ライフサイエンスコーパス: toward

1 ntaining DHTKD1 displaying improved kinetics towards 2-oxoadipic acid.

2 ribe the evolution of our synthetic strategy toward 4 and report the series of discoveries that promp

3 An Arabidopsis DXO1 variant is active toward 5'-OH RNA but prefers 5'-PO4 RNA.

4 ylation features and is a crucial first step toward a better understanding of the mechanisms regulati

5 nable marketing edge while treading the path toward a circular economy.

6 roof of concept level, offers a new approach toward a cleaner route to recycling nylons.

7 Secretion steers the polymers toward a common exit point, which could facilitate proto

8 phototrophs and represent an important step toward a comprehensive assessment of greenhouse gas emis

9 s it is a variant of the bulk result shifted toward a higher bias.

10 can either exhibit mild symptoms or progress toward a life-threatening acute respiratory distress syn

11 ng loss of cellular identity and progression toward a metastatic state.

12 ich T cells were the sole central actors and toward a more complex paradigm with B cells having an es

13 omic surveillance systems, an essential step toward a more comprehensive understanding of resistance

14 iferative phase would manifest as a tendency toward a more linear morphology.

15 Toward a more rigorous inspection of food contact materi

16 e report a two-step, high-yielding synthesis toward a new class of heterobifunctional triarylmethane

17 s made within these three frameworks to move toward a paradigm that formulates RNA-targeting question

18 These findings point toward a predisposing vulnerability in the causation of

19 shift from highly inflammatory cell subsets toward a resting state upon demethylase inhibition.

20 random diffusive error and systematic drift toward a set of stable states ("attractors").

21 f fitness based on free-energy minimization, toward a social system-centered view.

22 completing direct laser writing on graphene toward a spatially resolved 2D-patterned architecture.

23 s sufficient to shift the protein population toward a structurally closed structure of the complex.

24 ells and exhibited a skewing of CD8+ T cells toward a terminally differentiated/senescent phenotype.

25 duced CD4+ T-cell responses that were biased toward a Th1 phenotype.

26 lmark for adaptation to humans and evolution toward a transmittable virus.

27 t have regenerative deficits and are shifted towards a de-differentiated state.

28 e needed to confirm the nonsignificant trend towards a lower graft survival in CMV high-risk patients

29 ly preserving ciliary structure and function towards a normal phenotype.

30 promotes allograft tolerance while immunity towards a range of pathogenic microbes is maintained.

31 irecting the functionality of the perovskite towards a solid-state electrolyte with electrochemical s

32 However, most proposed solutions evolve towards a target geometry without considering time-depen

33 a-homologue Eip75B drives ISC daughter cells towards absorptive enterocyte lineage ensuring epithelia

34 the resulting binding energies are corrected toward accurate reference values from higher-level calcu

35 worldwide attention due to its contribution toward achieving the United Nations Sustainable Developm

36 nd implement evidence-informed interventions toward achieving this goal that undergirds NIH's mission

37 ving with HIV, and make substantial progress towards achieving 90-90-90 in a relatively short period.

38 defect engineering, down to a single defect, towards achieving the smallest memristor for application

39 lectrophiles that were previously unreactive toward addition of alkyl-Cr reagents.

40 rd based on full chart abstraction, pointing towards additional efficiency in the abstraction process

41 ne individual particle acidity and is a step toward addressing a key measurement gap related to our u

42 f ALX dysregulated energy metabolism driving toward age-related obesity.

43 air flask as it shows negligible sensitivity toward air/moisture.

44 ental data indicates the behavior of 4 and P toward Al(3+) is pH independent in medium conditions.

45 presenting the state-of-the-art in the field toward algorithms with nonexponential complexity for cor

46 artment can skew the patient's immune system toward an anti-inflammatory phenotype and therefore coul

47 ess mechanosignals a functional shift in iMo toward an inflammatory phenotype associated with CAD pro

48 Our results point toward an intricate coupling between the dynamics of the

49 eins that modulate the vector gut microbiota towards an environment that favours colonization by the

50 orientation of phenolic compounds from algae towards an industrial application.

51 proves phenotype switching of TAMs from pro- towards anti-tumor expression in vitro.

52 This preliminary study is a first step toward automated PET/CT assessment for lymphoma.(C) RSNA

53 ntration increases significantly from summer towards autumn, possibly linked to the ocean freeze-up a

54 clear receptors that promote differentiation towards beta-catenin, a driver of proliferation and colo

55 Their translation toward biological applications is limited owing to the u

56 the second cycle, AS microbiome was enriched toward caproate production and showed the highest caproa

57 CD36 signaling blunts the VSG-induced shift toward carbohydrate preference.

58 ate and an impaired ability to differentiate towards cardiac mesoderm.

59 to hole transport layer and expels electrons toward cathode side, which reduces the charge recombinat

60 etely pilot-less: they are unable to migrate toward chemokines despite their normal ability to move r

61 ental illness may be to target interventions toward children who are exposed to adversity, particular

62 cterization of exosomes is an important step toward clinical applications that require effective and

63 restingly, ES24 shows antibacterial activity toward clinically relevant strains.

64 e Si=C bonds show a distinguished reactivity toward CO(2), depending on the reaction conditions.

65 mechanisms would represent an important step toward combating this disease.

66 Resources have been appropriately allocated toward combating this outbreak, but where does this leav

67 livery and sequential release of dual cargos toward combinatorial therapy.

68 epts and carbon-derived battery technologies towards commercial implementation.

69 del as input, representing an important step toward comprehensive modeling of the MHC class I pathway

70 g feature selection methodologies are biased towards considering only one out of multiple biological

71 ensembles of atoms(4,8,9) and paves the way towards controlling many-body physics with light(5,6,11)

72 le or reversibly covalent binding mechanisms towards cysteine thiols and other amino acids.

73 Average titers peaked on day 7 and declined toward day 14 (P = .004).

74 myosarcoma cell growth in vitro and trending toward decreased tumor growth in vivo.

75 the probability distribution of transitions towards decreasing order.

76 cm(-2), respectively, toward detection of SARS-CoV-2 in biological media, whil

77 ified biosensor also offered its credibility towards detection of MP in vegetable samples with recove

78 sment of the efficiency of protective layers toward deterioration of hybrid organic-inorganic perovsk

79 The proposed framework is a first step toward developing asthma remission as a treatment target

80 Our aim was to make progress toward developing rational frameworks for selecting elec

81 These findings are a step towards developing a panel of genetic markers assessing

82 ts may turn out to be of immense consequence towards developing novel point-of-care hematological ana

83 iruses also exhibited an increased tolerance toward disinfection by free chlorine.

84 er along the spectrum from strict modularity toward distributed representation.

85 ay be prudent to prevent a substantial shift toward early vaccination.

86 Molecular-level multielectron handling toward electrical storage is a worthwhile approach to so

87 this case, yttria-stabilized zirconia (YSZ), toward eliminating filaments.

88 ease burden, a necessary step in the pathway towards elimination.

89 Our work marks an important step towards enabling application-specific analog computing p

90 the treatment of diabetes mellitus, the path toward endogenous renewal of beta-cell populations has r

91 ndent of glycosylation and is not inhibitory toward endoRNase activity.

92 superconductivity in TBG and open up avenues towards engineering quantum phases in moire systems.

93 Local adaptation directs populations towards environment-specific fitness maxima through acqu

94 of particular importance for future efforts toward establishing prophylactic interventions for AD on

95 Our findings open a path towards exploration of higher-dimensional topological ph

96 icant enhancement of the composite stability towards exposure to ambient conditions, up to 20 days.

97 confers defense, robustness, and adaptation toward external aggressions, most critically to colonizi

98 r-related disorders, such as PTSD, is biased toward females, we examined whether H2A.Z cKO also has s

99 ing on an Nrf2-operated pathological program toward ferroptosis in cardiomyocytes, thereby worsening

100 with abundant hydrocarbons, and maps a route towards future catalytic systems.

101 on enables nanodisplay of diverse symmetries towards generation of potent vaccines.

102 ts and transcription factors that contribute toward GIN function may provide new insight into the pat

103 the AuNP-MIP sensor revealed a high affinity toward glucose with a dissociation constant (K(d)) of 3

104 observations indicate that a metabolic shift toward glycolysis accompanies collective cellular migrat

105 switch, which rendered them more susceptible toward glycolytic inhibitors.

106 taining dye 'coomassie brilliant blue' (CBB) towards GMP.

107 umbidgee, Macintyre) experience step changes towards greater discontinuity, characterised by pronounc

108 of terrorist attacks on prejudiced attitudes toward groups linked to the perpetrators as the cause of

109 ]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18.

110 affects the substrate selectivity of ADAM17 toward Heparin-binding epidermal growth factor like grow

111 chain charge transfer, is a logical strategy toward high-mobility p-type polymers.

112 There was a trend toward higher risk of acute kidney injury requiring rena

113 increase in mean insulin levels and a trend towards higher C-peptide levels.

114 s and enhance PRC1 ubiquitin ligase activity towards histone H2A.

115 A87) endows Fpr with an enhanced selectivity toward HJ cleavage but with a target sequence preference

116 esults in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylchol

117 The skull is specialized toward hunting in an aquatic environment, indicated by t

118 organic, organic and silicon-based materials towards hybrid organic-inorganic materials to develop in

119 a consequence, the positive-predictive value toward ICM configuration was significantly lower for seg

120 These results justify policy change towards imminent death donation.

121 response from past events are critical steps toward improving predictions of future marine heatwaves

122 titutional accountability that ties progress toward inclusive excellence to institutional values and

123 The trend toward increasing rates of ciprofloxacin resistance in S

124 by a transition in hand use, from locomotion towards increasingly dexterous manipulation, concomitant

125 ide endoplasmic reticulum, which contributes toward inhibition of MHC class I:beta2M:peptide complex

126 erspective, we highlight recent developments toward innovative medicinal chemistry strategies based o

127 s of these lipids appear to be more negative toward insulin sensitivity than others.

128 o mimic conventionally manufactured outputs, toward integrated approaches from a design perspective i

129 us of bioinformatics research has been aimed toward integrating these data to identify active pathway

130 energetic investment in many small offspring towards investing less total energy into fewer, better p

131 South even as economic activity has shifted toward it.

132 se complex as well as its catalytic activity toward its substrate Notch, a critical regulator of B ce

133 e contribution of host and bacterial factors toward K. pneumoniae dissemination.

134 verted more acetyl-CoA away from lipogenesis toward ketogenesis and TCA cycle, a milieu which can has

135 ro-inflammatory cytokine production, a shift towards ketone bodies as the metabolic substrate for the

136 The work also constitutes an important step towards large-scale quantum dot simulators of correlated

137 ate against the model cue to avoid orienting toward larvae in nearby nursery habitats.

138 ce compositions of the two lava units change towards less radiogenic Nd, Hf, and Pb isotope ratios.

139 Wolves and bears were also attracted towards LFs, whereas prey species avoided them.

140 rients, motile bacteria can actively migrate towards locations of richer resources.

141 poor, with an undesirable shift (over 7 nm) toward longer wavelengths under operating conditions, de

142 ansporter activity reduces migration of GSCs towards low concentrations of S1P in vitro In addition,

143 LA2) or lipoxygenase (Lox) blocks chemotaxis towards low concentrations of S1P.

144 This biases binding toward lower methylated states.

145 This study represents a critical advancement toward making squid genetically tractable.

146 on of glucose to fructose is a critical step towards manufacturing petroleum-free chemicals from lign

147 The ACA approach takes a step toward maximizing the capabilities of existing real-time

148 s for incarceration provides an initial step toward mitigating the excess morbidity and mortality of

149 nt years research efforts have been directed towards modeling the structure and dynamics of the under

150 However, shifts toward more mesic communities also occurred and multiple

151 pain treatment may require a paradigm shift toward more personalized approaches.

152 laid the foundation for further developments toward more potent and selective inhibitors for the tumo

153 how a transition from linear DNA structures toward more structurally complex nanostructures has revo

154 f infection-related complications as we move towards more personalized medicine.

155 nience samples and offer guidance for moving towards more representative and timely population estima

156 ure classification but have low contribution towards movement type and frequency classification.

157 ensing components outlines feasible pathways towards multifunctional and multimodal sensor platforms.

158 toms into phase-stable PICs marks a key step towards multiplexed quantum repeaters(7,8) and general-p

159 the cryogels showed negligible cytotoxicity toward murine fibroblasts and prevented activation of pr

160 The intervention improved behaviors toward Muslim peers: Christians with Muslim teammates we

161 rials while enabling their rapid repurposing toward new sequence targets.

162 To fully exploit this method, we must move towards new alloys and processes.

163 Partial river flow recovery (towards non-forested conditions) has been reported in de

164 trate scope of the carboxylic acid reductase toward noncognate omega-hydroxylic acids.

165 entricular and pulmonary arterial pressures, toward normal levels of right-side pressure (about 20 mm

166 is very poor in HSAN III but can be improved towards normal by application of elastic kinesiology tap

167 o display high conductivities and mobilities toward novel (opto)electronic devices.

168 d by biasing the remodeler-actin interaction toward nucleosomes with the non-canonical histone H2A.Z,

169 tates the movement of tumor epithelial cells toward nutrient-rich territories.

170 lies is one of the most promising strategies toward obtaining nanoparticle-based materials and device

171 ms can adapt to existing pressures and shift towards ocean stewardship through incorporation of niche

172 Sensitivity of dsDNA structure towards OH radicals as the pro-oxidants has been utilize

173 a nutritional constraint can drive predators towards omnivory.

174 The host T3 showed certain selectivity toward one enantiomer over the other.

175 rceived directionality of the movement (i.e. towards or away from the observer) was found to be criti

176 earning songs; however, song is not directed towards other individuals and has no obvious, immediate

177 However, their chemical instability towards oxygen, light and heat limits its applications i

178 commensals, cipR S. sonnei may be propelled towards pan-resistance by adherence to outdated internat

179 on biosensors and biosensing-related issues towards pandemic outbreaks.

180 e been shown to actuate a directional choice toward paths of least hydraulic resistance (barotaxis),

181 ssue-based prostate cancer biomarkers geared toward patient selection for active surveillance, identi

182 tinual feature of human history, with biases toward people's own groups shown in both experimental an

183 h is generally more periportally restricted, toward pericentral hepatocytes, as was visualized using

184 ratification based on kidney biopsy findings towards personalized management based on clinical, morph

185 16-fold lower binding affinity than (Hs)CRM1 toward PKI-NES and significant differences in affinities

186 ES and significant differences in affinities toward potential CRM1 inhibitors.

187 dology/strategy establishment, and a roadmap toward practical applications.

188 diseases as a necessary and fundamental step towards precision medicine, which will benefit men's and

189 rm-function associations reflect convergence towards predictable trait combinations, indicating that

190 the concentration of a metastable bioanalyte toward predicting tumor drug sensitivity.

191 ng of specific human tissues, may contribute toward prioritizing subthreshold variants for disease as

192 in a subset of ASD patients, indicate a bias toward processing information of high spatial frequencie

193 first and second positions, an initial step towards producing completely unnatural polypeptides in v

194 ral databases and fusion of prediction tools toward protein disorder characterization in health and d

195 sitivity/specificity of developed nanosystem toward rapid identification of ill people even at incuba

196 h arbitrarily small separation and is a step toward realizing strongly interacting atomic defect ense

197 y, these advancements represent a major step toward realizing the enormous potential of surrogate sir

198 ate amide iodine(V) complexes are unreactive toward redox reactions due to the fact that in such case

199 Other blood management strategies geared toward reducing surgical blood loss such as autologous t

200 ehavioural response of 131 A. oculatus males towards relevant and controlled conspecific versus heter

201 ss factors among these countries with a lens toward replicability.

202 ties: incentive stimuli orient the attention toward reward-seeking, whereas instructive stimuli infor

203 advanced sensing of pharmaceutical compounds toward safeguarding human health and ecosystems on a glo

204 ttention, prediction, and learning processes towards salient information, at the timescale of online

205 All programs were biased towards selecting start codons that were upstream of the

206 tic capability began their evolutionary path toward self-replication.

207 ents, and inhibition analysis of GD3-binding toward Siglec-7 using synthetic sialoglycoconjugates and

208 revailing winds can disrupt migratory routes towards slightly different goals, and thereby promote mi

209 rmacologic and probiotic approaches directed towards specific TLR2 signaling processes might be devel

210 the low lithiated phase of Li(4) Ti(5) O(12) toward Spiking Neural Network applications, due to the s

211 al in modern science, and requires an effort towards standardising data publication practices.

212 e to photodecomposition, and poorly reactive towards sterically bulky alkene substrates.

213 ision medicine approach, with research aimed towards stratifying patients into more homogeneous cohor

214 Any transition towards sustainability can only be effective if far-reac

215 The drive toward sustainable phosphorus (P) recovery from agricult

216 ver a wide temperature range, paving the way toward T-dependent high-throughput screening application

217 onducted instructed walk-and-reach movements towards targets flexibly positioned in the cage.

218 a and TNFalpha, which dramatically increased toward term in lungs of WT fetuses, was markedly reduced

219 idely recognized as a necessary intervention toward that goal.

220 ACL regeneration and signal a promising step toward the clinical translation of a functional bioengin

221 puting the neuronal output, which propagates toward the CNS, thus shaping the pain sensation.

222 ynein-driven translocation of the centrosome toward the contact site leads to reorganization of micro

223 o-4-methylcoumarin derivatives will find use toward the development of new fluorescent coumarin-based

224 memory Th17 compartment predispose aged mice toward the development of severe corneal epithelial dise

225 the factors that influence their reactivity toward the electron-poor trichloroacetyl isocyanate.

226 onor liver transplantation activity in India toward the end of the study period.

227 migratory polarity radially from the cluster toward the endoderm.

228 An evolving trend toward the ever-growing market of portable and wearable

229 polarized movement of the surrounding cells toward the extruding transformed cells.

230 Each printing technique has merits toward the fabrication of microfluidic devices.

231 model to identify an unrecognized deep flow toward the Faroe Bank Channel.

232 Finally, we look toward the future at strategies to better identify peopl

233 in the donor lung exhibited active sprouting toward the host at the anastomosis within the first 3 da

234 nanocrystals and its exceptional activities toward the hydrogen evolution reaction (HER) in aqueous

235 n cells, grow directly from microtubule tips toward the leading edge in growth cones of hippocampal n

236 stance correlates significantly with a shift toward the memory T cell compartment in SAT.

237 The sialylation showed selectivity toward the N-glycan compared to another glycan substrate

238 essively from NW to SE, from northern Latium toward the Neapolitan area, crossing the city of Rome.

239 at exhibits high sensitivity and specificity toward the production of H(2) O(2) .

240 different Pt sizes and represents a key step toward the rational design of new heterogeneous catalyst

241 conjoined sugar and nucleobase, part-by-part-toward the ultimate goal of forming RNA and DNA by polym

242 Recently, researchers have turned toward the use of biomimetic nanotechnology as a means o

243 users are exposed to by tailoring news diets toward the users' preferences.

244 is a clear shift in the recruitment of cells toward the ventromedial, and away from the ventrolateral

245 test if EGFRvIII influences the sensitivity towards the alkylating agent temozolomide (TMZ).

246 While searches were biased towards the beacons, we did not find any evidence that p

247 cold ions in the inner wall surface implode towards the central axis.

248 er resistance and high transduction activity towards the co-enzyme NADH, delivering a wide linear ran

249 Future approaches towards the definition of refractory RA and the applicat

250 posed method can be used as a stepping stone towards the development of an accessible PD screening to

251 ion, while the ART group appeared to recover towards the diversity level of the healthy control.

252 Southern Hemisphere tropospheric circulation towards the end of the twentieth century, including a po

253 ter the diversity of our membership and work towards the engagement of all members, from diverse back

254 y ecostates of infected individuals progress towards the healthy ecostate, coinciding with viral clea

255 ozygous regions causes crossover remodelling towards the heterozygous regions in wild type Arabidopsi

256 to four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are ge

257 the transport of many intracellular cargoes towards the minus end of microtubules (MTs).

258 for dynein-mediated intracellular transport towards the minus-ends of microtubules.

259 d diel coefficient as the surveys progressed towards the monsoon season suggest temporal shifts in GR

260 clude a decline in lymphopoiesis and skewing towards the myeloid lineage.

261 ose a means of refocusing research questions towards the rich and complex components that comprise le

262 13)C over the transect from the control site towards the seep, suggesting that CO(2) exerts a strong

263 hlet extraction) were evaluated and compared towards the selective recovery of bioactive compounds.

264 This work paves a path towards the skyrmionic devices based on van der Waals la

265 8-1 complexes in multiple intermediate steps towards the SNARE complex.

266 on of novel substrates and enzyme activities towards the synthesis of monolignols.

267 These in turn skew differentiation towards the tumor cell-of-origin and alter interactions

268 3D-SMART represents a critical step towards the untethering of single molecule spectroscopy.

269 ificity of action of promoters and enhancers towards their targets in a tissue specific manner.

270 Our findings may open a new gate toward therapeutics.

271 eloped a caged glutamate probe that is inert toward these receptors at concentrations that are effect

272 The efficiency of these materials towards these described applications is heavily influenc

273 for patients with basal-like BC, and efforts toward this end are currently underway.

274 Toward this end, the steady-state and transient structur

275 Toward this end, we exploited gramicidin channels as mol

276 Toward this goal, here we present a convenient workflow

277 en (C-H) bonds represent a promising pathway toward this goal.

278 is article describes several current efforts toward this goal.

279 Toward this, we recently demonstrated that the laterally

280 Towards this end, positron emission tomography (PET) ima

281 rse array of fields are collectively working towards this goal.

282 elied on a variety of available data sources towards this objective, including electronic health reco

283 Towards this, our current work seeks to develop the tech

284 help to stratify treatments, guiding choice towards those which most effectively resolve the obstruc

285 usible, and increasing attention is directed towards thrombotic microembolism as the underlying cause

286 tion was more frequent from San Diego county towards Tijuana than vice versa.

287 al sensor features of the Cu-SWCNT-Pc hybrid towards to physostigmine pesticide were performed.

288 MDK-modulated secretome educated macrophages towards tolerant phenotypes that promoted CD8(+) T cell

289 how increased cytokine production, migration toward tumor cells, and tumor cell killing.

290 The new receptor displays selectivity towards two out of the seven PIPs, namely PI(3)P and PI(

291 ensor, a live-cell tubulin nanobody specific towards tyrosinated microtubules.

292 tRNA fragments advocate paramount importance toward understanding BEX family involvement in neurodeve

293 ld problem, thus providing an important step toward understanding human sequential decision making.

294 Our framework may also help toward understanding the effects of habituation in other

295 These results may help toward understanding the strength and erodibility of nat

296 in situ is a challenging but important step toward understanding their function and subsequently bui

297 o all manifestations of GBS disease, studies towards understanding granadaene's toxic activity are hi

298 To provide potential clues towards understanding this high mortality, detailed clin

299 rtant role in the wide range of applications towards which polypeptides have been applied.

300 f the Au@Pt/Au NPs electrocatalytic activity toward WOR.