ライフサイエンスコーパス: topically

1 ible horn flies and stable flies were tested topically.

2 rug resistance and was nontoxic when applied topically.

3 ering in mice and was effective when applied topically.

4 rine, or a relevant vehicle was administered topically.

5 espective corticosteroids previously applied topically.

6 or model animals when administered orally or topically.

7 nce of sodium nitrite (30 nmol) administered topically 1 min before reperfusion.

8 Flagellin applied topically 24 h prior to C. albicans inoculation signific

9 -dependently inhibited PCA when administered topically 24 hours before antigen challenge but provoked

10 , or DEX (0.1%) were repeatedly administered topically 3 hours before paracentesis and continued for

11 Either eye drop treatment of 1% apoEdp topically 4 times a day for 14 consecutive days or intra

12 5-Fluorouracil 1% administered topically 4 times daily for 1 week followed by a drug ho

13 ravenously 5 min before ischemia and 50 nmol topically 6 min before reperfusion).

14 lying a soft-drug concept in the design of a topically acting PDE4 inhibitor for treatment of dermato

15 morphological and histological evidence that topically active cimetidine is a potent inhibitor of P.

16 Potent, topically active corticosteroids with minimum systemic a

17 Resiquimod (R-848), a topically active immune response modifier, induced produ

18 When topically added to rabbit eyes, lacritin promotes basal

19 The authors examined whether topically administered biliverdin can counteract the eff

20 tion through the outer BRB may be needed for topically administered drugs to exert effects in the ret

21 up 3 was treated with buffer (10 ul; n = 12) topically administered four times a day for up to 7 days

22 nsions containing B. bacteriovorus HD100 was topically administered in the subgingival region of MFMs

23 animalis subsp. lactis (B. lactis) HN019 was topically administered in the subgingival region of MFMs

24 The results of this study suggest that topically administered ketorolac 0.45% may allow meaning

25 Topically administered lewisite induced potent acute inf

26 ible subjects were randomized 1:1 to receive topically administered lifitegrast (5.0%) or placebo (ve

27 Topically administered mecamylamine could provide an app

28 Topically administered non-steroidal anti-inflammatory d

29 We imaged topically administered peptide using a fluorescence conf

30 -benzotria zin-7-yl)phenyl benzoate ( 12), a topically administered prodrug delivered as an eye drop

31 icient skin exhibits enhanced sensitivity to topically administered retinol.

32 en together, these findings demonstrate that topically administered sodium nitrite protects the rat k

33 ional activity of taste cells in response to topically administered tastants in live mice.

34 closporine (0.05%), or artificial tears were topically administered to eyes of normal New Zealand Whi

35 lumilast, tofacitinib, and ruxolitinib, were topically administered to the mouse ears, which were sub

36 study indicate that mercaptoalkylguanidines, topically administered, may significantly reduce experim

37 uld widen the range of compounds that can be topically administered.

38 l or TLR9 siRNA before infection and treated topically afterward.

39 and 20 rabbits were inoculated in both eyes topically and intrastromally to study the formation of s

40 Thm1 mutant against Galleria mellonella both topically and via intrahemocoel injection assays that co

41 an adjustable vascular loop around the right topically anesthetized eye of Sprague-Dawley rats.

42 Topically applied "moisturizers" work by acting as humec

43 Capsaicin and menthol, two other topically applied agents widely used for similar purpose

44 nstituents of prosthetic device coatings, as topically applied agents, and within dental materials ar

45 Topically applied all-trans retinoic acid can repair pho

46 It was hypothesized that topically applied allogeneic MSCs would improve wound he

47 vailable and emerging evidence of the use of topically applied analgesics with particular reference t

48 adsorbed to the waxy leaf cuticle both when topically applied and when produced by cells on plants.

49 mutual medication that improves coverage of topically applied anti-parasite medicines.

50 sal SHIV (an HIV/SIV chimaera) challenge and topically applied antibodies can protect macaques agains

51 Both systemically injected and topically applied antibodies to the conserved cell surfa

52 e the potential to serve as a novel class of topically applied antimicrobials for the treatment of cu

53 1-Tetradecanol complex (1-TDC) was topically applied at 1- and 10-mg/ml concentrations in f

54 an advantage over the previous detection of topically applied BA using microdialysis coupled to HPLC

55 Topically applied bevacizumab has limited capacity to pe

56 The topically applied bimatoprost insert may provide an alte

57 ervational trial the prophylactic effects of topically applied Ca-SP were compared with those of syst

58 Topically applied camphor elicits a sensation of cool, b

59 These effects of topically applied capsaicin and bradykinin were not due

60 Effects of topically applied cardiac glycosides on intraocular pres

61 he haptens FITC and oxazolone confirmed that topically applied cFLIP antisense could reduce inflammat

62 s challenge, the diffusion, in real time, of topically applied chemicals into the human nail has been

63 ntal periodontitis in rabbits in response to topically applied cimetidine.

64 These studies suggest that while most of topically applied clonidine reaches the retina by a syst

65 trial as a first in class, VEGFr2 targeting, topically applied compound for the treatment of AMD.

66 e development of efficient microbicides, the topically applied compounds that protect uninfected indi

67 These data show that topically applied CpG-ODN induces intraocular inflammati

68 Recent studies show that topically applied CRT has diverse and profound biologica

69 SPACE-peptide (SP50) delivered about 30% of topically applied CsA into the porcine skin in vitro and

70 ex-NW has comparable therapeutic efficacy to topically applied Dex eye drops in experimental mouse dr

71 tion with comparable efficacy to twice a day topically applied dexamethasone eye drop treatment.

72 r results indicate that functional fat-1 and topically applied DHA potentiate cellular defense agains

73 veloped a T-cell-mediated immune response to topically applied DMBA.

74 Nevertheless, low ocular bioavailability of topically applied drug molecules can considerably limit

75 roscopy was used to assess the permeation of topically applied drugs and formulation excipients into

76 skin and mapping of penetration pathways of topically applied drugs in mice and humans.

77 tic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin.

78 Topically applied fibronectin was found to significantly

79 E-mediated passive cutaneous anaphylaxis) we topically applied fingolimod prophylactically, as well a

80 Topically applied flunarizine reduces IOP and attenuates

81 y large increase in the rate of clearance of topically applied fluorescein from the cornea and anteri

82 visualization of skin burn severity using a topically applied fluorescein-loaded liquid bandage and

83 We hypothesized that topically applied fluoride would readily penetrate such

84 There was slight cross-resistance between topically applied fluralaner and permethrin in all five

85 We show that topically applied FLX improves cutaneous wound healing i

86 nflammatory reaction to microbicide products topically applied for the prevention of sexually transmi

87 Topically applied formulations (e.g., emollients and moi

88 In this study, we topically applied gamma-aminobutyric acid (GABA) in the

89 A suspension of topically applied gold-coated silica microparticles exhi

90 In this study, we examined the ability of a topically applied Hh-agonist to modulate follicular cycl

91 tissue biopsies obtained from patients after topically applied immunodulatory treatment resulted in i

92 cacy and mechanism of action of imiquimod, a topically applied inducer of cytokines.

93 These results led to the conclusion that topically applied insulin accumulates in the retina and

94 Furthermore, when exogenous FXIII was topically applied into the wound pocket of rats, eleven

95 the involvement of the superficial layers we topically applied lidocaine.

96 This was based on the observation that topically applied LT induces migration of activated anti

97 Topically applied medications are frequently used in oph

98 Topically applied mesenchymal stromal cells (MSCs) provi

99 Topically applied methylene blue dye chromoendoscopy is

100 Compounds (4a-4q') were screened as topically applied mosquito repellents by measuring the d

101 In diabetic mice, knockout or topically applied nanoconstruct-mediated knockdown of GM

102 Topically applied nanomaterials have been shown to enter

103 molecules targeting the cp gene of ToMV were topically applied on plants prior to virus inoculation.

104 Resveratrol was topically applied on the skin of SKH-1 hairless mice at

105 ororuacil (5-FU) coated with eucalyptus oil, topically applied onto the skin.

106 Interestingly, nine topically applied OP or MC insecticides or analogs also

107 Topically applied PAO induces cutaneous erythema, edema

108 These studies demonstrate that topically applied peroxisome proliferator activated rece

109 A topically applied phosphorothioate antisense oligonucleo

110 The ability of topically applied pTT to induce protective physiologic r

111 These results demonstrate that topically applied RDP58 is an effective anti-inflammator

112 Topically applied ripasudil prolonged graft survival by

113 These results suggest that topically applied RMR-linked FLG monomers are able to pe

114 We used the method to detect topically applied salicylic acid.

115 e findings suggest that a simple strategy of topically applied Shh gene therapy may have significant

116 These results demonstrate that the topically applied single-chain antibody fragment ESBA105

117 While locally injected or topically applied siRNA has progressed into numerous cli

118 The initiation of RNA interference (RNAi) by topically applied small interfering RNA has potential ap

119 estimates of the epidermal concentrations of topically applied solutes.

120 tion of epidermal cholesterol synthesis with topically applied statins only modestly affects epiderma

121 or infectious agents and potential toxins in topically applied substances.

122 Furthermore, topically applied Tat-Smad7 on K5.TGFbeta1 skin wounds a

123 Topically applied THC can effectively attenuate contact

124 We evaluated the impact of topically applied THC on DNFB-mediated allergic contact

125 Thus, the same topically applied therapeutic could be used to improve t

126 nd establish a potentially safe and painless topically applied therapeutic option for treating vision

127 Bevacizumab 1% was topically applied three times a day to the corneas of mi

128 s using Porphyromonas gingivalis (10(9) CFU) topically applied three times a week for a 6-week period

129 Therefore, topically applied THs deserve further exploration as can

130 easibility and excellent safety profile of a topically applied TLR7 agonist used as a vaccine adjuvan

131 he protease-rich tumor microenvironment, was topically applied to 90 specimens ex vivo immediately fo

132 lloid 1 agonist capsaicin and placebo creams topically applied to contralateral areas on the skin of

133 ons of toluidine blue or methylene blue were topically applied to fresh thick skin excisions for seve

134 g Bbcyp52x1 displayed reduced virulence when topically applied to Galleria mellonella, but no reducti

135 Kinetic analysis of oligonucleotide topically applied to hair-clipped BALB/c mouse skin show

136 Antibodies to PVL or control sera were topically applied to infected corneas 0, 24, and 32 hour

137 mino)-17-demethoxygeldanamycin (17AAG), when topically applied to mouse skin, inhibits UVR-induced de

138 ate through the stratum corneum barrier when topically applied to mouse skin.

139 Vehicle was topically applied to one eye, and 2 microg PGF(2alpha)-i

140 ive mitogen that promotes basal tearing when topically applied to rabbit eyes.

141 The 1 alpha-OHase-GFP plasmid was topically applied to shaved C57/BL6 mice.

142 f 0.5% clonidine appeared to be greater when topically applied to the eye that received ischaemia tha

143 ts were highly attenuated for virulence when topically applied to the skin following exponential grow

144 Omeprazole topically applied to the skin of UV-irradiated human sub

145 In this study, GFP-MSCs were topically applied to the surface of cerebral cortex with

146 enetrate the gram-negative cell wall and was topically applied to the wound and was followed by red-l

147 fic p38 MAPK inhibitor or vehicle, which was topically applied to wounds.

148 complicated by poor patient compliance with topically applied treatments.

149 3% MEG, 0.3% GED, or placebo (vehicle) gels, topically applied twice daily to premolar teeth.

150 kingly, reduced basal epidermal melanin when topically applied twice daily, 5 d per wk, for 3 wk to s

151 XPL can be topically applied, rapidly curing at the skin interface

152 rrier typically excludes nucleic acid entry, topically applied, spherically arranged oligonucleotide

153 Topically-applied L-SNAs targeting the gene encoding the

154 soriasis and to investigate the potential of topically applying small interfering RNA targeting Pcsk9

155 the acid SC-buffer system was accelerated by topically applying the LXR activator, 22(R)-hydroxychole

156 bility and activity of ONYX-015 administered topically as a mouthwash to patients with clinically app

157 We conclude that C34, if used topically at susceptible mucosal sites, and if continual

158 compartment by delivery as either an oral or topically based formulation, offering both convenience a

159 lity to successfully deliver siRNA molecules topically brings these novel RNAi-based therapeutics one

160 d in a similar way to clonidine when applied topically but because of the number of experiments carri

161 ly before or after ischaemia or when applied topically by a specific regime.

162 When delivered topically, CFTRact-K089 doubled basal tear volume for 4

163 When topically challenged via dermal ear skin, hALX transgeni

164 BALB/c mice were topically challenged with SRW pollen after they were sen

165 , into a nanoemulsion that when administered topically curbed the progression of disease in a novel r

166 udies, indicate that it might be feasible to topically deliver a therapeutically useful amount of som

167 Topically delivered 12 may be efficacious in human dry e

168 This topically delivered compound exhibited excellent ocular

169 es may be promising agents for personalized, topically delivered gene therapy of cutaneous tumors, sk

170 n IL-7-encoding plasmid (pCMV-Tag1-IL-7) was topically delivered to sites flanking the stressed skin

171 We generated topically-delivered gene-regulating nanoconstructs, comp

172 Topically-delivered lentiviral vectors encoding interleu

173 PAP-1 was equally effective when applied topically, demonstrating that it effectively penetrates

174 contact/rub with other volunteers previously topically dosed.

175 voriconazole (1%) or natamycin (5%), applied topically every hour while awake until reepithelializati

176 ibited plasma leakage in hamster cheek pouch topically exposed to tissue culture trypomastigotes (TCT

177 The present study reveals that when applied topically, fingolimod attenuates both immediate and late

178 eceived 3 doses of acidified nitrite applied topically for 12 weeks with an additional 12 weeks of fo

179 Ingenol mebutate gel applied topically for 2 to 3 days is effective for field treatme

180 e immunized intraperitoneally and challenged topically for 7 consecutive days with short ragweed poll

181 kin integrity and function both when applied topically for anti-inflammatory treatments and during co

182 temic toxic effects when brimonidine is used topically for hemostasis is unknown.

183 e show that gold conjugates can be delivered topically for imaging throughout the whole epithelium.

184 tion inhibitor in vitro and can be delivered topically for prolonged periods through controlled relea

185 short ragweed (SRW) allergen and challenged topically for seven consecutive days with SRW allergen.

186 irus, EBOV, ZIKV, IAV and measles), and also topically for the successful treatment of active lesions

187 e immunized subcutaneously, intranasally, or topically had serum antibody titers of 10,240, 187, and

188 However, only mice with CpG ODN administered topically had significant numbers of CD103(+) Ag-specifi

189 Rabbits that were subcutaneously or topically immunized for endophthalmitis experiments had

190 Topically immunized mice have also demonstrated resistan

191 Rabbits were inoculated topically in both eyes with the CDV-resistant variants R

192 morpholino antisense applied systemically or topically in conjunction with antigen, sensitizes T cell

193 tulated by estradiol treatment both in vivo (topically in male mice) and in vitro (corneal epithelial

194 New Zealand White rabbits were treated topically in one eye with the adenosine A(1) agonist CHA

195 pertoire of therapeutics that can be applied topically in the mouth and beyond.

196 Both morphine and lidocaine were active topically in the tail formalin assay, although their tim

197 These were applied topically in vivo in five doses over a 3-hour period exc

198 0 approximately 250 nM, which when delivered topically increased tear fluid secretion in mice and sho

199 mice and control mice after GAS was applied topically, indicating that MC activity is most important

200 eport to demonstrate a promising approach to topically induce PGD(2) for improving pruritus.

201 However, agents that can topically induce PGD(2) for itch relief are not well est

202 n the nodes increased 2-3-fold when skin was topically inflamed by the TLR7 agonist imiquimod.

203 ied corneas of BALB/c and C57BL/6J mice were topically inoculated and observed daily for keratitis se

204 In vivo, 40 rabbits were topically inoculated in both eyes with Ad5 after corneal

205 Corneas of BALB/c mice were scarified and topically inoculated with 10(5) or 10(6) colony-forming

206 Corneas of BALB/c mice were scarified and topically inoculated with 10(6) colony-forming units of

207 Burn wounds were topically inoculated with a lethal dose of Pseudomonas a

208 f young and aged A/J mice were scarified and topically inoculated with a log phase S. aureus parent s

209 Scarified corneas of BALB/c mice were topically inoculated with Candida albicans and compared

210 Scarified corneas of adult BALB/c mice were topically inoculated with Candida albicans strain SC5314

211 lophosphamide-treated adult BALB/c mice were topically inoculated with Fusarium solani after corneal

212 or cyclophosphamide-treated BALB/c mice were topically inoculated with one of three human isolates of

213 ed virulence of the DeltaMakatG1 mutant when topically inoculated, but no impairment when the insect

214 tibacterial clays, when hydrated and applied topically, kill human pathogens including antibiotic res

215 The probes can also be used to topically label human carotid plaques demonstrating simi

216 The probes could also be used to topically label human carotid plaques demonstrating simi

217 Additionally, human carotid plaques were topically labeled with the probe and analyzed by both so

218 Topically loaded Mn(2+) did not diffuse into the vitreou

219 MEMRI with topically loaded MnCl(2) was also conducted in eyes with

220 curcumin application (either systemically or topically) may be an effective radiation modifying modal

221 onazole, itraconazole, and posaconazole) and topically (miconazole and clotrimazole) and by a tetrazo

222 treated adult NIH Swiss and BALB/c mice were topically mock inoculated or inoculated with 10-fold inc

223 ncentrations of TA (0-16 ng/mL) were applied topically on embryonic day (E) 7 to the chorioallantoic

224 encapsulating a fluorescent dye were applied topically on porcine nipples using a Franz diffusion cel

225 When applied topically on rabbit eyes, these derivatives potently red

226 sive cynomolgus monkeys (n = 8) were treated topically once daily with four 5-muL drops of 0.5% R-DOI

227 nhibitor of the reverse mode of NCX, applied topically onto rat cerebral cortex prior to and during i

228 oncept, we showed that calcitriol, delivered topically or intraperitoneally, increased tumoral accumu

229 and fresh human biospecimens when delivered topically or intravenously.

230 xis studies evaluated tenofovir administered topically or orally (with or without emtricitabine).

231 uronic F-127 (F-127) was administered either topically or systemically and in conjuction with deminer

232 est that CTSS inhibitors administered either topically or systemically can mitigate aspects of the oc

233 Administration of pazopanib topically or systemically suppressed retinal vascular le

234 s, which may be dosed intravenously, orally, topically, or by other routes of administration.

235 In an initial challenge, BCD applied topically prior to SIV(mac251) prevented intravaginal tr

236 dicate that caffeine, administered orally or topically, promotes apoptosis of UVB-irradiated keratino

237 Such an inhibitor could be applied topically provided it was sufficiently permeable via the

238 robing (defined as asking > or =1 additional topically related question), providing open-ended opport

239 et simple-to-implement non-viral approach to topically reprogram tissues through a nanochannelled dev

240 these polymeric nanomicelles and by applying topically resulted in significant reduction in inflammat

241 lling ant lion Myrmeleon carolinus, although topically sensitive to formic acid, is able to prey on f

242 bacterial burdens in the cornea when applied topically starting 8 hours post-infection.

243 breach the skin barrier and deliver vaccines topically, suggesting significant clinical and practical

244 zyme in a liposomal delivery vehicle applied topically (T4N5 liposome lotion) to lower the rate of ne

245 When applied topically, the most alpha2-selective derivatives effecti

246 If applied topically, there are additional issues with rinsing off

247 Mice eyes were treated with PGE(2) (100 ng topically, three times a day) for up to 7 days.

248 Imiquimod cream, 5%, was applied topically to a designated target lesion once per day for

249 y also carry cargos into retina when applied topically to eyes, and cross blood brain barrier when ad

250 genital HSV-2 applied resiquimod or vehicle topically to herpes lesions 2 times weekly for 3 weeks a

251 Pilocarpine and atropine were applied topically to manipulate resting refraction, accommodativ

252 his silicon-based hybrid and applied in vivo topically to mice eyes penetrated across all cornea laye

253 /v) solution of 17AAG (500 nmol) was applied topically to mouse skin in conjunction with each UVR exp

254 lied to cultured human skin keratinocytes or topically to mouse skin.

255 e expression of PPAR-alpha mRNA when applied topically to mouse skin.

256 n shown to increase bone growth when applied topically to murine bone; however, it causes considerabl

257 both when sodium dodecyl sulfate is applied topically to normal human skin as well as when it is add

258 Silver diamine fluoride (SDF) is used topically to prevent or arrest dental caries and has bee

259 BKCa protocol: (1) EMLA cream (EMLA, applied topically to skin surface), (2) tetraethylammonium (TEA)

260 nized anti-CD29 monoclonal antibody (OS2966) topically to skin using minimally-invasive fractional la

261 abbits were inoculated in both eyes with Ad5 topically to study adenovirus replication, and 20 rabbit

262 group LPS+HU, HU-308 (500 ng/mL) was applied topically to the GT daily.

263 n-complexed plasmid DNA vaccines are applied topically to the murine pulmonary mucosa as an immune pr

264 emic vaccination, when conjugate was applied topically to the nasal mucosae whereas gp140 alone was p

265 whether lacritin is prosecretory when added topically to the ocular surface of normal living rabbits

266 and the analgesic efficacy of icilin applied topically to the paws or intrathecally was tested in rat

267 to determine: (i) whether oxysterols applied topically to the skin of mice induce differentiation in

268 such as curcumin are effective when applied topically to the skin or administered orally to affect t

269 laryngeal mucosa, or by citric acid applied topically to the trachea or larynx.

270 ts might be more effective if they were used topically to treat inflammatory dermatoses.

271 formation and number of tumors when applied topically to UVB-pretreated high-risk mice.

272 reptomyces hyaluronidase (StrepH), delivered topically, to degrade epidermal HA and blunt the accumul

273 secondary outcome assessed wound closure of topically treated erosions.

274 unds (0.8 cm) were created on the dorsum and topically treated over 7 days with either vehicle (phosp

275 response, mice were infected with HSV-1 and topically treated with dexamethasone (DEX) or control ey

276 SKH-1 hairless mice were topically treated with GTP (5 mg/0.2 ml acetone/mouse) a

277 s of EP2 and EP4, UVB-exposed CD-1 mice were topically treated with indomethacin to block endogenous

278 ice depleted of complement component C3 were topically treated with MAb F429 starting 8 hours post-in

279 ght measurements, right eyes of rabbits were topically treated with vehicle, BOL-303242-X (1.0% or 0.

280 rEP) is a promising strategy, which utilizes topically (vaginally or rectally), orally or other syste

281 ecules, including those that cannot be given topically, was increased by 1 to 2 orders of magnitude.

282 Some rats were treated topically with 1 mM Compound 49b.

283 dermis and upper hair follicles when treated topically with 12-O-tetradecanoylphorbol-13-acetate (TPA

284 Cynomolgus monkeys were treated topically with 150 microg ECHO in one (n = 4 eyes) or bo

285 Hairless mice were treated topically with activators of PPARalpha (WY14643), PPARde

286 nosuppression amongst mice that were treated topically with available anti-cancer drugs (imiquimod an

287 g the next several months, were then treated topically with caffeine (6.2 micromol) or (-)-epigalloca

288 neous carcinogenesis, mice were treated once topically with DMBA followed by twice weekly with PMA fo

289 Eyes were treated either topically with drops of lysostaphin (0.3%) or with a sin

290 Mice were then treated topically with either AZM or vehicle.

291 H, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.

292 House flies were tested topically with fluralaner in comparison to permethrin at

293 cted subconjunctivally prior to or coapplied topically with gatifloxacin 16 hours after infection.

294 ed with house dust mite allergen and treated topically with HOCl hydrogel both preventively and thera

295 Eyes were treated topically with spermidine before and after lens applicat

296 D-2(-/-) mice and in C57BL/6 mice pretreated topically with the MD-2 antagonist eritoran tetrasodium.

297 We treated mice topically with the Toll-like receptor 7 (TLR7) agonist i

298 tion and keratinocyte apoptosis when treated topically with TPA.

299 FP+ neurofluorescent mouse eyes were treated topically with vehicle or BAK (0.01% or 0.1%).

300 mice chronically exposed to UVB and treated topically with vitamin E alone showed a trend towards in