ライフサイエンスコーパス: trans-acting factor

1 nd RNA-binding proteins known as ITAFs (IRES trans-acting factors).

2 dentifying all regions bound by a particular trans-acting factor.

3 the genome-wide specificity of a particular trans-acting factor.

4 ongly suggest that PTB-1 is a universal IRES-trans-acting factor.

5 that exon repetition is caused by a specific trans-acting factor.

6 y the nascent transcript in the absence of a trans-acting factor.

7 able to confer regulation in response to the trans-acting factor.

8 ral component of the flagellum, but rather a trans-acting factor.

9 st genes by adenosine triphosphate-dependent trans-acting factors.

10 cription is also influenced and regulated by trans-acting factors.

11 r genes, which are bound by numerous unknown trans-acting factors.

12 combination and are themselves regulated by trans-acting factors.

13 f functioning in the presence of the correct trans-acting factors.

14 fication of RNA-binding proteins that act as trans-acting factors.

15 nfluenced by both local sequence context and trans-acting factors.

16 nscriptional regulator that binds to several trans-acting factors.

17 in metazoans without prior knowledge of the trans-acting factors.

18 edox activator (and named Ref-1) for several trans-acting factors.

19 onfiguration in which they are shielded from trans-acting factors.

20 on by modulating the DNA binding activity of trans-acting factors.

21 n the precursor messenger RNA and a range of trans-acting factors.

22 ccurs in the absence of other viral cis- and trans-acting factors.

23 y influenced by supplementary host and viral trans-acting factors.

24 lationally with the help of various cis- and trans-acting factors.

25 rplay of cis-acting sequences and associated trans-acting factors.

26 mining the accessibility of chromatin DNA to trans-acting factors.

27 lencing of this exon is mediated by multiple trans-acting factors.

28 er, suggesting the superimposed influence of trans-acting factors.

29 that act through ubiquitous cis-elements and trans-acting factors.

30 r autosomal phenotypes may be due to cis- or trans-acting factors.

31 m involving several cis-acting sequences and trans-acting factors.

32 ustered redundant protein-binding motifs and trans-acting factors.

33 by the availability of positive and negative trans-acting factors.

34 forms with tRNA in the absence of additional trans-acting factors.

35 the HIV-1 PPT/U3 junction in the absence of trans-acting factors.

36 ndently controlled by the locally associated trans-acting factors.

37 es are responsive to a multitude of distinct trans-acting factors.

38 lation, mainly because it affects binding of trans-acting factors.

39 lation requires the modulated interaction of trans-acting factors.

40 tial to identify predicted binding sites for trans-acting factors.

41 combination is tightly regulated by cis- and trans-acting factors.

42 g is determined by underlying sequence or by trans-acting factors.

43 regulated by a variety of different cis- and trans-acting factors (4, 5).

44 mutation (SHM) require transcription and the trans-acting factor activation-induced cytidine deaminas

45 cis- and trans-acting factors affect gene expression and response

46 nism of mutagenesis, we examine here cis and trans-acting factors affecting thyA131 mutational hotspo

47 egion of the message, and in the presence of trans-acting factors allow the ribosome to be recruited

48 protein-protein interactions that engage the trans-acting factor also contribute to context-dependent

49 3' adenylation and uridylation status, with trans-acting factors also impacting RNA homeostasis.

50 Trans-acting factors also modulate TNR instability risk,

51 of a human porphyria due to a mutation in a trans-acting factor and the first association of CEP wit

52 omes during cell division is ensured by both trans-acting factors and cis-acting chromosomal sites.

53 This system can be used for studying trans-acting factors and cis-acting sequence elements an

54 The identification of the trans-acting factors and cis-regulatory modules that are

55 a link between the complex of commonly used trans-acting factors and Enc, a factor that is required

56 lthough it has been suggested that identical trans-acting factors and Gap1p ubiquitin acceptor sites

57 rough a complex interaction between cis- and trans-acting factors and the endoplasmic reticulum trans

58 sis requires the action of approximately 200 trans-acting factors and the incorporation of 79 ribosom

59 s how cis-acting sequence elements influence trans-acting factors and the local chromatin environment

60 recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NM

61 us transcription, upon induction by specific trans-acting factors, and plays a significant role in cl

62 The three known trans-acting factors are a Sec-specific translation elon

63 torial regulatory activity and that multiple trans-acting factors are involved in the regulatory effe

64 of ribosomes occurs in the cytoplasm, where trans-acting factors are removed and critical ribosomal

65 ry elements, e.g., promoters, enhancers, and trans-acting factors, are essential for the proper contr

66 lar cis requirements reflect conservation of trans-acting factors, as human Shn1 (hShn1; HIVEP1) can

67 ssection of both cis-regulatory elements and trans-acting factors, as well as the interpretation of v

68 KLF4 was identified as a major trans-acting factor at two proximal Sp1 sites; active Rh

69 grams requires the choreographed assembly of trans-acting factors at enhancers and promoters during c

70 s-regulatory target sites of known and novel trans-acting factors at the transcriptional and post-tra

71 As a variety of trans-acting factors [AU-binding protein (AUBP)] are kno

72 f libraries to provide a prediction of which trans -acting factors binding sites are disrupted/create

73 We have further identified key trans-acting factor binding sites and nuclear factors AP

74 regulation in certain contexts via enhancing trans-acting factor binding to chromatin in vivo.

75 Trans-acting factor binding to small DNA motifs (cis-ele

76 tified the splicing factor SAP155, as an RNA trans-acting factor binding to the purine-rich CRCE 1.

77 previously mapped deletions, and studied the trans-acting factors binding to these sites in the beta-

78 to the enhanced production of viral or host trans-acting factors, but is associated with cis-acting,

79 Unlike most trans-acting factors characterized so far in Chlamydomon

80 ass the intricate interplay between cis- and trans-acting factors, chromatin, and the core transcript

81 hown that alterations in the expression of a trans-acting factor constitute a critical driver of gene

82 However, RNA cis-regulatory elements and trans-acting factors contributing to HPV18 alternative R

83 RNA cis elements and trans-acting factors contributing to HPV18 alternative R

84 oach to identify the cis-acting elements and trans-acting factors contributing to the tight repressio

85 se data highlight the nature of the cis- and trans-acting factors controlling the beta-cell-specific

86 of nuclear levels and acetylation status of trans-acting factors critical in determining the off/on

87 s cis-acting sequences in the mRNA and novel trans-acting factors dedicated to Sec incorporation.

88 or recessive model, and is not determined by trans-acting factors differing between hMLH1 expressing

89 These trans-acting factors display overlapping RNA substrate s

90 ge portion of the binding sites for the same trans-acting factor do not reside in alignable regions.

91 This suggests that at least some detected trans-acting factors do not equally affect recombination

92 These trans-acting factors enable the faithful delivery of sev

93 o condition specific binding of at least one trans-acting factor essential for site recognition.

94 Recent studies indicate that trans-acting factors establish this stereotypical array.

95 Combinatorial interactions among trans-acting factors establish transcriptional circuits

96 In this report, we show that the trans-acting factor FliX predominantly functions as a ne

97 Genetic experiments have indicated that the trans-acting factor FliX regulates FlbD in response to t

98 ng protein 1) was originally discovered as a trans-acting factor for the "zipcode" in the 3' untransl

99 ow that Zar2 contains a zinc finger and is a trans-acting factor for the TCS in maternal mRNAs in imm

100 analysis and define cis-acting elements and trans-acting factors for the core LANAp.

101 eneral, cellular IRESs require non-canonical trans-acting factors for their activity, however, very f

102 their biogenesis is partially dependent on a trans-acting factor FPA.

103 results illustrate a mechanism that controls trans-acting factor function in a locus-specific manner,

104 hemical studies, we investigated whether the trans-acting factors function indirectly or directly by

105 ory elements, and possibly the corresponding trans-acting factors, function via mechanisms highly spe

106 To gain insight into trans-acting factors, genetic rescue of AdoMetDC RNAi kn

107 ents, raising the possibility that undefined trans-acting factors governing mRNA stability and transl

108 To identify cis- and trans-acting factors governing nucleocytoplasmic traffic

109 ment activity requires the binding motif for trans-acting factors Gsh1/Barx2/Brn3.

110 ression is controlled exclusively by protein trans-acting factors has been challenged recently by the

111 A number of trans-acting factors have also been described to play a

112 These IRES trans-acting factors have been elegantly studied in vitr

113 Although no proven trans-acting factors have been identified, a likely cand

114 or distinguishing cis-acting components from trans-acting factors-have provided the impetus for these

115 d causes defects in the recycling of several trans-acting factors (hEnp1, hRio2, hLtv1, hDim2/PNO1, a

116 al mediator of this transport process is the trans-acting factor heterogeneous nuclear ribonucleoprot

117 ng the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleopro

118 on are considered an important complement to trans-acting factors, histone modifications and non-codi

119 n rates are potentially affected by cis- and trans-acting factors, i.e., genotype-specific modifiers

120 However, little is known about the trans-acting factors important for the intranuclear traf

121 Furthermore, we identified trans-acting factors important for tricRNA biogenesis, i

122 We speculate that an unidentified trans-acting factor in enterohemorrhagic E. coli (EHEC)

123 in the coding region of LHR mRNA, acts as a trans-acting factor in this process.

124 histone tail domains regulate the binding of trans-acting factors in chromatin.

125 in the upstream region of the gene, multiple trans-acting factors in the gene network can influence t

126 cause both alleles are subjected to the same trans-acting factors in the hybrid, the data suggest the

127 Our data reveal distinct roles of cis- and trans-acting factors in the rotational positioning of nu

128 siRNA was used to evaluate the role of trans-acting factors in transcription of TJ genes in res

129 that the assembly specificity is imposed by trans-acting factors in vivo.

130 Isolation of trans-acting factors, in vitro transcriptional and gel r

131 microtubules, the molecular motor dynein and trans-acting factors including Egalitarian and Bicaudal-

132 This localization requires several trans-acting factors, including Barentsz and the Mago-Y1

133 o well-characterized binding sites for known trans-acting factors, including hepatocyte nuclear facto

134 oximal sequence was independent of all known trans-acting factors, including ppGpp.

135 d by mat1 cis-acting elements and by several trans-acting factors, including swi1 (for switch), swi3,

136 ivo functional assays indicate that distinct trans-acting factors, including the E-protein/Daughterle

137 both the cis-acting element, the origin, and trans-acting factors, including virally encoded origin-b

138 are more stable, suggesting that cis- and/or trans-acting factors influence S. aureus mRNA stability.

139 ps, which we predict act as landing pads for trans-acting factors influencing miRNA processing.

140 Regulation of Bril involves trans-acting factors integrating at conserved promoter e

141 controlled by multiple positive or negative trans-acting factors interacting with distinct cis-eleme

142 (mtRNAP) from Trypanosoma brucei, the first trans-acting factor involved in kinetoplast mitochondria

143 understanding of the cis-acting elements and trans-acting factors involved in expression of CBF2.

144 Trans-acting factors involved in the early meiotic recom

145 en together, these results identify cis- and trans-acting factors involved in the regulation of PF-2

146 A screen designed to identify trans-acting factors involved in these mechanisms in Sac

147 ribosomal particles have identified numerous trans-acting factors involved in this process, many prot

148 s and to analyze the cis-acting elements and trans-acting factors involved in this regulation.

149 The structure indicates that the binding of trans-acting factors is required to remodel the tertiary

150 EFG1, which encodes a trans-acting factor, is expressed as a more abundant 3.2

151 and/or post-translationally modify specific trans-acting factors, it is unclear how these mechanisms

152 Depletion of the SHMT1 IRES-specific trans-acting factor (ITAF) CUG-binding protein 1 (CUGBP1

153 gs are consistent with NCL acting as an IRES trans-acting factor (ITAF) for ORF2 translation and henc

154 mportant internal ribosome entry site (IRES) trans-acting factor (ITAF) for poliovirus IRES-mediated

155 tion factors, type 2 IRESs also require IRES trans-acting factors (ITAFs) that are hypothesized to st

156 nitiation on Type 1 IRESs also requires IRES trans-acting factors (ITAFs), and several candidates hav

157 ion-dependent CNSHA caused by mutations in a trans-acting factor (Kruppel-like factor 1) and reveal a

158 tional plasmids expressing the minimal viral trans-acting factors L and NP under control of RNA polym

159 he MOR gene is regulated by various cis- and trans-acting factors, many questions remain unanswered r

160 Finally, trans-acting factors may participate in the regulatory m

161 that these "seed" nucleosomes--together with trans-acting factors--may facilitate the establishment o

162 s a multifaceted process involving a host of trans-acting factors mediating numerous chemical reactio

163 te (-1808/-1804) and CREB being the cis- and trans-acting factors mediating the induction, respective

164 -opioid receptor (MOR1) and revealed a novel trans-acting factor, miRNA23b, that binds to the K box m

165 s local activity of super-enhancers and that trans-acting factors modulate DNA methylation profiles w

166 An interplay of cis-acting sequences and trans-acting factors modulates the splicing of regulated

167 ly silenced and intrinsically insensitive to trans-acting factors must be reevaluated.

168 The trans-acting factors necessary for the increased rate of

169 Although recent studies have uncovered trans-acting factors necessary for this regulation, limi

170 We have mapped interactions of three trans-acting factors-NF-kappaB, STAT4, and T-bet-with ci

171 ected with LCMV to provide the minimal viral trans-acting factors, NP and L, that are required for LC

172 the downstream beta major promoter, despite trans-acting factor occupancy at both sites.

173 oligoadenylate synthetase (OAS), stimulated trans-acting factor of 50 kDa (STAF-50), and ISG-15.

174 s resistance protein 1 (MxA), and stimulated trans-acting factor of 50 kDa.

175 eukaryotic pre-mRNAs requires recognition by trans-acting factors of a complex array of cis-acting RN

176 ine tract binding protein (PTB, a known IRES trans-acting factor or ITAF) is pivotal in regulating th

177 Identification of trans-acting factors or drugs capable of reactivating ga

178 ay for the effects on splicing efficiency of trans-acting factors or of alterations in the sequences

179 e motifs within the enhancer and a number of trans-acting factors play critical roles in the regulati

180 tated initiation of translation requires two trans-acting factors poly (rC) binding protein 1 (PCBP1)

181 gent cadicivirus IRESs require the same IRES trans-acting factor, poly(C)-binding protein 2 (PCBP2).

182 Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to

183 ft assay, we show that binding factor A, the trans-acting factor proposed to convey repression by its

184 Such a dual-targeted trans-acting factor provides a means to coregulate the e

185 Three trans-acting factors regulate expression via the 1.3-kb

186 vide the very first analyses of the cis- and trans-acting factors regulating Bril transcription.

187 rovirus (JSRV) encodes within the env gene a trans-acting factor (Rej) necessary for the synthesis of

188 ibition in this effect, suggesting that host trans-acting factors repress IRES function in a cell-typ

189 s nuclear ribonucleoprotein A2 (hnRNP A2), a trans-acting factor required for dendritic delivery.

190 fied hnRNP A1 (A1) and RPS25 as IRES-binding trans-acting factors required for ER stress-activated ac

191 and CCAAT hotspots, and identify associated trans-acting factors required for hotspot activity.

192 Alternatively, while the trans-acting factors required for LANA expression in B c

193 To identify trans-acting factors required for mediating DNA transfer

194 Here we analyze the cis- and trans-acting factors required for MEI-S332 localization.

195 lthough genetic screens have identified some trans-acting factors required for the localization of th

196 other than Pl1-Rhoades, or in the absence of trans-acting factors required to maintain repressed stat

197 the process of cap-dependent initiation, the trans-acting factor requirements for cellular internal r

198 been well studied, little is known about the trans-acting factors responsible for developmental contr

199 this study, we sought to define the cis- and trans-acting factors responsible for initiation and main

200 To map trans-acting factors responsible, we performed flow sort

201 Trans-acting factors ribosome modulation factor (RMF) an

202 Our data suggest that the trans-acting factors rtf1p and rtf2p act through the rep

203 that the glucose response factor(s) acts as trans-acting factor(s) binding to the cis-acting repress

204 pressed U12-type splicing, suggesting that a trans-acting factor(s) binds the enhancer element to sti

205 Glucose-induced activity of the repressor trans-acting factor(s) reached a maximum at 4 h, which c

206 Furthermore, we found a trans-acting factor(s) that binds within a positive cis-

207 of evidence suggest that there is a limiting trans-acting factor(s) that plays a role in packaging.

208 oop interaction, suggesting a model in which trans-acting factor(s) that stabilize this interaction m

209 Equally important are the trans-acting factors SBP2, Sec-tRNA[Ser]Sec, and eEFSec.

210 Tristetraprolin (TTP) is the only trans-acting factor shown to be capable of regulating AU

211 of TNF-alpha mRNA stability and is the only trans-acting factor shown to be capable of regulating AU

212 e aim of this study was to discover cis- and trans-acting factors significantly affecting mRNA expres

213 both the cis-acting element, the origin, and trans-acting factors such as virally encoded origin-bind

214 of RNA are regulated by interactions between trans-acting factors, such as microRNA and RNA-binding p

215 y cis-acting elements within the mRNA and by trans-acting factors, such as RNA-binding proteins.

216 n a manner that blocks it from responding to trans-acting factors, such that it is silent even when a

217 Different trans-acting factors (TFs) collaborate and act in concer

218 about the nucleotide sequence specificity of trans-acting factors (TFs) is essential for computationa

219 e provide evidence that the abundance of the trans-acting factor that binds the LdNT3 stem-loop in vi

220 erefore, we have identified SAP155 as an RNA trans-acting factor that binds to CRCE 1, functions to r

221 says, we discovered that Sam68 is a possible trans-acting factor that binds to this region and regula

222 binding factor (CTCF) is the only identified trans-acting factor that confers enhancer-blocking insul

223 t the class II flagellar gene fliX encodes a trans-acting factor that couples flagellar assembly to F

224 silencing is largely due to an unidentified trans-acting factor that is thought to bind to the prime

225 nizes the glucocorticoid receptor as a novel trans-acting factor that regulates CFTR expression in vi

226 Here we identify hnRNP A1 as an IRES trans-acting factor that regulates cyclin D1 and c-myc I

227 edundancy has hampered the identification of trans-acting factors that act specifically to effect pos

228 promoter B to characterize cis-elements and trans-acting factors that affect its regulation.

229 -species complementation, demonstrating that trans-acting factors that are background-dependent contr

230 ular situations when IRESs are required, the trans-acting factors that are necessary for IRES functio

231 forward-genetic screens aimed at identifying trans-acting factors that are required for expression of

232 We also identify two trans-acting factors that are required for post-internal

233 esults advance our knowledge of the cis- and trans-acting factors that are required for transcription

234 e better addressed by a method that maps all trans-acting factors that bind particular regions rather

235 ults should facilitate the identification of trans-acting factors that bind to these cis elements and

236 ults should facilitate the identification of trans-acting factors that bind to these elements and the

237 ) sequences, as well as by binding sites for trans-acting factors that can evict nucleosomes, such as

238 unlocalized nanos mRNA during oogenesis, but trans-acting factors that carry out this function have r

239 fy cis-regulatory elements and corresponding trans-acting factors that contribute to EC identity and

240 an intracellular network of nucleus-encoded, trans-acting factors that control almost all aspects of

241 a difference in cis-regulatory elements and trans-acting factors that control ASE laterality.

242 ack to alterations of cis-acting elements or trans-acting factors that control the establishment, mai

243 To identify trans-acting factors that control VEGF mRNA translation

244 n, including the cis-regulatory elements and trans-acting factors that determine general de novo m(6)

245 ide a robust basis for extracting motifs and trans-acting factors that determine particular patterns

246 We also discuss protein trans-acting factors that have been implicated and the e

247 which indicates the presence of variation in trans-acting factors that influence recombination genome

248 However, the trans-acting factors that interact with the methylated a

249 variations in either cis-acting elements or trans-acting factors that lead to aberrant splicing and

250 of the PAR and identify controlling cis- and trans-acting factors that make the PAR the hottest segme

251 To study the cis- and trans-acting factors that mediate programmed death 1 (PD

252 er, the array of cis-regulatory elements and trans-acting factors that mediate these transcriptional

253 However, trans-acting factors that mediate XCI remain largely unk

254 ne cis-regulatory elements and their cognate trans-acting factors that modulate promoter activity in

255 Over the years, many trans-acting factors that orchestrate transcription by t

256 NA, the specific cis-acting determinants and trans-acting factors that participate in stabilizing bet

257 However, the trans-acting factors that promote the rapid decay of MFA

258 eukaryotes, these events are facilitated by trans-acting factors that propel ribosome maturation fro

259 The repression is largely mediated by trans-acting factors that recognize a conserved sequence

260 ation of a number of cis-acting elements and trans-acting factors that regulate its activity.

261 ined, little is known regarding the cis- and trans-acting factors that regulate its expression.

262 a identify Eed as a member of a new class of trans-acting factors that regulate parent-of-origin expr

263 ered its expression pattern, indicating that trans-acting factors that regulate the D. melanogaster y

264 study, we identified cis-acting elements and trans-acting factors that regulate the expression of the

265 The cis-acting DNA regulatory elements and trans-acting factors that regulate the majority of cold-

266 ically dissected the cis-acting sequence and trans-acting factors that regulate the stability of gamm

267 ternative splicing is generally regulated by trans-acting factors that specifically bind pre-mRNA to

268 ophoblasts is secondary to dominant negative trans-acting factors that suppress class II transactivat

269 shed in the maternal germline indicates that trans-acting factors that target methylation to this imp

270 ARE-binding proteins (AUBP) that function as trans-acting factors that transduce this function.

271 shared cis-regulatory signature and a common trans-acting factor, the phylogenetically conserved COE

272 The proximity of a gene or trans-acting factor to heterochromatin can have profound

273 nscripts, suggesting that PCBP1 can act as a trans-acting factor to stabilize sortilin transcripts.

274 abidopsis relies in large part on binding of trans-acting factors to cis-localized DNA sequence motif

275 erve to integrate the activities of multiple trans-acting factors to control smooth muscle alpha-acti

276 nd complex process that requires hundreds of trans-acting factors to dynamically build the highly-org

277 throughput system for systematically linking trans-acting factors to endogenous RNA regulatory events

278 ription is orchestrated by multiple cis- and trans-acting factors to ensure appropriate expression of

279 ion of changes in cis-regulatory elements or trans-acting factors to interspecies differences in gene

280 llows measurement of the ability of cis- and trans-acting factors to promote the export and translati

281 ranslation of dicistroviral RNAs may require trans-acting factors to stabilize PKI.

282 refore the ability of a range of known viral trans-acting factors to stimulate the Bag-1 IRES was tes

283 ells is associated with decreased binding of trans-acting factors to the ARE.

284 ranscription led to decreased binding of the trans-acting factors to their corresponding cis-acting e

285 ys showed that differences in the binding of trans-acting factors to these three elements accounts fo

286 Both activation domains employ trans-acting factors to trigger mRNA decay, and the N-te

287 In this study, we identified two p53 IRES trans-acting factors, translational control protein 80 (

288 iquitin-mediated sorting steps employ unique trans-acting factors, ubiquitination sites on Gap1p, and

289 s RNA sequence is able to bind directly to a trans-acting factor, Vg1RBP, which was previously shown

290 ne if Spn1 causes a fitness defect through a trans-acting factor, we constructed an Spn1(+) mutant th

291 Sec incorporation requires both cis- and trans-acting factors, which are known to be sufficient f

292 translation is codetermined by cellular IRES trans-acting factors, which can influence viral propagat

293 e codes governing splicing and their cognate trans-acting factors, which have illuminated important c

294 , GCA for X-linked phenotypes must be due to trans-acting factors, while GCA for autosomal phenotypes

295 e four ribosomal RNAs, mediated by a host of trans-acting factors whose specific functions remain lar

296 th C residues was deleterious, implicating a trans-acting factor with a preference for U over mixed p

297 re well studied, but how the interactions of trans-acting factors with cis-regulatory modules (CRMs)

298 binatorial interactions of sequence-specific trans-acting factors with localized genomic cis-element

299 show that two recently identified c-myc IRES trans-acting factors, Y-box binding protein 1 (YB-1) and

300 ivery of the corresponding cognate synthetic trans-acting factor ZF6-DB without the intrinsic transcr