ライフサイエンスコーパス: topical

1 , and infants younger than 6 months received topical 1% tetracycline ointment.

2 as on treatment for androgenic alopecia with topical 5% Minoxidil application on scalp two times a da

3 In mice treated with topical 5-fluorouracil, use of STAR particles increased

4 Topical ACHP also reduced the NF-kappaB and IL-17 inflam

5 In mice, topical ACHP prevented the cutaneous inflammation induce

6 Swallowed topical-acting corticosteroids are effective in bringing

7 MRSA, but its clinical use is restricted to topical administration because of its limited plasma sta

8 fungi are difficult to treat by conventional topical administration because of poor drug penetration

9 nM) and fast onset (k = 1.6 min) to support topical administration in vivo.

10 This study evaluated the effects of topical administration of Bdellovibrio bacteriovorus HD1

11 Importantly, topical administration of Myr-CBD7 peptide on mouse derm

12 Our aim was to explore the effects of topical administration of ripasudil, a selective Rho-ass

13 ancing PMN-mediated bacterial killing, while topical administration of such drug in a murine model of

14 In conclusion, the topical administration of the selected neuroprotective a

15 Topical administration of Z-FL to a different cohort of

16 For patients with mild psoriasis, topical agents remain the mainstay of treatment, and the

17 on and may point toward a potential role for topical AhR agonists in supportive cancer care.

18 topical amphotericin B 0.15% alone, and (4) topical amphotericin 0.15% plus CXL.

19 lone, (2) topical natamycin 5% plus CXL, (3) topical amphotericin B 0.15% alone, and (4) topical amph

20 n patients who have not responded to oral or topical analgesics.

21 In both topical and fumigant bioassays, carvacrol and thymol wer

22 The topical and fumigant toxicity of 15 compounds was evalua

23 oncomitant immunosuppressive medications and topical and oral steroids were used similarly during tre

24 Both topical and systemic treatments that block IFN-gamma sig

25 corticosteroids (systemic, intravitreal, and topical), and 2 eyes underwent vitrectomy without improv

26 senior residents (65.5%, 205/313) and under topical anesthesia (78.0%, 244/313).

27 on around the lids and facial nerve (n = 6), topical anesthesia (n = 5), and general anesthesia (n =

28 nt nasolacrimal duct probing conducted under topical anesthesia in the operating theatre.

29 optimal dosing regimen of the most effective topical anti-inflammatory drugs, corticosteroids, are st

30 be an alternative approach in particular for topical anti-psoriatic treatment, an area with high need

31 y directly delivering the combination of the topical antibiotic minocycline and the retinoid tazarote

32 ial plastic surgery, patients treated with a topical antibiotic ointment showed a lower risk of surgi

33 The usefulness of topical antibiotic prophylaxis for routine oculofacial p

34 ncy of infection with and without the use of topical antibiotic prophylaxis.

35 Topical antibiotics (89%) were the most commonly prescri

36 met, we added the mandatory use of fortified topical antibiotics after cultures are obtained.

37 She was treated with topical antibiotics and achieved satisfactory recovery.

38 Infections were treated with oral or topical antibiotics and resolved without complication, e

39 ts always use a lid speculum, 21% administer topical antibiotics before injection, 36% wear a mask, 7

40 Topical antibiotics or cohousing of ft/ft mice with unaf

41 Despite receiving systemic and topical antibiotics, her clinical symptoms and signs wor

42 though using the combination of systemic and topical antibiotics, his clinical status progressively d

43 Topical antibiotics, oral acyclovir, low-dose topical st

44 Total recovery under topical antiglaucomatous therapy could be observed after

45 Topical antihistamines, mast cell stabilizers, or double

46 from murine data and clinical outcome after topical antipsoriatic treatment in human patients.

47 the conjunctiva both before instillation of topical antisepsis and 10 minutes after IVIs were given.

48 dose and extended taper of combined oral and topical antiviral and steroid prophylaxis was administer

49 r biomarker on fresh human cancer tissues by topical application (spraying) of a molecular sensor.

50 her on human volunteers to assess safety for topical application against bacterial infections.

51 ro and animal studies have demonstrated that topical application and oral consumption of pomegranate

52 After gentle topical application for 10 s to porcine skin ex vivo, de

53 Drug delivery by topical application has higher patient acceptance and lo

54 Repeated topical application in rabbits reveals a proteoform turn

55 age towards posterior segment delivery after topical application is ocular surface penetration and ex

56 sues of the eye are accessible by injection, topical application is preferable for the frequent treat

57 cal trial was to evaluate the effects of the topical application of 1% ALN gel in intrabony defects d

58 s currently used to delineate those lesions (topical application of acetic acid or Lugol iodine) lack

59 Importantly, topical application of CDK4/6 or EZH2 inhibitors on the

60 Early clinical studies suggest that topical application of commensal organisms (eg, Staphylo

61 cific cell type, and (iii) models induced by topical application of exogenous agents.

62 Topical application of extracellular calreticulin (eCRT)

63 L-induced inflammation was attenuated by the topical application of HI-TOPK-032 in SKH1 hairless mice

64 ggered by the overproduction of TSLP through topical application of MC903, and (2) induced by epicuta

65 In this study, we show that a single topical application of neomycin, an inexpensive and vagi

66 Results: After topical application of PARPi-FL on freshly excised cone

67 Topical application of rh-NGF twice daily for 3 weeks si

68 Intraperitoneal or topical application of the pharmacologic hydroxylase inh

69 as coated into reservoir patches followed by topical application onto AFL-treated skin.

70 ivery into human skin when compared to other topical application techniques.

71 After topical application to psoriatic 3-dimensional rafts, an

72 Topical application was also given twice a week until co

73 n epidermal keratinocytes and 3D rafts after topical application, affirming a role for SR-As in SNA u

74 On topical application, the hypotonic formulation forms a h

75 the eye or reach the posterior segment after topical application.

76 Current research focuses on topical applications and it is unclear how to design pep

77 principles, various synthetic protocols and topical applications of these versatile materials.

78 anslation as a therapeutic may be limited to topical applications such as wound rinses and dressings.

79 Remarkably, topical auranofin completely eradicated MRSA (8-log(10)

80 Anterior uveitis secondary to topical brimonidine administration is rare and not well-

81 Topical calcineurin inhibitors may be used in steroid-de

82 eceived difluprednate with the addition of a topical carbonic anhydrase inhibitor in 6 eyes and nonst

83 To evaluate the effects of topical citicoline and vitamin B12 (Cit-B12: OMK2, Omikr

84 These results are topical considering growing evidence supporting use of f

85 redecessors, as recently demonstrated in the topical contexts of metathesis macrocyclization and the

86 not week 24 because of an increased placebo/topical corticosteroid effect (36.8% vs 21.1%, P = .06).

87 The topical corticosteroid regimen used in this study was si

88 Of the 60 eyes in 40 patients who received topical corticosteroid therapy, there was a dose-depende

89 ncluded a history of ocular surgery (62.5%), topical corticosteroid use (35.4%), and dry eye syndrome

90 In our cohort, topical corticosteroid use was associated with an increa

91 Poor ocular surface, topical corticosteroid use, previous ocular surgery, and

92 ed fashion, treatment with <3 drops daily of topical corticosteroid was associated with an 87% lower

93 Swallowed topical corticosteroids (STC) belong to the therapeutic

94 were removed from the study and treated with topical corticosteroids according to best medical judgme

95 terior synechiae, active uveitis, and use of topical corticosteroids at presentation were significant

96 czema in 2009 compared to 51.4% in 2018) and topical corticosteroids decreased (57.3%-52.0%).

97 However, chronic use of topical corticosteroids dosed at <3 drops daily seemed t

98 njections every 4 weeks versus placebo, with topical corticosteroids in adults with moderate-to-sever

99 Although our results using topical corticosteroids in mice are highly promising for

100 g less prescribing of potent and very potent topical corticosteroids in non-white ethnicities and peo

101 ren, because conventional treatments such as topical corticosteroids might be inadequate or cause con

102 We further determined the impact of topical corticosteroids to reactivate Borrelia locally i

103 Use of topical corticosteroids was associated with cataract for

104 Additionally, topical corticosteroids were prescribed in 18 eyes and t

105 sing the 3 Ds: drugs (particularly swallowed topical corticosteroids), dietary restriction, and endos

106 the mainstay of treatment, and they include topical corticosteroids, vitamin D analogues, calcineuri

107 e assessed with attention paid to the use of topical corticosteroids.

108 oton pump inhibitors, elimination diets, and topical corticosteroids.

109 hritis (JIA)-associated uveitis treated with topical corticosteroids.

110 of cataract development among eyes receiving topical corticosteroids.

111 ive exclusion of food triggers and swallowed topical corticosteroids.

112 systemic T cell memory can be generated with topical CpG ODN at the time of s.c. immunization, sugges

113 In this study, we evaluated the use of topical CpG oligodeoxynucleotide (ODN) as adjuvant to ge

114 en anaesthetised prior to the procedure with topical creams such as EMLA (Eutectic mixture of local a

115 ndly strategy that can significantly enhance topical delivery inside human nose.

116 cleic acids overcome this barrier and enable topical delivery of antisense oligonucleotides capable o

117 t registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compar

118 We show the feasibility of topical delivery of QR-313 in a carbomer-composed gel fo

119 nalized, and scalable platform for effective topical delivery of siRNA for treating genetic skin dise

120 Topical delivery of siRNA is an attractive alternative o

121 Herein, we describe topical delivery of siRNA using ionic liquids (ILs) capa

122 Moreover, topical delivery of tetanus toxoid vaccine to mice using

123 In vivo, one single topical deposition of CURC-muPLs outperformed multiple,

124 Here, we evaluated whether topical DFO administration using a transdermal drug deli

125 iquimod, photodynamic therapy, nicotinamide, topical diclofenac, and selenium) and immunosuppression

126 Despite the introduction of biologics, topical dithranol (anthralin) has remained one of the mo

127 ization in turn increases the geographic and topical diversity of Landsat-enabled research.

128 wth factor injections, photodynamic therapy, topical dorzolamide, oral dosing of eplerenone or acetaz

129 Further, the topical drug delivery platform has important implication

130 Further studies on topical drug delivery should consider the potential of t

131 ation to other microbicide modalities and to topical drug delivery to vaginal mucosa more generally.

132 en developed that aim to follow and quantify topical drug pharmacokinetics, these tools can come with

133 skin microchannels (MCs) gradually dissolve topical drug powder to elicit multi-day sustained drug d

134 gating the penetration and distribution of a topical drug's active pharmaceutical ingredient (API) al

135 Topical effects of IDL in skin were compared with those

136 Here, we evaluate direct application of topical EGCG compared with zonal priming, a unique conce

137 posed which is associated with its role as a topical enhancer.

138 tor 5 cell signalling is augmented following topical estrogen application.

139 s to investigate, in vitro, the effects of a topical estrogen treatment on vaginal epithelial respons

140 We developed a murine skin topical exposure model for C. auris to dissect risk fact

141 e, we assessed the neuroprotective effect of topical eye delivery of the p38 MAPK inhibitor BIRB 796

142 Topical eye-drop delivery of a highly selective caspase-

143 Here, we review topical findings in organismal metabolism and infection

144 sume sugary drinks between meals, 4) receive topical fluoride from a health professional, 5) visit th

145 Topical fluralaner was 6- to 28-fold as toxic as permeth

146 ct of different UV blocking agents and other topical formulations.

147 A topical gel (BPX-05) was recently developed to treat mod

148 Overall, the mean number of topical glaucoma medications was unchanged from baseline

149 Greater baseline IOP and number of baseline topical glaucoma medications were significant predictors

150 Vascular K(ATP) channel function (topical glibenclamide superfused onto hindlimb skeletal

151 lysis of human skin transcriptome induced by topical glucocorticoid clobetasol propionate (CBP) in he

152 ery low certainty about the effects of using topical glucocorticosteroids as maintenance therapy.

153 e is moderate certainty in the evidence that topical glucocorticosteroids effectively reduce esophage

154 te the efficacy of miltefosine combined with topical GM-CSF (M+GM) versus miltefosine and placebo (M+

155 ents in the ICMA Group and 26 (89.7%) in the Topical Group.

156 ) diabetics [16 (7.3%) non-diabetics] in the Topical group.

157 ients in the ICMA Group and 5 (16.7%) in the Topical Group.

158 .1%) in the ICMA Group and 33 (57.9%) in the Topical Group; intention-to-treat (ITT) set].

159 The topical hydrogen-borrowing reactions and hydroboration o

160 In conclusion, we have shown that topical imiquimod can induce a robust immune response in

161 diminished, likely due to the nanoemulsion's topical instability.

162 f Sunb-malate eye drops administered through topical instillation limits its therapeutic efficacy and

163 Topical instillation of eye drops remains the most commo

164 he most recent advances of DDS applicable by topical instillation, that have shown better performance

165 Topical intra-nasal sprays are amongst the most commonly

166 eadth of offerings in this domain, including topical introductions, computational solutions, and theo

167 angle glaucoma who were using 0-4 classes of topical IOP-lowering medication underwent Goldmann appla

168 derly and the role of medical treatments are topical issues in aging societies.

169 s demonstrated that both single and repeated topical KB105 administration induced TGM1 protein expres

170 GM1 deficiency in patients with ARCI through topical KB105 application represents a promising strateg

171 rocess of diabetic wound healing and suggest topical mast cell stabilization as a potentially success

172 Through examples from several topical materials systems, including topological insulat

173 diabetic mice, both pre- and post-wounding, topical MCS-01 application accelerated wound healing com

174 n objective of this study was to clarify the topical mechanisms underlying diclofenac-induced gastric

175 patients with IOP >=21 mm Hg taking maximal topical medication and scheduled for trabeculectomy were

176 Patients randomized to SLT or topical medication and treated to predefined target intr

177 The USPSTF recommends prophylactic ocular topical medication for all newborns to prevent gonococca

178 t disease progression or need for additional topical medication over 36 months after SLT.

179 d eyes received either conservative therapy [topical medications (n = 363)] or definitive management

180 ence data) were randomized to treatment with topical medications and followed up for an average of 7.

181 nical trial comparing initial treatment with topical medications to trabeculectomy for 607 participan

182 =16.0 mm Hg under anesthesia without or with topical medications, respectively, and poor if the infan

183 ents when comparing CXL with no CXL or the 2 topical medications.

184 owever, it is necessary to consider not only topical medicine but also other additional treatments wh

185 The ocular hypertension was responsive to topical medicines.

186 que plasmid that conferred resistance to two topical microbiocides, mupirocin and chlorhexidine, freq

187 eloped CSCR following prolonged therapy with topical Minoxidil solution and was treated with oral epl

188 d with CSCR as a possible consequence of the topical minoxidil solution.

189 a rare side-effect noted following prolonged topical minoxidil therapy for androgenic alopecia.

190 a rare side-effect noted following prolonged topical minoxidil therapy for androgenic alopecia.

191 esults demonstrate, for the first time, that topical miR-155 inhibition increases diabetic wound fibr

192 Topical miR-155 inhibition targets both excessive inflam

193 to controls, leading us to hypothesize that topical miR-155 inhibition would improve diabetic wound

194 ived one of the following after MMED without topical mitomycin: no stenting or packing (group 1, n =

195 Still, topical modulation of Piezo2 in the cornea may be useful

196 This was superior to both topical mupirocin (1.96-log(10) reduction) and oral clin

197 As such, oral steroids, topical nasal sprays or irrigation, and surgery can be u

198 The treatment arms included (1) topical natamycin 5% alone, (2) topical natamycin 5% plu

199 included (1) topical natamycin 5% alone, (2) topical natamycin 5% plus CXL, (3) topical amphotericin

200 topical natamycin plus ISV injection versus topical natamycin alone.

201 and visual acuity worse than 20/70 received topical natamycin and were randomized to either receive

202 randomized to CXL regardless of medication (topical natamycin or amphotericin) had 1.32-fold increas

203 Study eyes were randomized to topical natamycin plus ISV injection versus topical nata

204 f NSAIDs before versus after IVI, as well as topical nepafenac relative to ketorolac or diclofenac.

205 of NSAIDs before the procedure, specifically topical nepafenac, was associated with the greatest impr

206 ticle, we describe a clinically translatable topical, neuroprotective treatment (recombinant human ne

207 Topical nonsteroidal anti-inflammatory agents (NSAIDs) p

208 The role of topical nonsteroidal anti-inflammatory drugs (NSAIDs) fo

209 non-low back, musculoskeletal injuries with topical nonsteroidal anti-inflammatory drugs (NSAIDs) wi

210 l analog scale was significantly lower after topical NSAID administration relative to control at 1 ho

211 The RCTs that treated patients with a topical NSAID and assessed postprocedural pain were incl

212 y and elevation of intraocular pressure with topical NSAID and steroid therapy that resolved when the

213 D and steroid therapy that resolved when the topical NSAID was stopped and difluprednate was tapered

214 exercise and weight loss as core treatments, topical NSAIDs as first-line treatments and oral NSAIDs

215 Topical NSAIDs, followed by oral NSAIDs and acetaminophe

216 The NTG group received topical NTG ointment application instead of sildenafil.

217 at would change its previous conclusion that topical ocular prophylaxis is effective in preventing go

218 usion that there is convincing evidence that topical ocular prophylaxis of all newborns is not associ

219 eatment of an EMT-mediated condition using a topical ophthalmic agent.

220 Topical or s.c. CpG ODN adjuvant administration at the t

221 ImAEs were defined as AESIs treated with topical or systemic corticosteroids.

222 d to the testing and development of numerous topical, oral, and injectable targeted therapeutic agent

223 The use of compounded topical pain creams has increased dramatically, yet thei

224 In addition, topical PG ameliorated skin lesions and inflammation in

225 histological and patient outcomes following topical phenytoin (PHT) treatment of experimental palata

226 vented the cutaneous inflammation induced by topical phorbol myristate acetate or imiquimod, reduced

227 he present study, the first one to report on topical PHT as palatal wound treatment, suggest that PHT

228 Topical povidone-iodine (PI) is widely used as an ocular

229 Participants concurrently used topical prednisolone acetate 1% 4x daily for 3 months, 3

230 placebo group (n = 49) or the steroid group (topical prednisolone phosphate; n = 57); both regimens w

231 gned to 2 groups: Group 1 (30 eyes) received topical preservative-free lubricating gel and drops, chl

232 g5,7Ac(2) and CMP-Kdn remain viable leads as topical preventive/therapeutic agents against the global

233 cular-based methods to improve the safety of topical products and to advance transdermal drug deliver

234 Both eyes received topical proparacaine 0.5%.

235 or underwent a procedure initially (13.5%); topical prostaglandin analogs (n = 2887/5120 [56.4%]) an

236 with a controlled intraocular pressure under topical quadritherapy and a best corrected Snellen visua

237 tes, with potential advantages compared to a topical regimen including reduced systemic risk, better

238 ized study, comparing ICMA to a conventional topical regimen.

239 ate ring or generalisable to other sustained topical release formulations of tenofovir or its prodrug

240 activity and shows therapeutic similarity to topical retinoids in vitro and in vivo.

241 This topical review discusses early clinical successes, precl

242 This topical review introduces the basic principles of networ

243 Topical rh-NGF also promotes greater axonal survival and

244 Collectively, these results suggest that topical rh-NGF exhibits neuroprotective effects on retin

245 As topical rh-NGF is already involved in early clinical tri

246 helial defect or corneal ulcer, treated with topical rhNGF, and age-matched healthy controls.

247 Murine small bowel ulcers were generated by topical serosal acetic acid or subcutaneous indomethacin

248 class of bandage has promise for challenging topical situations in humans and other animals, especial

249 In contrast, topical SL/B immunizations generates minimal IgG respons

250 An effective topical steroid treatment in EoE patients is important.

251 All patients required topical steroid treatment, 3 required amniotic membrane

252 prescribed drug class by volume, followed by topical steroids (86%) and nonsteroidal anti-inflammator

253 Treatment included topical steroids (93%), with 1% supplemented by oral ste

254 rs between patients by treatment response to topical steroids (oral viscous budesonide), thus offerin

255 opical antibiotics, oral acyclovir, low-dose topical steroids and systemic steroids were started.

256 reated with very strong or strongest potency topical steroids for 3-9 years.

257 lograft rejection successfully reversed with topical steroids in 2 eyes (9%), secondary graft failure

258 avoid mis-diagnosis and over-treatment with topical steroids which in turn may increase intraocular

259 es in EoE treatment with regard to swallowed topical steroids, biological agents, dietary approaches,

260 istence of AD severity and responsiveness to topical steroids, calcineurin inhibitors and step-up tre

261 etween patients treated postoperatively with topical steroids, nonsteroidal anti-inflammatory medicat

262 ance of food antigens; broad applications of topical steroids; and, eventually, pathway-specific biol

263 nsive treatment with potent corticosteroids (topical, subtenon, intravitreal, or systemic) is recomme

264 P = 0.7197) for psoriasis patients receiving topical, systemic nonbiologic, and biologic therapy, res

265 f POAG patients with normal IOP treated with topical Tafluprost (n = 20) compared to surgically treat

266 cular injection, albeit at a higher dose for topical than intramuscular vaccine administration.

267 Topical therapies remain the cornerstone for treating mi

268 sesses transcorneal penetration of candidate topical therapies, allowing rates of trans-corneal penet

269 For milder forms of psoriasis, topical therapies, primarily corticosteroids, remain the

270 Topical therapy achieved high closure rates in secondary

271 ve intrastromal injection of voriconazole or topical therapy alone.

272 One aphakic patient required topical therapy for glaucoma.

273 Topical therapy was attempted in 9 eyes (8 patients).

274 22, 2019, for secondary FTMHs who underwent topical therapy were included.

275 ocular pressure was 26 mmHg, despite maximal topical therapy.

276 istration at weeks 16 and 32, or twice-daily topical timolol maleate 0.5% (n = 198).

277 be limited to autoimmune disorders and that topical tofacitinib application should be considered a s

278 Imiquimod is a topical toll-like-receptor-7 agonist currently used for

279 severe pruritus, and inadequate control with topical treatment (n = 226).

280 When glaucoma patients requiring topical treatment are admitted, approximately one quarte

281 penetration enhancer represents an effective topical treatment for psoriasis.

282 Topical treatment of mild-to-moderate psoriasis with cor

283 inhibitor that is being investigated for the topical treatment of psoriasis.

284 ted suppression of IL17RA is a promising new topical treatment strategy for psoriasis.

285 B-EGF has the potential to be developed as a topical treatment to mitigate oral mucositis following r

286 acebo-controlled design was used to mask the topical treatment used.

287 Here we show that combining topical treatment using PC945, a novel inhaled triazole,

288 to severe disease and inadequate control by topical treatment were randomized 1:1:1:1, using an inte

289 We studied those characteristics following topical treatment with a designed synthetic pseudocerami

290 signaling regulator was beta-estradiol, and topical treatment with beta-estradiol confirmed its func

291 He was placed on a 6 weeks course of topical treatment with budesonide, which needed to be ex

292 Topical treatment with rhNGF was effective in promoting

293 D8 T cells in vitro and in vivo systemic and topical treatment, with tofacitinib protecting mice from

294 Both groups received topical trifluridine.

295 Topical use of B. bacteriovorus HD100 promotes a protect

296 Here, we investigate whether topical vaccines that transfer among individuals through

297 s from circulation to the genital mucosa via topical vaginal application of chemokines in mice.

298 Clinically, topical vaginal estrogen treatment has a prophylactic ef

299 The 5 topical with sedation anesthesia-related claims were due

300 These questions have become even more topical with the recent progress brought by genome-wide