ライフサイエンスコーパス: tolerize

1 L-12 restored the ability of low-dose LPS to tolerize.

2 epitopes, against which wild-type mice were tolerized.

3 nstrate that this repertoire is peripherally tolerized.

4 ce traffic to the prostate where they become tolerized.

5 ay express antigens to which the host is not tolerized.

6 responsive to the sialylated antigen become tolerized.

7 K1 or the E3 ubiquitin ligase Itch cannot be tolerized.

8 ed very weak effector function and were soon tolerized.

9 ail to develop cytolytic function and become tolerized.

10 ot ignorant and naive CD4(+) T cells are not tolerized.

11 could control tumor growth without becoming tolerized.

12 self-peptides to which the host has not been tolerized.

13 tigen-specific T cells were induced after a "tolerizing-administration" of antigen and that GRAIL exp

14 which IFN-gamma-producing CD8(+) T cells are tolerized after type 1 immune responses to chronic virus

15 on with vaccination restores the function of tolerized Ag-specific CD8 T cells in models of self and

16 was unexpectedly influenced by the source of tolerizing Ag and help was selectively required to facil

17 e CD8 cell effector differentiation when the tolerizing Ag derived from self.

18 When Th1 effector CD4 cells encounter tolerizing Ag in vivo, their capacity to express the eff

19 , when parenchymal self-Ag was the source of tolerizing Ag, enforced dual costimulation selectively b

20 Similarly, LEW rats neonatally tolerized against either Rhsp65 or Bhsp65 were significa

21 Mice tolerized against either TSKB20 or TSKB74, or both epito

22 loreactive T cells were not detected in mice tolerized against specific alloantigens.

23 Furthermore, BALB/c mice tolerized against the TSKD14 peptide effectively control

24 adjuvant, when administered together with a tolerizing agent such as nondepleting anti-CD4, can faci

25 the PD-1/PD-L1 pathway is needed to rapidly tolerize alloreactive CD8 cells in a model that requires

26 Thus, the requirements for tolerizing alloreactive and autoreactive NOD CD4 cells a

27 y of human and mouse TADCs, respectively, to tolerize and induce suppressive activity by T cells.

28 ressed as a self-antigen become functionally tolerized and express high levels of surface PD-1 by the

29 However, the major difference when comparing tolerized and primed T cells was that the latter formed

30 Although both tolerized and rejecting alloreactive CD8 cells up-regula

31 esponse to self-antigen: instead of becoming tolerized and repressed from secreting autoantibody, Pik

32 cells, offspring B cells were not centrally tolerized and retained their ability to respond to the i

33 to determine whether an immunocompetent rat, tolerized and transplanted with a human hepatoma cell li

34 HCV-inoculated immunocompetent rats tolerized and transplanted with Huh 7 cells support HCV

35 in both human and mouse prostate cancer that tolerizes and induces suppressive activity in tumor-spec

36 monocytes and in vitro-differentiated naive, tolerized, and trained macrophages.

37 or obstacle to antitumor immunity because it tolerizes/anergizes tumor-reactive T cells by binding to

38 The DC of the tolerized animal, especially plasmacytoid DC, produced i

39 11b(+) DCs, which are abundant in the CNS of tolerized animals, play a crucial role in i.v. tolerance

40 n of OVA with low-dose LPS was suppressed in tolerized animals.

41 Aiming to tolerize anti-rabbit responses, we coadministered a brie

42 paternal Ag during insemination activated or tolerized anti-paternal CD8+ T cells.

43 mouse allergic model, injection of high-dose tolerizing antigen failed to block the development of ai

44 ession is upregulated in T cells by self and tolerizing antigens in the thymus and periphery, governe

45 reg cell development in response to self and tolerizing antigens.

46 In vitro CD8(+)CD28(-)CD56(+) T cells tolerize APCs, prevent the priming of naive CD4(+) T cel

47 velopmental blockade implies the presence of tolerizing autoantigens that are mimicked by the membran

48 reveal the mechanisms on how mixed chimerism tolerizes autoreactive B cells in T1D.

49 but it is still unclear how mixed chimerism tolerizes autoreactive B cells.

50 nvestigate the ability of mixed chimerism to tolerize B cells producing antibodies of this important

51 h the 2.5HIP Ag (2.5HIP-coupled PLG NPs) can tolerize BDC-2.5 T cells.

52 high levels of self-reactivity that must be tolerized before entry into the mature B cell pool.

53 of a promoter site of MARCO was increased in tolerized BMDM.

54 ssion of MARCO, and impaired phagocytosis in tolerized BMDM.

55 ed allogeneic or xenogeneic chimerism indeed tolerizes both preexisting anti-Gal-producing B cells an

56 nfluences their decision to become primed or tolerized, but this has not been examined directly in vi

57 in this model, the autoreactive B cells are tolerized by anergy.

58 sponse, resulting from their inability to be tolerized by B. burgdorferi.

59 Mice were immunized or tolerized by DST or DST plus anti-CD40L mAb.

60 , TLR4 endocytosis is induced in macrophages tolerized by exposure to either LPS or UT12 and is indep

61 opulation that is naturally autoreactive and tolerized by functional anergy (BND cells).

62 frequently arise in the bone marrow but are tolerized by mechanisms including receptor editing, func

63 ts survived much longer and were more easily tolerized by non-immunosuppressed recipients.

64 These can be tolerized by nonmyeloablative induction of mixed chimeri

65 tored T-cell responsiveness to Ag previously tolerized by oral administration.

66 an thymocytes in human thymus grafts are not tolerized by the presence of an additional porcine thymu

67 Immune-tolerized canines achieved increased tissue enzyme level

68 the steady-state phenotype of DCs and their tolerizing capacity in vivo.

69 MHC-II molecules, suggesting they might also tolerize CD4 T cells.

70 for CD4 and CD8 is an effective strategy to tolerize CD4(+) and CD8(+) T cells in a tissue-specific

71 whether immature DCs in general are able to tolerize CD4(+) T cells or if this is a prerogative of s

72 ve mechanism where LN-resident stromal cells tolerize CD4(+) T cells through the presentation of self

73 imulation is partially restored when self-Ag-tolerized CD4 cells are retransferred into mice infected

74 gene gains transcriptional competence, these tolerized CD4 cells fail to express substantial amounts

75 Dby-SP-tolerized CD4(+) T cells fail to proliferate, secrete IF

76 hether Ag-SP tolerance could also be used to tolerize CD8+ T cells.

77 It is unclear whether tolerized CD8 T cells coexpress PD-1 and LAG-3 or whethe

78 injection of Ag-loaded DCs also reactivated tolerized CD8 T cells in the tumor tissue.

79 ntial for licensing CD8alpha+ DC and helping tolerized CD8 T cells.

80 nuation of chemokine expression in endotoxin-tolerized cells as shown in interferon regulatory factor

81 LPS-tolerized cells were observed to regain responsiveness i

82 ve regulators of TLR4 signaling, increase in tolerized cells.

83 and CD40 during infection, consistent with a tolerizing condition.

84 functional consequences to CD8 T cells under tolerizing conditions and manipulation of both Ag and cy

85 e populations of CD8 T cells activated under tolerizing conditions based on LAG-3 and PD-1 staining,

86 In contrast, p27delta cells proliferated in tolerizing conditions because of Cdk kinase activation a

87 enotypes on CD8 T cells under activating and tolerizing conditions.

88 OVA-specific IgE, as compared to uninfected tolerized control mice.

89 The lungs of surviving mice contained tolerized CXCR3-deficient Teff, as well as a large incre

90 n this article, we examined the self-antigen-tolerized DC phenotype, function, and mechanisms respons

91 r, the pathways essential for conferring the tolerizing DC phenotype and optimal methods for their in

92 te is not terminally differentiated and that tolerized DCs can recover their ability to induce immuni

93 However, tolerized DCs demonstrated a novel inducible expression

94 Moreover, tolerized DCs from sulfatide-treated animals can adoptiv

95 Tolerized DCs share some characteristics with immature D

96 We conclude that ex vivo A(2)AR-induced tolerized DCs suppress NKT cell activation in vivo and p

97 Tolerized DCs were not refractory to maturation after st

98 uced due to H. pylori gGT enzymatic activity tolerizes DCs by inhibiting cAMP signaling and dampening

99 evelopment of selective S1P3 antagonists for tolerizing DCs for cell-based therapy or for systemic ad

100 ells interacting with recipient class II MHC tolerize directly alloreactive CD8 cells.

101 Myelin microarrays demonstrate that tolerizing DNA vaccination plus GpG-ODN further decrease

102 Moreover, the addition of GpG-ODN to tolerizing DNA vaccination therapy effectively reduced o

103 BHT-3009 is a tolerizing DNA vaccine for MS, encoding full-length huma

104 desired CpG-induced inflammatory effect of a tolerizing DNA vaccine in a Th1-mediated autoimmune dise

105 (EAE), combining a myelin cocktail plus IL-4-tolerizing DNA vaccine with a suppressive GpG oligodeoxy

106 argeting pathogenic T cells with Ag-specific tolerizing DNA vaccines encoding autoantigens is a power

107 that will boost the efficacy of Ag-specific tolerizing DNA vaccines used for treating Th1-mediated a

108 Tolerized donor-reactive T-cell receptor transgenic CD8

109 al application of this novel class of T-cell-tolerizing drugs for patients with optic neuritis.

110 TLRs and inflammatory cytokines, may become tolerized during sustained exposure to bacterial structu

111 Immature dendritic cells (imDCs) can have a tolerizing effect under normal conditions or after trans

112 ing systemic responses are refractory to the tolerizing effects of mucosal Ag encounter.

113 critically and nonredundantly to H. pylori's tolerizing effects on murine DCs in vitro and in vivo.

114 erally expressed endogenous superantigen are tolerized either by deletion or TCR revision.

115 of antibody and miRNA-150 was established by tolerizing either panimmunoglobulin-deficient JH(-/-) or

116 sponse can be initiated by a DC vaccine, the tolerizing environment created by the tumor still exerts

117 ells at high levels after stimulation within tolerizing environments.

118 PKs; conversely, IL-13(-/-) macrophages were tolerized equivalently to WT MPhis by LPS pretreatment.

119 ells (DCs) is generally a noninflammatory or tolerizing event to prevent the development of autoreact

120 dentified IL-10 as the secreted inflammasome-tolerizing factor that acts in an autocrine manner to co

121 se model in which CD8 T cells are neonatally tolerized following interaction with a parenchymal self-

122 TNF tolerized genes encoding inflammatory molecules to preve

123 deposit active histone marks at promoters of tolerized genes.

124 ontrast, cytokine induction was preserved in tolerized GILZ KO animals.

125 ng identifies clear features in T cells from tolerized grafts that are distinct from those involved i

126 uch as hBD2 and LL-37 was augmented, even in tolerized HCECs.

127 RNEU(420-429) in nontolerized FVB/N but not tolerized HER-2/neu (neu-N) mice.

128 ed that tumor-free survival in up to 100% of tolerized HER-2/neu transgenic mice can be achieved by a

129 cted groups of mice were immunized (s.c.) or tolerized (i.v.) with the SVL9 peptide before transplant

130 Like WT mice, 100% of LPS-tolerized IL-4Ralpha-deficient mice survived LPS + d-gal

131 ivity and had an increased ability to resist tolerizing immune microenvironments.

132 Ag-specific tolerizing immunotherapy is considered the optimal strat

133 To understand whether tolerizing immunotherapy with a single peptide could con

134 a model, we found that CD8(+) T cells became tolerized in <24 h in an established tumor environment.

135 Research into how self-reactive T cells are tolerized in lymph nodes has focused largely on dendriti

136 or many years, how are self-specific T cells tolerized in the periphery?

137 ptively transferred into TRP-SIY mice became tolerized in the prostate draining lymph nodes.

138 nants of a native self protein are generally tolerized in the thymus, whereas those potentially direc

139 e host and that effector T cells are rapidly tolerized in the tumors.

140 Additionally, macrophages were partially tolerized in their ability to respond to TLR agonists.

141 Fetal rats were tolerized in utero with 10(5) Huh 7 cells.

142 In contrast, CD4 cells are tolerized independently of this pathway following BMT wi

143 ander regulation raises the possibility that tolerized individuals might also have a reduced capacity

144 mal cell expression of B7-H1 is required for tolerizing infiltrating T cells and preventing the persi

145 icularly challenging for NK cells, for which tolerizing inhibitory receptors for self-MHC class I is

146 must be present to protect from diabetes and tolerize islet-specific CD8(+) T cells, SCID mice were r

147 rom insulitis and diabetes, and to partially tolerize islet-specific CD8(+) T cells.

148 or activated islet antigen-specific T cells, tolerized islet antigen-specific T cells moved freely an

149 oreactive B cells escape elimination and are tolerized later in their lives via anergy.

150 portant in restoration of immune function of tolerized leukocytes under inflammatory events.

151 vity in response to a second LPS exposure in tolerized macrophages is accompanied by failure to depos

152 ical to MARCO expression and phagocytosis in tolerized macrophages, but did not affect the inflammato

153 ous CD4(+) T-cell proliferation by endotoxin-tolerized macrophages.

154 n salmonella-infected and lipopolysaccharide-tolerized macrophages.

155 y primed to overcome tumor Ag presented in a tolerizing manner and protected from the suppressive mec

156 ls because, in their absence, these uniquely tolerized MBP-specific T cells can again induce autoimmu

157 naturally autoreactive and controlled by the tolerizing mechanism of functional anergy.

158 A model for a new tolerizing mechanism that could account for the C delta-

159 ndritic cell (DC) vaccine could overcome the tolerizing mechanisms of tumor-bearing transgenic adenoc

160 Tolerizing mechanisms within the host and tumor microenv

161 Moreover, CD4(+)CD25(+) Tregs from tolerized mice adoptively transferred dominant tolerance

162 uction, adoptive transfer of CD4+ cells from tolerized mice at 6 weeks after treatment protected reci

163 sary for resistance to infection, we epitope-tolerized mice by high-dose i.v. injections of TSKB20 or

164 Tolerized mice demonstrated significantly reduced diseas

165 CD103(+) DCs from tolerized mice efficiently induced Foxp3 in cocultured n

166 e T-dependent antigen bacteriophage Phix174, tolerized mice exhibited normal primary and secondary an

167 epletion, the recovered B cells in long-term tolerized mice exhibited xenodonor-specific hyporesponsi

168 ive nanovesicles that were isolated from the tolerized mice for testing in active and adoptive cell-t

169 Of interest, tolerized mice had more pronounced Th17-type inflammatio

170 ach directly suppressed by CD8+ T cells from tolerized mice in a contact-independent manner.

171 tive transfer of regulatory populations, and tolerized mice in which bystander regulation has been de

172 the inhibitory function of CD8+ T cells from tolerized mice is sustained for up to 8 wk and at all ti

173 t-sensitized and challenged mice, whereas in tolerized mice levels were significantly reduced.

174 1/PDL1 interactions in the CD8+ T cells from tolerized mice reduced their expression of Foxp3 and the

175 c lymph nodes, and Peyer's patches of orally tolerized mice showed increased transforming growth fact

176 T cells from MPO409-428- but not OVA323-339-tolerized mice to animals with established anti-MPO auto

177 iveness of autoantigen-reactive T cells from tolerized mice was associated with a dramatic loss of 3G

178 The DC population derived from tolerized mice was predominantly CD11c(+), B220(+), Gr-1

179 Additionally, CD8+ Ti cells from pCons-tolerized mice were longer-lived suppressors that up-reg

180 Additionally, CD8+ T cells from tolerized mice were weakly cytotoxic against syngeneic B

181 eated plasmid gene transfer is applicable in tolerized mice without eliciting immune responses.

182 tory T cells (Tregs) enriched in the skin of tolerized mice, and depletion of Tregs or adoptive exper

183 dual effects on CD8+ suppressor T cells from tolerized mice, increasing the intracellular expression

184 e, proliferation of T cells was inhibited in tolerized mice, whereas systemic applications of cortico

185 mph nodes of both OVA323-339- and MPO409-428-tolerized mice.

186 2 and Th17 response to OVA in both naive and tolerized mice.

187 of non-T cells derived from the spleen of Ag-tolerized mice.

188 , neutrophils treated with P. gingivalis LPS-tolerized monocyte supernatant showed a high migration i

189 ter and promoting IL6 locus accessibility in tolerized monocytes.

190 ctor binding to the IL6 and TNF promoters in tolerized monocytes.

191 not alter proximal TLR4 signaling defects in tolerized monocytes.

192 In this study, we confirm that tolerized mouse bone marrow-derived macrophages (BMDM) s

193 Tolerized MPS I dogs treated with the higher dose receiv

194 in vivo generated lytic effector cells from tolerized, noncytolytic cells.

195 We found that chronic Nod2 stimulation cross-tolerizes not only to TLRs but also to the interleukin (

196 Whether B cells are tolerized or can be recruited into humoural immune respo

197 Lymph node and spleen cells from tolerized or control donors were harvested and cultured

198 POT T cells were not tolerized or deleted during thymic development and proli

199 response, CD4(+)T lymphocytes either remain tolerized or undergo clonal expansion.

200 eraction of DCs with naive CD4(+) T cells in tolerizing or priming conditions.

201 ineering variants that retain the ability to tolerize pathogenic CD4+ T cells, but do so in the absen

202 in PLNs, where they subsequently recruit and tolerize pathogenic T cells.

203 LR4) serves as one of the microbiota-induced tolerizing pathways.

204 Current protocols tolerize patients using cytotoxic immunosuppressives, wh

205 evelopment is rare in multiply exposed, well-tolerized patients.

206 ance induction, whereas adoptive transfer of tolerized pDCs induced Treg cell development and prolong

207 Tolerizing pDCs acquired alloantigen in the allograft an

208 Exposure to a tolerizing peptide Ag regimen instead induced aggressive

209 at the time of allogeneic BM transplantation tolerizes peripheral alloreactive T cells and permits es

210 bone marrow transplantation as the means of tolerizing peripheral CD4 T cells to alloantigens.

211 relapse was associated with acquisition of a tolerized phenotype in tumor-specific CD4(+) T cells, ch

212 tain stimuli can lead to a hypo-inflammatory tolerized phenotype or a hyper-inflammatory trained phen

213 tion of monocytes to macrophages with immuno-tolerizing phenotypes (HLA-DRlow, CD86low, PD-L1high, IL

214 s at the Pdcd1 locus therefore determine the tolerizing potential of TCR-ligation.

215 effectors of rejection, but both also have a tolerizing potential.

216 CD40L in combination with xenogeneic BMT can tolerize preexisting peripheral and intrathymic CD4 cell

217 We have examined anti-influenza responses in tolerized primary heart recipients, secondary recipients

218 A-specific TCR-transgenic mice that the same tolerizing protocol (CD4 blockade) and the same target A

219 ecific effector cells with cells from col(V)-tolerized rats suppressed severe vasculitis and bronchio

220 okine, and antibody responses were tested in tolerized rats.

221 ne response to mycobacterial Hsp65 in B cell-tolerized rats.

222 were deficient in the ability of these cross-tolerized receptors to phosphorylate effector signaling

223 NKG2D blockade in tolerized recipients did not cause acute rejection but i

224 ction showed that intragraft Foxp3 levels in tolerized recipients were approximately 100-fold higher

225 trongly downregulated after treatment with a tolerizing regimen.

226 tromal cells (LNSCs), have been described to tolerize self-reactive CD8(+) T cells in LNs.

227 ntigens (TSAs), which are presented and help tolerize self-reactive thymocytes.

228 The central tolerance phenotype implies that tolerizing self-Ag is expressed in bone marrow.

229 llowing replacement of the initial source of tolerizing self-Ag with a viral form of the same Ag.

230 ation and IL-2 production in response to the tolerizing self-antigen.

231 ge hypothesis") or by dominance of negative (tolerizing) signaling over proinflammatory signaling ("b

232 re remains incomplete knowledge about how DC-tolerizing signals evolve during tumorigenesis.

233 r findings reveal novel insights into how DC-tolerizing signals evolve in cancer to promote immune es

234 m to render responder T cells susceptible to tolerizing signals.

235 cells of a given clone can be activated and tolerized simultaneously in different microenvironments

236 o design more effective strategies to better tolerize small bowel grafts, prevent rejection and, ulti

237 with a TLR3 agonist, demonstrating that this tolerized state is not terminally differentiated and tha

238 gly, microRNA expression analysis during the tolerized state of THP-1 cells showed only miR-146a over

239 tivated APCs to differentiate into a unique, tolerized state with the ability to produce IL-10 and TG

240 esponsible for inducing or maintaining their tolerized state.

241 full development of anergy in response to a tolerizing stimulus.

242 nd that, in the absence of such recruitment, tolerizing strategies such as CD154 mAb therapy are inef

243 cells do not proliferate in response to the tolerizing superantigen, implicating TCR revision as a m

244 Such tolerized surroundings, however, can be exploited by cer

245 ells (DCs) have the potential to activate or tolerize T cells in an Ag-specific manner.

246 g and cell-intrinsic anergy is sufficient to tolerize T cells.

247 cells (DCs) determines whether they prime or tolerize T cells.

248 ly dispensable in the adult, as a previously tolerized T cell pool can buffer newly generated autorea

249 isease development in both models and safely tolerized T cell responses in an Ag-specific manner in p

250 -)CD86(-/-) DCs failed to reactivate already tolerized T cells in the tumor tissue, whereas interferi

251 nduction as well as refunctionalizes already tolerized T cells in the tumor tissue.

252 T cells and restoration of responsiveness of tolerized T cells.

253 capacity to inhibit IFN-gamma production in tolerized T cells.

254 CD8(+) T cell- and FasL-mediated lysis, and tolerizes T cells by reverse signaling through T cell-ex

255 CD5-dependent mechanisms to actively adjust tolerizing T cell responses under steady-state condition

256 In addition, TADCs tolerized TCR(hi) T cells but not TCR(lo) T cells in vit

257 1 effectors, was partially down-modulated in tolerized Th1 effectors.

258 and BCR-signaling capacity, thus being less tolerized than BND cells from healthy control subjects.

259 ill bacteria, but also those that protect or tolerize the host to potentially damaging antibacterial

260 A major goal for immunotherapy is to tolerize the immune cells that coordinate tissue damage

261 Finally, we could tolerize the potential for a hyperacute response, by pre

262 arify how the kidney/renal lymph node system tolerizes the immune system against circulating innocuou

263 that whereas CD8 T cells sensed TAg and were tolerized, the CD4 T cells remained ignorant throughout

264 to host lymphohemological tissues as well as tolerizing them in the host.

265 but also validate therapeutic strategies for tolerizing them.

266 Strikingly, in LPS-tolerized THP-1 monocytes, only miR-146a showed a contin

267 als were deficient in their ability to cross-tolerize to subsequent treatment with TLR2 and TLR4 liga

268 Splenic B cells from animals that have been tolerized to alglucosidase alfa with methotrexate can tr

269 chain (alphaMYHC) cause myocarditis and mice tolerized to alphaMYHC are protected from virus challeng

270 Peripheral CD4(+)Vbeta5(+) T cells are tolerized to an endogenous mouse mammary tumor virus sup

271 mmadelta T cells, when transferred from mice tolerized to an inhaled conventional Ag, suppress the al

272 This risks that the immune system tolerized to antigens expressed by progenitors may still

273 ating that NK cells in the chimeras had been tolerized to beta(2)m(-/-).

274 individuals with the intron 22 inversion are tolerized to FVIII and thus do not develop inhibitors.

275 Anti-ICOS-treated mice tolerized to hFVIII generated normal primary and seconda

276 lls expressing such activating receptors are tolerized to host tissues.

277 competent mice of two different strains were tolerized to human F.IX by hepatic gene transfer mediate

278 rly, adoptive lymphocyte transfers from mice tolerized to human FIX by hepatic AAV gene transfer indi

279 A total of 24 canines with MPS I were either tolerized to iduronidase or left nontolerant.

280 e beta (CAIKKbeta) in airway epithelium were tolerized to inhaled ovalbumin.

281 sm by which highly self-reactive B cells are tolerized to membrane and soluble self-Ags.

282 Repeated infection of infant mice tolerized to ovalbumin (OVA) through their mother's milk

283 s lacking cognate ligand, gradually becoming tolerized to self by day 100.

284 In contrast, T cells that were tolerized to the superagonist were unable to respond to

285 Remarkably, macrophages tolerized to TNF-alpha, but not to LPS, retained full se

286 Early demonstrations that mice could be tolerized to transplanted tissues with short courses of

287 The mammalian immune system is tolerized to trillions of microbes residing on bodily su

288 Therefore, in vivo expansion of tolerized transplanted cells is emerging as a novel and

289 In tolerized, transplanted, and HCV-infected rats, Huh 7 ce

290 In tolerized, transplanted, inoculated rats, but not contro

291 effector T cells and to restore function to tolerized tumor-infiltrating T cells for cancer immunoth

292 nical immunotherapeutic strategies rely on a tolerized tumor-reactive T-cell repertoire, resulting in

293 sis for broad-based therapeutic targeting of tolerizing tumor antigens.

294 ous T cell-based cancer immunotherapy is the tolerizing-tumor microenvironment that rapidly inactivat

295 lly, two injections of cCTLA4-Ig effectively tolerized two dogs against eight consecutive challenges

296 Tolerized wild-type cells had impaired Cdk2 and Cdc2 kin

297 to citrullinated proteins in CIA, mice were tolerized with a citrulline-containing peptide, followed

298 Mice were tolerized with Ag-SP before or after initiation of OVA/a

299 eous polygenic systemic lupus erythematosus, tolerized with an artificial peptide (pConsensus) based

300 ecruited to cardiac allografts in recipients tolerized with CD154 monoclonal antibody (mAb) plus dono