ライフサイエンスコーパス: torpor

1 (diurnal variation, response to stress, and torpor).

2 asticity in the ground squirrel brain during torpor.

3 genous torpor-producing signals and initiate torpor.

4 t would appear to preclude multiday bouts of torpor.

5 ys important roles in the timing of bouts of torpor.

6 othalamus that serves as a core regulator of torpor.

7 hypothermic and hypometabolic state known as torpor.

8 apid reperfusion upon periodic arousals from torpor.

9 lized or that transcription continues during torpor.

10 icating that translation is depressed during torpor.

11 e and leptin in the regulation of entry into torpor.

12 al NREM sleep, reminiscent of emergence from torpor.

13 ng well and, with prolonged fasting, entered torpor.

14 odulatory role for the DMH in the control of torpor.

15 vely entering a hypometabolic state known as torpor.

16 emperature to 2 degrees C-4 degrees C during torpor.

17 ans survival and germination after return to torpor.

18 anced omega 6:3 ratio, increases AGS T(b) in torpor.

19 ndition of regulated hypometabolism known as torpor.

20 ositioned to contribute to the expression of torpor.

21 UFAs may play a role in thermogenesis during torpor.

22 bernation, aestivation, brumation, and daily torpor.

23 stivating vertebrates that undergo metabolic torpor.

24 se torpor, inducing a state called synthetic torpor.

25 amus contains neurons that are active during torpor.

26 sal medial hypothalamus are activated during torpor.

27 all-sized species that can more easily enter torpor.

28 ower, similarly to that occurring in natural torpor.

29 important role in adaptive thermogenesis and torpor.

30 ction in metabolic regulation for entry into torpor.

31 nown, although the CNS is a key regulator of torpor.

32 por was similar to spontaneous entrance into torpor.

33 ophylline reversed spontaneous entrance into torpor.

34 MSX-3 failed to reverse spontaneous onset of torpor.

35 n and core body temperature as indicators of torpor.

36 ed regulation of metabolism and sleep during torpor.

37 nsitizes mice to a hibernation-like state of torpor.

38 al nervous system remains active during deep torpor.

39 such as leptin, influence the expression of torpor [4-7].

40 Torpor, a controlled rapid drop in metabolic rate and bo

41 Here we show that entry into mouse torpor, a fasting-induced state with a greatly decreased

42 izer, the suprachiasmatic nucleus, abolishes torpor, a hibernation-like state, implicating the circad

43 conditions, certain mammalian species enter torpor, a state characterized by reduced metabolism, bod

44 gulation by combining whole-brain mapping of torpor-activated neurons, cell-type-specific manipulatio

45 thetic nervous system (SNS) in mediating the torpor adaptation to fasting by telemetrically monitorin

46 tivity at beta3-AR-containing tissues in the torpor adaptation to limited energy availability and coo

47 dily reduced serum leptin levels and entered torpor after a fast in a cool environment.

48 ostaglandin D2 synthase declined during late torpor and arousal but returned to a high level on retur

49 processes controlling the transition between torpor and arousal states cause ageing suppression.

50 During hibernation, animals cycle between torpor and arousal.

51 squirrels, comparing hibernating (late in a torpor and during torpor re-entry after arousal) and sum

52 challenges and energetic bottlenecks, daily torpor and hibernation are two metabolic strategies that

53 rgy-conserving survival strategies-including torpor and hibernation-during which their body temperatu

54 e regulation of Tb and metabolic rate during torpor and identify critical nodes of the torpor regulat

55 (TLS; S. tridecemlineatus) during prolonged torpor and in squirrels that did not hibernate or had no

56 endent mechanisms: active penetration during torpor and induced endocytosis during arousal.

57 ating squirrels alternate between periods of torpor and interbout arousal (IBA), when animals tempora

58 us (MnPO) neurons that are required for both torpor and lipopolysaccharide-induced fever(8).

59 Synthetic 5'-AMP induced torpor and mClps expression in LD animals.

60 ipid oxidation nearly exclusively fuels deep torpor and most of the rewarming process.

61 c-Jun, but not junD, commencing during late torpor and peaking during the arousal phase of individua

62 t mortality includes increased arousals from torpor and premature fat depletion during winter months.

63 Despite cerebral ischemia during torpor and rapid reperfusion during arousal, hibernator

64 Incidences of torpor and reduced body temperature were observed in the

65 s identify hypothalamic circuits involved in torpor and reveal GPR50 to be a novel component of adapt

66 etermine the synaptic changes that accompany torpor and to investigate the mechanisms behind these ch

67 significantly reduced following arousal from torpor and undetectable in mRNA obtained from summer gro

68 ut and early and late following arousal from torpor) and from active ground squirrels sacrificed in t

69 Both hibernation, also called multiday torpor, and daily torpor are common among mammals and oc

70 d animation-like states such as hibernation, torpor, and estivation.

71 uring the cycle of heterothermia: euthermia, torpor, and interbout arousal.

72 ds can affect the depth and duration of deep torpor, and saturated fatty acids may be preferentially

73 A(3)AR agonist 2-Cl-IB MECA failed to induce torpor, and the A(2a)R antagonist MSX-3 failed to revers

74 rmines when mice naturally initiate and exit torpor, and the inhibition of which disrupts the natural

75 tion, also called multiday torpor, and daily torpor are common among mammals and occur in at least 11

76 ughout the hibernation season, bouts of deep torpor are punctuated by periodic arousals in which brow

77 Hibernation and short daily torpor are states of energy conservation with reduced me

78 The torpor-arousal cycles occur multiple times during hibern

79 Our results demonstrate that altered torpor-arousal cycles underlie mortality from WNS and pr

80 reorganization on return to euthermy during torpor-arousal cycles.

81 varied metabolic activity across annual and torpor-arousal cycles.

82 tance of the antidiuretic pathway during the torpor-arousal transition and reveals that the neurophys

83 upraoptic nucleus (SON) neurons early in the torpor-arousal transition.

84 itor blood osmolality throughout the dynamic torpor-arousal transition.

85 ease in body temperature and metabolic rate (torpor) as a strategy to survive food scarcity in a cool

86 tabolic rate and body temperature similar to torpor, as measured by body temperature, physical activi

87 During the mid-summer, birds entered torpor at consistently low fat stores (~5% of body mass)

88 control squirrels were more likely to enter torpor at night and to arouse during the day in the pres

89 ostructure from animals at several stages of torpor at two different ambient temperatures, and during

90 hibernation states (early and late during a torpor bout and early and late following arousal from to

91 Mean torpor skin temperature (T(sk)) and torpor bout duration varied significantly among species

92 nt temperature was the greatest predictor of torpor bout duration, and food ingestion and night lengt

93 a wide range in torpid skin temperature and torpor bout duration.

94 to WNS, M. leibii, had significantly shorter torpor bout durations (37.67 +/- 26.89 h) than M. sodali

95 mice, their effects on thermoregulation and torpor bout initiation exhibit differences across sex.

96 r T(sk) (14.42 degrees C +/- 0.36) but short torpor bouts (72.36 +/- 32.16 h).

97 DMH neurons that were active during natural torpor bouts in female mice.

98 During torpor bouts in which T(b) rhythms were unaffected by T(

99 In this latter bat, we documented 5 torpor bouts that lasted >/=16 days and a flightless per

100 ontrol squirrels; the duration of individual torpor bouts was 2 days shorter and far more variable in

101 showing the interruption of low-temperature torpor bouts with periodic interbout arousals (IBAs).

102 ll dwarf lemurs displayed daily and multiday torpor bouts, including bouts lasting ~ 11 days.

103 son and the temporal structure of individual torpor bouts.

104 moted torpor, resulting in longer and deeper torpor bouts.

105 heterothermy - wherein they exploit episodic torpor bouts.

106 res and food restriction induce hypothermic (torpor) bouts and characteristic metabolic and sleep cha

107 rine concentrating ability diminished during torpor but returned during IBA.

108 ystem is robust in animals that show shallow torpor, but its activity in hibernators is at least damp

109 n lesser bushbaby, which is capable of daily torpor, but uses it only under extremely adverse conditi

110 e show that squirrels remain hydrated during torpor by depleting osmolytes from the extracellular flu

111 se Tissue (BAT) drives periodic arousal from torpor by generating essential heat.

112 During torpor, c-fos expression in the cortex was suppressed wh

113 ating ground squirrels retract on entry into torpor, change little over the course of several days, a

114 muscle fibers was reduced by 77-107% during torpor compared to active periods.

115 Some SCNx squirrels cycled through bouts of torpor continuously for nearly 2 years.

116 es of animals can drop during hibernation or torpor covering a large range of temperatures.

117 Water is also lost during torpor due to a positive vapor pressure difference creat

118 to replacement of gene products lost during torpor due to degradation of mRNA.

119 ently low fat stores (~5% of body mass), and torpor duration was negatively related to evening fat lo

120 of cave-exiting activity after arousal from torpor during hibernation for these species before the a

121 e increase in the frequency of arousals from torpor during hibernation, and were emaciated after 3-4

122 esis is that they spend too much time out of torpor during hibernation, depleting vital fat reserves

123 physiological feedback between adiposity and torpor during migration.

124 , naturally undergoing photoperiod-dependent torpor during winter-like photoperiods.

125 Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme

126 Torpor encompasses diverse adaptations to extreme enviro

127 Activity in these neurons promotes torpor entry and maintenance, but their activation alone

128 ion of which disrupts the natural process of torpor entry, maintenance and arousal.

129 n of torpor-TRAPed DMH neurons did not block torpor entry, suggesting a modulatory role for the DMH i

130 n alone does not appear to be sufficient for torpor entry.

131 confirmed that Etruscan shrews readily enter torpor even in the absence of strong physiological trigg

132 s sufficient to initiate the key features of torpor, even in mice that are not calorically restricted

133 behavior exhibited during hibernation (i.e., torpor expression and arousal frequency).

134 patic inflammation, increased mortality, and torpor, findings which were attributed to impaired PPARa

135 d squirrel, endure severe hypothermia during torpor followed by periodic rewarming (REW) during inter

136 irrel (GS) cycles through repeated CI during torpor, followed by warm ischemia/reperfusion (WI) durin

137 ity, however, dwarf lemurs generally express torpor for periods far shorter than the hibernation seas

138 y high metabolic rate and are known to enter torpor frequently, presumably as an energy-saving measur

139 ateral septum also distinguished 2DG-induced torpor from other 2DG-induced behaviors.

140 Genus to study multiple and diverse forms of torpor from publicly-available RNA-seq datasets that spa

141 ere is a peculiar situation, because to date torpor has been almost exclusively reported for Malagasy

142 However, the impact that prolonged torpor has on cognitive function is poorly understood.

143 To date, signaling pathways required for torpor have not been identified.

144 The high slopes of torpor, hovering and flight potentially explain the high

145 in blood pressure and heart rate during the torpor-IBA transition are not associated with massive fl

146 ene expression patterns in multiple forms of torpor, implying a common evolutionary origin for this p

147 ew MPN is a specialization for orchestrating torpor in a mammal with an exceptional metabolism.

148 neither leptin nor thyroid hormone prevented torpor in A-ZIP/F-1 mice.

149 d for the full expression of fasting-induced torpor in both female and male mice, their effects on th

150 ol oxalate] severely blunted fasting-induced torpor in control mice, whereas other AR antagonists wer

151 Torpor in hibernating mammals defines the nadir in mamma

152 e observed Myh2 hyper-phosphorylation during torpor in I. tridecemilineatus, which was predicted to s

153 chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice.

154 may be one first step toward safe synthetic torpor in medicine and space flight.

155 here are at least two signals for entry into torpor in mice, a low leptin level and another signal th

156 ea (MPA) as a key site for the regulation of torpor in mice.

157 area (MPA) as a key brain region to regulate torpor in mouse, little is known about neural control of

158 use, little is known about neural control of torpor in other endothermic animals, including the Etrus

159 We induced synthetic torpor in rats by injecting adenosine 5'-monophosphate m

160 muscle energy expenditure during periods of torpor in response to cold exposure.

161 ild-type mice, Gpr50(-/-) mice readily enter torpor in response to fasting and 2-deoxyglucose adminis

162 urnal rhythms of entry into and arousal from torpor in SCNx animals held under a light/dark cycle, an

163 onist N(6)-cyclohexyladenosine (CHA) induced torpor in six of six AGSs tested during the mid-hibernat

164 uced responses was absent during 2DG-induced torpor in the present experiment.

165 s), a species that naturally undergoes daily torpor in which Tb decreases by as much as 15-20 degrees

166 uspended animation state, resembling natural torpor, in a nonhibernator.

167 Torpor induced by metabolic stress was associated with e

168 enditure in species that do not normally use torpor, inducing a state called synthetic torpor.

169 e key neuronal populations involved in daily torpor induction in mice, in particular, projections fro

170 eep deprivation, however, show that the post-torpor intense sleep is not homeostatically regulated, b

171 omprises weeks of hypometabolic, hypothermic torpor interspersed with 24-48-h periods of an active-li

172 ed by long periods of metabolic suppression (torpor) interspersed by short periods of increased metab

173 Daily torpor involves reductions in body temperature, as well

174 Torpor is a naturally occurring, hypometabolic, hypother

175 Torpor is a short-term hibernation-like state that allow

176 The hypometabolic state of torpor is a widely utilized and well-orchestrated respon

177 Long-term torpor is an adaptive strategy that allows animals to su

178 The view that torpor is an evolutionary extension of sleep is supporte

179 Entry into torpor is associated with a 50-65% loss of synapses, as

180 Torpor is caused by preoptic neurons that express a vari

181 Hibernation or torpor is considered a possible tool to protect astronau

182 abolic rate and body temperature (Tb) during torpor is controlled by the brain, the specific neural c

183 p immediately following torpor suggests that torpor is functionally a period of sleep deprivation.

184 und the diet-induced increase in T(b) during torpor is most easily explained by an increase in the ma

185 otein clustering occurring during entry into torpor is not attributable to protein loss.

186 hat were activated during a previous bout of torpor is sufficient to initiate the key features of tor

187 e primary determinants of arousal state, and torpor is the most extreme state change that occurs in m

188 h here we apply StrokeofGenus to analysis of torpor, it can be used to interrogate any other complex

189 orthern Vietnam during winter indeed undergo torpor lasting up to 63 h, that is, hibernation.

190 Hibernation consists of prolonged periods of torpor, lasting up to 18 days, which are characterized b

191 Coupled with radiation exposure, induced torpor led to a stress response but also revealed mainte

192 2-deoxy-d-glucose (2DG) produces pronounced torpor-like hypothermia (not< approximately 15 degrees C

193 tructures activated during the initiation of torpor-like hypothermia induced by 2DG treatment.

194 dings demonstrate that a deeply hypothermic, torpor-like state can be pharmacologically induced in a

195 cyclohexyladenosine to induce a hypothermic, torpor-like state in the (nonhibernating) rat.

196 erature, central A1AR stimulation produced a torpor-like state similar to that in hibernating species

197 ally suppress energy expenditure and enter a torpor-like state; this behavior is markedly enhanced in

198 ng rodent torpor provides insight into human torpor-like states such as near drowning in cold water a

199 sts that the processes involved in prolonged torpor may have a fundamentally different impact on memo

200 Here we describe an induced torpor model we developed using the zebrafish.

201 cle, these SCNx squirrels expressed bouts of torpor nearly continuously throughout 2.5 yr of cold exp

202 In animals that undergo hibernation and torpor, neurally regulated metabolic and thermoregulator

203 Neither the incidence of torpor nor its depth or duration was related to NPY dose

204 xpression programs and affecting metabolism, torpor, obesogenesis, and foraging in distinct ways.

205 k cycle, whereas entry into and arousal from torpor occurred at random clock times in both SCNx and c

206 of cave-exiting activity after arousal from torpor of hibernating bats is important for bat ecology

207 tion period, birds were more likely to enter torpor on nights when they had higher fat stores, and fa

208 as the arctic ground squirrel (AGS), display torpor only during the winter, hibernation season.

209 sults show that metabolic suppression during torpor onset is regulated within the CNS via A(1)AR acti

210 he mechanism of metabolic suppression during torpor onset is unknown, although the CNS is a key regul

211 ed in a programmed manner by undergoing deep torpor or hibernation during which the hypothalamic setp

212 ficing high body temperature through modest (torpor) or severe (hibernation) curtailments to metaboli

213 A cohort of transcripts increased during torpor, paradoxical because transcription effectively ce

214 rnators are defined by body temperature, not torpor per se.

215 During torpor, physiological processes such as respiration, car

216 c systems that normally integrate endogenous torpor-producing signals and initiate torpor.

217 Despite the low levels of AVP and OXT during torpor, profound increases in blood pressure and heart r

218 We conclude that synthetic torpor protects animals from cosmic ray-simulated radiat

219 Studying rodent torpor provides insight into human torpor-like states su

220 ing hibernating (late in a torpor and during torpor re-entry after arousal) and summer active animals

221 t differences in extent of retraction during torpor, recovery reaches the same final values of cell b

222 Induced torpor reduced metabolism and increased pro-survival, an

223 we identify the neural circuits involved in torpor regulation by combining whole-brain mapping of to

224 ng torpor and identify critical nodes of the torpor regulatory network.

225 We show torpor-related alterations in synaptic protein localizat

226 These findings suggest that torpor-related changes in synapses stem from dissociatio

227 sed, yet the neural mechanisms that regulate torpor remain unclear [3].

228 lowered serum leptin levels and rescued the torpor response.

229 neurons in calorie-restricted mice promoted torpor, resulting in longer and deeper torpor bouts.

230 hypothalamus that controls entry into daily torpor.SIGNIFICANCE STATEMENT Daily heterotherms, such a

231 e of the CNS in the induction of hibernation/torpor, since CNS-driven changes in organ physiology hav

232 Mean torpor skin temperature (T(sk)) and torpor bout duration

233 Recent studies that employ post-torpor sleep deprivation, however, show that the post-to

234 mage to the lungs, suggesting that synthetic torpor spares tissues from energetic ion radiation.

235 We also identify torpor-specific gene expression patterns that are shared

236 nimals from the fall; these fall animals use torpor sporadically with body temperatures mirroring amb

237 f either cell type is necessary to enter the torpor state.

238 no decline in total RNA or total mRNA during torpor; such a decline had been previously hypothesized.

239 Poly(A) tail lengths were not altered during torpor, suggesting either that mRNA is stabilized or tha

240 Deep sleep immediately following torpor suggests that torpor is functionally a period of

241 species, Perimyotis subflavus, exhibited low torpor T(sk) (14.42 degrees C +/- 0.36) but short torpor

242 Myotis leibii also had significantly higher torpor T(sk) (18.57 degrees C +/- 0.20) than M. grisesce

243 sufficient to reach the criterion for daily torpor (Tb < 32 degrees C for at least 30 min).

244 Throughout torpor the suprachiasmatic nucleus ('biological clock')

245 To further characterise our model of induced torpor, the zebrafish model was compared with hepatic tr

246 erated in the animals reaching criterion for torpor; the decrease in food intake was positively corre

247 However, in hibernation or torpor, this canonical thermoregulatory response is repl

248 hese findings demonstrate the versatility of torpor throughout the annual cycle and suggest a fundame

249 TEMENT Daily heterotherms, such as mice, use torpor to cope with environments in which the supply of

250 mmalian hibernators periodically rewarm from torpor to high, euthermic body temperatures for brief in

251 is has led to the investigation of synthetic torpor to mitigate the deleterious effects of chronic lo

252 when they up-regulate heat production during torpor to prevent freezing.

253 Many small endotherms use torpor to reduce metabolic rate and manage daily energy

254 me mammals employ bouts of deep hypothermia (torpor) to cope with reduced food supply and harsh clima

255 Chemogenetic inhibition of torpor-TRAPed DMH neurons did not block torpor entry, su

256 Chemogenetic reactivation of torpor-TRAPed DMH neurons in calorie-restricted mice pro

257 s that influence the expression of sleep and torpor uncover significant differences.

258 mice failed to reduce serum leptin and enter torpor under fasting conditions, whereas restoration of

259 shrew and rat, a mammal that does not enter torpor under physiological conditions.

260 s, changes in myosin metabolic states during torpor unexpectedly led to higher levels in energy expen

261 We tracked torpor use and body composition in ruby-throated humming

262 wever, the physiological 'rules' that govern torpor use are unclear.

263 o record sub-hourly patterns of activity and torpor use, in one case over a period of 224 days that s

264 was positively correlated with the amount of torpor used.

265 Interestingly, during torpor very strong c-fos activation was seen in the epit

266 In ob/ob mice, fasting-induced torpor was completely reversed by leptin treatment.

267 Torpor was expressed in fasted Dbh-/- mice immediately a

268 CHA-induced torpor was similar to spontaneous entrance into torpor.

269 During entrance into torpor, we detected activation of the ventrolateral subd

270 mals, some low-amplitude T(b) rhythms during torpor were driven by small (<0.1 degrees C) diurnal cha

271 In torpor, when body temperature (T(B)) reaches 4 degrees C

272 Inducing torpor with a prolonged fast revealed larger and more va

273 -ZIP/F-1 (but not control) mice entered deep torpor, with a minimum core body temperature of 24 degre

274 exhibit a dramatic form of plasticity during torpor, with dendritic arbors retracting as body tempera

275 CHA-induced torpor within the hibernation season was specific to A(1

276 After the induction of arousal from torpor, within 2 h, the apical dendritic lengths, branch

277 suspended animation state similar to natural torpor would be greatly beneficial in medical science, s