1 ic genome through a high-fidelity convergent
total synthesis.
2 new natural products were also confirmed by
total synthesis.
3 lementation of radical fragment couplings in
total synthesis.
4 the diarylprolinol silyl ether catalysts in
total synthesis.
5 en, its main application has been its use in
total synthesis.
6 igned to (+)-subincanadine E on the basis of
total synthesis.
7 step routes afforded to organic chemistry by
total synthesis.
8 the use of cyclic ketones ring expansion in
total synthesis.
9 ssive efficiency, which are of high value in
total synthesis.
10 ovide a solution for its preparation through
total synthesis.
11 NAs produced by transcription rather than by
total synthesis.
12 cyclic core of the molecule and complete the
total synthesis.
13 ion of spectroscopic data, ECD analysis, and
total synthesis.
14 ple revisions and has been confirmed through
total synthesis.
15 word most would associate with the field of
total synthesis.
16 alin analogs, synthesized utilizing diverted
total synthesis,
allowed the identification of the struc
17 To generate inhibitors of CD38 by
total synthesis,
analogues based on the cyclic inosine 5
18 A unified enantioselective
total synthesis and anticancer evaluation of all known e
19 Herein, we report the diverted
total synthesis and biological evaluation of a rationall
20 provide inspiration for further advances in
total synthesis and chemical biology.
21 arious fields of synthetic chemistry such as
total synthesis and drug discovery as well as from devel
22 eptides and proteins that can be produced by
total synthesis and has also numerous applications in bi
23 Building upon our earlier achievements in
total synthesis and medicinal chemistry, we used chemica
24 Since the pioneering days of
total synthesis and retrosynthetic analysis, the communi
25 ith loss of the furanyl acetate, has enabled
total synthesis and stereochemical elucidation of the ma
26 We also describe an enantioselective
total synthesis and stereochemical revision of (-)-caesa
27 The
total synthesis and structural revision of (+)-cryptocon
28 The first
total synthesis and structural validation of phosdiecin
29 n of d-sarmentosyl donors enabling the first
total synthesis and structure validation of cardenolide
30 parallel with collective synthesis, diverted
total synthesis and the preparation of truncated natural
31 diastereomers were independently prepared by
total synthesis,
and it is the former, not the latter, t
32 Utilizing a
total synthesis approach, the first 8-heterocyclyltetrac
33 in drug diversification and natural product
total synthesis are described.
34 f natural products provides opportunities in
total synthesis,
biology, and medicine due to their nove
35 ct modifications and were introduced through
total synthesis but are also remarkable in that they are
36 ules of this complexity be prepared today by
total synthesis but such efforts can be extended to the
37 Herein, we report its
total synthesis by a highly convergent Ser ligation appr
38 Overall, our work demonstrates that a
total synthesis can address the issue of limited materia
39 tal-mediated cleavage of C-C single bonds in
total synthesis can be ascribed to a communal recognitio
40 A biomimetic approach to
total synthesis can offer several benefits, including th
41 The continuous development of
total synthesis chemistry has allowed many organic and b
42 The success in
total synthesis,
designed with a novel convergent strate
43 we synthesized 16 analogs utilizing diverted
total synthesis (
DTS).
44 applications of gold catalysed reactions in
total synthesis during the years since our last article
45 ionship profile throughout the course of the
total synthesis effort.
46 plex scaffold, okaramines have inspired many
total synthesis efforts, but the enzymology of the okara
47 The
total synthesis enabled us to establish the absolute con
48 The
total synthesis features the first application of the tr
49 Total synthesis followed by derivative synthesis has his
50 of inspiration for chemists in the field of
total synthesis for the development of innovative method
51 III (3), have succumbed to enantioselective
total synthesis for the first time in only 18 steps from
52 Total synthesis has been an effective and broadly practi
53 e decades ago (1984), and in natural product
total synthesis has been conducted.
54 A
total synthesis has been developed that builds off prior
55 e the value that programs in natural product
total synthesis have in advancing organic chemistry, her
56 However, recent studies in
total synthesis have inspired a number of collaborative
57 In fact, the spirit of
total synthesis is all-too-often reputed as being more c
58 ctives for the use of this transformation in
total synthesis is also included.
59 s nucleophilic and electrophilic partners in
total synthesis is elegantly demonstrated.
60 ion of length, because the efficiency of the
total synthesis is the numerical product of the individu
61 The first
total synthesis now proves that the structure of this co
62 Reported herein is a
total synthesis of (+)-6-epi-ophiobolin A in 14 steps, a
63 An asymmetric
total synthesis of (+)-6-hydroxythiobinupharidine (1b) a
64 The asymmetric (er > 99:1)
total synthesis of (+)-anti- and (-)-syn-mefloquine hydr
65 We report the first
total synthesis of (+)-granatumine A, a limonoid alkaloi
66 We report the first
total synthesis of (+)-hypercalin C employing a converge
67 Total synthesis of (+)-mesembrane featuring the catalyti
68 A gram-scale enantioselective
total synthesis of (+)-peganumine A was accomplished in
69 This first
total synthesis of (+)-pestalazine A also allowed us to
70 ynthesis strategy to achieve enantiospecific
total synthesis of (+)-phorbol in only 19 steps from the
71 by the protecting groups and applied to the
total synthesis of (+)-varitriol and of two diastereoiso
72 A short, 5-step
total synthesis of (+/-)-3-demethoxyerythratidinone from
73 The
total synthesis of (+/-)-aspergilline A (1) is described
74 tion of analogues, a flexible and convergent
total synthesis of (+/-)-aureothin is presented.
75 l synthesis of (+/-)-picropodophyllone and a
total synthesis of (+/-)-brazilin.
76 The methodology was used for the
total synthesis of (+/-)-chelonin A.
77 the thermic ring contraction applied to the
total synthesis of (+/-)-Gelsemoxonine.
78 The first
total synthesis of (+/-)-gelsenicine is reported.
79 Here we report a
total synthesis of (+/-)-morphine that employs two key s
80 Its application was demonstrated in a short
total synthesis of (+/-)-paeonilide.
81 The development of a concise
total synthesis of (+/-)-phyllantidine (1), a member of
82 to the natural product provides the shortest
total synthesis of (+/-)-vibralactone reported to date.
83 The first stereoselective
total synthesis of (-)-(2S,4R)-3'-methoxy citreochlorol
84 Herein we report a concise
total synthesis of (-)-albocycline in 14 steps from comm
85 Described is a concise
total synthesis of (-)-ambiguine P, a cycloheptane-conta
86 A unified and concise first asymmetric
total synthesis of (-)-citreoisocoumarin (2), (-)-citreo
87 The first biomimetic enantioselective
total synthesis of (-)-communesin F based on a late-stag
88 ward these molecules, resulting in a 10-step
total synthesis of (-)-curvulamine, a dimeric member wit
89 The first enantioselective
total synthesis of (-)-cycloclavine was accomplished in
90 e culminated in the development of the first
total synthesis of (-)-daphlongamine H, provided access
91 The first enantioselective
total synthesis of (-)-deoxoapodine is described.
92 accomplishment of the first enantioselective
total synthesis of (-)-gamma-gurjunene, a sesquiterpene
93 The enantioselective
total synthesis of (-)-hodgkinsine, (-)-calycosidine, (-
94 The first
total synthesis of (-)-marinisporolide C is described, w
95 We recently reported a
total synthesis of (-)-myrocin G (4), the putative activ
96 A convergent
total synthesis of (-)-nahuoic acid Ci(Bii) (3), a novel
97 Reported here is a short chemoenzymatic
total synthesis of (-)-podophyllotoxin and related arylt
98 n in natural product synthesis and the first
total synthesis of (2S)-hydroxy-3,4-dehydroneomajucin, t
99 The catalytic enantioselective
total synthesis of 1 was accomplished in 7 steps and 38%
100 The first
total synthesis of 1 was successfully established via 31
101 n this study, we report the first asymmetric
total synthesis of 19,20-epoxydocosapentaenoic acid (19,
102 ndings have been successfully applied to the
total synthesis of 2-epi-lepadiformine C.
103 A scalable and modular
total synthesis of 3-lipid I and 3-lipid II was accompli
104 An asymmetric
total synthesis of [(13) C(4) ]-anatoxin-a ([(13) C(4) ]
105 A full account on the first
total synthesis of a chroman meroterpenoid, (-)-phomoarc
106 The first
total synthesis of a chromodorolide diterpenoid is descr
107 We report the
total synthesis of a complex beta-1,2-mannosyloxymannito
108 The
total synthesis of a dimeric thymol derivative (thymarni
109 ably, this synthesis is the first gram-scale
total synthesis of a guaianolide natural product.
110 The first
total synthesis of a lipid mediator derived from natural
111 route was also successfully applied for the
total synthesis of a natural 1,2-diketone.
112 and has been exploited by application to the
total synthesis of a natural occurring benzodioxole and
113 s" to reveal a masked carboxylic acid in the
total synthesis of a natural product.
114 Total synthesis of a structurally diverse group of Aureo
115 An efficient
total synthesis of A54145 factor D (A5D), a member of th
116 The
total synthesis of acredinone A features two different P
117 trategies and tactics that culminated in the
total synthesis of ajudazol B, the most potent and least
118 he new synthetic route was effective for the
total synthesis of all members in the homohalichondrin s
119 ion of macrolactone 33a we describe a formal
total synthesis of amphidinolide Q.
120 ssful outcome was utilized to accomplish the
total synthesis of an aminopropyl linker-attached trisac
121 An improved and enantioselective
total synthesis of antibiotic CJ-16,264 through a practi
122 A five-step
total synthesis of arborisidine, a caged pentacyclic mon
123 The first
total synthesis of arborisidine, a unique Kopsia indole
124 On this basis, a
total synthesis of arcutinidine is reported herein, feat
125 A concise
total synthesis of artalbic acid has been enabled by a s
126 in the final product and thus completing the
total synthesis of aspergillide A.
127 Herein we report the first
total synthesis of berkeleyone A, a potential gateway co
128 The first
total synthesis of bifidenone, a novel natural tubulin p
129 or vinylic halogenations and to complete the
total synthesis of bioactive natural products, obolacton
130 The
total synthesis of bottromycins involves at least 17 ste
131 Here, we report a
total synthesis of bryostatin 1 that proceeds in 29 tota
132 Here, we report a concise
total synthesis of bryostatin 3 using 22 steps in the lo
133 We achieved a
total synthesis of C52-halichondrin-B amine (E7130) on a
134 ein we describe synthetic efforts toward the
total synthesis of calyciphylline B-type alkaloids.
135 ient seven-step, protecting-group-free first
total synthesis of chatenaytrienin-2 based on ring-closi
136 thermore, using the same strategy, the first
total synthesis of chatenaytrienin-4, the proposed unsat
137 The result is a highly convergent
total synthesis of chivosazole F through the orchestrati
138 Described here is the
total synthesis of CHX and analogues, and the establishm
139 erodimeric intermediate, including the first
total synthesis of communesins C-E, and G-I, and facilit
140 Strategies for the
total synthesis of complex natural products that contain
141 We identify a short
total synthesis of congeners in the reverse-prenylated i
142 Herein, we describe the first
total synthesis of cystobactamid 919-2 from three fragme
143 and convergent route for the stereoselective
total synthesis of cytotoxic macrolides pestalotioprolid
144 Synthetic studies toward the
total synthesis of dehaloperophoramidine have led to the
145 The
total synthesis of dehydromicrosclerodermin B and micros
146 n, we report a short olefin-metathesis-based
total synthesis of Delta(12)-PGJ(2) and its application
147 We report a concise
total synthesis of dictyodendrin F and the first total s
148 An asymmetric
total synthesis of diplobifuranylone B was achieved in 1
149 A five-step
total synthesis of Dysoxylum alkaloids has been achieved
150 The first
total synthesis of emindole PB is accomplished in 13 ste
151 The
total synthesis of enantiomerically pure (+)-mesembrine
152 The first
total synthesis of five austalide natural products, (+/-
153 The work extends the divergent
total synthesis of four to now six different natural pro
154 with its potential demonstrated in the short
total synthesis of four venom alkaloids.
155 A novel
total synthesis of fully protected idraparinux has been
156 The first
total synthesis of galanal A and B has been achieved fro
157 earrangement strategy resulting in a 10-step
total synthesis of garsubellin A, an enhancer of choline
158 The first
total synthesis of Gliomasolide C, the short synthesis o
159 Herein, we describe a divergent
total synthesis of glycinocins A-C, which differ in the
160 An efficient
total synthesis of goadsporin is reported in which the k
161 The first
total synthesis of halistatins 1 and 2 has been complete
162 Herein, we describe an expeditious
total synthesis of hemiasterlin featuring a four-compone
163 A simple
total synthesis of herqulines B and C is reported, model
164 Here, we report the first
total synthesis of hinduchelins A-D, a family of nontoxi
165 Here, we report the first
total synthesis of hybrubin A, a bipyrrole tetramic acid
166 ork of the baulamycin family, as well as the
total synthesis of its most potent member, baulamycin A.
167 aining polyenes and application to a concise
total synthesis of leukotriene B(3).
168 accomplishment paves a path for the eventual
total synthesis of lomaiviticins A and B and opens oppor
169 The
total synthesis of lundurines A-C has been accomplished
170 The
total synthesis of lycoricidine and narciclasine is enab
171 Herein, we report the first
total synthesis of marine ladder polyether gymnocin B (1
172 An asymmetric
total synthesis of Merck's hNK(1) antagonist and three o
173 A stereocontrolled first
total synthesis of muraymycin D1 (1) has been achieved.
174 protecting group-free, and enantioselective
total synthesis of mycothiazole, a naturally occurring a
175 etone rearrangement was applied in a concise
total synthesis of naphthomevalin, a prominent member of
176 The
total synthesis of narciclasine is accomplished by the l
177 The first
total synthesis of natural (-)-clavicipitic acid from ga
178 A stereoselective
total synthesis of natural product aspergillide A is rep
179 ion of carbonyls is of key importance in the
total synthesis of natural products and in medicinal che
180 n of first-row metal-mediated methods to the
total synthesis of natural products is discussed.
181 ely new retrosynthetic disconnections in the
total synthesis of natural products.
182 on reactions have found broad application in
total synthesis of natural products.
183 Enantioselective first
total synthesis of naturally occurring cytotoxic (+)-sub
184 s which has been successfully applied to the
total synthesis of naturally occurring pyrolidine alkalo
185 is provides access to many natural products,
total synthesis of numerous complex molecules is not eco
186 Here, we report the
total synthesis of P-A1 and P-A2, as well as two analogu
187 natural products is demonstrated through the
total synthesis of Pandalizine A.
188 A concise formal
total synthesis of pericoannosin A, by the synthesis of
189 ion of strategies that ultimately led to the
total synthesis of phomactins A, K, P, R, and T, as well
190 The first
total synthesis of potent cannabinoid, 9beta-11-hydroxyh
191 The
total synthesis of principinol D, a rearranged kaurane d
192 The first
total synthesis of psychrophilin E, a potent antiprolife
193 Here, we describe a
total synthesis of PvD(1), the defensin from the common
194 motifs are important building blocks for the
total synthesis of pyrroloindoline alkaloids.
195 A biomimetic
total synthesis of racemic homodimericin A was achieved
196 The
total synthesis of representative members of the schizoz
197 Completion of the first
total synthesis of resolvin D4 established the absolute
198 ach has been applied to the enantioselective
total synthesis of rumphellaone A.
199 hesis of anhydroryanodol and thus the formal
total synthesis of ryanodol.
200 yl cross-coupling reaction was probed in the
total synthesis of salmochelins (siderophores) and comme
201 ication of "hydrogenative metathesis" to the
total synthesis of sinularones E and F concurred with th
202 no substituted ketones is exemplified in the
total synthesis of sphingolipid HPA-12 and the sedamine
203 Here we report the
total synthesis of stolonidiol starting from (R)-(+)-lim
204 Herein, we report the first
total synthesis of streptide that confirms the regiochem
205 ategy (3 + 2 + 6) to accomplish a gram-scale
total synthesis of teixobactin.
206 ulted in the most brief and highest yielding
total synthesis of the alkaloid in three steps and a 36%
207 rmediate associated with a recently reported
total synthesis of the alkaloid kopsihainanine A (1).
208 The methodology has been used for the
total synthesis of the antidepressant agent (+/-)-5-phen
209 ted alpha-amino acids including an expedient
total synthesis of the antiepileptic drug levetiracetam.
210 d products was illustrated in the nonracemic
total synthesis of the bioactive alkaloid (-)-epibatidin
211 First,
total synthesis of the cell surface phospholipomannan an
212 The first
total synthesis of the complex hexacylic Daphniphyllum a
213 The first enantioselective
total synthesis of the complex tricarbocyclic sesquiterp
214 Here, we report the first
total synthesis of the conjugation-ready trisaccharide r
215 Described is the
total synthesis of the cyanotoxin microcystin-LF (MC-LF,
216 A formal
total synthesis of the cytotoxic macrolide amphidinolide
217 The first enantioselective
total synthesis of the cytotoxic natural product (+)-psi
218 A highly stereoselective
total synthesis of the diacetonide derivative of the ant
219 A
total synthesis of the diastereoisomeric pair of compoun
220 We report the concise, biomimetic
total synthesis of the dimeric, Diels-Alder natural prod
221 ghly enantioselective and diastereoselective
total synthesis of the diterpenoid (-)-mitrephorone A is
222 synthesis of tubocurine represents a formal
total synthesis of the famous arrow poison alkaloid tubo
223 Herein, we report the
total synthesis of the fully glycosylated monomeric unit
224 A 13-step
total synthesis of the fungal meroterpenoid berkeleyone
225 on tactic, was successfully employed for the
total synthesis of the highly cytotoxic marine macrolide
226 subsequent elaboration to complete the first
total synthesis of the juvenimicin, M-4365, and rosamici
227 An enantioselective
total synthesis of the labdane diterpene andrographolide
228 We report the first
total synthesis of the limonoid andirolide N using a 12-
229 The first
total synthesis of the marine natural product avrainvill
230 Herein, we describe the
total synthesis of the most common pseudaminic acid, 5,7
231 Based on these findings, a concise
total synthesis of the natural product (+)-varitriol and
232 A new
total synthesis of the natural product (-)-depudecin, a
233 odular biosynthetic enzymes, we describe the
total synthesis of the natural product aeruginosamide B
234 n an original convergent and stereoselective
total synthesis of the natural product.
235 ow accessible as a result of advances in the
total synthesis of the natural product.
236 A streamlined
total synthesis of the naturally occurring antitumor age
237 rance of this method were exemplified by the
total synthesis of the neolignan natural product, (+)-ob
238 The first
total synthesis of the norcembranoid diterpenoid scabrol
239 An enantioselective
total synthesis of the norditerpenoid alkaloid nigelladi
240 The first
total synthesis of the novel cyclohexylethanoid natural
241 A short
total synthesis of the novel unnatural parthenolide dias
242 A
total synthesis of the oleander scale [ Aspidiotus nerii
243 The
total synthesis of the oligosaccharide moiety of disialo
244 emerging technology, a unified, asymmetric,
total synthesis of the phomactin terpenoids was develope
245 We report the first
total synthesis of the polyunsaturated fatty acid 7-hydr
246 l ketone building blocks, an efficient first
total synthesis of the potent anti-trypanosomal macrolid
247 The first
total synthesis of the potent antibiotic berkeleylactone
248 A convergent and stereoselective
total synthesis of the previously assigned structure of
249 However, the
total synthesis of the proposed structure of briarellin
250 A
total synthesis of the proposed structure of nhatrangin
251 The first asymmetric
total synthesis of the putative structure of diplopyrone
252 lpha,beta-unsaturation is exemplified in the
total synthesis of the quinolizidine alkaloid natural pr
253 A
total synthesis of the racemic modification, (+/-)-2, of
254 The enantioselective
total synthesis of the rearranged spongian diterpenoid (
255 The first
total synthesis of the reported structure of 13a-hydroxy
256 nd flexible strategy for the stereoselective
total synthesis of the reported structure of baulamycin
257 The first
total synthesis of the resveratrol tetramers vitisin A a
258 scopic evidence has been corroborated by the
total synthesis of the revised structure of echinosulfon
259 has been readily extended to accommodate the
total synthesis of the spider toxins Agel 416 and HO-416
260 The methodology was used in the
total synthesis of the Stemona alkaloid (-)-stemaphyllin
261 The
total synthesis of the Strychnos alkaloid (+/-)-minfiens
262 Here we report the
total synthesis of the three largest circular bacterioci
263 Herein we report the
total synthesis of the trans-fused 8,12-guaianolide (+)-
264 t-controlled enantio- and diastereoselective
total synthesis of the two most likely diastereomeric ca
265 A
total synthesis of the vasicinone family of natural prod
266 The first
total synthesis of the yellow pigment chalcitrin, a stru
267 Herein, we disclose the first
total synthesis of this highly strained target in 13 ste
268 Two distinct strategies toward the
total synthesis of this interesting target are reported.
269 The
total synthesis of this intermediate is based on the uti
270 inhibitor of rosettes (IOR-1) as well as the
total synthesis of this molecule and all of its stereois
271 studies with shishijimicin A resulted in the
total synthesis of this scarce marine natural product an
272 he application of these methodologies in the
total synthesis of THP-based natural products.
273 nes as well as in the first enantioselective
total synthesis of three members of the carexane family
274 mon precursor to accomplish collective first
total synthesis of titled natural products and proposed
275 t-coupling strategy for the enantioselective
total synthesis of trans-clerodane diterpenoids is descr
276 design toward a concise and enantiospecific
total synthesis of tubingensin B, which hinges on the st
277 dged bicycle, these efforts have enabled the
total synthesis of tubingensin B.
278 In addition, the
total synthesis of tubocurine represents a formal total
279 he enantioselective, scalable, and divergent
total synthesis of two symmetrical pentacyclic dithiodik
280 A next-generation
total synthesis of vancomycin aglycon is detailed that w
281 vancomycin aglycon, this provides a 19-step
total synthesis of vancomycin.
282 rd-Eschenmoser collaboration that led to the
total synthesis of vitamin B(12) is also discussed.
283 is general methodology was successful in the
total synthesis of Xyridin A, an important natural produ
284 Here we report the first
total synthesis of YM-254890 and FR900359, as well as of
285 te the prominence of pericyclic reactions in
total synthesis,
only three naturally existing enzymatic
286 ine ring have been highlighted to accomplish
total synthesis or to obtain bioactive compounds, one of
287 very of one such reaction in the course of a
total synthesis program, we delineate herein that it has
288 ernative to the highly complex approaches of
total synthesis recently reported to the same aim.
289 Academic
total synthesis research has worked to solve this proble
290 The completion of the
total synthesis revealed that the natural levo-isomer po
291 This
total synthesis revealed that the reported structure of
292 via biosynthetic gene cluster manipulation,
total synthesis,
semisynthesis, or a combination of thes
293 re, we report an approach to natural product
total synthesis that we term 'pharmacophore-directed ret
294 These include a biomimetic
total synthesis to access the natural alkaloid and biosy
295 This
total synthesis unambiguously proves the correct stereoc
296 The design and evolution of our succinct
total synthesis underscores the utility of long-avoided
297 A four-step colloidal
total synthesis was developed, where the key step in the
298 ring disorazole B(1) molecule, a symmetrical
total synthesis was devised with a monomeric advanced in
299 Using
total synthesis,
we found that the peptidic alkaloid try
300 e been obtained either formally or by direct
total synthesis,
with efforts toward one of these-the co