1 The catalytic enantioselective
total synthesis of 1 was accomplished in 7 steps and 38%
2 The first
total synthesis of 1 was successfully established via 31
3 An asymmetric
total synthesis of [(
13) C(4) ]-anatoxin-a ([(13) C(4) ]
4 n this study, we report the first asymmetric
total synthesis of 19,20-epoxydocosapentaenoic acid (19,
5 ndings have been successfully applied to the
total synthesis of 2-epi-lepadiformine C.
6 n in natural product synthesis and the first
total synthesis of (
2S)-hydroxy-3,4-dehydroneomajucin, t
7 The first stereoselective
total synthesis of (-)-(
2S,4R)-3'-methoxy citreochlorol
8 A scalable and modular
total synthesis of 3-lipid I and 3-lipid II was accompli
9 A short, 5-step
total synthesis of (+/-)-
3-demethoxyerythratidinone from
10 Reported herein is a
total synthesis of (+)-
6-epi-ophiobolin A in 14 steps, a
11 An asymmetric
total synthesis of (+)-
6-hydroxythiobinupharidine (1b) a
12 product classes and also enabled a nine-step
total synthesis of (-)-
6-epi-ophiobolin N, a member of t
13 A full account on the first
total synthesis of a chroman meroterpenoid, (-)-phomoarc
14 The first
total synthesis of a chromodorolide diterpenoid is descr
15 We report the
total synthesis of a complex beta-1,2-mannosyloxymannito
16 The
total synthesis of a dimeric thymol derivative (thymarni
17 ably, this synthesis is the first gram-scale
total synthesis of a guaianolide natural product.
18 The first
total synthesis of a lipid mediator derived from natural
19 route was also successfully applied for the
total synthesis of a natural 1,2-diketone.
20 and has been exploited by application to the
total synthesis of a natural occurring benzodioxole and
21 s" to reveal a masked carboxylic acid in the
total synthesis of a natural product.
22 have also been employed as key steps in the
total synthesis of a number of natural products.
23 Total synthesis of a structurally diverse group of Aureo
24 An efficient
total synthesis of A54145 factor D (A5D), a member of th
25 The
total synthesis of acredinone A features two different P
26 Described herein is a catalytic asymmetric
total synthesis of (-)-
actinophyllic acid, with the key
27 trategies and tactics that culminated in the
total synthesis of ajudazol B, the most potent and least
28 Herein we report a concise
total synthesis of (-)-
albocycline in 14 steps from comm
29 he new synthetic route was effective for the
total synthesis of all members in the homohalichondrin s
30 tion of this synthetic route resulted in the
total synthesis of all three known 10-oxygenated Lycopod
31 Described is a concise
total synthesis of (-)-
ambiguine P, a cycloheptane-conta
32 ion of macrolactone 33a we describe a formal
total synthesis of amphidinolide Q.
33 The
total synthesis of (-)-
amphidinolide K (1) based on asym
34 ssful outcome was utilized to accomplish the
total synthesis of an aminopropyl linker-attached trisac
35 starting material and its application to the
total synthesis of an antiepileptic drug (R)-lacosamide
36 The asymmetric (er > 99:1)
total synthesis of (+)-
anti- and (-)-syn-mefloquine hydr
37 A concise asymmetric (>99:1 e.r.)
total synthesis of (+)-
anti- and (-)-syn-mefloquine hydr
38 An improved and enantioselective
total synthesis of antibiotic CJ-16,264 through a practi
39 The
total synthesis of antroquinonol has been accomplished t
40 A five-step
total synthesis of arborisidine, a caged pentacyclic mon
41 The first
total synthesis of arborisidine, a unique Kopsia indole
42 On this basis, a
total synthesis of arcutinidine is reported herein, feat
43 A concise
total synthesis of artalbic acid has been enabled by a s
44 in the final product and thus completing the
total synthesis of aspergillide A.
45 The
total synthesis of (+/-)-
aspergilline A (1) is described
46 an application in the first enantioselective
total synthesis of (-)-
aspewentins A, B, and C is demons
47 Moreover, the first enantioselective
total synthesis of aspidophylline A is described.
48 tion of analogues, a flexible and convergent
total synthesis of (+/-)-
aureothin is presented.
49 Herein we report the first
total synthesis of berkeleyone A, a potential gateway co
50 The first
total synthesis of bifidenone, a novel natural tubulin p
51 or vinylic halogenations and to complete the
total synthesis of bioactive natural products, obolacton
52 Also presented is an enantioselective
total synthesis of both (-)-mitragynine and its unnatura
53 The
total synthesis of both side chain epimers of the origin
54 The formal
total synthesis of both the enantiomers of cyclophellito
55 The
total synthesis of bottromycins involves at least 17 ste
56 l synthesis of (+/-)-picropodophyllone and a
total synthesis of (+/-)-
brazilin.
57 Here, we report a
total synthesis of bryostatin 1 that proceeds in 29 tota
58 Here, we report a concise
total synthesis of bryostatin 3 using 22 steps in the lo
59 We achieved a
total synthesis of C52-halichondrin-B amine (E7130) on a
60 e ylide 1,3-dipolar cycloaddition toward the
total synthesis of (+/-)-
caldaphnidine C is presented.
61 ein we describe synthetic efforts toward the
total synthesis of calyciphylline B-type alkaloids.
62 crossover reaction, a highly stereoselective
total synthesis of cephalosporolide E (which is typicall
63 ient seven-step, protecting-group-free first
total synthesis of chatenaytrienin-2 based on ring-closi
64 thermore, using the same strategy, the first
total synthesis of chatenaytrienin-4, the proposed unsat
65 The methodology was used for the
total synthesis of (+/-)-
chelonin A.
66 The result is a highly convergent
total synthesis of chivosazole F through the orchestrati
67 Described here is the
total synthesis of CHX and analogues, and the establishm
68 A unified and concise first asymmetric
total synthesis of (-)-
citreoisocoumarin (2), (-)-citreo
69 The first biomimetic enantioselective
total synthesis of (-)-
communesin F based on a late-stag
70 erodimeric intermediate, including the first
total synthesis of communesins C-E, and G-I, and facilit
71 Strategies for the
total synthesis of complex natural products that contain
72 a highly efficient, scalable approach to the
total synthesis of conformationally unrestricted, electr
73 We identify a short
total synthesis of congeners in the reverse-prenylated i
74 The
total synthesis of (+)-
cryptocaryol A was achieved in 20
75 ward these molecules, resulting in a 10-step
total synthesis of (-)-
curvulamine, a dimeric member wit
76 The first enantioselective
total synthesis of (-)-
cycloclavine was accomplished in
77 Herein, we describe the first
total synthesis of cystobactamid 919-2 from three fragme
78 and convergent route for the stereoselective
total synthesis of cytotoxic macrolides pestalotioprolid
79 r variants of the method were applied to the
total synthesis of danaidal and suffrutine A from the re
80 e culminated in the development of the first
total synthesis of (-)-
daphlongamine H, provided access
81 Synthetic studies toward the
total synthesis of dehaloperophoramidine have led to the
82 The
total synthesis of dehydromicrosclerodermin B and micros
83 n, we report a short olefin-metathesis-based
total synthesis of Delta(12)-PGJ(2) and its application
84 The first enantioselective
total synthesis of (-)-
deoxoapodine is described.
85 We report a concise
total synthesis of dictyodendrin F and the first total s
86 An asymmetric
total synthesis of diplobifuranylone B was achieved in 1
87 A five-step
total synthesis of Dysoxylum alkaloids has been achieved
88 The first
total synthesis of emindole PB is accomplished in 13 ste
89 The
total synthesis of enantiomerically pure (+)-mesembrine
90 The first
total synthesis of five austalide natural products, (+/-
91 odology is eventually employed in the formal
total synthesis of (+)-
folicanthine (1b).
92 The work extends the divergent
total synthesis of four to now six different natural pro
93 with its potential demonstrated in the short
total synthesis of four venom alkaloids.
94 A novel
total synthesis of fully protected idraparinux has been
95 of this method as it enabled the convergent
total synthesis of G-CSF aglycone.
96 The first
total synthesis of galanal A and B has been achieved fro
97 accomplishment of the first enantioselective
total synthesis of (-)-
gamma-gurjunene, a sesquiterpene
98 earrangement strategy resulting in a 10-step
total synthesis of garsubellin A, an enhancer of choline
99 l account of our studies directed toward the
total synthesis of gelsemoxonine that relies on a concep
100 the thermic ring contraction applied to the
total synthesis of (+/-)-
Gelsemoxonine.
101 The first
total synthesis of (+/-)-
gelsenicine is reported.
102 The first
total synthesis of Gliomasolide C, the short synthesis o
103 Here we report the
total synthesis of glucosepane, enabled by the developme
104 Herein, we describe a divergent
total synthesis of glycinocins A-C, which differ in the
105 An efficient
total synthesis of goadsporin is reported in which the k
106 The first catalytic enantioselective
total synthesis of (-)-
goniomitine, along with divergent
107 We report the first
total synthesis of (+)-
granatumine A, a limonoid alkaloi
108 The first enantioselective
total synthesis of griseusin A, griseusin C, 4'-deacetyl
109 The first
total synthesis of halistatins 1 and 2 has been complete
110 Herein, we describe an expeditious
total synthesis of hemiasterlin featuring a four-compone
111 A simple
total synthesis of herqulines B and C is reported, model
112 Here, we report the first
total synthesis of hinduchelins A-D, a family of nontoxi
113 The enantioselective
total synthesis of (-)-
hodgkinsine, (-)-calycosidine, (-
114 Here, we report the first
total synthesis of hybrubin A, a bipyrrole tetramic acid
115 We report the first
total synthesis of (+)-
hypercalin C employing a converge
116 ork of the baulamycin family, as well as the
total synthesis of its most potent member, baulamycin A.
117 A formal
total synthesis of ivorenolide A has been accomplished e
118 We have devised a highly selective
total synthesis of ladderane lipid tails and a full phos
119 ltimately allowed us to go on and complete a
total synthesis of lasonolide A.
120 We report the first
total synthesis of laspartomycin C as well as a series o
121 aining polyenes and application to a concise
total synthesis of leukotriene B(3).
122 ntifungal agents leupyrrin A1 and B1 and the
total synthesis of leupyrrin A1 are reported.
123 An efficient and highly convergent
total synthesis of Leustroducsin B was achieved in 17 lo
124 accomplishment paves a path for the eventual
total synthesis of lomaiviticins A and B and opens oppor
125 The
total synthesis of lundurines A-C has been accomplished
126 The
total synthesis of lycoricidine and narciclasine is enab
127 Herein, we report the first
total synthesis of marine ladder polyether gymnocin B (1
128 The first
total synthesis of (-)-
marinisporolide C is described, w
129 An enantioselective
total synthesis of martinellic acid is described.
130 An asymmetric
total synthesis of Merck's hNK(1) antagonist and three o
131 Total synthesis of (+)-
mesembrane featuring the catalyti
132 with enamine 3 as the key step of a concise
total synthesis of methoxatin is described.
133 to furnish the final E ring and complete the
total synthesis of (+/-)-
minfiensine (2).
134 Here we report a
total synthesis of (+/-)-
morphine that employs two key s
135 NMR data, and complete the enantioselective
total synthesis of muironolide A.
136 A stereocontrolled first
total synthesis of muraymycin D1 (1) has been achieved.
137 protecting group-free, and enantioselective
total synthesis of mycothiazole, a naturally occurring a
138 We recently reported a
total synthesis of (-)-
myrocin G (4), the putative activ
139 A streamlined
total synthesis of N(14)-desacetoxytubulysin H (Tb1) bas
140 A convergent
total synthesis of (-)-
nahuoic acid Ci(Bii) (3), a novel
141 etone rearrangement was applied in a concise
total synthesis of naphthomevalin, a prominent member of
142 The
total synthesis of narciclasine is accomplished by the l
143 The first
total synthesis of natural (-)-clavicipitic acid from ga
144 A stereoselective
total synthesis of natural product aspergillide A is rep
145 ion of carbonyls is of key importance in the
total synthesis of natural products and in medicinal che
146 n of first-row metal-mediated methods to the
total synthesis of natural products is discussed.
147 t become suitable starting materials for the
total synthesis of natural products, ingredients, and in
148 ely new retrosynthetic disconnections in the
total synthesis of natural products.
149 on reactions have found broad application in
total synthesis of natural products.
150 Enantioselective first
total synthesis of naturally occurring cytotoxic (+)-sub
151 s which has been successfully applied to the
total synthesis of naturally occurring pyrolidine alkalo
152 is provides access to many natural products,
total synthesis of numerous complex molecules is not eco
153 Here, we report the
total synthesis of P-A1 and P-A2, as well as two analogu
154 Its application was demonstrated in a short
total synthesis of (+/-)-
paeonilide.
155 natural products is demonstrated through the
total synthesis of Pandalizine A.
156 A gram-scale enantioselective
total synthesis of (+)-
peganumine A was accomplished in
157 A concise formal
total synthesis of pericoannosin A, by the synthesis of
158 This first
total synthesis of (+)-
pestalazine A also allowed us to
159 ion of strategies that ultimately led to the
total synthesis of phomactins A, K, P, R, and T, as well
160 ynthesis strategy to achieve enantiospecific
total synthesis of (+)-
phorbol in only 19 steps from the
161 The development of a concise
total synthesis of (+/-)-
phyllantidine (1), a member of
162 h were successfully overcome to complete the
total synthesis of picrinine.
163 Reported here is a short chemoenzymatic
total synthesis of (-)-
podophyllotoxin and related arylt
164 The first
total synthesis of potent cannabinoid, 9beta-11-hydroxyh
165 sed on a C-H activation strategy and a short
total synthesis of pretubulysin D (PTb-D43) are describe
166 The
total synthesis of principinol D, a rearranged kaurane d
167 ise and convergent route for stereoselective
total synthesis of promising anticancer natural lipid my
168 The first
total synthesis of psychrophilin E, a potent antiprolife
169 Here, we describe a
total synthesis of PvD(1), the defensin from the common
170 motifs are important building blocks for the
total synthesis of pyrroloindoline alkaloids.
171 A biomimetic
total synthesis of racemic homodimericin A was achieved
172 The
total synthesis of representative members of the schizoz
173 Completion of the first
total synthesis of resolvin D4 established the absolute
174 The first
total synthesis of resorcyclic acid lactone spiroketal c
175 mediated by Mn(OAc)3 as a key operation, the
total synthesis of retrojusticidin B, justicidin E, and
176 ded an efficient means to complete the first
total synthesis of rifsaliniketal and salinisporamycin.
177 e key step of the first catalytic asymmetric
total synthesis of (-)-
rocaglamide (natural) and (+)-roc
178 The first
total synthesis of rottlerin is described.
179 ach has been applied to the enantioselective
total synthesis of rumphellaone A.
180 hesis of anhydroryanodol and thus the formal
total synthesis of ryanodol.
181 yl cross-coupling reaction was probed in the
total synthesis of salmochelins (siderophores) and comme
182 y of this method is highlighted in the first
total synthesis of (+)-
sibirinine.
183 ication of "hydrogenative metathesis" to the
total synthesis of sinularones E and F concurred with th
184 no substituted ketones is exemplified in the
total synthesis of sphingolipid HPA-12 and the sedamine
185 Herein, we report an efficient
total synthesis of (-)-
spinosyn A with 15 steps in the l
186 Here we report the
total synthesis of stolonidiol starting from (R)-(+)-lim
187 Herein, we report the first
total synthesis of streptide that confirms the regiochem
188 Although
total synthesis of such terpenes is widely studied, synt
189 ategy (3 + 2 + 6) to accomplish a gram-scale
total synthesis of teixobactin.
190 The transformation was applied to a concise
total synthesis of the 14-membered macrolactone, Sch 725
191 ulted in the most brief and highest yielding
total synthesis of the alkaloid in three steps and a 36%
192 rmediate associated with a recently reported
total synthesis of the alkaloid kopsihainanine A (1).
193 erial O-glycans, as exemplified by the first
total synthesis of the amino linker-attached, conjugatio
194 The methodology has been used for the
total synthesis of the antidepressant agent (+/-)-5-phen
195 ted alpha-amino acids including an expedient
total synthesis of the antiepileptic drug levetiracetam.
196 pment of a strategy culminating in the first
total synthesis of the architecturally complex daphniphy
197 A convergent
total synthesis of the architecturally complex indole di
198 A highly convergent, stereocontrolled
total synthesis of the architecturally complex marine sp
199 d products was illustrated in the nonracemic
total synthesis of the bioactive alkaloid (-)-epibatidin
200 First,
total synthesis of the cell surface phospholipomannan an
201 The first
total synthesis of the complex hexacylic Daphniphyllum a
202 The first enantioselective
total synthesis of the complex tricarbocyclic sesquiterp
203 Here, we report the first
total synthesis of the conjugation-ready trisaccharide r
204 Described is the
total synthesis of the cyanotoxin microcystin-LF (MC-LF,
205 A formal
total synthesis of the cytotoxic macrolide amphidinolide
206 The first enantioselective
total synthesis of the cytotoxic natural product (+)-psi
207 A highly stereoselective
total synthesis of the diacetonide derivative of the ant
208 A
total synthesis of the diastereoisomeric pair of compoun
209 The first
total synthesis of the dimeric berberine alkaloid ilicif
210 We report the concise, biomimetic
total synthesis of the dimeric, Diels-Alder natural prod
211 ghly enantioselective and diastereoselective
total synthesis of the diterpenoid (-)-mitrephorone A is
212 synthesis of tubocurine represents a formal
total synthesis of the famous arrow poison alkaloid tubo
213 Herein, we report the
total synthesis of the fully glycosylated monomeric unit
214 A 13-step
total synthesis of the fungal meroterpenoid berkeleyone
215 on tactic, was successfully employed for the
total synthesis of the highly cytotoxic marine macrolide
216 A stereocontrolled
total synthesis of the indole diterpenoid natural produc
217 subsequent elaboration to complete the first
total synthesis of the juvenimicin, M-4365, and rosamici
218 An enantioselective
total synthesis of the labdane diterpene andrographolide
219 We report the first
total synthesis of the limonoid andirolide N using a 12-
220 The first
total synthesis of the marine natural product avrainvill
221 Herein, we describe the
total synthesis of the most common pseudaminic acid, 5,7
222 Based on these findings, a concise
total synthesis of the natural product (+)-varitriol and
223 A new
total synthesis of the natural product (-)-depudecin, a
224 odular biosynthetic enzymes, we describe the
total synthesis of the natural product aeruginosamide B
225 CPA), has enabled the first enantioselective
total synthesis of the natural product piperarborenine B
226 n an original convergent and stereoselective
total synthesis of the natural product.
227 ow accessible as a result of advances in the
total synthesis of the natural product.
228 re now accessible because of advances in the
total synthesis of the natural product.
229 A streamlined
total synthesis of the naturally occurring antitumor age
230 rance of this method were exemplified by the
total synthesis of the neolignan natural product, (+)-ob
231 s are reported, which culminated in a formal
total synthesis of the neurotrophic agent (-)-jiadifenol
232 An asymmetric
total synthesis of the nootropic alkaloid (-)-huperzine
233 The first
total synthesis of the norcembranoid diterpenoid scabrol
234 An enantioselective
total synthesis of the norditerpenoid alkaloid nigelladi
235 The first
total synthesis of the novel cyclohexylethanoid natural
236 be the isolation, structure elucidation, and
total synthesis of the novel marine natural product rifs
237 A short
total synthesis of the novel unnatural parthenolide dias
238 A
total synthesis of the oleander scale [ Aspidiotus nerii
239 The
total synthesis of the oligosaccharide moiety of disialo
240 emerging technology, a unified, asymmetric,
total synthesis of the phomactin terpenoids was develope
241 An enantioselective
total synthesis of the polycyclic diterpene (+)-chatanci
242 A 10-step
total synthesis of the polycyclic polyprenylated acylphl
243 We report the first
total synthesis of the polyunsaturated fatty acid 7-hydr
244 l ketone building blocks, an efficient first
total synthesis of the potent anti-trypanosomal macrolid
245 The first
total synthesis of the potent antibiotic berkeleylactone
246 The development of a practical asymmetric
total synthesis of the potent HIV-1 integrase inhibitor
247 A convergent and stereoselective
total synthesis of the previously assigned structure of
248 However, the
total synthesis of the proposed structure of briarellin
249 A
total synthesis of the proposed structure of nhatrangin
250 hod has been applied in the enantioselective
total synthesis of the purported structure of pulveraven
251 The first asymmetric
total synthesis of the putative structure of diplopyrone
252 lpha,beta-unsaturation is exemplified in the
total synthesis of the quinolizidine alkaloid natural pr
253 A
total synthesis of the racemic modification, (+/-)-2, of
254 The
total synthesis of the rare but extremely potent antitum
255 The enantioselective
total synthesis of the rearranged spongian diterpenoid (
256 The first
total synthesis of the reported structure of 13a-hydroxy
257 nd flexible strategy for the stereoselective
total synthesis of the reported structure of baulamycin
258 The first
total synthesis of the resveratrol tetramers vitisin A a
259 scopic evidence has been corroborated by the
total synthesis of the revised structure of echinosulfon
260 The method was further applied to the
total synthesis of the sesquiterpene natural products (+
261 has been readily extended to accommodate the
total synthesis of the spider toxins Agel 416 and HO-416
262 The
total synthesis of the spliceosome inhibitor thailanstat
263 The methodology was used in the
total synthesis of the Stemona alkaloid (-)-stemaphyllin
264 arine natural product rifsaliniketal and the
total synthesis of the structurally related variants sal
265 A
total synthesis of the structure, 1, assigned to the rec
266 The
total synthesis of the Strychnos alkaloid (+/-)-minfiens
267 Herein we report the
total synthesis of the substance with the assigned struc
268 veloped that culminated in a stereoselective
total synthesis of the tetracyclic antimalarial Myrioneu
269 Here we report the
total synthesis of the three largest circular bacterioci
270 Herein we report the
total synthesis of the trans-fused 8,12-guaianolide (+)-
271 t-controlled enantio- and diastereoselective
total synthesis of the two most likely diastereomeric ca
272 An efficient
total synthesis of the unusual polyketide portentol is r
273 lecules to date have been facilitated by the
total synthesis of the various PP-InsP isomers and by th
274 A
total synthesis of the vasicinone family of natural prod
275 The first
total synthesis of the yellow pigment chalcitrin, a stru
276 Herein, we disclose the first
total synthesis of this highly strained target in 13 ste
277 Two distinct strategies toward the
total synthesis of this interesting target are reported.
278 The
total synthesis of this intermediate is based on the uti
279 inhibitor of rosettes (IOR-1) as well as the
total synthesis of this molecule and all of its stereois
280 studies with shishijimicin A resulted in the
total synthesis of this scarce marine natural product an
281 he application of these methodologies in the
total synthesis of THP-based natural products.
282 nes as well as in the first enantioselective
total synthesis of three members of the carexane family
283 mon precursor to accomplish collective first
total synthesis of titled natural products and proposed
284 The enantioselective
total synthesis of trans-clerodane diterpenoid 1 reporte
285 t-coupling strategy for the enantioselective
total synthesis of trans-clerodane diterpenoids is descr
286 The formation of 7p represents a
total synthesis of (+)-
trans-whisky lactone.
287 thod was successfully applied to the concise
total synthesis of trichodermamide A (in gram quantities
288 design toward a concise and enantiospecific
total synthesis of tubingensin B, which hinges on the st
289 dged bicycle, these efforts have enabled the
total synthesis of tubingensin B.
290 In addition, the
total synthesis of tubocurine represents a formal total
291 w reaction manifold is also showcased in the
total synthesis of two proteins.
292 he enantioselective, scalable, and divergent
total synthesis of two symmetrical pentacyclic dithiodik
293 a streamlined and practical enantioselective
total synthesis of uncialamycin that is amenable to the
294 A next-generation
total synthesis of vancomycin aglycon is detailed that w
295 vancomycin aglycon, this provides a 19-step
total synthesis of vancomycin.
296 by the protecting groups and applied to the
total synthesis of (+)-
varitriol and of two diastereoiso
297 to the natural product provides the shortest
total synthesis of (+/-)-
vibralactone reported to date.
298 rd-Eschenmoser collaboration that led to the
total synthesis of vitamin B(12) is also discussed.
299 is general methodology was successful in the
total synthesis of Xyridin A, an important natural produ
300 Here we report the first
total synthesis of YM-254890 and FR900359, as well as of