ライフサイエンスコーパス: tonsillar

1 tes included bladder (95; 16%), laryngeal or tonsillar (92; 15%), cutaneous (84; 14%), and pulmonary

2 y of tonsillar T follicular helper cells and tonsillar Ag-specific Ab-secreting cells.

3 most exclusive to GC T(FH) cells among human tonsillar and blood CD4(+) T cell subsets.

4 type 2 cytokines IL-5 and IL-13, from human tonsillar and blood ILC2s in response to stimulation wit

5 ed IL-22, IL-17F, and GM-CSF production from tonsillar and gut ILC3s.

6 Tonsillar and systemic T-cell responses differed between

7 ial and breast epithelia, and throughout the tonsillar and vaginal epithelia.

8 ical, vaginal, vulvar, penile, anal, tongue, tonsillar, and oropharyngeal).

9 planned neck dissection for carcinoma of the tonsillar area and to compare these data with the result

10 Tonsillar B and T cells expressed CD154 at a similar den

11 e; similar observations were made in primary tonsillar B cell cultures.

12 activation, strongly perturbed CD40-induced tonsillar B cell proliferation while potentiating the B

13 ty of the IgD(+)Strictly-IgM(-)CD38(+) human tonsillar B cell subpopulation have now allowed detectio

14 uli, including ligation of CD40, dense human tonsillar B cells (>98% cells in G(0)) have increased cl

15 egularly detected in purified naive (IgD(+)) tonsillar B cells (13 of 16 tonsils tested) but was neve

16 hanced significantly on peripheral blood and tonsillar B cells after activation by cross-linking surf

17 de Burkitt's B-cell lymphoma lines, isolated tonsillar B cells and at low levels in peripheral blood

18 in or B cell antigen receptor (BCR) on human tonsillar B cells and B cell lines promoted tyrosine pho

19 coprecipitates with Ig in lysates from human tonsillar B cells and B cell lines.

20 Gene expression profiling of human tonsillar B cells and mouse B cell lymphomas showed that

21 sed by a relatively large percentage of IgD+ tonsillar B cells and this percentage is proportional to

22 Here we show that activated blood and tonsillar B cells can be productively infected with HHV-

23 or KSHV reservoir, and virus activation from tonsillar B cells can result in salivary shedding and vi

24 CFSE staining of purified human tonsillar B cells demonstrated that naive IgD(+) and CD2

25 -derived dendritic cells (DCs) differed from tonsillar B cells in the set of cell fate genes they exp

26 gly costimulate proliferation of dense human tonsillar B cells ligated via their B-cell antigen recep

27 ene copies and the proportion of IgD-bearing tonsillar B cells that react with G6.

28 Here we show with purified tonsillar B cells that SDF-1alpha also attracts naive an

29 gement in multiple B cell lines and in human tonsillar B cells to define the role of p38 MAPK in prol

30 We performed a comparative analysis of human tonsillar B cells to identify the closest normal in vivo

31 pare BCR signaling responses in mature human tonsillar B cells undergoing germinal center (GC) reacti

32 ated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype.

33 Pretreating CD40-stimulated tonsillar B cells with anti-CD95 abolished B cell antige

34 Interestingly, pretreatment of tonsillar B cells with cytochalasin B dramatically reduc

35 ted by IRF8, we transfected purified primary tonsillar B cells with enhanced green fluorescent protei

36 In this study, we found that human tonsillar B cells with high surface expression of IgM or

37 Splenic and tonsillar B cells, CD34(+) stem cells, resting T cells,

38 Here, we subdivided human tonsillar B cells, including IgD(-)CD38(+) GC B cells, i

39 observed in certain B cell lines but not in tonsillar B cells, indicating a more general role for HE

40 4 beta7 integrins on B cell lines and normal tonsillar B cells, induces tyrosine phosphorylation of m

41 In model cell lines and human tonsillar B cells, we found that tunable DM/DO stoichiom

42 ssed on the surface of transfected cells and tonsillar B cells.

43 No such restriction was observed in tonsillar B cells.

44 velopment- and function-based transitions in tonsillar B cells.

45 critical for infection of MC116, as well as tonsillar B cells; in contrast, we confirm previous repo

46 8 density on freshly isolated unfractionated tonsillar B lymphocytes and on the activated 1,25(OH)2D3

47 hocyte infection with KSHV in which infected tonsillar B lymphocytes were expanded by providing mitog

48 is up-regulated upon activation of quiescent tonsillar B lymphocytes, although mRNA for the protein m

49 h a germinal center phenotype (RAMOS) or the tonsillar B-cell centroblast fraction with CD40 rapidly

50 Analysis of human tonsillar B-cell subpopulations revealed that FOXP1 show

51 esults suggest that fermentation products of tonsillar bacteria may play an important role in the lon

52 f the injured artery in the proximity of the tonsillar bed should be suspected.

53 cal progression were typical of other cases, tonsillar biopsy and subsequent examination of multiple

54 ve detectable prion deposition in diagnostic tonsillar biopsy or markers of prion infection in blood.

55 tissues from a necropsy series and assessed tonsillar biopsy samples as a diagnostic investigation f

56 HPV-positive tonsillar cancer in particular is emerging as a specific

57 eloped human papillomavirus (HPV)-associated tonsillar cancer within 12 months of each other.

58 In patients with tonsillar cancer, the mean difference in SUV(max) betwee

59 t compare radiotherapy (RT) with surgery for tonsillar cancer.

60 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral

61 Recent data suggest that the incidence of tonsillar carcinoma in the United States is increasing,

62 in 2 couples with concurrent development of tonsillar carcinoma who did not have other risk factors,

63 d HIV-infected men are at increased risk for tonsillar carcinoma.

64 ect diagnosed with moderately differentiated tonsillar carcinoma.

65 These tonsillar CCR6(+)B helper T cells were phenotypically di

66 experiments, we found that VZV infects human tonsillar CD4(+) T cells in culture, with 15 to 25% bein

67 CR3 was expressed in vivo on newly activated tonsillar CD4(+) T cells.

68 or for Tfh cells) represses HIV infection of tonsillar CD4(+) Tfh ex vivo, reduces GC formation, and

69 A significant increase in cross-reactive tonsillar CD8+ T cells recognizing conserved epitopes fr

70 ymography in two Burkitt cell lines and in a tonsillar cell suspension, while gelatinase A and inters

71 nal centers (GCs), we isolated GC cells from tonsillar cell suspensions and exposed them to EBV in vi

72 ubsets sorted from a unique collection of IM tonsillar cell suspensions.

73 med the presence, annotation, and markers of tonsillar cell types and provided evidence of age-relate

74 Recent work using human tonsillar cells demonstrated that ILC3s exposed to exoge

75 direct EBV infection into HPV16-immortalized tonsillar cells grown in organotypic raft culture, we sh

76 ers its cellular phenotype, we exposed human tonsillar cells to KSHV and characterized infected cells

77 However, clusters of infected tonsillar cells were detected where the epithelial surfa

78 Additionally, coculture of tonsillar cells with infected hepatoma cells lead to an

79 both established HIV infection in individual tonsillar cells.

80 the presence of double-stranded viral RNA in tonsillar cells.

81 ay be found in the centroblastic fraction of tonsillar cells.

82 parallel those reported in ex vivo isolated tonsillar centroblasts, centrocytes, and memory B cells.

83 he goals of surgery are to reduce cerebellar tonsillar crowding and restore posterior cerebral spinal

84 ofluorescence staining demonstrated that the tonsillar crypts are enriched with myeloid populations t

85 Here we found that ECs lining tonsillar crypts formed pockets populated by B cells exp

86 erium avium subsp. paratuberculosis into the tonsillar crypts of neonatal calves resulted in peripher

87 lymphocytes into the squamous epithelium of tonsillar crypts, beneath which germinal centers play ke

88 e show membranous expression of PD-L1 in the tonsillar crypts, the site of initial HPV infection.

89 In ex vivo tonsillar cultures, we observed that EBER1-loaded exosom

90 Tonsillar cytokine expression is closely related to exis

91 arged Meckel caves, cephaloceles, cerebellar tonsillar descent, and bilateral transverse venous sinus

92 One of three survivor strains isolated from tonsillar discard material from patients expressed high

93 vely) and a greater likelihood of cerebellar tonsillar ectopia (30.7%; P < .002 and P < .001, respect

94 e presence of GpIb alpha mRNA and protein in tonsillar endothelium.

95 th obstructive sleep apnea (OSA) followed by tonsillar enlargement (OR = 2.0; 95% CI, 1.0-3.8), enlar

96 ized criteria such as the presence of fever; tonsillar enlargement or exudate; tender and enlarged an

97 e absence of tender anterior cervical nodes, tonsillar enlargement, or exudate (negative likelihood r

98 levels of miR-200 family members in oral and tonsillar epithelia and in saliva.

99 Using immortalized human tonsillar epithelial (HTE) cells, increased radiation se

100 SJ755 blocked Fn binding by human tonsillar epithelial and A549 cells, suggesting that int

101 rnalization of streptococci by primary human tonsillar epithelial cells and immortalized human epithe

102 that membrane vesicles secreted by oral and tonsillar epithelial cells may serve as a tissue-specifi

103 fected cells, and immune response within the tonsillar epithelium to analyse potential factors that m

104 V can infect both T and B cells from primary tonsillar explant cultures.

105 e likelihood of strep throat are presence of tonsillar exudate, pharyngeal exudate, or exposure to st

106 the four Centor criteria: history of fever, tonsillar exudates, no cough, and tender anterior cervic

107 TdT(+) cells found within the tonsillar fibrous scaffold expressed CD34 and/or CD1a, i

108 ly (3-7 days post-vaccination) activation of tonsillar follicles and influenza-specific TFH-cell (CXC

109 s the prevalence of relevant immune cells in tonsillar follicles and support the use of tonsils as ly

110 T lymphocyte clusters in synovium and within tonsillar follicles.

111 ally in the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity.

112 ally in the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity.

113 er RT for early-stage cancers was higher for tonsillar fossa/posterior pillar cancers than for those

114 Here, we show that human tonsillar FRCs undergo dynamic reprogramming during life

115 d the ability of cytokines to maintain human tonsillar GC B cells (IgD-/CD39-/CD38+/CD77+) in the "CD

116 ated PC differentiation using purified human tonsillar GC B cells and a GC B cell-like cell line.

117 siologic mechanism, we screened single human tonsillar GC B cells for mutations occurring in the BCL-

118 miniscent of the feature of CD40L-stimulated tonsillar GC B cells.

119 ysis, we found that PD-1-expressing cTfh and tonsillar GCTfh cells were clonally related.

120 ition, staining for IRF8 was most intense in tonsillar germinal center (GC) dark-zone centroblasts.

121 escribed in vitro culture system using human tonsillar germinal center B cells was used to study the

122 Tonsillar herniation, foramen magnum stenosis, and sever

123 L40 completely blocked lymphocyte binding to tonsillar HEVs, whereas MECA-79 inhibited only 60%.

124 tags from a cDNA library prepared from human tonsillar high endothelial cells, we have identified a c

125 In human tonsillar histocultures, NL4-3 replicated to higher leve

126 ential induction of cell cycle regulators in tonsillar human B cell subpopulations that were activate

127 equent in acute infectious mononucleosis and tonsillar hyperplasia and identical to those observed in

128 with infectious mononucleosis and 12/16 with tonsillar hyperplasia).

129 nucleosis and 16 Swiss children with chronic tonsillar hyperplasia.

130 ildren without recurrent throat infection or tonsillar hypertrophy (304 enrolled; 266 followed up) we

131 gery and 6 months postsurgery in adults with tonsillar hypertrophy (sizes 2, 3, or 4 according to the

132 DB (Obstructive Apnea-Hypopnea Index <3 with tonsillar hypertrophy [Brodsky scale grade >=2]) were ra

133 tive than TE alone in treating patients with tonsillar hypertrophy and moderate to severe OSA.

134 ers are myriad, from subtle findings such as tonsillar hypertrophy to fulminant manifestations such a

135 5 years, boys, children with grade III or IV tonsillar hypertrophy, and non-asthmatic children.

136 elief, particularly in younger children with tonsillar hypertrophy.

137 involves the latent infection of a subset of tonsillar IgMl-expressing B cells, which then proliferat

138 Tonsillar ILC3s and regulatory B cells were visualized w

139 Tonsillar ILC3s minimally expressed granzyme B when expo

140 Transcriptomes of sorted tonsillar ILC3s were assessed by using microarray analys

141 ligand (CD40L) expression on circulating and tonsillar ILC3s.

142 The relationships between tonsillar immune responses, and viral infection and alle

143 s to evaluate the effectiveness of nasal vs. tonsillar immunization with S. mutans antigens in induci

144 y of human tonsil sections demonstrates that tonsillar interdigitating DC are also DO(+).

145 Tonsillar intraepithelial lymphocytes were also enriched

146 Tonsillar lymphocytes and SKW3 T lymphoma cells tethered

147 r, PSGL-1 levels were substantially lower on tonsillar lymphocytes than on circulating lymphocytes, s

148 ginating from nondissected tonsil tissue and tonsillar lymphocytes were found to have sequences predo

149 ldren's nondissected tonsil tissue, isolated tonsillar lymphocytes, and isolated stromal cells that d

150 n tandem repeats but were isolated only from tonsillar lymphocytes.

151 (XLA) lacking Btk expression, as well as in tonsillar lymphoid cells.

152 ation led to apoptosis that was localized to tonsillar lymphoid follicles.

153 e lymphocytic effusion and an EBV-associated tonsillar lymphoproliferative disorder suggested that th

154 Here we show that EBV-infected tonsillar marginal zone (MZ) B cells, which are GC-indep

155 Here, we demonstrate that EBV-infected tonsillar marginal zone (MZ) B cells, which are GC-indep

156 Tonsillar MBC responses correlated with systemic MBC and

157 In contrast, only tonsillar memory B cells (MB) and PCs, from both tonsil

158 nter centroblasts and centrocytes as well as tonsillar memory B cells express a more restricted patte

159 pattern we have found in latently infected, tonsillar, memory B cells is used because it allows for

160 increase in M158-66-specific CD8+ T cells in tonsillar mononuclear cells (MNC) of HLA-matched individ

161 in M158-66 peptide-specific CD8+ T cells in tonsillar mononuclear cells of HLA-matched individuals.

162 locations, transcriptomes, and responses of tonsillar MZ B cells to different T(H)- cell subsets wer

163 Tonsillar naive B cells express the EBNA2-dependent lymp

164 th obstructive sleep apnea had predominantly tonsillar obstruction, whereas children with Down syndro

165 eratinocyte cell clones derived from primary tonsillar or foreskin epithelia immortalized with HPV-16

166 ng cells in human lymphoid tissue, we used a tonsillar organ culture model.

167 -producing B cell differentiation in a human tonsillar organoid model.

168 n toll-like receptor activation, or in human tonsillar organoids.

169 All consecutive unilateral tonsillar patients with SCC undergoing TORS as primary t

170 Tfh cells or exogenous IL-21 reduce tonsillar PC apoptosis and increases PC recovery but doe

171 nduced a marked increase of Ig production by tonsillar PC, and this effect was impaired when endogeno

172 id and transient phosphorylation of STAT3 in tonsillar PC.

173 Children with obesity had greater tonsillar (percentage of complete obstruction, 74% vs 54

174 e of 5.6 vs 4.8; Cohen d, 0.46), and greater tonsillar (percentage of complete obstruction: 65% vs 54

175 ers than for those arising from the anterior tonsillar pillar.

176 osterior border of the soft palate, abnormal tonsillar pillars, and velopharyngeal insufficiency.

177 The in vitro coculture of purified tonsillar plasma cells and T cells revealed a T-cell sur

178 Tonsillar plasma cells were maintained within the grafts

179 cal variant CJD is uniformly associated with tonsillar prion infection, we screened 2000 anonymous su

180 Whereas the tonsillar process was a potentially malignant EBV-positi

181 for certain anatomical sites, especially the tonsillar region, with viral DNA identified in approxima

182 ifferentiated tumors arising from Waldeyer's tonsillar ring.

183 approximately 60% of SCCs of the Waldeyer's tonsillar ring.

184 oup immunized by the nasal compared with the tonsillar route, indicating that nasal immunization was

185 intravenous (i.v.), intratracheal (int), or tonsillar routes.

186 RNA-sequencing was performed on 52 tonsillar samples from atopic and non-atopic tonsillecto

187 d from peripheral blood of healthy donors or tonsillar samples.

188 curate imaging biomarker for differentiating tonsillar SCC from physiologic (18)F-FDG uptake.

189 bilateral TORS) patients with HPV-associated tonsillar SCC were evaluated, including 18 women and 139

190 ears + or - 10.45 [standard deviation]) with tonsillar SCC were included.

191 themselves, is critical for tumorigenesis of tonsillar SCC.

192 eral elective extracapsular tonsillectomy in tonsillar SCCa is safe with markedly low metachronous co

193 undergoing transoral surgery for unilateral tonsillar SCCa reporting at least 1 primary or secondary

194 ially HPV-16, is detected in the majority of tonsillar SCCs and is almost exclusively associated with

195 Well keratinized tonsillar SCCs lack HPV DNA and are associated with over

196 with markedly low metachronous contralateral tonsillar second primary tumor rates and no compromise i

197 27 (13.7%) had oral lesions and 9 (4.6%) had tonsillar signs.

198 ded adjuvant therapy is standard of care for tonsillar squamous cell carcinoma (SCCa).

199 the detection of its ligand, E-cadherin, on tonsillar squamous cells.

200 ogical and molecular definition of the human tonsillar stromal cell landscape reveals PI16(+) RCs as

201 eractions of lymphocytes with cultured human tonsillar stromal cells and their extracellular matrix u

202 ethered and rolled on monolayers of cultured tonsillar stromal cells and their matrix.

203 ereas the majority of clones from the DNA of tonsillar stromal cells had sequences characteristic of

204 opoietic precursor cells, B lymphocytes, and tonsillar stromal cells.

205 iver, primary human B lymphocytes, and human tonsillar stromal cells.

206 -Vtn) administered as an oral capsule or via tonsillar swab or nasal spray.METHODSViral shedding from

207 We identified 5 tonsillar T cell developmental intermediates: (a) CD34(+

208 Tonsillar T cells showed significant cytokine responses

209 ted in abundance on the surfaces of infected tonsillar T cells.

210 Tonsillar T follicular helper (Tfh) lymphocytes are know

211 rrelation was found between the frequency of tonsillar T follicular helper cells and tonsillar Ag-spe

212 Here, we have studied the early tonsillar T-cell responses induced in children after LAI

213 n together, demonstrate an important role of tonsillar TFH cells in LAIV-induced immunity in humans.

214 or FX1 can not only repress HIV infection of tonsillar Tfh ex vivo but also suppress HIV infection an

215 infection by combining in vitro infection of tonsillar Tfh with the ex vivo study of circulating Tfh

216 esponses, and a positive correlation between tonsillar TFH-cell and systemic IgG induction after LAIV

217 nza-specific salivary IgA concentrations and tonsillar TFH-cell responses, and a positive correlation

218 1 infection of peripheral CD4(+) T cells and tonsillar Tfh/non-Tfh CD4(+) T cells (P < 0.05) and tota

219 ssion of IFN-alpha was increased in lymphoid tonsillar tissue (LT) of patients with progressive (HIV(

220 We analyzed tonsillar tissue by combining flow cytometry, in situ im

221 ation of spirochetes inside the RWV-cultured tonsillar tissue demonstrated that the number of B. burg

222 d testing in autopsies: consented testing of tonsillar tissue is potentially attributable to interrup

223 tion of SARS-CoV-2-reactive B cells in human tonsillar tissue obtained from children who were negativ

224 dentified within the mucosal surfaces of the tonsillar tissue of HIV-1-infected persons.

225 d penile tissues and enhanced replication in tonsillar tissue relative to acute Envs.

226 Analysis of human tonsillar tissue revealed that plasma cells and their pr

227 We found that ex vivo-cultured tonsillar tissue supports productive infection by the Ne

228 ed against HIV-1 (in vitro and ex vivo human tonsillar tissue system) and human herpes viruses.

229 National prospective collection of tonsillar tissue to be tested anonymously for abnormal l

230 We inoculated blocks of human tonsillar tissue with B. burgdorferi spirochetes, cultur

231 ry for squamous cell carcinoma, including 42 tonsillar tissue, 17 base of the tongue, 4 buccal tissue

232 Tonsillar tissue, nasopharyngeal aspirate, and serum wer

233 In human tonsillar tissue, this vaccine strain infects naive (CD4

234 Asymptomatic individuals without tonsillar tissue, which is believed to be an important s

235 = 39) Hi resided intracellularly in the core tonsillar tissue.

236 IL-7R alpha status in blood did not hold in tonsillar tissue.

237 Human cervico-vaginal and tonsillar tissues ex vivo, and cell lines were infected

238 In a parallel study, adenoid and tonsillar tissues from children with obstructive sleep a

239 lation (CD20(hi)/CD27(lo)/CD21(lo)) in human tonsillar tissues was recently defined by the expression

240 Within tonsillar tissues, MZ B cells secreted copious IgM when

241 preparation (E-GTF) administered by nasal or tonsillar topical spray.

242 c sensitization is associated with extensive tonsillar transcriptomic alterations and changes in immu

243 tified all four components of the complex in tonsillar vessels.

244 Tonsillar virus detection showed a strong negative assoc

245 without OSA do not have increased adenoid or tonsillar volume; reduced upper airway size is caused by

246 ually involves one or more of the following: tonsillar zones, larynx, soft palate, uvula, and nasal c