ライフサイエンスコーパス: trabeculation

1 rade the cardiac jelly and prevent excessive trabeculation.

2 ber demarcation, hypocellularity and lack of trabeculation.

3 wed that TBX5 inhibits myocardial growth and trabeculation.

4 e head and yolk sac as well as in myocardial trabeculation.

5 e snai1b expression and Notch-ErbB2-mediated trabeculation.

6 dial protrusions modulate CM behavior during trabeculation.

7 ic shear stress coordinate the initiation of trabeculation.

8 Yap1 nuclear-cytoplasmic distribution during trabeculation.

9 ted by Yap, which has not been implicated in trabeculation.

10 he formation and function of embryonic heart trabeculation.

11 glycolytic enzyme pyruvate kinase M2 impairs trabeculation.

12 ar matrix and growth factors is critical for trabeculation.

13 tivated to initiate delamination for cardiac trabeculation.

14 llenge the established literature on cardiac trabeculation.

15 le are implicated in cardiac development and trabeculation.

16 B2 is critical for myocyte proliferation and trabeculation.

17 stress-activated Notch signaling to modulate trabeculation.

18 ing and prevents cardiomyocyte sprouting and trabeculation.

19 lation of Notch signaling and attenuation of trabeculation.

20 ss and downregulation of Notch signaling and trabeculation.

21 yocytes, as well as regulation of myocardial trabeculation.

22 novel cellular behaviors underlying cardiac trabeculation.

23 ardial wall defect with dramatically reduced trabeculation.

24 ation, cardiac morphogenesis, and myocardial trabeculation.

25 erized by a thinned myocardium and prominent trabeculations.

26 tracing techniques for papillary muscles and trabeculations.

27 gnancy, 26 women (25.4%) developed increased trabeculations.

28 sh and three treated fish types that disrupt trabeculation: (a) chemical treatment using AG1478, an E

29 that Erbb2 signaling, which is required for trabeculation, activates glycolysis to support changes i

30 ntury ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall.

31 At e10.5, attenuation in cardiac trabeculation and compact layer expansion is noted, with

32 Although, ventricular trabeculation and compaction are key morphogenetic event

33 Trabeculation and compaction of the embryonic myocardium

34 liferation and growth form the basis of both trabeculation and compaction, and mouse models indicate

35 r signaling pathways involved in ventricular trabeculation and compaction, we generated a series of F

36 regulating the morphogenesis of ventricular trabeculation and compaction.

37 ere was no association between the degree of trabeculation and diffuse fibrosis measured with T1 mapp

38 ated with abnormal ventricular cardiomyocyte trabeculation and impaired pump function.

39 with a deficiency of ventricular myocardial trabeculation and impairment of cranial ganglion develop

40 s, decreased ventricular size and defects in trabeculation and in atrioventricular (AV) valve develop

41 ckground The extent of left ventricular (LV) trabeculation and its relationship with cardiovascular (

42 arged fetal hearts with increased myocardial trabeculation and reduced cell compaction, mimicking the

43 gulin 1 (nrg1) in the endocardium to promote trabeculation and that forced Notch activation in the ab

44 The thickness of trabeculation and the compact myocardium were measured i

45 ent cardiomyopathy associated with excessive trabeculation and thin compact myocardium.

46 Trabeculation and valvular hyperplasia were diminished i

47 ement and defects in the ventricular septum, trabeculation and vasculature.

48 smooth muscle cells and impaired myocardial trabeculation and ventricular wall development.

49 RV trabeculations and papillary muscles were considered cav

50 Increased LV trabeculations and the presence of LV noncompaction were

51 ls, arterial walls, distal bronchi, and bone trabeculations) and their pathologies, as well as the id

52 cal inhibition of glycolysis impairs cardiac trabeculation, and cardiomyocyte-specific loss- and gain

53 proliferation of cardiomyocytes, ventricular trabeculation, and myocardium thickening were also impai

54 end-diastolic volume, LV myocardium mass, LV trabeculation, and trabeculation mass-to-total myocardia

55 ayer >2, (2) presence of >3 prominent apical trabeculations, and (3) deep intertrabecular recesses th

56 en (73%) demonstrated complete resolution of trabeculations, and 5 showed a marked reduction in the t

57 of heart failure severity, not the extent of trabeculation-appears to be an important determinant of

58 Trabeculations are fascinating and important cardiac str

59 ance (MR) data were evaluated to quantify LV trabeculation as a fractal dimension (FD).

60 has smaller chambers and reduced myocardial trabeculation at E10.5.

61 proliferation and differentiation of cardiac trabeculation; (b) injection of gata1a morpholino oligom

62 r titanium (P < 0.0001), while the effect on trabeculation between treatments was not significantly d

63 ansition-like gene expression, and prolonged trabeculation, blocking compact myocardium maturation.

64 tif (NTF(DeltaGPS)) in zebrafish rescued the trabeculation but not the previously described myelinati

65 looping and the establishment of ventricular trabeculation but that myocyte proliferation becomes NT-

66 ricular tissue internal stresses can disrupt trabeculation, but a subsequent restoration of ventricul

67 ng hematopoiesis and resulting in attenuated trabeculation; (c) weak-atriumm58 mutant (wea) with inhi

68 , we observed that the initiation of cardiac trabeculation can be divided into two processes.

69 During cardiac trabeculation, cardiomyocytes delaminate from the outerm

70 s in this process, which is known as cardiac trabeculation, cause cardiomyopathies and embryonic leth

71 se of FD numerically showing changes in bone trabeculation, changes in the alveolar bone can be detec

72 P10 are associated with abnormal ventricular trabeculation/compaction and wall maturation.

73 ion in mouse second heart field (SHF) led to trabeculation defects in the right ventricle, ventricula

74 ns that alter Notch signaling also result in trabeculation defects.

75 amined the formation of these protrusions in trabeculation-deficient animals, including erbb2 mutants

76 Using genetic mosaics in trabeculation-deficient zebrafish models-that is, in the

77 ue internal stresses via vasopressin rescues trabeculation, demonstrating that tissue stresses are im

78 s a possible regulatory mechanism of cardiac trabeculation development.

79 We find that trabeculations enhance cardiac wall deformability, reduc

80 olic function changes among the quintiles of trabeculation extent.

81 These were considered in quintiles of trabeculation extent; the NC/C ratio of quintile 5 was 2

82 quent to high fluid pressures are needed for trabeculation formation through a rescue experiment, dem

83 ortant as fluid flow wall shear stresses for trabeculation formation.

84 fraction, not the extent of left ventricular trabeculation, had an important influence on the variabi

85 and smaller chambers and reduced myocardial trabeculation in mutant hearts.

86 Hyperoxia therapy reduced excessive trabeculation in Nkx2-5 mutant mice compared to normoxic

87 this study was to determine if excessive LV trabeculation in population-representative individuals i

88 that results from the failure of ventricular trabeculation in the developing heart, a faithful phenoc

89 Histologic evaluation confirmed increased trabeculation in the U groups.

90 rning and cell-fate decisions during cardiac trabeculation in zebrafish.

91 ribution of N-cadherin (Cdh2) during cardiac trabeculation in zebrafish.

92 Pregnancy induces de novo LV trabeculations in a significant proportion of women.

93 rid zone results in persistence of excessive trabeculations in postnatal heart.

94 cardiomyopathy, is characterised by abnormal trabeculations in the left ventricle, most frequently at

95 LV parameters counting papillary muscles and trabeculations in the LV mass, pooled normative referenc

96 ce either counting the papillary muscles and trabeculations in the LV volume or mass.

97 LV parameters counting papillary muscles and trabeculations in the LV volume, pooled normative refere

98 ion, to assess the development of de novo LV trabeculations in women with morphologically normal hear

99 We tested factors important for ventricular trabeculation including Nrg/ErbB and Notch signaling and

100 Cardiac trabeculation is a crucial morphogenetic process by whic

101 ermine if excess greater left ventricle (LV) trabeculation is associated with decreased average regio

102 Trabeculation is dependent on the signaling protein Nrg1

103 Left ventricular (LV) trabeculation is highly variable among individuals and i

104 Trabeculation is influenced by race and/or ethnicity and

105 splantation studies, we propose that cardiac trabeculation is initiated by directional cardiomyocyte

106 Failure of proper ventricular trabeculation is often associated with congenital heart

107 Ventricular wall formation (trabeculation) is initiated by cardiomyocyte delaminatio

108 erentiation factor essential for ventricular trabeculation, is sufficient to induce ectopic expressio

109 ventricle, ventricular dysfunction, and deep trabeculations, is also inherited, and the genes identif

110 nd-diastolic short-axis cine cardiac MRI: LV trabeculations, LV myocardium, LV papillary muscles, and

111 Automatic quantification of the trabeculation mass-to-TMM ratio had a higher correlation

112 e, LV myocardium mass, LV trabeculation, and trabeculation mass-to-total myocardial mass (TMM) ratio

113 for LV myocardium, and 0.62 +/- 0.08 for LV trabeculation (mean absolute error, 3.63 g +/- 3.4).

114 0.03 for LV myocardium, and 0.62 0.08 for LV trabeculation (mean absolute error, 3.63 g 3.4).

115 Greater extent of, and even excessive, LV trabeculation measured in end-diastole in asymptomatic p

116 ght ventricular myocardium (n=37; 38.1%), LV trabeculations (n=5; 5.2%), papillary muscle (n=3; 3.1%)

117 efects, hypoplastic left heart, and aberrant trabeculation) observed in patients with Holt-Oram syndr

118 The results suggest that LV trabeculations occur in response to increased LV loading

119 Average trabeculation of newly formed bone in the defect after h

120 a cardiomyopathy characterized by excessive trabeculation of the left ventricle, progressive myocard

121 c chamber, neuregulin-1 was shown to promote trabeculation of the ventricular wall.

122 der characterized by excessive and prominent trabeculations of the left ventricle, associated with pr

123 paction (LVNC) is characterized by excessive trabeculations of the LV and may be associated with redu

124 m, of blood-myocardium interface in areas of trabeculation or papillary muscles, and of the atriovent

125 ut is at least partly independent of cardiac trabeculation or shear stress.

126 d quality-controlled segmentation of cardiac trabeculations, outperforming inter- and intraobserver a

127 red in the assessment of individuals with LV trabeculations outside the context of symptoms of heart

128 hearts, but gata1 morphants with a disrupted trabeculation process retain a spatial stiffness heterog

129 Endocardial roughness of the RVOT, such as trabeculations, recesses, or muscular bridges, are prese

130 Trabeculation represents the initial ventricular growth

131 We show that trabeculation requires Brg1, a chromatin remodeling prot

132 How trabeculations resolve to form compact myocardium is poo

133 ulations of glycolysis decrease and increase trabeculation, respectively.

134 Abnormal myocardial trabeculation results in specific cardiomyopathies in hu

135 Presence of prominent left ventricular trabeculation satisfying criteria for left ventricular n

136 VNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over an

137 ntricular morphogenesis, reduced ventricular trabeculation, septal defects, and valvular overgrowth.

138 At the trabeculation stage of heart development, CHAMP expressi

139 tudy the role of N-cadherin expressed at the trabeculation stage, a replication-defective retrovirus

140 bsence of cardiomyocyte proliferation during trabeculation stages.

141 ion was worse in individuals with greater LV trabeculation, supporting the concept of hypertrabeculat

142 ts1 transcription such that ADAMTS1-mediated trabeculation termination was impaired.

143 m(2), Chinese American participants had less trabeculation than white participants (sbeta = -0.15; P

144 ications through right ventricular free wall trabeculations that can occur after repair of conotrunca

145 Even in subjects with excessive trabeculation, there were no clinically relevant differe

146 ng non-cell-autonomously promotes myocardial trabeculation through Erbb2 and bone morphogenetic prote

147 wed that cardiac contraction is required for trabeculation through its role in regulating notch1b tra

148 , we assessed whether shear stress modulates trabeculation to influence contractile function.

149 on of neuregulin1 mRNA with gata1 MO rescued trabeculation to restore contractile function in associa

150 Eight women showed sufficient trabeculations to fulfill criteria for LV noncompaction.

151 t of 48 patients, the mean Dice value for LV trabeculation was 0.63 +/- 0.10 or higher compared with

152 t of 48 patients, the mean Dice value for LV trabeculation was 0.63 0.10 or higher compared with the

153 After adjustment, greater trabeculation was associated with 21% worse myocardial s

154 sed in CHD4(M195I) hearts, and the excessive trabeculation was associated with accumulation of ECM (e

155 entire cohort, adjusted for anthropometrics, trabeculation was higher in African American participant

156 In G+LVH- patients, apical left ventricular trabeculation was increased compared with controls (maxi

157 LV trabeculation was measured with the maximal apical fract

158 Automated segmentation of trabeculations was performed using a deep learning algor

159 ular mechanisms of ErbB2 function in cardiac trabeculation, we analyzed erbb2 mutant hearts more clos

160 Bone volume and trabeculation were reduced in beta-TCP compared with all

161 his is concomitant with onset of ventricular trabeculation, where a subset of cardiomyocytes lose api

162 For technical reasons, the extent of trabeculation, which is expressed as the ratio of noncom

163 s characterized by the presence of extensive trabeculations, which could lead to heart failure and ma

164 frequently demonstrate left ventricular (LV) trabeculations, which may be compatible with the diagnos