ライフサイエンスコーパス: trans isomer

1 he protein-ligands about the Mg(2+) (cis and trans isomers).

2 oid mechanism via disolvated monomer for the trans isomer.

3 stituted porphyrin without the corresponding trans isomer.

4 toisomerization of 11-cis-retinal to its all-trans isomer.

5 ild-type-like conformations that contain the trans isomer.

6 n addition product was observed only for the trans isomer.

7 se reaction, endowing the selectivity toward trans isomer.

8 he corresponding difference for the C-3, C-4 trans isomer.

9 at 382 nm indicates that the compound is the trans isomer.

10 ion of the intermediate to the product trans,trans isomer.

11 ulated rate acceleration with respect to the trans isomer.

12 the proton in the spectrum for the C-3, C-4 trans isomer.

13 the dark consisted predominantly of the all-trans isomer.

14 TCC is significantly faster than that of the trans isomer.

15 es of retinoic acids is specific for the all-trans isomer.

16 The third step leads back to the stretched trans isomer.

17 sted the cis isomer was more stable that the trans isomer.

18 accumulate cis-lycopenes instead of the all-trans isomer.

19 ediate, and isomerization of cis-gDFC to its trans isomer.

20 e in cis-beta-carotene and a decrease in the trans isomer.

21 M followed by Fischer indolization gives the trans isomer.

22 mer is 0.7 kcal mol(-1) more stable than the trans isomer.

23 formation of the species with the incorrect trans isomer.

24 ch in turn interacts more favorably than the trans isomer.

25 )-anti-trans-isomer and 18% for the (+)-anti-trans-isomer.

26 ed when the cis-isomer was supplement by the trans-isomer.

27 dinated metal complex into the corresponding trans-isomer.

28 2.8 (P for trend <0.01) for a total of 18:2 trans isomers.

29 ution and exhibits the same ratio of cis and trans isomers.

30 d to establish the identities of the cis and trans isomers.

31 s isomers, and 0.7-3.2 for cis/cis and trans/trans isomers.

32 r species indicates a 1:2 mixture of cis and trans isomers.

33 ad better affinity for the receptor than the trans isomers.

34 able cis products from the otherwise favored trans isomers.

35 nterstellar medium that can exist as cis and trans isomers.

36 nsitivity for distinguishing between cis and trans isomers.

37 f polyunsaturated fatty acids (PUFA) and cis/trans isomers.

38 corporation of the cis faster than their all-trans isomers.

39 lta8 desaturation products, predominantly as trans isomers.

40 are slightly more likely to react than their trans isomers.

41 was photoisomerized to a mixture of cis- and trans-isomers.

42 nes are more reactive than the corresponding trans-isomers.

43 te yields as a separable mixture of cis- and trans-isomers.

44 ze a sinapate ester with equivalent cis- and trans-isomers.

45 c-pVDZ//BHHLYP/6-311+G**) than the known tri-trans isomer 1 (CTCTCT) and 2.4 kcal/mol lower than the

46 ) and cross-reactivity for anions, while the trans-isomer 1 shows a more selective response to anions

47 The trans-isomer 10b inhibited AD169 strain of HCMV (EC50 15

48 -3 is only about 2-fold more potent than its trans isomer (+)-11.

49 peridionone 16a is epimerized to the desired trans isomer 16b, which is directly crystallized from th

50 Amino alcohol 2-MAP was prepared from its trans isomer 2, which in turn was synthesized via hydrob

51 wo central five-membered rings then gave the trans isomer 26.

52 limination to give the alkyl 3cCO, while the trans isomer, 2c, does not react; retro alpha-eliminatio

53 The geometric trans-isomer 3a of combretastatin A-4 was converted to t

54 reement with previous work, the "twist-boat" trans isomer (3A) is the most stable isomer of 1,7,9-tri

55 logically active compounds from the inactive trans isomer (3a) of stilbene 1a, after asymmetric dihyd

56 (CTCTCT) and 2.4 kcal/mol lower than the di-trans isomer 4 (CCTCCT), for which there is indirect evi

57 derivatives were synthesized and the racemic trans isomer, (+/-)-5, was further resolved into two ena

58 cy was noted between cis analogue 43 and its trans isomer 54.

59 levated 11,000-fold and that of the (+)-anti-trans-isomer 6000-fold, relative to the reversion freque

60 when compared to their isomeric alpha,beta-(trans)-isomer (8b, 9b, and 10b).

61 emical cis-trans isomerization of enone 9 to trans isomer 9a followed by a thermal Diels-Alder reacti

62 cis-4-fluoroproline is more active than the trans isomer, a distinction that appears to originate fr

63 planar, chiral conformations in the MOF, the trans isomer adopts a planar, achiral form in solution,

64 The trans isomer adopts two well-defined turns in solution,

65 new methodology for identifying 16:1 cis and trans isomers allowed us to address the subject presente

66 y in cis conformation is chiral, we show the trans isomer also possesses a nonplanar, chiral conforma

67 s of zeatin have been directed mostly at the trans isomer, although cis-zeatin and its riboside occur

68 much higher enantioselectivity than with the trans isomers, although CPO gives similar catalytic acti

69 cal properties, subnanomolar affinity of the trans isomer and a 50-fold decrease in affinity upon swi

70 5-oxodecahydroquinoline to the corresponding trans isomer and a coupling, followed by a diastereosele

71 plex DNA but that only the presence of a (+)-trans isomer and a methylated C 5' to the adduct resulte

72 fied from molecular modeling studies for the trans isomer and five conformations for the cis isomer,

73 expected to increase the propensity for the trans isomer and perturb the isomerization reaction requ

74 ether with chemical isomerization to its all-trans isomer and reduction to all-trans-retinol by RDH c

75 eaction affording a 50/50 mixture of cis and trans isomers and (2) a direct nucleophilic substitution

76 3.1 (P for trend <0.01) for a total of 18:1 trans isomers and 1.0, 1.5, 2.5, and 2.8 (P for trend <0

77 chnologically important strain produces only trans isomers and additionally homologs from 5 to 15 iso

78 bypass was found to be 32% for the (-)-anti-trans-isomer and 18% for the (+)-anti-trans-isomer.

79 nteraction appeared preferential for the all-trans-isomer and was directly measurable through fluores

80 ly in the stratum corneum of the skin as the trans-isomer and, upon exposure to UVB radiation, conver

81 as present as 9-cis, 11-cis, 13-cis, and all-trans isomers, and the total levels were higher in neura

82 acids, particularly unsaturated fatty acids, trans-isomers, and specific released free fatty acids.

83 Both the enantiomeric forms of the trans isomer are obtained in excellent yields and enanti

84 Steric and torsional strains present in the trans isomer are responsible for this unexpected relativ

85 ne-directed kinases acting on the GR, as cis/trans isomers are distinct pools with different interact

86 As previously found, trans isomers are nonselective blockers of DA, 5HT, and

87 Faster reactions of trans isomers are observed for substitutents known (RS,

88 the equilibrium fractions of 13-cis and all-trans isomers are pH dependent; the fraction of all-tran

89 The slower reactions of the trans isomers are the judged to be "abnormal".

90 from all cis to all trans and supports a cis,trans isomer as a tenable intermediate.

91 Therefore, we suggest that the trans isomer assembles on the NP surface giving the enha

92 (tetraol tetraacetates, two pairs of cis and trans isomers at the 9,10 positions) by the exocyclic N2

93 to accommodate the nonnative peptidyl-prolyl trans-isomer at Pro32.

94 -photoisomer has a greater affinity than the trans-isomer at the 5-HT(2A)R and binds at nanomolar con

95 Pin1 that isomerizes ATR from cis-isomer to trans-isomer at the phosphorylated Ser428-Pro429 motif.

96 e can be explained by destabilization of the trans isomer because of unfavorable electronic and steri

97 ed to be an "upside-down" version of the all-trans isomer because the structural rearrangements obser

98 The trans isomer binds the WW domain with approximately 22 m

99 We identified the zeatin isolated as the trans isomer by HPLC and by a radioimmunoassay in which

100 stituted piperidine chair conformer, whereas trans isomers can be considered as unusual "boat" piperi

101 chloropropene (1,3-D, which includes cis and trans isomers), chloropicrin (CP), and methyl iodide (Me

102 in the ternary complex generates the active trans-isomer competent for carbonyl bond activation by a

103 When DMS could not separate cis and trans isomers completely, as was the case with sphingomy

104 The trans isomer composition changes from 68% in the cationi

105 to any form prior to analysis increases the trans isomer composition.

106 For the first time, the cis/trans isomer content of menaquinone-7 in food products h

107 e, with the deprotonated cis- and protonated trans-isomers corresponding to its ON and OFF states, re

108 c factors, with a dr of 1:1 to 3:1 (cis- and trans-isomers could be separated).

109 he cyclic peptides, with the ratio of cis to trans isomers depending on the position and stereochemis

110 isomer has anti-cancer activity, whereas the trans-isomer does not.

111 nverts stearoyl-ACP into the allylic alcohol trans-isomer (E)-10-18:1-9-OH via a cis isomer (Z)-9-18:

112 omers, whereas oxazolidines were produced as trans-isomers exclusively.

113 A change to a diaxial conformation for the trans isomer facilitates anchimeric assistance by the no

114 Both, cis- and trans-isomers for jasmonic acid can be detected.

115 distinct isomers, presumably TTC and TTT cis-trans isomers, for the open-ring merocyanine product, an

116 scribes the suppression of unwanted transoid-trans isomer formation in photochromic 3H-naphthopyran d

117 two-state mixture of 13-cis,15-syn, and all-trans isomers found in the dark-adapted wild-type protei

118 by all three isozymes; a preference for the trans isomer, geranial, was observed by HPLC and by enzy

119 : 2 mixture of isomers: cis isomer neral and trans isomer, geranial; the latter structurally resemble

120 Importantly, the deprotonated trans-isomer governs LSS emission at 620 nm, while the d

121 The 26-trans isomers had an activity about 400-fold more potent

122 The trans/trans isomers had the most potent activity, suggesting s

123 process consists of two states, in which the trans isomer has a stretched and the cis isomer a compac

124 The RFP mKeima, with coexisting cis- and trans-isomers, holds significance as an archetypal syste

125 isomer cannot convert to the more stable all-trans isomer in the 21Ag- state, resulting in the striki

126 The content of cis/trans isomers in certain dietary supplements exceeded th

127 ations of total lycopene and its cis and all-trans isomers in human plasma has been developed using h

128 role of selective recognition of cis versus trans isomers in response to phosphorylation of APP.

129 ier for conversion between the 4-cis and all-trans isomers in the S1 state.

130 stal into a polycrystalline aggregate of its trans-isomer in a photomechanical transformation that in

131 ladium allows selective access to either the trans isomer (in generally good to excellent yield with

132 rmation, in opposition to the most populated trans isomer, in order to select the specific antibody c

133 affect the relative distribution of cis- and trans-isomers, indicating a separate CO-binding site.

134 Both cis and trans isomers interact with transcriptional regulators,

135 somer to the highly nonplanar and disordered trans isomer is accompanied by a dramatic rearrangement

136 yields primarily the cis isomer, whereas the trans isomer is the major product from the intramolecula

137 nert to thermal N(2) scission, and the trans,trans-isomer is also inert to photolytic N(2) cleavage.

138 nd, we show that locking the switch into the trans isomer leads to shortened circadian periods.

139 we diagnostic ion abundances is >4.8 for cis/trans isomers, <0.5 for trans/cis isomers, and 0.7-3.2 f

140 to the general preference of proline for the trans isomer, making indoline-2-carboxylic acid a good c

141 -isomer stabilizes an alpha-helix, while the trans-isomer may introduce energetic frustration facilit

142 l followed by thermal relaxation to the all- trans isomer, mimicking the bacteriorhodopsin photocycle

143 Subsequent analysis of cis and trans isomer mixtures of PC 18:1/18:1 (Delta9), PC 16:1/

144 photoisomerization upon exposure to visible (trans isomer, more hydrophobic) or UV (cis isomer, more

145 maintain normal visual sensitivity, the all-trans isomer must be metabolized and reisomerized to pro

146 alene anion radical precursor was the 1,7-di-trans isomer of [12]annulene.

147 ified by the active cis but not the inactive trans isomer of diamminedichloroplatinum(II), are implic

148 eaction mixture is probably due to the trans-trans isomer of diradical 3 in the triplet state.

149 The trans-trans isomer of diradical 3 was calculated to be more st

150 , palmitate, stearate, oleate, elaidate (the trans isomer of oleate), linoleate, and linolenate blend

151 vated M(I) state of rhodopsin giving the all-trans isomer of the chromophore.

152 -phase HPLC enables the isolation of the all-trans isomer of the Fe(II) terpyridine complex 1, which

153 The trans isomer of the keto-acid products is also observed

154 alysis revealed the conversion of the cis to trans isomer of unsaturated fatty acid upon short-term n

155 low energy conformers of the various cis and trans isomers of 1,1,2,2,5,5,6,6-octamethyl-1,2,5,6-tetr

156 Comparison between the cis and trans isomers of 1,2-dimethylcyclohexane, 1,4-dimethylcy

157 ctivity was observed in formation of cis and trans isomers of 1,3-d2-2-fluoropropene, whereas cis-1,3

158 Both cis and trans isomers of 1-(E)-propenyl-2-methylcyclobutane form

159 on and emission spectra of the 4-cis and all-trans isomers of 2,4,6,8,10,12,14-hexadecaheptaene are a

160 re of 2,6-cyclohexananone yields the cis and trans isomers of 2,6-dimethylcyclohexanone-2,6-bis(diaze

161 and 5-fold decreases in activity against the trans isomers of 4-OH-TAM and endoxifen, respectively, c

162 ion of these two mechanisms for both cis and trans isomers of a system employing two monodentate liga

163 nd at Pro102-Pro103 and a coexistence of cis/trans isomers of Ala104-Pro105.

164 for establishing the coexistence of cis and trans isomers of both dipeptides in solution.

165 and ERbeta binding affinity of both cis and trans isomers of dimethyl, diethyl, and dipropyl THCs wa

166 ectable glucuronidation activity against the trans isomers of either 4-OH-TAM or endoxifen.

167 y assess more than 50 C=C positional and cis/trans isomers of fatty acids and phospholipids from sele

168 f Pgp-mediated drug transport by the cis and trans isomers of flupentixol are mediated through a comm

169 d in future studies that distinguish between trans isomers of linoleic acid and trans isomers of olei

170 5% CI, 0.5 to 1.2), whereas higher levels of trans isomers of linoleic acid were associated with 3-fo

171 acids is associated with modest increase and trans isomers of linoleic acid with a larger increase in

172 enges is the differentiation between cis and trans isomers of lipids, which differ only by the geomet

173 n at different temperatures produce only all-trans isomers of menaquinones from MK-5 (menaquinone wit

174 to unambiguously distinguish between cis and trans isomers of monounsaturated fatty acids by the rela

175 However, trans isomers of oleic acid were not associated with ris

176 h between trans isomers of linoleic acid and trans isomers of oleic acid.

177 d phase method can baseline separate the cis-trans isomers of phosphatidylglycerol and phosphatidylch

178 d under thermal conditions were dominated by trans isomers of the azobenzene macrocycles, whereas lig

179 e(Ph)PN](3), yielded mixtures of the cis and trans isomers of the cyclic phosphazene trimers, [Me(Ph)

180 g = 1.74 and 1.09 for the respective cis and trans isomers of the diosmium cluster.

181 Both cis and trans isomers of the dopamine receptor antagonist flupen

182 of 6 with EtPCl(2) gave a 6:1 mixture of cis/trans isomers of the ethyl-substituted heterocycles 12a,

183 lves the interconversion between the cis and trans isomers of the N-terminal amide bond of the amino

184 Further, both cis and trans isomers of the photodechelated ligand-loss solvent

185 Furthermore, the equilibrium ratio of cis to trans isomers of the Pro residues is unaffected by the p

186 ed them to be selectively transformed to the trans isomers of their respective dimers under photoirra

187 rter inhibitory activity of both the cis and trans isomers of these 3,4-disubstituted piperidines in

188 d if their method could separate the cis and trans isomers of vitamin A.

189 eneous unfolded state (consisting of cis and trans isomers of X-Pro peptide groups) to the native str

190 A), AA methyl ester, and linoelaidic acid (a trans-isomer of linoleic acid) failed to stimulate adhes

191 e) is reduced under N(2) to afford the trans,trans-isomer of the bimetallic complex [(PONOP)ReCl(2)](

192 acid dehalogenase (CaaD), which converts the trans-isomers of 3-bromo- and 3-chloroacrylate to malona

193 onstants similar to those determined for the trans-isomers of 3-bromo- and 3-chloroacrylate.

194 he hydrolytic dehalogenation of the cis- and trans-isomers of 3-chloroacrylate to yield malonate semi

195 ction (SPME) method to quantify the cis- and trans-isomers of 4-MCHM.

196 d mononuclear Pt(II) compounds, the cis- and trans-isomers of [PtCl2(NH3)(L)] (L = 1-methyl-7-azaindo

197 The cis- and trans-isomers of a silacycloheptene were selectively syn

198 Moreover, the amide bond cis- and trans-isomers of the ring-expanded products were found,

199 re applied to obtain optically pure cis- and trans-isomers of whisky lactone 4a and 4b.

200 s-zeatin serves as a precursor to the active trans-isomer or has any other unique function remains to

201 Trans-isomer OSDA leads to the small-pore zeolite SSZ-39

202 1,2,3,4-tetrahydro-beta-carbolines, with the trans isomer predominating.

203 While the trans isomer primarily engages calcium influx, the cis i

204 The all-trans isomer produced by isomerization of both 9-cis and

205 The trans-isomer promotes the formation of favorable interfa

206 trans fatty acids (r(s)=0.43) and total 18:1 trans isomers (r(s)=0.42) in erythrocytes were also more

207 id concentration and unsaturation level, cis/trans isomer ratio, sphingolipids and cholesterol levels

208 g but not through an influence on the cis to trans isomer ratio.

209 In this study, we determined the cis:trans isomer ratios of PC (18:1/18:1) and related this r

210 stiff-stilbene-based bis-urea monomers whose trans isomers readily form supramolecular polymers in a

211 benzisoxazol-5(3H)-ylidene)ethanal (10), the trans isomers recombined forming the corresponding nitro

212 e 1R stereoisomeric adduct, with the S and R-trans-isomers related to one another by inversion in a m

213 ic experiments performed on both the cis and trans isomers reveal the formation of a long-lived inter

214 room and low temperatures indicates that the trans-isomer should be dominant when attached onto the s

215 state and the hardness parameter eta of the trans isomer show that azobenzene and F-azobenzene are t

216 h intraperitoneal administration, all of the trans isomers showed a slow onset of at least 20 min and

217 abilizing the standard nematic phase and the trans isomers stabilizing the NTB phase.

218 es have indicated the presence of DA and its trans-isomer (tDA, 12-OH-9E,12Z-octadecadienoic acid) in

219 s indicated that it was the level of the (+)-trans isomer that was specifically increased.

220 ique case of stereoselective activity of cis/trans isomers that can discriminate between structurally

221 dipole moments, particularly, with cis- and trans-isomers that have different polarities.

222 For the trans isomers the 2-substituent itself is oriented for h

223 In contrast, for the trans isomer this ratio shows a 2-fold decrease with dec

224 n stereospecific conversion of the bound all-trans isomer to 11-cis-retinal.

225 o ceratospongamide isomers showed the trans, trans isomer to be quite planar, whereas the cis,cis iso

226 or the system to escape very easily from the trans isomer to cis isomer, and vice versa.

227 tropanes, which allows both the cis and the trans isomers to adjust themselves to the binding site o

228 toisomerization from the naturally occurring trans-isomer to the cis-isomer on exposure to ultraviole

229 acids (FAs) of the membrane lipids to their trans-isomers to rigidify the membrane and thereby resis

230 C) cells to cisplatin and its less effective trans-isomer, transplatin.

231 he isomerization of cis-arylalkenes to their trans isomers using a palladium(II) catalyst is describe

232 stituted tetrahydro-beta-carbolines into the trans isomers via a potential carbocationic intermediate

233 the selective generation of 1,2-cis and 1,2-trans isomers via the manipulation of C2-protected silic

234 cis-isomer to the thermodynamically downhill trans-isomer via a hypothesized pentavalent intermediate

235 nd trans IC(50) = 12 +/- 3 microM, where the trans isomer was equipotent to that of the saturated C(1

236 The trans isomer was found to be more favorable than cis iso

237 -2-methylcyclobutane uncontaminated with the trans isomer was prepared efficiently in five steps; the

238 tion of cis,trans and trans,cis CLA to trans,trans isomers was observed mainly for the methyl form of

239 Identification of cis/trans isomers was performed by HRMS-QTOF, whereas their

240 requency of bypass synthesis of the (-)-anti-trans-isomer was elevated 11,000-fold and that of the (+

241 ed that the activation energy of the cis- to trans-isomer was increasing in the series C(5)G3 < C(4)G

242 The trans-isomer was photoisomerized to a mixture of cis- an

243 substituted cyclopropane ring, a pair of cis/trans-isomers was obtained that introduced a spatial con

244 reduced analogue 11 (as a mixture of cis and trans isomers) was the most active in the naphthyridine

245 upled to the binding equilibrium through the trans isomer, was found to fit the data well.

246 genous PC (18:1/18:1)-cis and PC (18:1/18:1)-trans isomers were examined in mitochondrial and serum p

247 th isomers showed similar potencies, but the trans isomers were more metabolically stable in human he

248 Both the cis and trans isomers were obtained for all of the cyclic peptid

249 os of the (2S,4S)/(2R,4S) diastereomers (cis/trans isomers) were 1:1, 2:1, and 10:1 for the methyl, b

250 analogues thus obtained (three pairs of cis/trans-isomers) were growth inhibitory at low-micromolar

251 ronger hyperporphyrin effect compared to the trans isomer, which can be explained based on simple res

252 epimerization of the product mixture to the trans isomer, which is generally highly crystalline, has

253 to switch a small molecule between cis- and trans-isomers, which inhibits the catalytic activity of

254 3,6-dimethylcyclohexene in preference to its trans isomer, while the cis starting material gives neit

255 benzoyl group (via an amide bond) yields the trans isomer with a diastereoselectivity (de) of 71% wit

256 Upon irradiation of the trans isomers with UV light, >95% of the cis forms are o

257 EB2A-ABS proline residue populating cis- and trans-isomers with remote impact on the RIM.

258 the serine118-proline119 bond from a cis to trans isomer, with a concomitant increase in AF1 transcr

259 BI chromophore, corresponding to the cis and trans isomers, with each one either protonated (neutral)