ライフサイエンスコーパス: trans factor

1 ctors and ATP-dependent chromatin modifiers (trans-factors).

2 t in the promoters with DNA binding factors (trans-factors).

3 iting of the ndhD site requires a depletable trans-factor.

4 endogenous psbL transcript for a depletable trans-factor.

5 ion between the RNA cis-element and putative trans-factor.

6 RNP E1 also interacted with placental 43-kDa trans-factor.

7 A, mt-tRNAs, recycling factor and additional trans factors.

8 re able to map genes diverging in cis and/or trans factors.

9 ng condition largely affects trans and cis + trans factors.

10 tract, independent of other cis-elements or trans-factors.

11 iting of initiation codons involves a common trans-factor, a chimeric gene containing the ndhD editin

12 In the absence of an open domain, trans-factor access is denied, and the initiation of tra

13 c genome must be selectively opened to grant trans-factor access to cis-regulatory elements to overco

14 The trans-factor activity profiles across multiple experimen

15 Here, we examine the cis-elements and trans-factors affecting the expression of asparagine syn

16 epresented in microsequenced peptides of the trans-factor) also recognized the purified trans-factor

17 We also identified two trans-factors, AMN1 and FLO8, that modulate Ste12 bindin

18 te with the endogenous rpoB for a depletable trans factor and to reduce editing of endogenous site I.

19 Importantly, in ATCC 33384, strain-specific trans factors and promoter sequence differences are equa

20 e data favor identity of the FR mRNA-binding trans-factor and hnRNP E1, confirm its critical role in

21 , the types of the recoding events involved, trans-factors and cis-elements that influence recoding.

22 e is systematically associated with specific trans-factors and cis-elements, and we discover combinat

23 ion contributed by disease locus-independent trans-factors and demonstrate that expansion per se is n

24 Here, we search for trans-factors and identify Yy1 as a required cofactor fo

25 vention of gene-specific nucleus-encoded PPR trans-factors and that their action does not necessarily

26 However, the responsible trans-factors and the mechanism by which they coregulate

27 omplex regulatory nexus modulated by various trans-factors and their posttranslational modifications

28 denylation is controlled by cis elements and trans factors, and is believed to occur in a tissue- or

29 minator, its regulation by different cis and trans factors, and the effects of the termination proces

30 ing potential redox-responsive cis-elements, trans-factors, and chromosomal regulatory hot spots.

31 pecific enhancers and super-enhancers, novel trans-factors, and cis-signatures allowing reverse engin

32 itical to understand whether structural anti-trans factors are associated with substance use outcomes

33 However, how different cis-elements and trans-factors are integrated to determine mRNA stability

34 ced phosphorylation and dephosphorylation of trans-factors are known to regulate alternative splicing

35 in Saccharomyces cerevisiae, but the cis and trans factors associated with them are surprisingly dive

36 this study, we identified hnRNP U as an RNA trans-factor associated with C9/E3.

37 We further identify sets of trans-factors associated with cell-type-specific accessi

38 is-elements, and we discover combinations of trans-factors associated with either induction or suppre

39 totic caspase-9b, which are regulated by RNA trans-factors associated with exon 3 of caspase-9 pre-mR

40 r cis element (5'-CTGGGTCGC-3') for specific trans factor binding.

41 NA turnover in mammalian cells by modulating trans-factor binding selectivity.

42 Knockdown of each one of these trans factors by siRNA confirmed the trans-activating ef

43 We identified trans-factors by profiling RNA-protein interactions and

44 Changes in cis or trans factors can drive expression divergence within and

45 Sharing of trans-factors can facilitate editing of the large number

46 the multiple specificities of the individual trans factors concerned, suggest possible roles in linki

47 and the autosomes suggests that both cis and trans factors contribute to variation for expression in

48 scillations remains elusive--neither cis nor trans-factors controlling circadian gene expression phas

49 Cis-regions and trans-factors controlling TCL1 oncogene expression are n

50 reading frame 30 (ORF30) and ORF34 as viral trans factors crucial for activating late gene transcrip

51 tivation centre, and also complexes with XCI trans-factors, Ctcf and Yy1, through protein-protein int

52 enhancers, promoters, and silencers) and the trans factors (e.g., transcription factors) that act upo

53 B2B induced the expression of regulatory DNA trans-factors (e.g. HIF1alpha and TWIST1).

54 he nature of the targeting mechanism and the trans-factors effecting such breaks and their repair rem

55 nt with the hypothesis that cluster-specific trans-factors exist and that some are less abundant in r

56 fect is driven by precise modulation of both trans-factor expression and chromatin accessibility of c

57 s demonstrate that YY1 indeed functions as a trans factor for transcriptional regulation and DNA meth

58 y 20% edited, indicating a low affinity of a trans-factor for this length of edited sequence.

59 les also have been suggested for the nuclear trans-factor GATA-1 in regulating progenitor cell prolif

60 An inherited 15q11-q13 mutation or a trans-factor gene mutation are unlikely; thus, the disea

61 Although a number of cis elements and trans factors have been identified that play a role in e

62 ntranslated region of FR mRNA and a cystolic trans-factor (heterogeneous nuclear ribonucleoprotein E1

63 tly examined the role of the cis element and trans factors in the turnover and translation of APP mRN

64 tween this cis-element and a putative 40-kDa trans-factor in nuclei and cytoplasm.

65 raction of cis-elements in FR-alpha mRNA and trans-factors in these cells was determined.

66 t the idea that YY1 plays a major role, as a trans factor, in the control of these imprinted domains.

67 es associated with variation or mutations in trans factors, including non-coding RNAs and chromatin r

68 is controlled by redundant cis elements and trans factors interacting with the proximal promoter tog

69 pressed APBP-1 mimics the native cis element-trans factor interaction in EMSAs.

70 that close linkage between compensatory cis-trans factors is common in spruce.

71 However, the ndhD trans-factor is distinct from that required for psbL edi

72 on of the 18-base cis-element and the 46-kDa trans-factors likely have an important role in translati

73 Several cis- and trans-factors likely involved in the latter were predict

74 olfactory neurons indicates that additional trans factors may be required for cholinergic locus expr

75 These results suggest that cis or trans factors may have a role in male germline repeat in

76 Here, we investigate the trans factors modifying these opposing histone states an

77 expression level has suggested that unknown "trans factors" modulate the intrinsic transcriptional ac

78 Clustering is dependent on the Polycomb trans-factors necessary for establishment of the FLC sil

79 P-Seq) is a powerful, unbiased method to map trans-factor occupancy.

80 e trans-factor) also recognized the purified trans-factor on Western blots.

81 n a dose-dependent manner by either purified trans-factor or hnRNP E1.

82 ny one of these features (e.g., cis-element, trans-factor, or cell-specific background) switched c-Ju

83 REs that promote preferential binding of one trans-factor over another are not well understood.

84 ange in nucleosome arrangement suggests that trans-factors play an important role in organizing nucle

85 In F1 allotetraploids, Arabidopsis arenosa trans factors predominately affect allelic expression di

86 te receptor (FR)-alpha mRNA with a cytosolic trans-factor protein is critical for the translation of

87 re consistent with a model in which the same trans factor recognizes several chloroplast or mitochond

88 We propose that the trans factors recruited by the three boxes interact with

89 protein determinants involved in subsequent trans-factor recruitment.

90 investigated how cis-regulatory elements and trans factors regulate nascent transcriptional activity

91 ircumstance in which the cis elements and/or trans factors regulating leptin RNA production are abnor

92 ondensability as the only input, without any trans factors, reproduced the A/B compartments.

93 quely responsive to mutant SF3B1 to identify trans factors required for aberrant mutant SF3B1 splicin

94 MEF10 is a trans-factor required specifically for the C to U editin

95 Distinct cissequences and trans-factor requirements for the psbL and ndhD editing

96 de-generated peptide fragments of the 43-kDa trans-factor revealed complete identity with 43-kDa hete

97 extract is due to the presence of inhibitory trans factor(s).

98 ation elements and also upon the activity of trans-factors She2p, She3p, and Myo4p.

99 sequences of DR1s and adjacent sequences and trans factors such as cobinding lineage-determining tran

100 we must also study the evolutionary role of trans-factors, such as transcription factors (TFs).

101 Arabidopsis arenosa trans factors tend to upregulate Arabidopsis thaliana al

102 in implicated in microRNA processing, as the trans factor that binds the sRSE family and similar stru

103 However, a trans factor that interacts with CE1 has yet to be chara

104 This can be the result of cis and trans factors that affect miRNA binding or action.

105 lator of the beta-like globin genes, but the trans factors that bind HS3 have only been partially cha

106 esting that the genes mutated may encode the trans factors that bind to the cis element in pgs1Delta

107 used RNA affinity chromatography to identify trans factors that bind to this sequence.

108 to be an important tool in analyzing cis and trans factors that influence gene expression.

109 We systematically interrogate cis and trans factors that influence the shape and position of e

110 We purified trans factors that recognize the motifs and identified h

111 used genome-scale CRISPR screens to identify trans factors that regulate gene expression through this

112 y exon 1-containing transcripts, and the cis-trans factors that regulate the expression levels of the

113 idisciplinary approach to define the cis and trans factors that regulate the stability of the STARD9

114 lication-dependent histone loci, the cis and trans factors that target HLB components to histone gene

115 hat members of an individual cluster share a trans-factor that is present in limiting amounts.

116 Thus, we have identified the first trans-factor that regulates counting, and ascribed new f

117 t a model in which cAMP induces or activates trans-factors that interact with the TH mRNA 3'UTR to in

118 n patterns of one or more of the regulatory (trans) factors themselves.

119 ressed target genes to couple these putative trans factors to corresponding cis-regulatory motifs in

120 cultures indicated that AD169 could provide trans factors to rescue Toledo during infection of endot

121 LPMC does not result in increased binding of trans-factors to the CD28RE, nor did Western blots detec

122 ional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA

123 allel evolution of both structural genes and trans-factors underpins the polyphyletic evolution of th

124 aliana alleles, whereas Arabidopsis thaliana trans factors up- or down-regulate Arabidopsis arenosa a

125 This trans-factor was isolated to apparent homogeneity as a 4

126 To identify potential trans factors, we analyzed a large compilation of expres

127 orthwestern blot analysis confirmed that the trans-factors were 46-kDa proteins.

128 a third C4 grass, we found that 82% of these trans-factors were also differentially expressed in eith

129 romoter domain, regulatory cis-elements, and trans-factors were identified in gonadal cells.

130 ar to two E box motifs, but no known "E box" trans-factors were identified.