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1 4Ile missense variant that were inherited in trans.
2 with Edc3 than Rps28 protein synthesized in trans.
3 enchymal niche controls tumour initiation in trans.
5 ve [2 + 2] cycloaddition of 1-octene to form trans-1,2-dihexylcyclobutane, a first-order dependence o
6 ray diffraction studies showed that cis- and trans-1,3-disubstituted housanes can be considered as fl
7 de (NDI) with 1,3-dibromopropane (NDI-NI) or trans-1,4-dibromo-2-butene (NDI-CI) via quaternization p
8 [OR (95% CI): 1.34 (1.08, 1.66); P = 0.007], trans 18:1n-7/vaccenic acid [OR (95% CI): 1.28 (1.04, 1.
9 se: 1.30 (1.05, 1.61); P = 0.015], driven by trans 18:1n-9(omega-9)/elaidic acid [OR (95% CI): 1.34 (
10 (95% CI): 1.28 (1.04, 1.58); P = 0.023], and trans 18:2n-6t,t [OR (95% CI): 1.26 (1.01, 1.57); P = 0.
11 wer-energy s-trans,s-trans (1tt) and s-cis,s-trans (1ct) product conformers at cryogenic temperatures
12 cid, isolation of the lower-energy s-trans,s-trans (1tt) and s-cis,s-trans (1ct) product conformers a
13 At higher temperatures, the corresponding trans-2,3-disubstituted tetrahydrofuran carbaldehydes ar
14 and C-terminal residues of homooligomers of trans-2-aminocyclobutanecarboxylic acid (tACBC)(n) with
15 ld-containing family B member 1, peroxisomal trans-2-enoyl-coenzyme A reductase, phospholipase A2 rec
16 ifferent chemical families (penta-2,3-dione, trans-2-hexen-1-al, ethyl hexanoate, nonan- and decan-2-
17 nger oxygen atom transfer (OAT) agent than 2-trans; 3 performs OAT to 1-trans or PPh(3) to yield 2-tr
22 me has allowed evolution of separate cis and trans acting functions, providing selective pressure to
23 captures microRNA390, contributing to reduce trans acting small interference Auxin Response Factor pr
25 n, including the cis-regulatory elements and trans-acting factors that determine general de novo m(6)
27 -function relationship, determining cis- and trans-acting lncRNAs in vivo, and generating new develop
28 genetically divergent strains, we mapped 86 trans-acting loci affecting the expression of ten genes.
31 ctivity and upon heptamerization, packing of trans-acting Tyr(290) against cis-acting Arg(349) compel
33 V-associated saliva exosomes contain the HIV trans-activation response element (TAR), Tat, and Nef RN
37 elta-dehydro-delta-azaproline exhibit strong trans amide rotamer propensities irrespective of ring co
40 filing revealed improved prediction based on trans-ancestry meta-analysis results for admixed African
44 A4 is not only required for the formation of trans- and 9'-cis-neoxanthin from trans-violaxanthin, bu
45 eparation of the n -> pai* bands between the trans- and cis-conformations, which allows for the gener
46 ilized aryldibromoborane yields a mixture of trans- and cis-diborenes in which the aryl groups are co
49 amples showed that eugenol (10.5-120 mg/kg), trans-anethole (10.7-42.7 mg/kg) and estragole (2.2-45.7
51 le patients were unsuitable or refractory to trans-arterial chemoembolization (TACE) and stereotactic
53 nt than Tel1 at phosphorylating chromatin in trans-at distant undamaged sites that are brought into p
55 ost distinctive enzymatic features common to trans-AT PKSs is their ability to introduce methyl group
56 try data, ruggedness, and backscatter from a trans-Atlantic corridor along the Vema Fracture Zone, co
58 the dibridged molecule reconstructs into the trans-bent and linear structures prevail over the intera
60 d syringaldehyde), while 4-ethylguaiacol and trans-beta-methyl-gamma-octalactone were significantly h
61 el-Crafts alkylations of N-methylindole with trans-beta-nitrostyrene and 2,2,2-trifluoroacetophenone
62 Beyond genotype-phenotype associations, our trans-biobank study offers a new value of PRSs in priori
63 d within an aaRS, a wrong tRNA is handled in trans by an aaRS cognate to the mischarged tRNA species.
64 binding in one active site is recognized in trans by an Asp-274 from the opposing half, which is pos
65 ificant (p < 0.05) positive correlation of N-trans-caffeoyltyramine, the most abundant phenylpropiona
66 consistent with the proposed mechanism of in trans catalysis, as well as with conventional catalysis
67 omyces cerevisiae was proposed to perform in trans catalysis, i.e. while localized in the ER, Opi3 wo
74 that azobenzene molecules undergo reversible trans-cis isomerization, despite being close-packed; thi
80 9 and gRNAs, into separate alleles to form a trans-complementing split-gene-drive (tGD) and demonstra
83 DDA) cleavage reaction between tetrazine and trans-cyclooctene (TCO) is a powerful way to control the
84 predicated on the in vivo ligation between a trans-cyclooctene (TCO)-bearing antibody and a tetrazine
85 esigned and synthesized a new C(2)-symmetric trans-cyclooctene linker (C(2)TCO) that exhibits excelle
86 tetrazine-linked antibody-drug conjugate by trans-cyclooctenes, affording efficient drug liberation
88 A and 11'-epi-exotine A in a 43% yield from trans-dehydroosthol and a mixture (4:1) of exotine B and
90 a hybrid macrocycle (BC-1), which contains a trans-dialkyl group in ring D and a gem-dimethyl group i
92 clude creating the macrocycle along with the trans-dialkyl substituents in both pyrroline rings (B an
93 y of these cells or their dynamic ability to trans-differentiate into other CD4(+) T cell subsets rem
94 f medulloblastoma: a fraction of tumor cells trans-differentiate into TuAstrocytes, which, in turn, p
95 strocytes within the TME (TuAstrocytes) were trans-differentiated from tumor granule neuron precursor
96 ue inflammation as a consequence of squamous trans-differentiation in pancreatic cancer, thus highlig
98 and Abiraterone and arises via a reversible trans-differentiation process, referred to as neuroendoc
99 al programs that can drive the division and (trans-)differentiation of non-beta cells to produce insu
100 ]ferrocenophane 1 leads to the formation 1,3-trans-dihydrotriboranes by formal hydrogenation and inse
101 that can help facilitate inter-, multi-, and trans-disciplinary communication and collaboration.
104 The method was also employed to synthesize trans-dragmacidine C and praziquantel-like molecules.
106 vide a platform for understanding how strong trans effect ligands and redox-active ligands work toget
113 g electric cell-substrate impedance sensing, trans-endothelial electrical resistance and FITC-dextran
115 pression data with five methods as traits in trans-eQTL analysis to limit multiple testing and improv
116 ession, which not only accounts for cis- and trans-eQTL of the target gene but also enables efficient
121 linical significance and predictive value of trans-ethnic variants in multiple populations and compar
122 ts were recorded in cardiomyocytes from mice trans-expressing human WT or p.P888L SAP97 and in Chines
123 existing TWAS methods do not assess distant trans-expression quantitative trait loci (eQTL) that are
124 expression level has suggested that unknown "trans factors" modulate the intrinsic transcriptional ac
126 ion contributed by disease locus-independent trans-factors and demonstrate that expansion per se is n
127 22:5n-3) and omega-6 PUFAs, SFAs, MUFAs, and trans FAs were 4.7 +/- 1.2, 38.0 +/- 2.0, 39.4 +/- 1.8,
128 wer glycemic index of diet; lower intakes of trans fat, sugar-sweetened beverages/fruit juices, and r
130 nd the selective exposure of animals to each trans-fatty acid of interest were confirmed in healthy r
135 the generation and presentation of aberrant trans-frame peptides at the cell surface after treatment
137 substrate provides an enantiomerically pure, trans-fused, podocarpane-type tricycle (from the E-geome
138 In the germline, nuclear RNAi can lead to trans-generational epigenetic inheritance (TEI) of gene
139 e the basis for a mechanistic description of trans-generational inheritance of epigenetic information
140 sults in an epigenetically driven multi- and trans-generationally transmitted asthmatic phenotype tha
141 ata and demonstrate the crucial roles of the trans-geometry of the [H-Pd(L)-Ge] complex, as well as o
146 This study revealed membrane tethers at the trans-Golgi as novel specific targets of ROS in cells.
148 the nuclear periphery, suggesting a role for trans-Golgi network (TGN) functions and retrograde trans
149 rting of integral membrane proteins from the trans-Golgi network (TGN) has been shown to occur throug
151 phosphatidylinositol 4-phosphate [PI(4)P] on trans-Golgi network (TGN) vesicles were recruited to mit
153 thways including retrograde transport to the trans-Golgi network (TGN), is involved in the presentati
154 in clathrin-coated vesicle formation at the trans-Golgi network (TGN), likely aiding the transport o
155 e autophagy protein ATG9A accumulated in the trans-Golgi network and was depleted from peripheral com
157 , we show that BACE1 is transported from the trans-Golgi network to the plasma membrane in an AP-1- a
158 of single enveloped viral particles from the trans-Golgi network within small vacuoles to the plasma
159 cleave at specific basic residues within the trans-Golgi network, granules, or at the cell surface/en
161 the AtUPS5L variant was also detected in the trans-Golgi network/early endosome and at the plasma mem
162 ERUS stabilizes LjVPY1 and LjVPY2 within the trans-Golgi network/early endosome, where they might fun
165 a framework for understanding mechanisms of trans-histone cross-talk and the dynamic role of H2B ubi
166 cture has been synthesized by double radical trans-hydroboration of benzo[3,4]cycloundec-3-ene-1,5-di
167 ous ruthenium-catalyzed reactions, including trans-hydrosilylation, the experimental confirmation pro
169 Identification of key regulators in HIV-1 trans-infection between DC and CD4(+) T cells has the po
172 absence of a structurally observable inverse trans-influence in 2-U(PN)NMes were examined by DFT and
174 cted alkenylbenzenes at high levels, whereas trans-isoeugenol (0.69-3.6 mg/kg) and safrole (0.20-3.0
175 novel riboswitch that selectively binds the trans isoform of a stiff-stilbene (amino-tSS)-a rapidly
176 ladium allows selective access to either the trans isomer (in generally good to excellent yield with
177 Steric and torsional strains present in the trans isomer are responsible for this unexpected relativ
179 in the Escherichia coli peptidyl-prolyl cis/trans-isomerase B following mutation of two phenylalanin
180 atomic insight into a tug-of-war between cis/trans isomerization and molecular chaperone activity.
181 solid-state (15)N NMR spectroscopy, the cis/trans isomerization in a two-dimensional (2-D) array of
186 eaction affording a 50/50 mixture of cis and trans isomers and (2) a direct nucleophilic substitution
187 ique case of stereoselective activity of cis/trans isomers that can discriminate between structurally
192 modification by anti-cancer therapeutics or trans-membrane efflux proteins that pump anti-cancer the
197 uals from COPD-enriched studies in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program.
198 he National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine (TOPMed) programme, a
199 Genomes Project, and an index of all 108 070 Trans-Omics for Precision Medicine Freeze 5 chromosome 1
200 sed imputed whole-genome sequencing from the Trans-Omics for Precision Medicine project to identify n
201 positories (e.g. The Cancer Genome Atlas and Trans-Omics for Precision Medicine) have the potential t
206 and acceptor DNA by CRISPR-Cas9 nickases (in trans paired nicking) mostly overcomes such disruptive g
210 phototransduction cascade begins with a cis-trans photoisomerization of a retinylidene chromophore a
212 the conformation around the X-Pro bonds (cis-trans) plays an important role in receptor subtype selec
214 and regulation of DNA cleavage activity via trans protein-protein interactions, is unexpectedly rigi
216 that DX314 can potentiate the effects of all-trans-RA in healthy and diseased reconstructed human epi
217 the results indicate that DX314 inhibits all-trans-RA metabolism with minimal off-target activity and
218 xpectedly discovered that DX314, but not all-trans-RA or previous RA metabolism blocking agents, appe
220 ural anticoagulation with bivalirudin (BIV), trans-radial intervention (TRI), and use of a vascular c
222 APK signaling pathway is a general switch to trans-regulate differential expression of aminopeptidase
223 st and human cells and showed that virus CUB trans-regulated tRNA availability, and therefore the rel
224 ve demonstrated that CUB of endogenous genes trans-regulates the translational efficiency of other ge
225 ctor MYB125 (Potri.003G114100) as a putative trans-regulator of the majority of genes in the lignin b
227 unlikely that incompatibilities between cis-trans regulatory changes explain the observed sterility.
228 mutations and characterizing their cis- and trans-regulatory effects on gene expression (particularl
229 dosage compensation, provided that autosomal trans-regulatory sequences with sex-limited effects are
230 ore, ERF6, ERF016 and ORA59 appear to act as trans-repressors of RPW8.1, with OAR59 being able to dir
231 of GSP results in a high yield (~1 mg/g) of trans-Res and improved photostability of infused trans-R
234 oglycan-defective strains was achieved by in trans rescue with a Nod factor-deficient S. meliloti mut
235 ons were consistent with a strong binding of trans-resveratrol to the CpLIP2 catalytic site via elect
237 for the reactions between four polyphenols (trans-resveratrol, apigenin, kaempferol and fisetin) and
239 pairments to the pathways that transform all-trans-retinal back to 11-cis-retinal are associated with
241 tone deacetylase inhibitor valproate and all-trans retinoic acid (ATRA) in treatment-naive elderly pa
242 , we evaluated the impact of exposure to all-trans retinoic acid (ATRA) on wild-type NK and CD38KO NK
243 the eyeballs are a source of diffusible all-trans retinoic acid (ATRA) that allow their targeting by
244 s of NTAL were associated with increased all-trans retinoic acid (ATRA)-induced differentiation, gene
248 rom the river mouth and cumulative height of trans-river structures from the river mouth to each site
250 oxalic acid, isolation of the lower-energy s-trans,s-trans (1tt) and s-cis,s-trans (1ct) product conf
251 t the importance of peripheral vision during trans-saccadic processing in building a coherent and sta
255 ting the JAK/STAT3 signaling pathway by IL-6 trans-signaling mechanisms, so promoting cancer aggressi
256 nical mode (myeloid cells) to a noncanonical trans-signaling mode (adipocytes and muscle) with increa
257 critically dependent on interleukin-6 (IL-6) trans-signaling via the soluble IL-6 receptor (IL-6R) an
258 the formation of an intermediate: committed trans-SNARE complexes that form large, stable pores.
262 arge and ancient supergene harbors conserved trans-species SNPs linked to colony social organization
264 water surface reveals that when MG is in the trans state, the methyl group repels interfacial water t
265 many synthetic methods afford PPVs with all-trans stereochemistry, very few deliver the all-cis cong
267 nd DFT) were used to rationalize the unusual trans stereoselectivity for 6b, and a keto-enol tautomer
268 ay experience inertial forces that result in trans-streamline movement and the reorganization of part
269 eroatom in oxapipecolic acid exerts a strong trans substantiating effect through lone pair repulsion.
270 lodges the C terminus, resulting in a cis-to-trans switch that is likely to enable protein-protein in
275 that organize synapses by binding to diverse trans-synaptic ligands, but how neurexins are regulated
276 regulating postsynaptic NMDA-receptors via a trans-synaptic mechanism that likely involves binding to
279 ing new safer and more effective anterograde trans-synaptic viral vectors for neural circuit analysis
280 presynaptic adhesion molecules that interact trans-synaptically with multitudinous postsynaptic adhes
283 onuclear non-heme iron(II)-cyclam complex, 1-trans, that activates O(2) to form the corresponding iro
284 y the significant increase (p = 0.0053) in K(trans) (the transfer coefficient from blood to brain ext
287 e-binding mode with the C1 carboxylate group trans to the distal histidine (His211); (2) The decay ra
288 in which the C1 carboxylate group of 2OG is trans to the proximal histidine (His134) of the 2-His-1-
289 off-state to a fluorescent on-state involves trans-to-cis chromophore isomerization and proton transf
290 the hydrolyzed product of PZA, could inhibit trans-translation by binding to Ribosomal protein S1 (Rp
291 -carbon tail that harbors two conjugated all-trans trienes separated by a stereogenic hydroxyl group.
292 t DNA strands to interact with each other in trans via a conserved protein-protein interface observed
293 e repeats regulate global gene expression in trans via piRNA-mediated gene silencing that is essentia
294 rm the corresponding iron(IV)-oxo complex, 2-trans, via a mechanism reminiscent of the O(2) activatio
296 rmation of trans- and 9'-cis-neoxanthin from trans-violaxanthin, but also controls 9-cis-violaxanthin
298 zed by prolyl isomerases, is shifted towards trans, while steady-state channel activity is unaffected
300 le, control water presented mainly cytokinin trans-zeatin riboside, procyanidin dimer, caffeoylshikim