ライフサイエンスコーパス: topologically

1 We have defined these steps topologically.

2 In addition to being topologically analogous, N-degrons and C-degrons are rel

3 RAAL and NATALIE, regularly produce the most topologically and biologically coherent alignments.

4 Several topologically and functionally distinct polyubiquitin ch

5 nd driver host proteins are significant both topologically and in controllability, therefore playing

6 ns suggest new opportunities for engineering topologically and symmetry-protected states via band inv

7 ly and address how they work together at the topologically and temporally complex cell-cell interface

8 The Nipped-B protein loads cohesin topologically around chromosomes to mediate sister chrom

9 sine 9 methyltransferase), including a large topologically associated 1.2-Mb domain conserved in huma

10 Boundaries of topologically associated chromatin domains frequently co

11 The cPcdh topologically associated domain (TAD(cPcdh)) in neurons

12 myeloid leukemia (AML) to alter HOXA-driven topologically associated domain (TAD) and gene expressio

13 ukemia (BCP-ALL) eliminate the boundary of a topologically associated domain (TAD) at the FLT3 locus,

14 The CFTR gene lies within an invariant topologically associated domain (TAD) demarcated by CTCF

15 CTCF is essential to define topologically associated domain boundaries and to facili

16 We reveal a switch in a topologically associated domain in differentiation of th

17 ription factors can promote formation of sub-topologically associated domain interactions involved in

18 Here, we explore quantitative aspects of topologically associated domains (TAD) between pluripote

19 ales, such as nucleosomes, chromatin fibers, topologically associated domains (TAD), chromosome compa

20 g sites are interwoven with enhancers within topologically associated domains (TADs) and a positive c

21 ates with cohesin binding and restoration of topologically associated domains (TADs) and results in t

22 The majority of A|B compartments or topologically associated domains (TADs) are consistent b

23 tural variants that affect the boundaries of topologically associated domains (TADs) increase risk fo

24 rse processes including (1) the formation of topologically associated domains (TADs) that coordinate

25 The genome is organized into topologically associated domains (TADs) that enclose sma

26 ltiple levels, including compartments(1) and topologically associated domains (TADs)(2,3) consisting

27 ucture, manifested as a global loss of local topologically associated domains (TADs), A/B compartment

28 l features identified by sequencing, such as topologically associated domains (TADs), and the nature

29 er on lamina-associated domains (LADs) or on topologically associated domains (TADs), defined by pref

30 at the genome is organized in a hierarchy of topologically associated domains (TADs), sub-TADs, and c

31 romoters, boundaries of chromatin loops, and topologically associated domains (TADs), was correlated

32 have revealed that chromatin is organized in topologically associated domains (TADs).

33 to self-interacting chromatin regions called topologically associated domains (TADs).

34 so correspond to boundaries of X-chromosomal topologically associated domains (TADs).

35 The genome is partitioned into topologically associated domains and genomic compartment

36 ns why chromosomal folding and insulation of topologically associated domains requires SNF2H, but not

37 characterize alterations to chromatin loops, topologically associated domains, and large-scale compar

38 Expression quantitative trait loci, topologically associated domains, and PrediXcan analyses

39 Large domains, referred to as topologically associated domains, participate in genome

40 profound changes, including the formation of topologically associated domains, refinements in nucleos

41 and whose span in many cases coincides with topologically associated domains.

42 ts and/or transcription in the regulation of topologically associated genes.

43 gulates transcription globally by generating topologically-associated DNA domains (TADs) that link pr

44 nome is folded into regulatory units termed 'topologically-associated domains' (TADs).

45 S) serves as chromatin boundary that defines topologically associating domain (TAD) and enhancer/prom

46 regulation of gene expression in relation to topologically associating domain (TAD) borders were seen

47 interaction networks and be associated with topologically associating domain (TAD) borders, while dC

48 additional interacting elements and defined topologically associating domain (TAD) boundaries, enric

49 nding across several megabases surrounded by topologically associating domain (TAD) boundaries.

50 version with one breakpoint located within a topologically associating domain (TAD) containing enhanc

51 A majority of transgenes that span a full topologically associating domain (TAD) function as butto

52 and inversions of a pluripotency-associated topologically associating domain (TAD) in mouse ESCs.

53 ns of compact chromatin that colocalize with topologically associating domain (TAD) sequences, follow

54 computational tool to systematically detect topologically associating domain (TAD) splits and merger

55 play a key role in organizing chromatin into topologically associating domain (TAD) structures.

56 data, showed that YPEL2 sits within its own topologically associating domain (TAD), rich in enhancer

57 nd its enhancer tend to be found in the same topologically associating domain (TAD), we started with

58 After imputation by scHiCluster, topologically associating domain (TAD)-like structures (

59 heir target genes tend to fall into the same topologically associating domain (TAD).

60 megakaryocyte enhancer found within the same topologically associating domain (TAD).

61 we show that the deletions lead to loss of a topologically associating domain border and an enhancer

62 ed enrichment of evolutionary breakpoints at topologically associating domain boundaries, which were

63 hed in translocation breakpoints, and map at topologically associating domain boundary-flanking regio

64 , the insertion of UMLILO into the chemokine topologically associating domain in mouse macrophages re

65 The murine chemokine topologically associating domain lacks an IPL, and the C

66 ic variants all appear to be within a single topologically associating domain.

67 enic effects, including the formation of new topologically associating domains (neo-TADs).

68 lding pathway that leads to the formation of topologically associating domains (TAD).

69 including the formation of chromatin loops, topologically associating domains (TADs) and compartment

70 on capture (3C) technologies have identified topologically associating domains (TADs) and larger A/B

71 genomic organization including compartments, topologically associating domains (TADs) and loops are p

72 (CTCF) plays a key role in the formation of topologically associating domains (TADs) and loops in in

73 architecture can influence the integrity of topologically associating domains (TADs) and rewire spec

74 multi-megabase compartments to sub-megabase topologically associating domains (TADs) and sub-TAD con

75 hromosomes are sequentially partitioned into topologically associating domains (TADs) and then into s

76 ression based on division of the genome into topologically associating domains (TADs) and then model

77 Topologically associating domains (TADs) are genomic reg

78 The notion that topologically associating domains (TADs) are highly cons

79 Topologically associating domains (TADs) are lost in mei

80 models propose that boundaries of mammalian topologically associating domains (TADs) arise from the

81 rtilized embryos, SCNT embryos show stronger topologically associating domains (TADs) at the 1-cell s

82 The Xic is organized into two topologically associating domains (TADs) but the role of

83 Deletions that fuse two adjacent topologically associating domains (TADs) can cause sever

84 nisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to

85 Genes within the same topologically associating domains (TADs) demonstrate sim

86 range of the same TF bound within different topologically associating domains (TADs) depend on intri

87 om one another and emanate from two distinct topologically associating domains (TADs) flanking HoxD,

88 romatin interactions both within and between topologically associating domains (TADs) frequently chan

89 Topologically associating domains (TADs) have been propo

90 retrovirus subfamily H (HERV-H) in creating topologically associating domains (TADs) in hPSCs.

91 f CTCF and cohesin, two causal regulators of topologically associating domains (TADs) in mammalian ce

92 e large scale of epigenomic compartments and topologically associating domains (TADs) is now relative

93 We found that compartments and topologically associating domains (TADs) remain unchange

94 ns, and transcriptome profiling, we identify topologically associating domains (TADs) that change in

95 The organization of the genome into topologically associating domains (TADs) was shown to ha

96 Topologically associating domains (TADs) were originally

97 At the sub-megabase scale, chromosomes form topologically associating domains (TADs)(1-4).

98 t the MAC chromosomes lack A/B compartments, topologically associating domains (TADs), and chromatin

99 chromosomal contact beads, Lamin-B1 enriched topologically associating domains (TADs), and H3K4me3 en

100 Mammalian genomes are folded into topologically associating domains (TADs), consisting of

101 Clusters of CNEs coincide with topologically associating domains (TADs), indicating anc

102 shown that their span coincides with that of topologically associating domains (TADs), making them us

103 are folded into a hierarchy of compartments, topologically associating domains (TADs), subTADs, and l

104 The human genome can be segmented into topologically associating domains (TADs), which have bee

105 omatin structures including compartments and topologically associating domains (TADs), which may serv

106 ase, the cohesin complex generates loops and topologically associating domains (TADs), while a separa

107 ifferent segments of chromatin have revealed topologically associating domains (TADs), within which m

108 l roles in organizing mammalian genomes into topologically associating domains (TADs).

109 ucleus, distinct chromatin compartments, and topologically associating domains (TADs).

110 maphrodite Xs and establishes megabase-sized topologically associating domains (TADs).

111 conformation by diminishing the formation of topologically associating domains (TADs).

112 between CTCF target sites and insulation of topologically associating domains (TADs).

113 s are organized into structural units called topologically associating domains (TADs).

114 y regulatory elements, which interact within topologically associating domains (TADs).

115 ll types exhibit an increased segregation of topologically associating domains (TADs).

116 and may play a role in the establishment of topologically associating domains (TADs).

117 by demarcating the boundaries of large-scale topologically associating domains (TADs).

118 nteract most frequently at the boundaries of topologically associating domains (TADs).

119 lled by large regulatory landscapes matching topologically associating domains (TADs).

120 matin organization-such as A/B compartments, topologically associating domains and chromatin loops-ar

121 HiC-Reg predictions identify topologically associating domains and significant intera

122 teraction mapping studies have revealed that topologically associating domains and subdomains are fun

123 xture model And Proportion test, to identify topologically associating domains and subdomains in Hi-C

124 ds in mitosis and by which cohesin generates topologically associating domains during interphase.

125 bona fide promoter-enhancer interactions and topologically associating domains involving repetitive g

126 high non-CG methylation that correspond with topologically associating domains of chromatin folding.

127 tag sequencing, ChIA-PET)(3), have revealed topologically associating domains(4) with frequent chrom

128 folding including compartment organization, topologically associating domains, and interactions betw

129 play weak genomic compartmentalization, weak topologically associating domains, and localized point i

130 ts to give networks resembling those seen in topologically associating domains, as switching markedly

131 l variability of chromatin organization into topologically associating domains, thus highlighting the

132 on encompasses larger chromatin loops termed topologically associating domains.

133 eases the chromatin density in a fraction of topologically-associating domains (TADs) enriched in act

134 find large genomic compartments and smaller topologically-associating domains (TADs) that undergo en

135 load in cancer genomes is co-localized with topologically-associating-domain boundaries.

136 l stereodefined peptidomimetic foldamers and topologically biased libraries necessary for future appl

137 Here, a topologically bound mechanical state, a different class

138 t the vulnerable set consists of a small but topologically central portion of the network and that la

139 Thus, the biogenesis of large and topologically challenging IgM complexes is dictated by a

140 OAM meta-transformer reconstructs different topologically charged beams into on-axis distinct patter

141 lyzes ATP, allowing DnaB to isomerize into a topologically closed, pre-translocation state competent

142 but plays a later role in the emergence of a topologically complex and branched shape of the synapse,

143 rly fused (-)-dehydrobrevianamide E into the topologically complex bridged-spiro-fused structure of (

144 to structurally model purification-resistant topologically complex integral membrane proteins.

145 enhances the rigidity of the channel-forming topologically complex molecules.

146 propose importin alpha3 evolved to recognize topologically complex NLSs that lie next to bulky domain

147 Protein chains are known to fold into topologically complex shapes, such as knots, slipknots o

148 The fold of the molecule is topologically complex, with the first beta-sandwich and

149 (S-layer), which surrounds their growing and topologically complicated outer surface.

150 The C=C linkages topologically connect pyrene knots at regular intervals

151 ps, we show that cis-regulatory elements are topologically connected according to their cell type spe

152 The cobalt(II) phthalocyanine catalysts are topologically connected via robust phenazine linkage int

153 In lipoxygenases, the topologically conserved C-terminal domain catalyzes the

154 oadly applicable given that transcription on topologically constrained DNA is the norm across organis

155 dynamics and kinetics of i-motif under such topologically constrained environments is highly relevan

156 al F-model, with exotic phase transitions on topologically-constrained configurational manifolds.

157 Here, we investigated proteins that topologically controlled different human pathways repres

158 the information loss and thus realize novel topologically-controlled access memory (TAM).

159 ntly improve discrimination capacity between topologically correct and incorrect trees.

160 These results argue that topologically correct microbial tissue growth and associ

161 , while the top surface (the (001) plane) is topologically dark with an absence of topological surfac

162 fined by polymer structures laser-written in topologically discontinuous states.

163 authors present a framework for identifying topologically distinct band-structures for all 3D space

164 also show that materials can be divided into topologically distinct classes requiring different optim

165 f the large-intestinal core microbiota where topologically distinct co-occurrence networks were const

166 In contrast, the topologically distinct figure-eight retains the configur

167 nuous and stable monolayer amorphous carbon, topologically distinct from disordered graphene.

168 These knots are robust and topologically distinct from the host medium, though they

169 While the monoarsenides (NbAs and TaAs) have topologically distinct left and right-handed Weyl fermi

170 e in the Weyl semimetal WTe(2), leading to a topologically distinct metastable phase.

171 e topological phase transition, yielding two topologically distinct phononic crystals.

172 s singular, its core fills with atoms in the topologically distinct polar magnetic phase.

173 thway are selected from the structurally and topologically diverse constellation of correctly folded

174 pping interfaces to form compositionally and topologically diverse oligomers.

175 This is due to the fact that when topologically edited DNA molecules, driven by electropho

176 conserved, ring-shaped protein complex that topologically embraces DNA.

177 p Cayley tree-like fractal DNA frameworks to topologically encode the fluorescence states for multipl

178 Scc1 to form a ring-shaped complex that can topologically engage chromatin to regulate chromatin str

179 ling fundamentally new design principles and topologically enhanced functionalities within ferroelect

180 long polymeric molecule that readily becomes topologically entangled whenever it has to be opened for

181 lencing by forming multimeric assemblages to topologically entrap and progressively loop and compact

182 ecome static as they grow into foci that are topologically entrapped on DNA.

183 ps and mediates sister chromatid cohesion by topologically entrapping DNA.

184 simple folds and less so if the fold is more topologically entwined.

185 Merons which are topologically equivalent to one-half of skyrmions can ex

186 Importantly, the introduction of mutations topologically equivalent to T401P into a rat homolog of

187 the lumen of the rough microsomal membranes (topologically equivalent to the extracellular surface in

188 Many of these processes are performed in topologically extracellular compartments or on the cell

189 ted domain of CEP250 is a coiled coil and is topologically featureless, embodying both a structural m

190 By temporarily trapping particles in topologically identified stable states, we also demonstr

191 l-kilobase-long chromosomal domains that are topologically independent from each other, meaning that

192 other low-dimensional materials, and enables topologically induced properties such as geometry-depend

193 We demonstrate explicitly the topologically induced spatial localisation of quantum st

194 ry aims of which is providing nonmetric, but topologically informative, preanalyses of data which mak

195 lks are consistent with distal domains being topologically insulated, that is, not catenated.

196 realization of semiconducting, magnetic, and topologically insulating MXenes.

197 has made it difficult to determine how they topologically interact in replicated chromosomes.

198 1 and Run2 sets of individual gene trees are topologically irreproducible for 9/15 phylogenomic datas

199 erred maximum likelihood (ML) gene trees are topologically irreproducible when executing two replicat

200 estering negative supercoils and stabilizing topologically isolated loops in the DNA.

201 eractions between MukB dimers that stabilize topologically isolated loops in the DNA.

202 Topologically isolating the 1,4-phenylene-bis(4-ethynylb

203 ynamically less stable, less structured, and topologically less rigid compared to ApoE3.

204 extends the RNAP RNA-exit channel, extruding topologically linked single-stranded RNA and preventing

205 esin protein complex organizes the genome by topologically linking distant loci, and is highly enrich

206 cillus subtilis, SMC-condensin complexes are topologically loaded at centromeric sites adjacent to th

207 e effectively described by a rich variety of topologically massive gauge theories.

208 pairing is the chiral p-wave state, which is topologically non-trivial and provides a natural platfor

209 Additionally, this study has found that topologically non-trivial magnetic domains separated by

210 We present a novel methodology to identify topologically non-trivial materials based on band invers

211 pillage is an excellent tool for identifying topologically non-trivial materials.

212 Magnetic skyrmions are topologically non-trivial nanoscale objects.

213 ditionally, we demonstrate that PdGa remains topologically non-trivial over a large energy range, exp

214 th subsequent dielectric doping and detect a topologically non-trivial pai Berry phase in quantum Hal

215 of T c in MoTe2 by disorder, we suggest that topologically non-trivial s (+-) state is more likely to

216 (XMR) property and the potential presence of topologically non-trivial surface states.

217 ced bandgaps are discussed as candidates for topologically non-trivial surface states.

218 tons and points to new avenues for realizing topologically non-trivial systems(16,17), exotic metasur

219 Bernal-stacked bilayer to realize narrow and topologically non-trivial valley-projected moire miniban

220 bservation of a third-harmonic signal from a topologically non-trivial zigzag array of dielectric nan

221 Magnetic skyrmions are topologically nontrivial chiral spin textures that have

222 So far, all of the experimentally identified topologically nontrivial Dirac semimetals (DSMs) possess

223 The discovery of topologically nontrivial electronic systems has opened a

224 is ascertained that band inversion induces a topologically nontrivial ground state in EuCd(2) As(2) .

225 pological excitations(7), in nearly flat and topologically nontrivial moire minibands.

226 n; Z(2) = 1 for MnBi(2)Te(4), confirming its topologically nontrivial nature.

227 on circuit, revealing that the states form a topologically nontrivial one-dimensional ring.

228 Magnetic skyrmions are topologically nontrivial particles with a potential appl

229 a novel quantum state of materials, possess topologically nontrivial valence and conduction bands th

230 our approach will enable the exploration of topologically ordered phases of matter.

231 Regarding their topologically ordered projection pattern, these neurons

232 as excitations with fractional charge in the topologically ordered states of the fractional quantum H

233 e RNA adopts a three-way junction structure, topologically organized by an adenine-rich stem-loop mot

234 the activation of GAS6 oncogene as part of a topologically organized region, as well as a larger netw

235 lex, SpmX, is distinct from the protein that topologically organizes the complex, BacA.

236 tion is a poorly understood process in which topologically planar monomers react to form planar macro

237 Topologically protected acoustic, mechanical, and optica

238 rs owing to a set of gapless states that are topologically protected against backscattering.

239 We thus resolve both topologically protected and nonprotected electronic prop

240 eak inversion symmetry and create nontrivial topologically protected bandgaps.

241 tems with non-equilibrium fluxes can support topologically protected boundary modes that resemble sim

242 e applications of dynamic self-assemblies of topologically protected but highly deformable particle-l

243 Skyrmions are topologically protected continuous field configurations

244 Magnetic skyrmions are topologically protected domain structures related to the

245 e electrons travel ballistically through the topologically protected edge states even in the presence

246 n, in which simple geometric control enables topologically protected in-plane elastic wave propagatio

247 As such, topologically protected interface waves are demonstrated

248 1,2) and now includes demonstrations such as topologically protected lasing(3-5) and single-photon tr

249 code and manipulate quantum information in a topologically protected manner(6,7).

250 ass of materials with an insulating bulk and topologically protected metallic surface states.

251 ving rise to a new type of lasing(5-8) using topologically protected photonic modes that can efficien

252 equires the ability to go beyond the robust, topologically protected properties of materials and to m

253 that stabilize chiral spin textures such as topologically protected skyrmions.

254 in a noncentrosymmetric helimagnet displays topologically protected spin textures with profound tech

255 Dissipationless topologically protected states are therefore of major fu

256 arch on topological materials has focused on topologically protected surface states.

257 critical for the experimental observation of topologically protected surface states.

258 erlying structure, owing to the existence of topologically protected valley edge states that circulat

259 ped terahertz quantum cascade laser based on topologically protected valley edge states(9-11).

260 l behaviour, negative refractive indexes and topologically protected wave motion.

261 cal phase, implying that its dynamics may be topologically protected.

262 eviation from a linear dispersion but remain topologically protected.

263 Here, we report our observation of topologically-protected high-frequency kink modes - kink

264 al isolators and full-duplex nanoantennas to topologically-protected networks.

265 Achieving topologically-protected robust transport in optical syst

266 ophan residue at position 316 and with other topologically proximal sites in the V1V2 domain.

267 ibit halide binding that is competitive with topologically related organic receptors (such as squaram

268 When compared with a topologically related oxo-iron(IV) complex bearing an eq

269 We identify topologically replicable gene networks enriched for dive

270 f this study was to analyze the temporal and topologically resolved protein changes taking place in h

271 ed DNA, where the orientation of the base is topologically restrained.

272 surface of the spirosome respectively, thus topologically separating these two activities.

273 pin distribution is different from that of a topologically similar compound composed of the same numb

274 radical attack on the peri-position versus a topologically similar six-membered ring formation at the

275 form hemichannels on the cell membrane, are topologically similar to connexins, but do not form cell

276 that adult and juvenile alligator skulls are topologically similar, whereas juvenile bird skulls have

277 ACBP is a topologically simple and highly conserved four-alpha-hel

278 eedom with the effect being most apparent in topologically simple folds and less so if the fold is mo

279 on-native contacts in a conformation that is topologically simpler than the native state.

280 ular axis is therefore a neurochemically and topologically specific pacemaker hub that determines the

281 Magnetic skyrmions are topologically stable spin swirls with a particle-like ch

282 d, an "alignment-free" method, gave the most topologically stable ToL.

283 A biskyrmion consists of two bound, topologically stable, skyrmion spin textures.

284 , and use of a metal-free (i.e., LSPR-free), topologically tailored nanostructure composed of porous

285 cs enables us to propose a robust design for topologically textured, icephobic surfaces.

286 Topologically, these flow states are a limit cycle and a

287 rs-shape-defined molecules that are formally topologically trivial but are interconvertible only by c

288 Class AI is topologically trivial in one to three spatial dimensions

289 n-grid alkene metathesis reactions to form a topologically trivial macrocycle (unknot), a doubly inte

290 with a symmetry change to a centrosymmetric, topologically trivial phase.

291 more likely to be realized in MoTe2 than the topologically trivial s (++) state.

292 (TNL) in SrAs(3), whereas CaAs(3) exhibits a topologically trivial state.

293 ed Weyl fermi surfaces, NbP is argued to be "topologically trivial" due to the fact that all pairs of

294 However, the topologically trivial, Lehn-type cyclic hexameric Fe(II)

295 k bismuth itself has been long thought to be topologically trivial.

296 We discovered that the MPC is topologically tuned to face and scene recognition, with

297 ocalized waves, called director bullets, are topologically unprotected multidimensional solitons of (

298 selective MT(1) inverse agonists-which were topologically unrelated to previously explored chemotype

299 wo- and three-dimensional polymers to create topologically well-defined polygonal lattices and built-

300 We show that Smc5/6 binds DNA topologically with affinity for supercoiled and catenate