ライフサイエンスコーパス: tolerization

1 kade of other homing receptors also prevents tolerization.

2 shed the disease-suppressing effect of nasal tolerization.

3 cific Ag in the absence of adjuvant leads to tolerization.

4 l alloreactive T cells that may have escaped tolerization.

5 ts that have repopulated the periphery after tolerization.

6 g dominant myosin epitopes must have escaped tolerization.

7 act responses to antigens not present during tolerization.

8 immune system is particularly susceptible to tolerization.

9 ice are not subject to central or peripheral tolerization.

10 activation of TCR-stimulating dendritic cell tolerization.

11 receptors on T cells implicated in antigenic tolerization.

12 7a (Lamp1) mobilization, hallmarks of T-cell tolerization.

13 followed by cyclophosphamide (CY) for T-cell tolerization.

14 t gut-homing receptors are required for oral tolerization.

15 ure Th1 effector cytokine) during peripheral tolerization.

16 Wild-type but not p27delta cells underwent tolerization.

17 riding determinants of T cell priming versus tolerization.

18 In the context of CY tolerization, a high, fixed dose of haploidentical T cel

19 tered in the eye result in specific systemic tolerization; a phenomenon akin to gut-induced oral tole

20 HP-1, and MonoMac-6 cells, whereas endotoxin tolerization abrogated LPS inducibility of Pellino-1.

21 However, peptide tolerization affected in Tregs the activity of the MAPK

22 h1 effector CD4 cells are induced to undergo tolerization after exposure to cognate parenchymally der

23 Furthermore, immune tolerization against MOG ameliorated symptoms.

24 idually, CY but not IL-2 can markedly impede tolerization, although their combination is the most eff

25 unctional differences during early stages of tolerization and priming, suggesting that these divergen

26 Blockade of PD-1 signals prevented T-cell tolerization and restored tumor immunity.

27 -II cells was required to prevent TcR-I cell tolerization and significantly slowed progression of TRA

28 he role of CTLA-4 in the expansion, decline, tolerization, and differentiation of T cells following t

29 improved CD8(+) T cell expansion and reduced tolerization, and it was dependent on presentation of bo

30 preproinsulin2, suggesting antigen-specific tolerization, and on the cytokine combination encoded.

31 velop and are required within the LNs during tolerization, and provide compelling evidence that disti

32 ligands that in theory could promote immune tolerization; and 3) the practical intranasal delivery o

33 standing of these mechanisms - which include tolerization, anergy, senescence, cell death, exclusion

34 Accordingly, we are developing a tolerization approach to dnaJP1, a peptide part of a pat

35 have significant implications for the use of tolerization approaches to prevent human GVHD.

36 S-induced DC maturation and fail to drive DC tolerization as assessed by induction of Treg properties

37 se against these parasites owing to neonatal tolerization become productively infected with the filar

38 These results demonstrate that cross-tolerization between Nod1 and Nod2 leads to increase rec

39 vity of CD4+FoxP3+ T cells changed following tolerization, but the serum level of anti-mycobacterial

40 ce, selectively lacking CD103(+) DCs, failed tolerization by inhaled Ag.

41 Thus, tolerization by injection of the virus during the neonat

42 r results reveal that CagA is crucial for DC tolerization by modulating IL-10 secretion and, in turn,

43 n still occurred, indicating that priming vs tolerization cannot be explained by pathogen-induced thi

44 Here, we unveil how 2-AA-driven immune tolerization causes distinct metabolic perturbations in

45 In contrast, myosin tolerization completely abrogated myocarditis in mice im

46 In contrast, SVL9 tolerization completely abrogated the development of OAD

47 Successful tolerization depended on high plasma levels of cyclospor

48 Thus, for this endogenous Ag, cross-tolerization does not appear to be an operative mechanis

49 -bet expression during Th1 effector CD4 cell tolerization does not impair IFN-gamma expression potent

50 e severity of future-onset disease, via oral tolerization, effectively acting as a protective vaccine

51 were prevented from undergoing PD-1-mediated tolerization, either by antibody blockade of the PD-1-PD

52 selectin every other day for 10 days (single tolerization group) or on two tolerization schedules sep

53 tion schedules separated by 11 days (booster tolerization group).

54 so found to be a prerequisite for successful tolerization in clinical responders.

55 per lymph node structure and function during tolerization in murine cardiac transplantation.

56 Nod2 deficiency was associated with impaired tolerization in response to pathogenic and commensal bac

57 nly tumor control but also susceptibility to tolerization in the tumor microenvironment.

58 eriphery they generally undergo a process of tolerization in which they become hyporesponsive/anergic

59 L(-/-), but not CD62L(+/+), T cells prevents tolerization in wild-type recipients.

60 cular modeling, may circumvent cell death or tolerization induced by tumor Ag, and thus, may provide

61 Thus, neonatal "tolerization" induces immune deviation, not tolerance in

62 that contribute to this breakdown in T cell tolerization mechanisms is beginning to be deciphered.

63 This tolerization method should be applicable to the treatmen

64 of the Ifng locus during peripheral CD4 cell tolerization might allow for preferential expression of

65 ction in vitro and in an ovalbumin-dependent tolerization model in vivo.

66 This tolerization occurred at the time when the peptide reach

67 specific Ag expression on the activation and tolerization of Ag-specific B cells was assessed in vitr

68 e, with a MUC1 peptide resulted in transient tolerization of all splenic DCs.

69 Exposure to donor bone marrow allows rapid tolerization of alloreactive CD4 cells when the CD40 pat

70 ce and identify a role for PD-1 in the rapid tolerization of an alloreactive T-cell population via a

71 eted deletion of autoreactive lymphocytes to tolerization of autoreactive T cells and active inhibiti

72 mmune complexes via CR1/CR2 receptors in the tolerization of B-1b cells.

73 Tolerization of B10.RIII mice (H-2r) with i.v.-injected

74 Although these studies have shown peripheral tolerization of CD8+ T cells, the mechanism of antigen t

75 ow-derived cells and cross-presented for the tolerization of CD8+ T cells.

76 Such systemically circulating CEA promoted tolerization of CEA-specific CD8 T cells in the endogeno

77 nt parenchymal self-Ag and contribute to the tolerization of cognate naive and Th1 effector CD4 cells

78 lls, or even self-tissue, for stimulation or tolerization of CTLs.

79 rine studies indicate that H. pylori induces tolerization of DCs and impairs DC maturation, the virul

80 y cells, such as activation of Th2 cells and tolerization of dendritic cells by suppressing IL-23 pro

81 bone marrow transplantation was critical for tolerization of diabetogenic and alloreactive host T-cel

82 tion, anergy, and regulation) to include the tolerization of donor antigens that are introduced throu

83 lation in vitro and are required for ex vivo tolerization of donor T cells, which results in their re

84 Moreover, neonatal tolerization of LysMcre mice with p105-119 or ML-M abrog

85 ne repertoire; and (c) adoptive transfer and tolerization of MCC-specific Vbeta3(+)/Valpha11(+) trans

86 able of Ag cross-presentation and subsequent tolerization of naive CD8(+) T cells.

87 Furthermore, reduced tolerization of Nod2-deficient macrophages in response t

88 providing a mechanism to explain the reduced tolerization of Nod2-deficient macrophages infected with

89 Mechanistically, reduced tolerization of Nod2-null macrophages was mediated by re

90 w that pretreatment with IFN-gamma prevented tolerization of primary human monocytes and restored TLR

91 Deletion or tolerization of SEB-reactive V beta T cells was not obse

92 lex rather than to the continual deletion or tolerization of self-reactive T cells.

93 h as the failure to affect HSK severity upon tolerization of susceptible BALB/c and B-cell-deficient

94 Tolerization of T cells directed against a target autoan

95 permanent marrow engraftment and intrathymic tolerization of T cells that develop subsequently.

96 Much work has focused on tolerization of T cells using proteins or peptides.

97 or-associated dendritic cells (TADC) reduced tolerization of TCR(hi) T cells and enhanced their antit

98 est that neuroendocrine axes are crucial for tolerization of the innate immune system to microbial en

99 EAE could be inhibited by prior tolerization of the mice with soluble PLP(139-151) pepti

100 hat different mechanisms are involved in the tolerization of the preexisting and newly-developing ant

101 We report that endotoxin tolerization of THP1 cells and human monocytes impairs L

102 A20 shRNA knockdown abolished LPS tolerization of THP1 cells, mechanistically linking A20

103 Aire promotes the tolerization of thymocytes by inducing the expression of

104 system to avoid autoimmune disease relies on tolerization of thymocytes to self-antigens whose expres

105 njection of Ag-loaded mature DCs delayed the tolerization of tumor-infiltrating effector CD8 T cells.

106 trategies to treat cancer is by impeding the tolerization of tumor-reactive effector T cells.

107 nduction, and the effects of this peripheral tolerization on myosin-induced myocarditis were assessed

108 tested was the effect of mycobacterial Hsp65 tolerization on T cell responses to AIA-related mycobact

109 The ideal scenario involves the tolerization or anergy of the donor T cell that attacks

110 d Ags in a manner that elicits either T cell tolerization or immunity, respectively.

111 latory pathway, would be a valuable tool for tolerization or immunization, respectively.

112 wed by ITI (rFVIIIFc 200 IU/kg per day until tolerization or maximum of 48 weeks).

113 venting the secondary booster response, oral tolerization permits repeated adenovirus-directed gene t

114 T cell tolerization prevents and improves T cell-mediated exper

115 Antigen (Ag)-specific tolerization prevents type 1 diabetes (T1D) in non-obese

116 ECs, suggesting that estrogens may alter the tolerization process and favor environment for an autoim

117 In autoimmune conditions, breakdown in the tolerization process results in activation of self-react

118 translocation to the nucleus to establish a tolerization program.

119 ut prevented long-term graft acceptance in a tolerization protocol that did not induce chimerism.

120 facilitated long-term graft acceptance in a tolerization protocol that induced mixed chimerism, but

121 An immunosuppression/tolerization protocol was initiated in case 2 because of

122 lowed for at least 30 months of therapy, the tolerization rate was 93%.

123 This tolerization regimen suppressed the strong myosin-specif

124 A tolerization regimen was developed that prevents a stron

125 s a promising target, although memory T cell tolerization remains challenging.

126 otransfer of TcR-II cells delayed TcR-I cell tolerization, repeated transfer of TcR-II cells was requ

127 gen-specific naive CD4(+) T cells, with this tolerization reversed by conditional ablation of MHC-II

128 In contrast to oral tolerization, s.c. immunization of transgenic animals wi

129 tin every other day for 10 days on a mucosal tolerization schedule suppressed delayed type hypersensi

130 0 days (single tolerization group) or on two tolerization schedules separated by 11 days (booster tol

131 Enforcing T-bet expression during tolerization selectively rescued the ability to express

132 6.SJL to BALB/c marrow transplants, but with tolerization, stable multilineage chimerism was obtained

133 fected with an irrelevant vaccinia, CD4 cell tolerization still occurred, indicating that priming vs

134 properties of H. pylori can be exploited for tolerization strategies aiming to prevent allergen-induc

135 daily practice, novel treatment options and tolerization strategies are underway.

136 s, using mutant-viral strains, peptide-based tolerization strategies, or short-term anti-IFN-gamma tr

137 0th, position on the peptide carrier; and 3) tolerization studies confirmed down-regulation of PDC-in

138 eptibility of effector T cells to undergoing tolerization suggests that tolerance might also negative

139 Finally, GM-CSF-induced LKS+ tolerization takes place in several murine models of tra

140 elf-Ag-expressing mice eventually succumb to tolerization, this delay results in an increased level o

141 mmatory context, while leaving available for tolerization those delivered in a noninflammatory contex

142 ary immune response can be abrogated by oral tolerization to adenoviral antigens, we immunized biliru

143 tissues are an important site for peripheral tolerization to alloantigen.

144 protease inhibitor 6, are also resistant to tolerization to alloantigen.

145 Tolerization to beta-gal96-103 significantly prolonged b

146 Tolerization to dnaJP1 leads to immune deviation and a t

147 g the first application of systemic-mediated tolerization to improve the efficacy of brain injections

148 ogether, these results suggest that CD4 cell tolerization to parenchymal self-Ags and priming to path

149 elicit tolerization toward self-HA, CD4 cell tolerization to viral-HA did not occur.

150 l insights and may prove instrumental in the tolerization toward non-self therapeutic proteins delive

151 s extended for the period required to elicit tolerization toward self-HA, CD4 cell tolerization to vi

152 e protected against acute disease, but after tolerization treatment a lethal demyelinating disorder e

153 , the signaling cascades engaged in human DC tolerization upon H. pylori infection remain unknown.

154 xploring an approach toward antigen-specific tolerization using erythrocyte-binding antigens, based o

155 n of potent immunoregulatory capacity during tolerization via CD40:CD40L blockade provides a fail-saf

156 The mean time for humoral tolerization was 28 months from initiation of therapy.

157 Blockade of T1D following CNP-T1D tolerization was characterized by regulatory T cell indu

158 TNF-induced cross-tolerization was mediated by suppression of LPS-induced

159 For oral tolerization, we administered to the immunized rats prot

160 his immune response can be abrogated by oral tolerization, we instilled protein extracts of a recombi

161 Thus, oral tolerization with adenoviral antigens permits long-term

162 After tolerization with an artificial peptide (pConsensus, pCo

163 We have previously shown that tolerization with an artificial peptide based on these T

164 Remarkably, tolerization with any one of the nucleosomal peptides im

165 We also demonstrate that immune tolerization with AQP4201-220-coupled poly(lactic-co-gly

166 data in ITI, rFVIIIFc offered short time to tolerization with durable responses in almost two-thirds

167 Single tolerization with E-selectin had only a slight trend tow

168 Here we show that oral or i.p. tolerization with H. pylori extract prevents the airway

169 ory cells from a CD4+CD25- population during tolerization with IL-10 and TGF-beta provides an additio

170 but containing plasmacytoid DCs (pDCs), fail tolerization with inhaled Ag and cannot support Foxp3 in

171 duced diabetes in the PVG.RT1u rat, neonatal tolerization with insulin B-chain peptides, but not A-ch

172 a model of organ-specific autoimmunity, oral tolerization with myelin basic protein was abrogated as

173 Our data suggest that tolerization with pCons activates different subsets of i

174 Tolerization with peptide:PDC conjugate resulted in abro

175 Primary end point was time to tolerization with rFVIIIFc defined by inhibitor titer <0

176 ammation in the local microenvironment, oral tolerization with self antigens may provide a therapeuti

177 Tolerization with soluble mycobacterial Hsp65 leads to s

178 The effects of preimmunization and tolerization with these epitopes on the development of d

179 nherited metabolic disease following central tolerization with thymic antigen.

180 sorbent (ELISPOT) analysis revealed specific tolerization (within 4 to 15 days) of both T helper 1 (T