ライフサイエンスコーパス: topical application

1 n penetrate the neovascularized cornea after topical application.

2 uate its in vitro and in vivo delivery after topical application.

3 and squamous cell carcinoma (SCC) in situ by topical application.

4 A by subconjunctival injection together with topical application.

5 the eye or reach the posterior segment after topical application.

6 oxidase-mediated antimicrobial developed for topical application.

7 , and commensal organisms also in trials for topical application.

8 t result in low ocular bioavailability after topical application.

9 ant cells and silencing of homologous RNA on topical application.

10 ool and Puerto Rico, respectively) following topical application.

11 dermis has significantly limited its use for topical application.

12 n limits the delivery of NAs into skin after topical application.

13 As can be used as functional ingredients for topical applications.

14 leaved in plasma, which supports its use for topical applications.

15 ate immune modulators limits clinical use to topical applications.

16 he infusion of 50 mg/kg/d mecamylamine or by topical application 0.1 or 1% mecamylamine to the cornea

17 n epidermal keratinocytes and 3D rafts after topical application, affirming a role for SR-As in SNA u

18 her on human volunteers to assess safety for topical application against bacterial infections.

19 leotide in the epidermis or dermis following topical application although immunostaining was associat

20 ells were not found in nonskin tissues after topical application, although fragments of E. coli DNA w

21 We used a trial design formulating C-82 for topical application and conducting a placebo-controlled,

22 ro and animal studies have demonstrated that topical application and oral consumption of pomegranate

23 Here, we demonstrate that the topical application and quantification of a multiplexed

24 Current research focuses on topical applications and it is unclear how to design pep

25 After topical application, DermaVir-transduced cells migrate f

26 After gentle topical application for 10 s to porcine skin ex vivo, de

27 Drug delivery by topical application has higher patient acceptance and lo

28 Repeated topical application in rabbits reveals a proteoform turn

29 be exercised when using capsaicin-containing topical applications in the presence of a tumor promoter

30 gap chalcogenide materials and some of their topical applications in the solar energy and biological

31 It paves the way for a wide range of topical applications including subsurface, chemically sp

32 controversy about whether its consumption or topical application is entirely safe.

33 age towards posterior segment delivery after topical application is ocular surface penetration and ex

34 sues of the eye are accessible by injection, topical application is preferable for the frequent treat

35 We have shown previously that topical application of (-)-epigallocatechin-3-gallate (E

36 Topical application of 0.02% MMC to intact goat globes r

37 Treatment consisted of topical application of 0.1% tacrolimus ointment three ti

38 These data show that topical application of 0.5% PVI could promote acute skin

39 cal trial was to evaluate the effects of the topical application of 1% ALN gel in intrabony defects d

40 Topical application of 1% ALN may be a promising and ben

41 The topical application of 1,000,000 MSCs on a collagen scaf

42 minutes of regional myocardial ischemia and topical application of 10 microg/mL bradykinin in a repr

43 es received clean dry cord care (control) or topical application of 10 mL of a 4% chlorhexidine solut

44 econd premolars bilaterally, followed by the topical application of 10(9) colony forming units (CFU)

45 lation of granulocytic IMCs in the skin upon topical application of 12-O-tetradecanoylphorbol-13-acet

46 We found that topical application of 15d-PGJ2 cream for 15min directly

47 Unilateral, consecutive CSDs, induced by topical application of 2 M KCl to the cortical surface o

48 In this murine study, topical application of 2% erythromycin and 3% tetracycli

49 gher PPIX formation after 4h, as compared to topical application of 20% w/w 5-ALA in a conventional c

50 pidly terminated in vivo seizures induced by topical application of 4-aminopyridine.

51 n activity was induced in adult epidermis by topical application of 4-hydroxytamoxifen (4OHT).

52 n of nevi in Dct-Survivin and non-Tg mice by topical application of 7,12-dimethylbenz(a)anthracene di

53 Topical application of [Met(5)]-enkephalin depressed tea

54 Finally, targeting AR by topical application of a compound (ASC-J9) that degrades

55 ncreases in DsRed signal were observed after topical application of a contact sensitizer, oxazolone,

56 ored with OCT in rabbit cornea in vivo after topical application of a glycerin-based hypertonic agent

57 Furthermore, topical application of a JP-153-loaded microemulsion aff

58 nversely, in a human acute dermatitis model, topical application of a Lawsone-containing cream amelio

59 e we show that in both mouse and human skin, topical application of a mitochondrially targeted antiox

60 ively, and decreases within 23 minutes after topical application of a muscarinic antagonist.

61 resent study has been planned to investigate topical application of a novel monounsaturated fatty aci

62 C57BL/6 mice were measured, with or without topical application of A or A+P.

63 Additionally, topical application of a pledget of cotton soaked with R

64 els in vitiligo, which can be reduced with a topical application of a pseudocatalase-K.U. Schallreute

65 Topical application of a reactive hapten, DNFB, augmente

66 Topical application of a small molecular chemical inhibi

67 30% total body surface area burn followed by topical application of a specific inhibitor of p38 mitog

68 Topical application of a specific VR1 antagonist, iodore

69 ractable model of cutaneous GVHD, induced by topical application of a Toll-like receptor agonist, to

70 s delivered to the rabbit cornea by a single topical application of AAV5 (100 muL; 6.5 x 10(12) mug/m

71 Thus, topical application of Abeta1-40 onto the somatosensory

72 s currently used to delineate those lesions (topical application of acetic acid or Lugol iodine) lack

73 sponse using a laser Doppler imager (LDI) to topical application of acetylcholine (ACh) and sodium ni

74 Our data suggest that topical application of acitretin may have a therapeutic

75 al keratinocytes (RXR-alphabeta(ep-/-)) or a topical application of active vitamin D3 (VD3) and/or al

76 Acute topical application of aducanumab to the brain resulted

77 Topical application of aganirsen was safe and well toler

78 Topical application of Aldara cream containing the Toll-

79 Topical application of Aldara cream, containing the Toll

80 In conclusion, a single topical application of AMD3100 promoted wound healing in

81 Our findings suggest that topical application of an A2AR antagonist prevents radia

82 Topical application of an acetone insecticide formulatio

83 ital antigen-specific immune responses after topical application of an adjuvanted antigen formulation

84 severed human dental pulps and suggest that topical application of an angiogenic factor prior to rep

85 Topical application of an esterified monounsaturated fat

86 trate that targeting interleukin 1 (IL-1) by topical application of an IL-1 antagonist is efficacious

87 The most plausible approaches involve topical application of antiretroviral agents with specif

88 In addition, topical application of asphalt fumes by painting the tai

89 Today, formulations for the topical application of ATRA rely on creams and emulsions

90 Topical application of azithromycin suppresses expressio

91 Topical application of BAK to the eye causes corneal neu

92 to determine and characterize the effect of topical application of benzalkonium chloride (BAK) on co

93 Moreover, topical application of Bis (100 microM) once daily for 9

94 teral barodenervation and cervical vagotomy, topical application of bradykinin (BK, 1-10 microg/ml, 5

95 In vivo experiments show that the topical application of c-Myc siRNAs delivered by SPACE-E

96 by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced

97 Topical application of caffeine immediately after irradi

98 s at 6 h by 214% and 467%, respectively, and topical application of caffeine immediately after irradi

99 Topical application of capsaicin (1%) on the tibial nerv

100 In conclusion, topical application of capsaicin causes a small fiber ne

101 We have found that chronic, long-term topical application of capsaicin increased skin carcinog

102 Similarly, topical application of capsaicin to skin innervated by t

103 o underwent a chemical 'axotomy' through the topical application of capsaicin, and regenerative sprou

104 Finally, we show that topical application of capsaicin, which selectively acti

105 cantly augmented in skin sensitized by acute topical application of capsaicin.

106 Topical application of carrageenan at 250 microg/mL in c

107 Prophylactic and therapeutic topical application of CD ameliorated corneal disease an

108 Importantly, topical application of CDK4/6 or EZH2 inhibitors on the

109 The findings suggest that topical application of cetylated monounsaturated fatty a

110 Topical application of cimetidine in a liposome carrier

111 Topical application of coal tar is one of the oldest the

112 Early clinical studies suggest that topical application of commensal organisms (eg, Staphylo

113 Topical application of compound 48/80, an MC secretagogu

114 fferent fibers were assessed in monkey after topical application of cowhage spicules or intradermal i

115 stent with these functions, we show that the topical application of CRT has profound effects on the p

116 t-derived growth factor-BB-treated controls, topical application of CRT to porcine excisional wounds

117 Topical application of CsA has the potential to overcome

118 In addition, we show that a topical application of CSA-13 penetrates the skin and re

119 Both systemic injection and topical application of CVF reduced local C3 levels >60%,

120 cisional skin lesions, we show that a single topical application of Cx43 antisense gel brings about a

121 Topical application of CYP11B1 inhibitors to reduce cuta

122 Congruently, chronic topical application of D3 inhibits ionizing radiation-in

123 roperties and morphology of the cornea after topical application of dehydrating agents.

124 Topical application of delphinidin (1 mg/0.1 ml DMSO/mou

125 Topical application of dibenzo[a,l]pyrene (DB[a,l]P) to

126 cts received one-time MN treatment and daily topical application of diclofenac sodium.

127 more susceptible to contact dermatitis after topical application of dinitrofluorobenzene, and show en

128 ed circulating levels of IFN-gamma following topical application of DMBA, whereas IL-17 was elevated

129 wever, induction of skin inflammation by one topical application of DNFB following MBL2 inoculation i

130 Topical application of docosahexaenoic acid (DHA), a rep

131 Topical application of DOTAP-SES on mice skin resulted i

132 Topical application of EGCG (1 mg/cm(2) skin) prevented

133 ceptor transfection strategy to determine if topical application of EGF-like ligands would enhance re

134 substantially within 69 or 46 minutes after topical application of either a muscarinic or nicotinic

135 Filtration surgery with concurrent topical application of either AgNPs or MMC was performed

136 Topical application of either goat IgG specific for rabb

137 Topical application of either of 2 mechanistically disti

138 ted to chemical carcinogenesis procedures by topical application of either the complete carcinogen 1-

139 to appraise and synthesise the evidence for topical application of emollients in the prevention of i

140 Our aim was to ascertain whether topical application of emollients to enhance skin barrie

141 Notably, topical application of epidermal lipids from wild-type o

142 We have previously reported that the topical application of erythropoietin (EPO) to cutaneous

143 cific cell type, and (iii) models induced by topical application of exogenous agents.

144 Topical application of extracellular calreticulin (eCRT)

145 Topical application of F-5 peptide promoted acute and di

146 This study examines whether topical application of fingolimod, an established SK/sph

147 human cytomegalovirus in cultured cells, and topical application of FIT-039 ointment suppressed skin

148 Topical application of FL2 siRNA nanoparticles to either

149 Topical application of flagellin induced profound protec

150 In this protocol, we outline methods for the topical application of fluorescently quenched activity-b

151 laminar electrophysiology, we verified that topical application of GABA for 20min does not affect la

152 and final scar size by about 50% compared to topical application of gentamicin alone.

153 Taken together, our results indicate that topical application of GFRalpha/RET receptor signaling m

154 The topical application of GM3S SNAs (50 nM) to splinted 6-m

155 Topical application of GTP resulted in significant decre

156 These results suggest that the topical application of Hh-agonist could be effective in

157 L-induced inflammation was attenuated by the topical application of HI-TOPK-032 in SKH1 hairless mice

158 the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amin

159 Topical application of HJ6.3 for only 14 d also decrease

160 Topical application of honokiol (0.5 and 1.0 mg/cm(2) sk

161 More intriguingly, topical application of hsp90alpha accelerated wound heal

162 Topical application of Hsp90alpha-Delta mutant protein p

163 Importantly, topical application of human MC chymase restores burn in

164 ents of skin thickness demonstrated that the topical application of hypobaric stress thinned the tiss

165 receptor increases Treg enrichment, whereas topical application of IL-1beta or alpha-toxin diminishe

166 In the current studies, the topical application of imiquimod at the site of subcutan

167 Topical application of imiquimod in vivo led to epiderma

168 vation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly us

169 JCI, Drobits and colleagues demonstrate that topical application of imiquimod suppresses cutaneous me

170 We have shown that topical application of immunostimulating (IS) patches co

171 In vivo, topical application of INCB018424 resulted in suppressio

172 kg i.v.) on central sensitization induced by topical application of inflammatory soup (IS) on the dur

173 Topical application of InsP(6) to early-stage somatic em

174 ells and Bacillus anthracis spores following topical application of intact particles of live or gamma

175 ratio imaging fluorescence microscopy after topical application of ion/pH-sensing, dual-wavelength f

176 induced from resting mouse hair follicles by topical application of JAK inhibitors, suggesting that J

177 n with Kr-h1 and E93 was also studied by the topical application of JH analog, methoprene, to N5.

178 We hypothesized that topical application of liposomes with glycolipids that c

179 afferent transmission in the vagus nerve by topical application of local anaesthetic.

180 We found that topical application of Lupeol (1-2 mg/mouse) 30 min prio

181 We first determined the effect of topical application of Lupeol to CD-1 mouse against 12-O

182 promotion, we next determined the effect of topical application of Lupeol to mouse skin against thes

183 o recruit PMN or systemic PMN depletion plus topical application of MAb F429 resulted in less patholo

184 ggered by the overproduction of TSLP through topical application of MC903, and (2) induced by epicuta

185 a model of PMA-elicited peritonitis, whereas topical application of MCV1 markedly reduced neointima f

186 Topical application of MK571 significantly decreased IOP

187 Topical application of mustard oil (allyl isothiocyanate

188 The combined topical application of ND-336 (a small molecule) and the

189 In this study, we show that a single topical application of neomycin, an inexpensive and vagi

190 amount of SP and KP retained in dermis after topical application of NLC-R11 was significantly higher

191 d that the CBF and ROS increases elicited by topical application of NMDA to the mouse neocortex were

192 Furthermore, topical application of non-steroidal anti-inflammatory d

193 Topical application of nucleic acids offers many potenti

194 Topical application of OG but not 5-(tetradecyloxy)-2-fu

195 d during contact hypersensitivity induced by topical application of oxazolone.

196 One topical application of P15-1 to full-thickness excisiona

197 Results: After topical application of PARPi-FL on freshly excised cone

198 Topical application of pathogen-specific double-stranded

199 asome activity in wounds of db/db mice using topical application of pharmacological inhibitors improv

200 Topical application of phorbol myristate acetate (PMA) e

201 In mice, topical application of phosphatidylserine-containing oin

202 Likewise, there has been work on the topical application of phytochemicals to the skin.

203 Here, we show that topical application of polymeric microbeads functionaliz

204 o, micro-coating channels (MCCs) followed by topical application of powder drug-coated array patches

205 nel (MC) arrays in the epidermis followed by topical application of powder drug/vaccine-coated array

206 three boys, gynecomastia coincided with the topical application of products that contained lavender

207 tes of stable baseline recording followed by topical application of proparacaine (0.5%, 10 microL) wi

208 Systemic delivery, intraocular injection or topical application of putative TRPV4 antagonist prodrug

209 Additionally, topical application of PX-12 significantly enhanced neut

210 We found that topical application of RA significantly improves wound h

211 Topical application of RDP58 to the epidermis following

212 Topical application of recombinant mMCP-5 or human neutr

213 Topical application of resveratrol resulted in significa

214 Topical application of rh-NGF twice daily for 3 weeks si

215 Most of these changes were ameliorated by topical application of Rho kinase inhibitor.

216 Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conf

217 In this study, we show that topical application of SC-560 (a COX-1 selective inhibit

218 Topical application of selective HA fragments (large ver

219 Topical application of silibinin before or immediately a

220 Topical application of siRNAs through the skin is a pote

221 The topical application of skin with resveratrol (both pre-

222 Topical application of Smad7 protein conjugated with a c

223 report that therapeutic Wnt inhibition with topical application of small-molecule Wnt inhibitors can

224 Topical application of SP50 significantly increased the

225 Repeated topical application of SRW allergen induces a form of mu

226 r induced by compound 48/80 was mitigated by topical application of STZ.

227 Topical application of sulforaphane-rich extracts of 3-d

228 Topical application of survivin antisense oligonucleotid

229 Furthermore, topical application of TAT-GIV-CT peptides enhanced the

230 Topical application of thapsigargin, which inhibits the

231 Topical application of the bioflavonoid 4',5,7-trihydrox

232 Topical application of the contact-sensitizing hapten, t

233 However, pigmentation could be rescued by topical application of the cyclic AMP agonist forskolin,

234 These behavioral changes were abolished with topical application of the dopamine antagonist fluphenaz

235 ost successful results were achieved through topical application of the drug formulation START (0.9%

236 distribution in different skin layers after topical application of the drug.

237 A single topical application of the EP2 agonist, butaprost, dose-

238 etected during the rehydration process after topical application of the HA.

239 significantly upregulated IL-17f, and IL-22; topical application of the IL-23 aptamer decreased both

240 he31Ile) was expressed in the epidermis upon topical application of the inducer RU486 (Aurora-AGS).

241 stemic intraperitoneal injection, as well as topical application of the MAb onto the infected eye, st

242 Topical application of the MRP4 inhibitor MK571 was test

243 These effects could be blocked by topical application of the muscarinic antagonist atropin

244 cutaneous inflammatory infiltrate following topical application of the NO donor-acidified nitrite (N

245 Topical application of the NRF2 activator sulforaphane t

246 Topical application of the patch onto laser-microperfora

247 Intraperitoneal or topical application of the pharmacologic hydroxylase inh

248 CAPRISA 004 trial recently demonstrated that topical application of the tenofovir could partially pre

249 esponses, we administered DLI alone or after topical application of the TLR7 ligand imiquimod, which

250 oriasiform skin inflammation is triggered by topical application of the TLR7/8 agonist imiquimod.

251 perplasia of interfollicular epidermis after topical application of the tumor promotor 12-O-tetradeca

252 odulates the expression of TLR and CRAMP and topical application of TLR agonists in EDE mice resulted

253 al responses in the cervicovaginal mucosa by topical application of TLR agonists prior to viral expos

254 A single topical application of TPA (5 nmol) to the skin, as earl

255 Topical application of troglitazone significantly reduce

256 Topical application of vascular endothelial growth facto

257 s to neural activity (functional hyperemia), topical application of vasodilators, and decreases in bl

258 Finally, topical application of vitamin C before exposure signifi

259 ressed in transgenic mice, or when driven by topical application of vitamin D3 or low-calcemic analog

260 ophic factor (GDNF) in skin keratinocytes or topical application of XIB4035, a reported nonpeptidyl a

261 Topical applications of 100 mg of Dermabase, Dermovan, E

262 Topical applications of a specially designed Custom Blen

263 chemical receptors gave similar responses to topical applications of acid.

264 in barrier homeostasis could be improved by topical applications of an acidic buffer, indicating tha

265 Acute topical applications of ARN077 attenuated key signs of D

266 Topical applications of caffeine immediately after UVB i

267 third week: 5 mg/day), and was followed with topical applications of clobetasol (0.05%) twice daily f

268 To test our hypothesis that topical applications of imiquimod may protect the skin i

269 s in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients affl

270 preconditioned sites followed by additional topical applications of imiquimod.

271 udies are needed to determine the effects of topical applications of moisturizing creams on sunlight-

272 Thirdly, topical applications of PAR-2 agonist peptide, SLIGRL, d

273 Previously, we demonstrated that topical applications of peroxisome proliferator-activate

274 and show enhanced inflammatory lesions after topical applications of phorbol ester.

275 e observed robust anti-pruritic effects with topical applications of selective inhibitors for TRPV4 a

276 s of dermatitis either induced by repetitive topical applications of the detergent SDS or by high-dos

277 Maintenance of a low pH by topical applications of the polyhydroxyl acid, lactobion

278 principles, various synthetic protocols and topical applications of these versatile materials.

279 Micro-application (topical application) of dsRNA to 5(th) instar of nymphs

280 In conclusion, topical application offers a direct and efficient delive

281 Topical application on the dural surface of the auditory

282 as coated into reservoir patches followed by topical application onto AFL-treated skin.

283 ability in situ; (iii) local intervention by topical application or intraocular injection; and (iv) r

284 epression could be induced in normal mice by topical application or micro-injection of alpha4* nAChR

285 ed EIU after 24 and 48 h or EIU treated with topical applications or with a single s.c. injection of

286 r biomarker on fresh human cancer tissues by topical application (spraying) of a molecular sensor.

287 anslation as a therapeutic may be limited to topical applications such as wound rinses and dressings.

288 ivery into human skin when compared to other topical application techniques.

289 On topical application, the hypotonic formulation forms a h

290 Three days after topical application, the MSCs homed to the injured paren

291 After topical application to psoriatic 3-dimensional rafts, an

292 eloping a more physiologic mix of lipids for topical application to skin.

293 utaneous penetration of macromolecules after topical application to the skin.

294 current state of the art in this field with topical applications to inorganic, especially microporou

295 nylephrine and time of measurement following topical application using random-effects models with inv

296 Topical application was also given twice a week until co

297 The anti-inflammatory activity of 5-8 after topical application was investigated in two mouse models

298 after systemic application as well as after topical application, which is therapeutically more relev

299 Topical application with the 15-epi-16-phenoxy-para-fluo

300 were 60 times greater than those achieved by topical application without microneedles.