and tumour growth delays for the parent compo

113 nidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF remains high.

114 CHX) has been described as a possibly better tolerated antimicrobial for ophthalmic procedures.

115 HD-MAP vaccination was safe and well tolerated; any systemic or local adverse events (AEs) we

116 Both Magnets components, which are well-tolerated as protein fusion partners, are photoreceptors

117 ults: Injections of (99m)Tc-ADAPT6 were well tolerated at all mass levels and not associated with adv

118 nd capecitabine, a prodrug of 5-FU, was well tolerated at biologically-active doses.

119 nce and cataplexy while generally being well tolerated at prescribed doses.

120 While a [4Fe-4S] cluster can be tolerated at the AuxI site, the aggregate findings sugge

121 s a safe and painless procedure that is well tolerated because it avoids rectal trauma and patients r

122 However, systemic delivery of R848 is poorly tolerated because of its poor solubility in water and sy

123 bability (TCP) of 99% and, second, a maximal tolerated biologically effective dose (BED(max)) for org

124 ucel-T immunotherapy as maintenance was well tolerated but the primary endpoint was not met.

125 The vaccine was relatively well tolerated, but a high percentage developed a fever >=37.

126 AGS-004 and VOR were safe and well-tolerated, but no substantial impact on RCI was measured

127 Results: (68)Ga-DOTA-Siglec-9 was well tolerated by all subjects.

128 er as well as more beneficial for and better tolerated by at-risk individuals.

129 troduced alleles (RAs) are more likely to be tolerated by modern humans than are introgressed Neander

130 Desmopressin is well tolerated by most patients, however adverse effects, suc

131 Rs also highlight the types of modifications tolerated by MutY and will guide the development of spec

132 e anti-inflammatory properties, and are well tolerated by the brain, D-serine, an endogenous amino ac

133 Desiccation of plants is often lethal but is tolerated by the majority of seeds and by vegetative tis

134 , in which loss-of-function variants are not tolerated, can be highly successful as targets of inhibi

135 e infusions of ketamine were relatively well tolerated compared to active placebo, except for greater

136 ved progression-free survival and was better tolerated compared with sorafenib in patients with metas

137 an be broadly induced by the clinically well-tolerated compound Quisinostat.

138 al ultrasound, an easily repeatable and well-tolerated diagnostic imaging modality, can address these

139 The maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D,

140 ive of phase Ib was to determine the maximum tolerated dose (MTD) for lenvatinib plus pembrolizumab (

141 At the maximum tolerated dose (MTD) of 400 mug/d, the response rate was

142 Once the maximum tolerated dose (MTD) was established, 21 patients were t

143 ty, dose-limiting toxicities (DLTs), maximum-tolerated dose (MTD), and preliminary antitumor activity

144 56.8 muM), and low in vivo toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with

145 ary objectives were to determine the maximum tolerated dose and dose limiting toxicities of brentuxim

146 The maximum tolerated dose and non-tolerated dose were not reached i

147 tor-initiated study was to determine maximum tolerated dose and safety.

148 s the MFIS measured while taking the highest tolerated dose at week 5 of each medication period, anal

149 wever, and whether escalation to the maximum tolerated dose confers clinical benefits that outweigh t

150 sion part, the starting dose was the maximum tolerated dose from the dose-escalation part).

151 The maximum tolerated dose of anetumab ravtansine was 6.5 mg/kg once

152 Maximum tolerated dose of EV was not established; however, the r

153 logical levels of erythropoietin with a well-tolerated dose of the inducer oligonucleotide.

154 n continuous 28-day cycles until the maximum tolerated dose or recommended phase 2 dose was determine

155 4;11 xenograft tumor model in mice at a well-tolerated dose schedule.

156 1:1 to liraglutide (1.8 mg daily or maximum tolerated dose up to 1.8 mg daily) or placebo plus stand

157 In phase 1, the established maximum tolerated dose was 40 mg of melflufen in combination wit

158 The maximum tolerated dose was 400 mg, and the recommended phase 2 d

159 The maximum tolerated dose was not reached; 500 mg once per day was

160 Maximum tolerated dose was not reached; there were no dose-limit

161 The maximum tolerated dose and non-tolerated dose were not reached in the dose escalation p

162 olerability, the non-tolerated dose, maximum tolerated dose, and recommended phase 2 dose (RP2D).

163 the tolerability, systemic exposure, maximum tolerated dose, and the antitumour activity of nivolumab

164 termine the safety and tolerability, the non-tolerated dose, maximum tolerated dose, and recommended

165 Primary endpoints were maximum tolerated dose, recommended phase 2 dose, and safety in

166 pite receiving statin therapy at the maximum tolerated dose.

167 imary objective was to determine the maximum tolerated dose.

168 primary objective was estimating the maximum tolerated dose; the secondary objectives were to assess

169 n who remained symptomatic despite maximally tolerated doses of GDMT were randomized 1:1 to the Mitra

170 esults of skin test and cellular assays, and tolerated drugs in subsequent pharmacological treatments

171 sy to repeat the study and the study is well tolerated during follow-up.

172 +) secondary MR were randomized to maximally tolerated GDMT plus MitraClip or GDMT alone; 599 had cor

173 n who remained symptomatic despite maximally tolerated GDMT, regardless of prior CRT implantation.

174 ucoma was defined as IOP >21 mmHg on maximum tolerated glaucoma medications or progressive visual fie

175 n who remained symptomatic despite maximally tolerated guideline-directed medical therapy (GDMT).

176 tive suppression of huntingtin was generally tolerated, however high dose AAV5-miHTT did induce astro

177 Siltuximab was well tolerated; however, adverse events of grade 3 or worse w

178 ed that a variant of AL002c is safe and well tolerated in a first-in-human phase I clinical trial and

179 resumed DR-TB infection is feasible and well tolerated in a high TB burden setting.

180 However, the switch to I438K expression is tolerated in adult mice, sparing normal cells but allowi

181 PCV20 was well tolerated in adults 60 to 64 years of age, with a safety

182 s kinase 1 inhibitor, was effective and well tolerated in adults with moderate-to-severe atopic derma

183 /- 28 MBq of the radiotracer, which was well tolerated in all patients over a follow-up period of 4 w

184 y demonstrates that (67)Cu-CuSarTATE is well tolerated in BALB/c nude mice and highly efficacious aga

185 DSR was well tolerated in both animals and human subjects and produce

186 Nivolumab was safe and well tolerated in children and young adults and showed clinic

187 ision with amplified centrioles, known to be tolerated in disease states, can occur as part of a norm

188 kably, PHP.eB-iMecp2 administration was well tolerated in female Mecp2 mutant or in wild-type animals

189 ous Ad26,MVA Ebola vaccine regimens are well tolerated in healthy adults, regardless of interval or d

190 ul, durable responses and was generally well tolerated in heavily pretreated patients with relapsed o

191 cate that these candidate compounds are well tolerated in mice without any significant side effects.

192 the analogue and established that 3 is well tolerated in mice, displays substantial PK improvements

193 yed excellent brain penetration and was well-tolerated in mice.

194 the presence of a certain level of rNMPs is tolerated in mitochondrial DNA (mtDNA) although aberrant

195 ophobic substitutions to levels that are not tolerated in monomers.

196 Treatment was well tolerated in most however serious AEs can occur in those

197 vacamten, a novel myosin inhibitor, was well tolerated in most subjects with symptomatic nHCM.

198 Although OGG1 depletion is well tolerated in non-transformed cells, we report here that

199 In contrast, type II is well-tolerated in normal monkeys and shows both acute and pro

200 ChAdOx1 nCoV-19 appears to be better tolerated in older adults than in younger adults and has

201 treatment of migraine and was safe and well tolerated in patients for whom multiple previous standar

202 PF-06700841 was generally effective and well tolerated in patients with moderate-to-severe plaque pso

203 y cohort.CONCLUSIONOral NAC is safe and well tolerated in patients with moderately advanced RP and ma

204 In summary, daratumumab is well tolerated in patients with relapsed AL amyloidosis and l

205 of life measures, and it was generally well tolerated in patients with uncontrolled, persistent (pha

206 BAT product was well tolerated in patients.

207 ADx-001 was well tolerated in rats and monkeys and exhibited the slow cle

208 The regimen was also well tolerated in the majority of patients in this older popu

209 targets showed that 2'-5' linkages were well tolerated in the sense strand, but only at a few positio

210 LAIV appears to be well tolerated in the vast majority of children with asthma o

211 CHMI was safe and well tolerated in this population.

212 Overall, MDMA was well-tolerated in this sample.

213 as single or multiple doses is safe and well tolerated in very young infants and is suitable for furt

214 Debio-1452-NH3 is well tolerated in vivo, reduces bacterial burden in mice and

215 a bioactive anti-inflammatory compound well tolerated in vivo, that shows efficacy in reducing disea

216 ved in vitro profiles, but these were poorly tolerated in vivo.

217 A wide array of alkene substrates are tolerated, including complex drug-like molecules and a t

218 verattenuated, but the 106 PFU dose was well tolerated, infectious (RSV/DeltaNS2/Delta1313/I1314L rep

219 -BEYOND clinical trial (NCT01864798) is well tolerated, inhibits RANK pathway and increases tumor inf

220 Although PI is generally well tolerated, it can be associated with significant ocular

221 ne in patients without rheumatic disease who tolerated LD-MTX during an active run-in period.

222 uncontrolled open-angle glaucoma on maximum tolerated medical therapy.

223 and optic nerve head changes despite maximal tolerated medical therapy.

224 rticles provides a simple, low-cost and well-tolerated method for increasing drug and vaccine deliver

225 gregarious nonhuman primates, eye contact is tolerated more and may be used to communicate other emot

226 D/C/F/TAF was well tolerated, no participants discontinued due to baseline

227 Ripretinib is a well-tolerated, novel inhibitor of KIT and PDGFRA mutant kina

228 and electron-releasing substituents are well tolerated on the phthalide core as well as on the aromat

229 t a substantial number of mutations are well tolerated or even enhance ACE2 binding, including at ACE

230 Most tolerated oral miltefosine well, with mild gastrointesti

231 Atogepant was safe and well tolerated over 12 weeks, supporting its phase 3 developm

232 Thus, there is a need for well-tolerated presurgical therapies that could reduce the si

233 for patients who have not benefited from or tolerated previous standard-of-care treatments.

234 Long-term PGDHi was well-tolerated, reduced the severity of pulmonary fibrotic le

235 stration as well as new, shorter, and better-tolerated regimens.

236 ted human airway organoid cultures, was well tolerated (selectivity index > 7,111) and orally bioavai

237 tion, all doses tested of JNJ-6379 were well tolerated, showed dose-dependent pharmacokinetics, and h

238 low LS BMD, 48 weeks of alendronate was well-tolerated, showed no safety concerns, and significantly

239 year leads to continued response from a well-tolerated, simple-to-use regimen.

240 nib, regorafenib for patients who previously tolerated sorafenib, or ramucirumab (for patients with a

241 ndrome and were on high-intensity or maximum-tolerated statin therapy, with a baseline low-density li

242 erolemia/mixed dyslipidemia taking maximally-tolerated statin therapy.

243 id levels in dyslipidemic PLHIV on maximally-tolerated statin therapy.

244 te coronary syndrome on intensive or maximum-tolerated statin treatment who were randomized to the PC

245 but reveal inherent constraints restricting tolerated substitutions due to epistasis.

246 ast majority of the surface-exposed residues tolerated substitutions without loss of RD3's inhibitory

247 with HIV-1 infection and were generally well tolerated, supporting the further development of islatra

248 However, although being generally far better tolerated than classic cytotoxic chemotherapy, this trea

249 latory activity and that these RAs were more tolerated than NDAs.

250 r dose of ChAdOx1 nCoV-19 is safe and better tolerated than priming doses.

251 Suicide attempters tolerated the breath-hold and cold-pressor challenges fo

252 ompared with baseline; and 13.5% (19 of 141) tolerated the full double-blind, placebo-controlled food

253 The non-human primates tolerated the implant without gross pathology or microsc

254 All animals tolerated the procedure very well and gained weight with

255 Although PT2385 was well tolerated, the findings indicate the need for caution in

256 Highly effective, well-tolerated therapies are now available with markedly simp

257 Six pediatric patients with glioma tolerated this combination without significant adverse e

258 ary analysis, and the PDS generally was well tolerated throughout the entire study period.

259 Oral miltefosine is a generally well-tolerated treatment adjuvant in patients with refractory

260 ipenem/relebactam is an efficacious and well-tolerated treatment option for carbapenem-nonsusceptible

261 sease and nutritional status in patients who tolerated treatment.

262 rs, nitriles, alcohols, and heterocycles are tolerated under the mild conditions.

263 ld type HTT (wtHTT) in Hu21 control mice was tolerated up to 7 months post-injection but may induce i

264 tive transdermal testosterone, although well tolerated, was not more effective than placebo in improv

265 The procedure was tolerated well in over 100 SHR and normotensive rats tha

266 potent antitumor activity and was very well tolerated when compared to the initial BTC.

267 8430 was well tolerated when delivered to mice and significantly suppr

268 nt antitumor activity in vivo but was poorly tolerated, which was hypothesized to be the result of un

269 with ROS1 fusion-positive NSCLC, and is well tolerated with a manageable safety profile, making it am

270 fusion-positive solid tumours, and was well tolerated with a manageable safety profile.

271 All treatment regimens were well tolerated with additional exposure.

272 IP RIT (131)I-omburtamab was well tolerated with minimal toxicities.

273 The treatment was well tolerated with minimal toxicities.

274 Treatment was well tolerated with no grade 5 treatment-related adverse even

275 C1-INH was well tolerated with no new safety signals identified in this

276 All regimens were well tolerated with no serious vaccine-related adverse events

277 Mavorixafor was well tolerated with no treatment-related serious adverse even

278 Subcutaneous VRC01 was safe and well tolerated with only mild-to-moderate local reactions, pr

279 nstrate that a wide array of substituents is tolerated with this novel scaffold that increased cellul

280 Remdesivir was well tolerated, with a low incidence of serious adverse event

281 Both regimens were well tolerated, with a low number of participants reporting a

282 Ivosidenib plus azacitidine was well tolerated, with an expected safety profile consistent wi

283 The vaccine was tolerated, with induction of neutralizing antibodies and

284 ication of the lipid tail was generally well tolerated, with longer alkyl chains enhancing analogue c

285 h concurrent ibrutinib for R/R CLL were well tolerated, with low CRS severity, and led to high rates

286 Overall, BUP/SAM was generally well tolerated, with most adverse events (AEs) being mild or

287 All doses were generally safe and well tolerated, with no clinically relevant changes in any sa

288 Results: (89)Zr-IAB22M2C infusion was well tolerated, with no immediate or delayed side effects obs

289 Daratumumab-CyBorD was well tolerated, with no new safety concerns versus the intrav

290 Infusions were well tolerated, with no participants removed from the study a

291 f AFM13 and pembrolizumab was generally well tolerated, with similar safety profiles compared to the

292 M6620 was well tolerated, with target engagement and preliminary antitu

293 ative changes at positions 1 and 2 were well-tolerated, with Val(1)-Val(2), Ile(1)-Ala(2), and Leu(1)

294 Stress CMR was well tolerated without any adverse events.

295 itamin D concentrations were significant and tolerated without developing hypercalcemia.

296 The vaccine was well tolerated without safety concerns throughout the study.

297 Both doses were well tolerated without significant changes in BP, weight, or

298 Both regimens were generally well tolerated without unexpected toxicities.

299 y monitoring revealed that the drug was well tolerated, without an increase in plasma triglycerides.

300 Selatogrel was well tolerated, without major bleeding complications.