ライフサイエンスコーパス: trabeculae

1 was measured in multicellular preparations (trabeculae).

2 IOP (posterior sclera) to 122 x IOP (laminar trabeculae).

3 man heart left ventricle muscle (contracting trabeculae).

4 nducted in isolated human cardiomyocytes and trabeculae.

5 hanical transduction in isolated skinned rat trabeculae.

6 )] relationships were studied in skinned rat trabeculae.

7 g mice, with increased numbers of plate-like trabeculae.

8 the endocardium that overlies the developing trabeculae.

9 rate in whole troponin-exchanged skinned rat trabeculae.

10 ineralization and elastic modulus within the trabeculae.

11 T/TnC and exchanged into skinned rat cardiac trabeculae.

12 had failed to differentiate and form normal trabeculae.

13 or the endogenous form in skinned guinea pig trabeculae.

14 antified by protein microarray of individual trabeculae.

15 9 +/- 2.0 to 20.5 +/- 3.1 mN/m(2), p < 0.05) trabeculae.

16 eaction analysis of rat tibial zones free of trabeculae.

17 e performed in isolated cardiac myocytes and trabeculae.

18 th plate hypertrophic cartilage and few bony trabeculae.

19 of 2.0 and 2.3 microm in skinned rat cardiac trabeculae.

20 increased lattice spacing at every SL in NTG trabeculae.

21 es form complex inner wall structures called trabeculae.

22 s in the formation of the cardiac valves and trabeculae.

23 5) for dichroism in cTnC(C84) reconstituted trabeculae.

24 superfused LV trabeculae (P=0.01) but not RV trabeculae.

25 eentry in the PM root and around endocardial trabeculae.

26 ivity of both force and dichroism in skinned trabeculae.

27 ty of force in both skinned psoas fibers and trabeculae.

28 esenchymal cells, myxoid matrix, and fibrous trabeculae.

29 the cells lining the surface of newly formed trabeculae.

30 l structures as the papillary muscle (PM) or trabeculae.

31 ownregulation of ERBB2 signaling in maturing trabeculae.

32 d normal formation of cushion mesenchyme and trabeculae.

33 Freshly obtained human myocardial trabeculae.

34 ng the maternal blood space between adjacent trabeculae.

35 +/- 0.14 s(-1), k(tr)= 2.69 +/- 0.30 s(-1)) trabeculae.

36 g a clone that forms a single or at most two trabeculae.

37 ease in Ca2+-activated force produced by the trabeculae.

38 ed apices, a thinned compact zone and coarse trabeculae.

39 revented the effects of calpain I on skinned trabeculae.

40 stunned 1.39 +/- 0.21 micromol/L; P = .0025) trabeculae.

41 ssociated with the zebrafish embryonic heart trabeculae.

42 delamination events that create ventricular trabeculae.

43 s) to seed the multicellular ridges known as trabeculae.

44 approaching reported values from adult human trabeculae.

45 ess are among the biomechanical functions of trabeculae.

46 cardiomyocytes that sprout and form nascent trabeculae.

47 to form complex muscular structures known as trabeculae.

48 ed size with a single-cell-thick wall but no trabeculae.

49 cluding crypts, abnormal mitral leaflets and trabeculae.

50 the formation of muscular protrusions called trabeculae.

51 r, and thickness and decreased separation of trabeculae.

52 orce (pCa(50)) similarly with WT and S23/24A trabeculae.

53 yocardium during the formation of valves and trabeculae.

54 se activity, and force generation in skinned trabeculae.

55 nd arrhythmias were recorded in human atrial trabeculae.

56 fail to form identifiable cardiac valves and trabeculae.

57 ated and flash-frozen porcine left-ventricle trabeculae.

58 es directly through tooth roots [5, 6], bone trabeculae [6], or bone canaliculi (i.e., dorsal canalic

59 acterized by prominent left ventricular (LV) trabeculae, a thin compacted layer, and deep intertrabec

60 centage of new bone area (NBA), area of bone trabeculae (ABT), new cementum (NC), and extension of re

61 d edematous wall with multiple hypertrophied trabeculae along its walls.

62 ated the contraction-relaxation cycle of HCM trabeculae, ameliorating diastolic function.

63 ated with a pronounced increase in calcified trabeculae and bone radiodensity.

64 Delayed bone resorption in metaphyseal trabeculae and diminished eroded perimeters despite an i

65 e became impacted on less highly mineralized trabeculae and embedded in the marrow space.

66 a signal(s) from the epicardium, but not the trabeculae and endocardium, is required in embryonic day

67 etaphysis is physically larger, with thicker trabeculae and greater bone volume fraction relative to

68 properties with thickened and more numerous trabeculae and had a uniquely altered morphology in depo

69 omyocytes (native and hiPSC-derived), intact trabeculae and hiPSC-EHTs revealed prolonged action pote

70 c receptor-expressing cells in the placental trabeculae and in neuronal cells in the brains of fetuse

71 vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

72 one studies because of high contrast between trabeculae and intertrabecular spaces.

73 which is normally expressed in the atria and trabeculae and is restricted from the developing compact

74 ction, twitch Delta[Ca2+]i, and lusitropy in trabeculae and isolated myocytes from failing human hear

75 Both trabeculae and isolated myocytes responded as poorly as

76 ume and trabecular number as well as thinner trabeculae and more trabecular separation in osseous def

77 diffraction data from electrically paced rat trabeculae and papillary muscles to provide a molecular

78 ns from relaxed permeabilized rabbit cardiac trabeculae and psoas muscle fibers were compared.

79 ifference time-domain modeling that expanded trabeculae and ridges, found across ultra-black butterfl

80 results in a significantly greater number of trabeculae and significantly lower spacing between trabe

81 n the medial right atrium, especially in the trabeculae and the crista terminalis of the right atrial

82 the larval anterior neurocranium: the paired trabeculae and the midline ethmoid.

83 8 kb-/- displayed lower bone volume, thinner trabeculae and thinner bone cortex as compared to WT.

84 n and formation, which induces a thinning of trabeculae and trabecular perforations.

85 alities, including overdeveloped ventricular trabeculae and underdeveloped arterial walls.

86 retch relations were measured in endocardial trabeculae and were not different for DCM and LV assist

87 lcium relationships were measured in skinned trabeculae and/or myocytes.

88 d to central arterioles, white pulp regions, trabeculae, and capsule.

89 icantly higher bone volume fraction, thicker trabeculae, and consequently lower relative bone surface

90 ained cartilage proteoglycans in metaphyseal trabeculae, and increased trabecular thickness.

91 gion, a greater number and thickness of bone trabeculae, and less bone porosity and separation betwee

92 ng epicardial vessels, ridges of endocardial trabeculae, and papillary muscle insertions.

93 hanisms for this influence in intact hearts, trabeculae, and skinned fibers from wild-type (+/+) and

94 or mitral valve leaflet elongation, abnormal trabeculae, and smaller LV systolic cavity is indicative

95 strips were mounted in parallel with cardiac trabeculae, and we demonstrated their ability to improve

96 Cardiac trabeculae are uneven ventricular muscular structures th

97 lopment (k(tr)) in demembranated rat cardiac trabeculae as [Ca(2+)] was varied.

98 ulae and significantly lower spacing between trabeculae as well as increased bone mass in both males

99 he contractility of isolated rat ventricular trabeculae at 24 degrees C using the work-loop technique

100 We show that in relaxed trabeculae at near-physiological temperature and filamen

101 nt concentrations to adult human ventricular trabeculae at physiological temperature.

102 moderate compression (1% dextran) of skinned trabeculae at SL=2.02 microm reduced LS (LS=42.29+/-0.14

103 al bone), which forms by coalescence of thin trabeculae at the metaphysis (corticalization), but the

104 ion as function of SL in skinned rat cardiac trabeculae bathed in 0% to 6% dextran solutions (MW 413

105 5% CI, 1.7-3.1; P<0.001), abnormal LV apical trabeculae (beta=1.6; 95% CI, 0.8-2.5; P<0.001), and sma

106 etics was studied in skinned rat ventricular trabeculae by measuring the kinetics of force redevelopm

107 tants, which we show completely lack cardiac trabeculae, cardiac function is significantly compromise

108 e bases of the PMs are seen to attach to the trabeculae carneae lining the ventricular wall rather th

109 ed soleus (SSM), psoas (FSM) and ventricular trabeculae (CM) of the rat under carefully controlled co

110 ain measurements show that the appearance of trabeculae coincided with enhanced deformability of the

111 mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum,

112 ract and valve morphogenesis and ventricular trabeculae compaction.

113 nd less bone porosity and separation between trabeculae compared to the PD group (p < 0.05).

114 ory shear index (OSI) in the grooves between trabeculae, compared to lower values on the ridges, in t

115 vidual cells of intact rat right ventricular trabeculae (composed of < 15 cells in cross section) mic

116 The bony trabeculae conferred the honeycomb or sunburst appearanc

117 At the level of isolated cardiac trabeculae, contractile performance, specifically of con

118 ed myocytes are applicable to intact cardiac trabeculae [corrected].

119 ntly define LVNC: prominent left ventricular trabeculae, deep intertrabecular recesses, and a thin co

120 in detergent-extracted fiber bundles from LV trabeculae demonstrated a relative decrease in maximum C

121 in ultra-thin isolated rat right ventricular trabeculae during a short 10 ms shuttered exposure eithe

122 f long bones is determined by coalescence of trabeculae during corticalization.

123 e segmented and labeled into regions of bone trabeculae, endosteum, active marrow, and inactive marro

124 ues for tracking alpha-particles across bone trabeculae, endosteum, and marrow cavities and (b) a spa

125 Although it has been suggested that cardiac trabeculae enhance cardiac contractility and intra-ventr

126 Although cMLCK treatment of ventricular trabeculae exchanged with rat or human troponin increase

127 Unlike controls, Tsp4(-)/(-) cardiac trabeculae failed to enhance contractility and cellular

128 inked with cardiac development, during which trabeculae form a network of branching outgrowths from t

129 ardium-layered myocardial projections called trabeculae form and mature into the adult ventricles is

130 ing cardiomyocyte-oriented cell division and trabeculae formation depends on endocardial Nrg1 to myoc

131 rating that tissue stresses are important to trabeculae formation.

132 Human atrial trabeculae from 17 patients (45-75 years old) were suspe

133 alcium cycling and contractile activation in trabeculae from a mutant mouse model of FHC (Arg403Gln k

134 Trabeculae from an additional 12 patients (53-73 years o

135 Total myocardial stiffness was increased in trabeculae from both mild and severe RV dysfunction in c

136 Trabeculae from both species had similar Ca2+ sensitivit

137 , and unloaded shortening velocity (V(u)) in trabeculae from both untreated and PTU-treated rats (at

138 efore and after skinning in thin ventricular trabeculae from control or stunned (20 minutes of ischem

139 earts but produced a moderate increase in RV trabeculae from failing hearts.

140 Next, intact left ventricular trabeculae from HF patient hearts were incubated with co

141 Trabeculae from HF showed a negative force-frequency rel

142 the Ca2+-dependent overshoot was larger for trabeculae from hypertrophied than from control hearts (

143 o+IPC), recovery of DF was 27 +/- 3%, but in trabeculae from insulin-treated patients (Ins+IPC), it w

144 duced little change in developed force in RV trabeculae from nonfailing hearts but produced a moderat

145 trast to in vivo studies, isolated isometric trabeculae from nontransgenic and TnIDD22,23 mice had si

146 not of ryanodine2 (Ser-2814), was reduced in trabeculae from patients with AF.

147 ic abnormalities of ventricular myocytes and trabeculae from patients with HCM, suggesting potential

148 es and serotonin cause arrhythmias in atrial trabeculae from patients with sinus rhythm (SR), but whe

149 nephrine, serotonin, and forskolin in atrial trabeculae from patients with SR and patients with AF.

150 Ischemic preconditioned (IPC) trabeculae from patients without oral hypoglycemic thera

151 espectively, in [Ca2+] within Triton-skinned trabeculae from rat and guinea pig hearts (22 degrees C)

152 tested this hypothesis by activating intact trabeculae from rat heart by electrical stimulation unde

153 fully dephosphorylated state in ventricular trabeculae from rat heart were determined using polarize

154 Trabeculae from rat right ventricles were skinned by 1%

155 associated with activation of demembranated trabeculae from rat ventricle by the C1mC2 region of rat

156 anism of calcium regulation in demembranated trabeculae from rat ventricle using polarized fluorescen

157 rgetical properties in permeabilized cardiac trabeculae from rat were studied to provide novel insigh

158 2+-dependent [NADH]m recovery was larger for trabeculae from rats with hypertrophied hearts (17+/-4%

159 Ca2+-independent initial fall was larger for trabeculae from rats with hypertrophied hearts than from

160 I(1,0)) were made in relaxed skinned cardiac trabeculae from rats.

161 t psoas fibers and skinned right ventricular trabeculae from rats.

162 mbryonic day 9 by the movement of myocardial trabeculae from the primitive ventricle towards the bulb

163 n electrically stimulated intact ventricular trabeculae from the rat heart to determine the isotonic

164 ated contractile regulation in demembranated trabeculae from the rat right ventricle.

165 from synchrotron light in intact ventricular trabeculae from the rat to measure the axial movement of

166 Ventricular trabeculae from the right ventricle of rat heart were su

167 Intact rat trabeculae from the right ventricle were mounted between

168 Trabeculae from the right ventricles of rat hearts were

169 Comparisons were made in trabeculae from untreated rats (predominantly V1 myosin)

170 Intact trabeculae from vehicle-treated mutants displayed inotro

171 , 2.2 microns) and stimulated at 0.2 Hz, the trabeculae generated approximately equal to 700 microgra

172 The function of these trabeculae in adults and their genetic architecture are

173 tudinal and transverse bands of cytoplasm or trabeculae in internodal Schwann cells and suggested tha

174 Fractal analysis has been used to define trabeculae in left ventricular noncompaction and to iden

175 inning of the compact myocardium and reduced trabeculae in mutant hearts, which were accompanied by r

176 Markedly decreased mineralized femur trabeculae in SCD females and males was partially rescue

177 Despite the important role of trabeculae in the development and physiology of the hear

178 est a previously unknown role for myocardial trabeculae in the function of the adult heart, identify

179 ction as a function of SL in skinned cardiac trabeculae in the passive state from both NTG and ssTnI-

180 due to the aborted development of myocardial trabeculae in ventricular muscle.

181 on, and preserved elastic modulus within the trabeculae, in both mouse and human bone.

182 PMA) of rapidly frozen papillary muscles and trabeculae incubated with ryanodine (1 microM) in either

183 rison of our results with those of activated trabeculae indicated that a large fraction of restoring

184 The ROI 1 and 4, at the mandibular angle trabeculae, indicated statistical significances on the r

185 onsequence of a defect in the coalescence of trabeculae into the developing ventricular septum, which

186 riments further reveal that the formation of trabeculae is associated with a spatial homogenization o

187 The isometric FFRs of LV trabeculae isolated from 15 patients with end-stage hear

188 sing fluorescence spectroscopy in intact rat trabeculae isolated from the right ventricular wall.

189 ial intensity ratio, I(11)/I(10), in skinned trabeculae isolated from wild-type and cMyBP-C null (cMy

190 h toward the heart lumen to form ventricular trabeculae-like structures.

191 phate to amide ratio together with disrupted trabeculae, loss of osteocytes, presence of calcified ma

192 ransport structures, such as lymph node (LN) trabeculae, lymph vessels, and conduits.

193 We hypothesized that trabeculae measured by fractal analysis of cardiovascula

194 sion of Ca2+ waves in intact rat ventricular trabeculae micro-injected with the calcium indicator flu

195 bone volume (BV)/total volume (TV) (+42.8%), trabeculae number (Tb.N) (+84.1%), structure model index

196 ineral content and bone mineral density, and trabeculae number were similar in SHAM and ZOL, and lowe

197 Right ventricular trabeculae, obtained from freshly explanted hearts of pa

198 s in neuroglial cells; and thickening of the trabeculae of connective tissue in the nerve.

199 vere premature atrial contractions in atrial trabeculae of patients with SDB, which could be blocked

200 r caliber Abeta fibers that terminate in the trabeculae of the cavernous sinus as an ending that rese

201 stretch of contracting permeabilized cardiac trabeculae of the rat on the rate of inorganic phosphate

202 eased osteoblast surfaces in the metaphyseal trabeculae of the tibia and femur.

203 vs. Ca2+ relationship in skinned ventricular trabeculae of transgenic mice in comparison with wild-ty

204 btained at the second procedure consisted of trabeculae of viable lamellar bone and associated fibrou

205 the structure that most dentists identify as trabeculae on intraoral radiographs.

206 y and reveal the influence of the myocardial trabeculae on susceptibility to cardiovascular disease.

207 Pillar-like trabeculae on the dorsal surface of each gill lamella in

208 Trabeculae (Oral Hypo+IPC) were obtained from patients t

209 -jump of 0.5-20 masculineC) of permeabilized trabeculae over a physiological range of sarcomere lengt

210 markedly depressed in both groups of stunned trabeculae (P < .001)).

211 p < 0.05) and the loss of the number of bone trabeculae (p < 0.05), and to reduce the severity of inf

212 requency relations of isolated superfused LV trabeculae (P=0.01) but not RV trabeculae.

213 bserved power-law kinetics of murine cardiac trabeculae passive stress decay.

214 ernibility of the osseous cortex and osseous trabeculae, perceived image noise level, and diagnostic

215 Also, a nonlinear increase in trabeculae perimeter coverage was found with increasing

216 r and quadratic) of baseline BTI of vertical trabeculae predicted knee OA progression based on 12- an

217 In skinned cardiac trabeculae reconstituted with a mono-cysteine mutant cTn

218 PKA treatment of WT and S23/24A trabeculae reduced pCa(50) at 2.3 but not at 2.0 mum SL,

219 In contrast, S23/24D trabeculae reduced pCa(50) at both SL values, primarily

220 ical simulations reveal that the presence of trabeculae reduces ventricular tissue internal stresses,

221 Individual variability is extreme, and trabeculae represent a sort of individual "cardioprintin

222 is filled with an extensive network of fine trabeculae resembling the endochondral bone of osteichth

223 Electrically paced ventricular trabeculae restored RLC phosphorylation, which was incre

224 lcium concentration and contractile force in trabeculae revealed a doubling of Ca2+ transient amplitu

225 Ca2+]i and contractile force measurements in trabeculae revealed the expected depression of myofilame

226 28 +/- 4% in control trabeculae, whereas IPC trabeculae showed 52 +/- 5% recovery (P < .05 versus con

227 vitro and force generation in demembraneated trabeculae showed that modification at Ser150 resulted i

228 on of myosin is disrupted by cooling relaxed trabeculae, similar to the effect induced by maximal cal

229 bserved mitochondrial NADH dynamics in heart trabeculae subjected to changes in pacing frequency.

230 e had significantly decreased number of bone trabeculae, suggesting disruption of their microarchitec

231 ular Ca(2+) ([Ca(2+)]i) were measured in rat trabeculae superfused with Krebs-Henseleit solution, wit

232 m the endocardial layer to form a network of trabeculae that characterize the ventricles of the verte

233 a2+] ([Ca2+]i) were measured in isolated rat trabeculae that had been micro-injected with fura-2 salt

234 lopment but, along with the mitral valve and trabeculae, their developmental trajectory is altered by

235 ctivity of osteoclasts, which perforate bone trabeculae, thus reducing their strength and increasing

236 30 minutes after direct exposure of skinned trabeculae to calpain I (18 microgram/mL, 20 minutes at

237 we used RLC probes in demembranated cardiac trabeculae to investigate the molecular structural basis

238 of these processes leads to the formation of trabeculae to optimize the internal structure of the ven

239 orhodamine, and exchanged into demembranated trabeculae to replace some of the native cRLC.

240 ine anatomic structures, such as endocardial trabeculae, to be resolved and potentially used as fiduc

241 imulations and direct experiments in cardiac trabeculae under normoxic conditions, recapitulating the

242 to those recorded in single cells, occur in trabeculae under physiological conditions and (2) coupli

243 -adrenergic response in isolated rat cardiac trabeculae undergoing either isometric or work-loop cont

244 y to investigate image-derived phenotypes of trabeculae using the fractal analysis of trabecular morp

245 chondrial [NADH] in isolated rat ventricular trabeculae, using a novel fluorescence spectroscopy meth

246 ) was corroborated experimentally in cardiac trabeculae utilizing the inhibitor titration method.

247 Trabeculae, vena cavae (inferior and superior), and the

248 A strut analysis of trabeculae was also performed and the results compared.

249 ontractions of chemically skinned guinea pig trabeculae was studied using laser photolysis of NP-EGTA

250 hanical measurements in isolated ventricular trabeculae, we demonstrate that human cMLCK is not a ded

251 responding data from cTnC(C98) reconstituted trabeculae were 5.53 (+/-0.03) and 3.1 (+/-0.17) for for

252 ereas the myofilaments of chemically skinned trabeculae were activated directly with solutions of var

253 Myocardial left and right ventricular trabeculae were dissected from nonfailing and end-stage

254 Right ventricular trabeculae were dissected from rat hearts subjected eith

255 Volumetry and distribution of bone trabeculae were evaluated by microCT imaging.

256 iescent and rhythmically contracting cardiac trabeculae were exposed to different concentrations of e

257 ally contracting isolated human right atrial trabeculae were exposed to MIF (100 ng/mL) for 60 minute

258 Demembranated rat cardiac trabeculae were incubated with varying ratios of the LKB

259 Left ventricular trabeculae were isolated from banded and control rat hea

260 Intact cardiac trabeculae were loaded with Rhod-2(AM), and [Ca(2+)](m)

261 Highly orientated trabeculae were more obvious in the lower limb than the

262 Human atrial trabeculae were obtained at the time of cardiac surgery,

263 Atrial trabeculae were obtained at the time of cardiac surgery.

264 In the heart, trabeculae were poorly developed, the myocardium was rem

265 Trabeculae were quantified by fractal analysis of cine s

266 hat the trabecular bone volume and number of trabeculae were significantly reduced in femoral and tib

267 The trabeculae were subjected to shortening ramps over a ran

268 Isolated human right atrial trabeculae were suspended in an organ bath at 37 degrees

269 Trabeculae were then permeabilized for mitochondrial res

270 Control trabeculae were then subjected to 45 minutes of simulate

271 In parallel experiments, skinned trabeculae were treated with calpain I for 20 minutes; W

272 I-(1-192) was exchanged into skinned cardiac trabeculae; Western blot analysis confirmed that 60-70%

273 snai1b leads to 51.6% cardiomyocytes forming trabeculae, whereas CRISPR-repression reduces trabecular

274 preischemic values was 28 +/- 4% in control trabeculae, whereas IPC trabeculae showed 52 +/- 5% reco

275 ncreased wall thickness because of excessive trabeculae, whereas widespread myocardial Notch activity

276 We compare rat permeabilized cardiac trabeculae, which have undergone exchange with different

277 frequency-doubled ruby laser focused on the trabeculae, while maintaining constant total [NP-EGTA] a

278 Compared with the trabeculae with a low level of RLC phosphorylation, RLC

279 ompared the mechanical properties of cardiac trabeculae with either ATP or 2-deoxy-ATP (dATP) as the

280 oponin (Tn) was exchanged in rat ventricular trabeculae with either wild-type (WT) Tn, non-phosphoryl

281 dral plate; and with thinner, less separated trabeculae with greater TMD and BS/BV in the trabecular

282 did not alter force development in isolated trabeculae with intact endothelial cells, but actomyosin