ライフサイエンスコーパス: toxicology

1 ead by the COMET (Consortium for Metabonomic Toxicology).

2 focus of biomedical research and regulatory toxicology.

3 ivity label-free assay utility in predictive toxicology.

4 ecognized as an important component of their toxicology.

5 ields, such as biomedicine, pharmacology and toxicology.

6 oses the 21st-century transition underway in toxicology.

7 ible, hPSC-derived hepatocyte for predictive toxicology.

8 are analogous to adverse outcome pathways in toxicology.

9 ch has important implications for regulatory toxicology.

10 ved tissues and details their application in toxicology.

11 ssue models for research, drug discovery and toxicology.

12 ways is one of the paramount goals of modern toxicology.

13 popular seafoods, their human metabolism and toxicology.

14 FID), a technique routinely used in forensic toxicology.

15 , evolution, genomics, molecular biology and toxicology.

16 believe these efforts foretell the future of toxicology.

17 t, genetics, pathogenesis, transgenesis, and toxicology.

18 detrimental contribution to side effects and toxicology.

19 applicability of these models for predictive toxicology.

20 ns in, e.g., therapeutic drug monitoring and toxicology.

21 is effectively a systems-biology approach to toxicology.

22 tance as the alternative matrix for forensic toxicology.

23 Ag materials has spurred interest into their toxicology.

24 " assays in pharmaceutical and environmental toxicology.

25 ied fields like food safety, environment, or toxicology.

26 D liver MT to be a valuable tool in particle toxicology.

27 e was assessed through self-report and urine toxicology.

28 es, with wide implications in physiology and toxicology.

29 model system for studying human disease and toxicology.

30 ons with heroin use history and acute opiate toxicology.

31 ing in, or closely linked with, the field of toxicology.

32 de-reaching implications for development and toxicology.

33 stigate liver damage due to drug exposure in toxicology.

34 articipants was controlled by hair and urine toxicologies.

35 al and police reports, alongside autopsy and toxicology analyses where available.

36 Transcriptome-based toxicology analysis predicted and risk-stratified patien

37 patients, for sport antidoping and forensic toxicology analysis.

38 of fundamental research on biocompatibility, toxicology and biopersistence in the living body as well

39 Cannabis use was measured by weekly urine toxicology and by self-report using the Timeline Followb

40 ool in several fields of research, including toxicology and cancer epidemiology.

41 way to expedite research in drug discovery, toxicology and cell-based sensing.

42 relevance to forensic science and as well as toxicology and clinical testing.

43 applications for metabolomics in regulatory toxicology and develop best practice guidelines, perform

44 could be a powerful tool for fields such as toxicology and developmental biology to investigate whol

45 ively at concentration levels encountered in toxicology and doping.

46 n/induction of CYP3A4 and PXR is critical in toxicology and drug-drug interaction (DDI) studies.

47 s also drive the development in the field of toxicology and ecotoxicology.

48 applied techniques in the field of nano(eco)toxicology and environmental sciences, including atomic

49 We assessed pre-clinical toxicology and first-in-human administration of C34-PEG4

50 lesions constitutes one of the main tasks in toxicology and in assessing health risks accompanied by

51 measurement remains one of the core tasks in toxicology and in evaluating human health risks associat

52 ly, the lack of information available on the toxicology and metabolism of acetyl fentanyl precludes i

53 (such as cell spreading, adhesion, invasion, toxicology and mobility).

54 omics (TGx) has contributed significantly to toxicology and now has great potential to support moves

55 ready-approved drugs with well-characterized toxicology and pharmacology is a novel way to reduce the

56 The toxicology and pharmacology literature also suggests tha

57 y the hormetic dose-response relationship in toxicology and pharmacology.

58 Preclinical GLP toxicology and safety pharmacology studies were without

59 Cannabis use was assessed by urine toxicology and self-report during treatment, and by self

60 able for use as reference materials for (eco)toxicology and surface water environmental studies.

61 ow an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk re

62 that are of great interest for environmental toxicology and wastewater treatment research, to conduct

63 ert panelists in the fields of epidemiology, toxicology, and atmospheric and exposure sciences led op

64 ential importance in pathological processes, toxicology, and cancer therapy.

65 environmental health science, translational toxicology, and clinical epidemiology.

66 al disorders, developmental pharmacology and toxicology, and drug screening.

67 on of the bioavailability, pharmacokinetics, toxicology, and efficacy of this series of compounds usi

68 studying aging, reproduction, neuroscience, toxicology, and infectious disease.

69 line panel) and in vivo antitumor activity, toxicology, and mouse pharmacokinetic and pharmacodynami

70 sms plays an important role in cell biology, toxicology, and nanotechnology.

71 research in the physiology, pathophysiology, toxicology, and pharmacology of the renal proximal tubul

72 search has spanned toxinology, biochemistry, toxicology, and pharmacology.

73 n Agency's National Center for Computational Toxicology, and the National Human Genome Research Insti

74 Developments in epigenomics, toxicology, and therapeutic nucleic acids all rely on a

75 cology assessment per Registry of Industrial Toxicology Animal data guidelines.

76 s for endocrine disrupters with a predictive toxicology approach that is suitable for high-throughput

77 However, toxicology as a field has often not produced efficient a

78 llenges and problems in current practices in toxicology as applied to decision making.

79 luding immediate reactogenicity, post-dosing toxicology ascertained 24 h after study drug administrat

80 a functional HNMT in patients using in vitro toxicology assay.

81 ration and, in particular, a cell-based drug toxicology assay.

82 experiments, in vitro counter screening, and toxicology assays demonstrated that the covalent bond fo

83 orted days of cocaine use and positive urine toxicology assays for cocaine metabolites.

84 used in the screening of therapeutics and in toxicology assays for potential liabilities of therapeut

85 ect human male fertility, which common mouse toxicology assays would not reveal.

86 h safety concerns should undergo nonclinical toxicology assessment including systemic carcinogenicity

87 ctions were submitted (blinded) for standard toxicology assessment per Registry of Industrial Toxicol

88 ols for physicochemical characterization and toxicology assessment to understanding and defining dose

89 ) in drinking water is of great interest for toxicology assessment, environmental protection and huma

90 itchable sulfonylurea JB253 to comprehensive toxicology assessment, including mutagenicity and maximu

91 ng regulations specify a reduced preclinical toxicology-assessment package in order to shorten the ro

92 However, extensive toxicology assessments in a substantial number of animal

93 lacking the previously observed preclinical toxicology at comparable exposures.

94 actions: advances in pesticide chemistry and toxicology, banning of many chlorinated hydrocarbons, th

95 unctions are tighter than those derived from toxicology-based, interspecies extrapolations.

96 This review takes a holistic view of bee toxicology by taking into account the spectrum of xenobi

97 Ten years ago, leaders in the field of toxicology called for a transformation of the discipline

98 vitro tool commonly used in human and rodent toxicology, can overcome such limitation.

99 tes valuable resources for disease modeling, toxicology, cell therapy, and regenerative medicine.

100 d -delta) agonist were profiled by classical toxicology (clinical chemistry) and high throughput meta

101 e by the exposure science, epidemiology, and toxicology communities to use informatics approaches to

102 n a current Standard of Knowledge in general toxicology compiled from the experience and opinions of

103 ive weeks of abstinence as measured by urine toxicology confirmed self-report.

104 terials with emphasis on currently available toxicology data and methodologies for evaluating nanopar

105 ly on integrated epidemiological and in vivo toxicology data and, to a lesser degree, on mechanistic

106 clinical and/or clinical data and sufficient toxicology data and/or company development efforts to wa

107 Therefore conventional particle toxicology data are useful and relevant to the determina

108 es an intuitive framework to relate in vitro toxicology data rapidly and quantitatively to exposures

109 fied using physiologic, pharmacokinetic, and toxicology data rather than simple BSA conversion.

110 roach for dose-response assessment of animal toxicology data similar to how nonprobabilistic referenc

111 73 compounds with rodent pharmacokinetic and toxicology data.

112 studied and have a direct impact on all (eco)toxicology data.

113 s, and civil society and included experts in toxicology, decision science, alternatives assessment, e

114 use of transcriptomic dose-response data in toxicology, drug design, risk assessment and translation

115 alidation, and application of evidence-based toxicology (EBT).

116 between exposure sciences, exposure biology, toxicology, epidemiology, biostatistics, risk assessment

117 e environmental health disciplines including toxicology, epidemiology, disease surveillance, and epig

118 omplex media such as environmental waters or toxicology exposure media, the same redox transformation

119 n nanoparticles and organisms, and classical toxicology fails to provide models for risk assessment.

120 most exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity

121 Because of toxicology findings identified in longer-term preclinica

122 inding, hepatic toxicity signal, and in vivo toxicology findings of an early lead compound 7 with a h

123 (AHR), which has been central to studies in toxicology for years as the receptor for the toxicant di

124 oxicology Program's (NTP) efforts to advance toxicology from a predominantly observational science at

125 stry from Uppsala University, and an M.S. in toxicology from the Karolinska Institute.

126 cardiovascular disease, apoptosis and other toxicology functions.

127 nts Analysis distinguished between these two toxicology genes and 11 other genes primarily involved i

128 Functional toxicology has enabled the identification of genes invol

129 Toxicology has long relied on animal models in a tedious

130 ion of genomic techniques into environmental toxicology has presented new avenues to develop exposure

131 Se) has a significant effect on mercury (Hg) toxicology; however, Hg exposure risk assessments usuall

132 wing compendium of data on drug efficacy and toxicology in patient populations.

133 at the 2014 annual meeting of the Society of Toxicology in Phoenix, Arizona.

134 dynamic properties, and in vivo pharmacology/toxicology in preclinical species.

135 lds of computational chemistry and molecular toxicology in recent decades allow the development of pr

136 The U.S. federal consortium on toxicology in the 21(st) century (Tox21) produces quanti

137 In addition, new approaches such as Toxicology in the 21st Century (Tox21) and exposure fore

138 High-throughput screening data from Toxicology in the 21st Century (Tox21) were also conside

139 tudy meets the urgent needs of computational toxicology in the current big data era and can be extend

140 membrane lipid bilayer, the pharmacology and toxicology in vitro and in vivo (mice and dogs), and the

141 opment of best practices in epidemiology and toxicology, including greater harmonization across these

142 rom experts in environmental health, medical toxicology, infectious disease, epidemiology, and chroni

143 adoption of ATS were the need for expedited toxicology information, the need for reduced toxicity te

144 ponse), and be used to improve the design of toxicology investigations (e.g. to inform how NMs should

145 Exploratory toxicology investigations showed that high doses of 5-NI

146 cate that the transformation of the field of toxicology is partly implemented, but significant barrie

147 Modern toxicology is seeking new testing methods to better unde

148 Modern toxicology is shifting from an observational to a mechan

149 e science, linked with comparable efforts in toxicology, is ushering in a new era of risk assessment

150 e dose-response curves be linear, whereas in toxicology, it results in the model of CA.

151 MS/MS datasets is still a common practice in toxicology laboratories, complicating metabolite discove

152 tation of THC and THCA will be efficient for toxicology laboratories.

153 known substance required coordination with a toxicology laboratory.

154 s reported in the environmental and nano(eco)toxicology literature and provide a tool for comparison

155 queous phase, changes in bioavailability and toxicology may result.

156 onship between activity in the DTT assay and toxicology measurements across particles of different or

157 there are little data on their stability in toxicology media.

158 The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international

159 egrated strategy combining pharmacokinetics, toxicology, metabonomics, genomics, and metagenomics to

160 All underwent autopsy, toxicology, microbiology, and genetic testing.

161 Traditional in vitro or ex vivo hepatic toxicology models are often limiting and/or troublesome

162 sm within a standard setup improves in vitro toxicology models in replacement strategies of animal ex

163 environmental fate of spilled oil, improved toxicology, molecular modeling of biotic/abiotic weather

164 most poorly understood areas of nanoparticle toxicology (nanotoxicology), in that low-to-moderate neu

165 the environmental behavior, biokinetics, and toxicology of (2)(1)(0)Po and identified the need for fu

166 eral effects that appear consistent with the toxicology of (2)(1)(0)Po.

167 s research provides a framework to study the toxicology of Bt toxins and mechanism of resistance in W

168 stion in human health sciences; however, the toxicology of chronic exposure to environmentally releva

169 enic chemicals, and monitoring the genotypic toxicology of environments.

170 Observations suggest the generational toxicology of glyphosate needs to be considered in the d

171 Hg, the physiology/toxicology of Se, and the toxicology of Hg, we propose a new criterion for Se/Hg e

172 Furthermore, the toxicology of MP4 by evaluating the cell proliferation e

173 s the importance of considering the fate and toxicology of nanoparticles in context with their releva

174 , which provides interesting insights in the toxicology of phthalates.

175 nteraction between Se and Hg, the physiology/toxicology of Se, and the toxicology of Hg, we propose a

176 relatively little is known about the aquatic toxicology of sealcoat-derived contaminants.

177 need for more research on the chemistry and toxicology of the complex product formation in e-cigaret

178 ting the pharmacodynamics and especially the toxicology of the macrolides and ketolides.

179 Pharmacology and toxicology of these compounds are discussed, with partic

180 has stimulated interest in the chemistry and toxicology of these compounds.

181 ch should examine the environmental fate and toxicology of these PFASs, especially their potential as

182 efore required to understand the ecology and toxicology of those bloom events and reduce their negati

183 nsions (nutrition, environment, economy, and toxicology) of diet sustainability were assessed using:

184 In 40 (19%) cases, predictable toxicology or histology testing accessible by PMCT infor

185 of NPs behavior in biological specimens for toxicology or nanomedicine purposes.

186 e weeks of any non-study opioid use by urine toxicology or self-report, or 7 consecutive days of self

187 ty/volume of distribution (V(d)) for in vivo toxicology outcomes, scaled microsome metabolism/calcula

188 duced cannabis use as measured both by urine toxicology (p=0.001) and by the Timeline Followback Inte

189 raphrasing the Swiss physician and father of toxicology Paracelsus (1493-1541) on chemical agents use

190 tion of a drug with antiviral properties and toxicology parameters similar to 2, but with a preclinic

191 Sub-acute toxicology performed on rats intravenously injected with

192 st for several application fields, including toxicology, pharmacology, and therapeutics.

193 is well compatible with the accuracy of the toxicology predictions.

194 needs to be compatible with the effect (e.g. toxicology) predictions.

195 Their therapeutic efficacy and preliminary toxicology profiles were assessed and compared in vivo i

196 Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is

197 tal Protection Agency (EPA) and the National Toxicology Program (NTP) are collaborating to develop a

198 nmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, m

199 In 2011, the National Toxicology Program (NTP) organized a workshop to assess

200 th Sciences (NIEHS) Division of the National Toxicology Program (NTP) organized a workshop to evaluat

201 al and summary animal data from the National Toxicology Program (NTP) testing program and other depos

202 ical studies being conducted by the National Toxicology Program (NTP).

203 se and luciferase, to screen a U.S. National Toxicology Program 1,408-compound library (NTP 1408, whi

204 sment and Translation (OHAT) of the National Toxicology Program and the Navigation Guide works.

205 synthesis under development at the National Toxicology Program and under consideration by the U.S. E

206 To that end, as of 2016, the National Toxicology Program assumed stewardship of BMDExpress.

207 ccess point for these purposes, the National Toxicology Program Interagency Center for the Evaluation

208 t would yield a broad assessment of National Toxicology Program's (NTP's) effectiveness across multip

209 ments with an important role in the National Toxicology Program's (NTP) efforts to advance toxicology

210 EPA CompTox Chemicals dashboard and National Toxicology Program's Integrated Chemical Environment.

211 sed using guidance developed by the National Toxicology Program's Office of Health Assessment and Tra

212 te of Environmental Health Sciences/National Toxicology Program, the U.S. Environmental Protection Ag

213 ch as the Superfund Program and the National Toxicology Program, work to discover mechanisms to prote

214 rmation System Program and the U.S. National Toxicology Program.

215 a 2-year bioassay conducted by the National Toxicology Program.

216 umors) previously studied by the US National Toxicology Program.

217 Evaluating the impact of the U.S. National Toxicology Program: a case study on hexavalent chromium.

218 e from ecology, chemistry, exposure science, toxicology, public health, bioethics, engineering, medic

219 rlying mechanisms causing cancer, regulatory toxicology relies on animal testing to predict carcinoge

220 when interlaboratory comparisons of PM(2.5) toxicology research are made.

221 Toxicology research into the global public health burden

222 canids to act as models for Arctic molecular toxicology research is unique and significant for advanc

223 animal model in biomedical and environmental toxicology research.

224 the process is important for infertility and toxicology research.

225 atabase (CEBS) is a comprehensive and unique toxicology resource that compiles individual and summary

226 These toxicology results have shown Ramizol is well-tolerated

227 personalized medicine and nutrition, inform toxicology risk assessment, and improve drug discovery a

228 nations can be used to prioritize cumulative toxicology risk assessments.

229 Computational toxicology scientists from 25 international groups contr

230 In toxicology screening (forensic, food-safety), due to sev

231 an enabling platform for predictive drug and toxicology screening and development of novel therapeuti

232 probability for a Bayesian model in targeted toxicology screening is introduced.

233 gerous "designer drug" analogues that escape toxicology screening, yet display comparable potency to

234 eering, and high-throughput pharmacology and toxicology screening.

235 Toxicology screens using primary human cells and high-th

236 tors; however, nephrotoxicity in preclinical toxicology species precluded development.

237 development, including pharmacokinetic (PK), toxicology, stability, and biochemical characterization

238 wide range of assays, from drug discovery to toxicology, stem cell research and therapy.

239 ecules that advanced into exploratory animal toxicology studies (two species) was examined to determi

240 metabolic profiles between animal groups in toxicology studies and clinical investigations of liver

241 s is crucial for early-stage drug discovery, toxicology studies and clinical trials.

242 ellent properties, it was progressed through toxicology studies and is being tested in phase 1 clinic

243 Results from animal toxicology studies are critical to evaluating the potent

244 ons in, e.g., drug discovery, synthesis, and toxicology studies are envisaged.

245 Additionally, plasma samples from toxicology studies confirmed that 8 did not form any rea

246 The use of chimeric mice in preclinical toxicology studies could improve the safety of candidate

247 th acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to hi

248 FDA for potentially waiving some nonclinical toxicology studies for sunscreens.

249 t understanding of nanoparticle behavior and toxicology studies for the alveolar region.

250 While toxicology studies have pinpointed DBPs with the greates

251 Since toxicology studies have shown that the product of C-nitr

252 Preclinical toxicology studies in mice, rats, dogs, and primates did

253 iviral activity, preclincial PK profile, and toxicology studies in rat and dog supported clinical dev

254 Toxicology studies indicate that inhalation of ultrafine

255 Toxicology studies of Ag-NP transformation products, inc

256 tified 18 epidemiology studies and 21 animal toxicology studies relevant to our study question.

257 ds away from traditional experimental animal toxicology studies to one based on target-specific, mech

258 emerged as a model organism in environmental toxicology studies, and increased knowledge of Ahr-media

259 Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight an

260 p experimental avenues for disease modeling, toxicology studies, regenerative medicine, and gene ther

261 ls may include interpretation of preclinical toxicology studies, selection of first in man dosing reg

262 Through a series of exploratory toxicology studies, we show that quantifying CatD target

263 promising alternative to traditional animal toxicology studies.

264 PBDEs, which may inform future environmental toxicology studies.

265 vitro disease modeling, drug discovery, and toxicology studies.

266 ice used for transgenesis, pharmacology, and toxicology studies.

267 nerative medicine strategies, as well as for toxicology studies.

268 was achieved for advancement into regulatory toxicology studies.

269 reversible hepatic lipidosis in repeat-dose toxicology studies.

270 the oral exposure at the efficacious dose in toxicology studies.

271 l epithelium model is potentially useful for toxicology studies.

272 eplacing animal models in drug discovery and toxicology studies.

273 e than 100 g of the final API BMS-986097 for toxicology studies.

274 t potential to be used in drug discovery and toxicology studies.

275 spectroscopy data collected in a preclinical toxicology study as part of a larger project lead by the

276 A pilot mouse toxicology study confirmed that no evidence of significa

277 In a single-dose rat toxicology study, a site-specific anti-Her2 NDC was well

278 This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to

279 In a toxicology study, SI-2 caused minimal acute cardiotoxici

280 hypersensitivity in a 90-day NHP regulatory toxicology study.

281 uirement to assess the pharmacokinetics in a toxicology study.

282 pectations that central questions of mixture toxicology such as for mechanisms of low dose interactio

283 ipants received behavioral therapy and urine toxicology testing throughout the trial.

284 uman development, accelerate predictive drug toxicology tests, and advance potential regenerative the

285 nvironmental hygiene technology, preliminary toxicology tests, mutagenicity of medicinal compounds, a

286 imeline follow back and ascertained by urine toxicology tests.

287 In regulatory toxicology, the dose-response relationship is a key elem

288 ound implications for animal-free predictive toxicology, this work paves the way to a more efficient

289 s and industries, ranging from environmental toxicology through to pharmaceutical and agrochemical in

290 f critical importance in fields ranging from toxicology to climate science, yet these properties are

291 timately be possible to develop personalized toxicology to determine interindividual susceptibility t

292 has been used in both both epidemiology and toxicology to develop the definition of "noninteraction,

293 In fields ranging from environmental toxicology to drug discovery, it is critical to identify

294 rms of pharmacokinetics, ammonia uptake, and toxicology to seek regulatory approval for a first-in-hu

295 t mainly as a result of a paradigm change in toxicology towards the use and integration of genome wid

296 -to-outcome continuum of modern experimental toxicology using cheminformatics approaches and big data

297 l for studies evaluating drug metabolism and toxicology using in vitro constructs.

298 se study, a literature survey of the nano-Cu toxicology values has been performed to calculate the ef

299 Pre-clinical toxicology was conducted in 2 species.

300 Combining computational toxicology with ExpoCast exposure estimates and ToxCast