ライフサイエンスコーパス: trans-sialidase

1 inetic isotope effect studies on recombinant trans-sialidase.

2 readily sialylated upon addition of parasite trans-sialidases.

3 The trans-sialidase action was independent of its catalytic

4 Instead, the trans-sialidase action was reproduced with a recombinant

5 ceptor TrkC is activated by T. cruzi surface trans-sialidase, also known as parasite-derived neurotro

6 se, expresses a membrane-bound neuraminidase/trans-sialidase, also known as parasite-derived neurotro

7 -1) along with the T. cruzi Tc24 antigen and trans-sialidase antigen 1 (TSA1), induced significant nu

8 y specific for the tandem repeat unit of the trans-sialidase C terminus.

9 The Trypanosoma cruzi trans-sialidase can sensitize mice to become highly susc

10 Trypanosoma cruzi trans-sialidase catalyzes a novel reaction that involves

11 with a trypomastigote population expressing trans-sialidase effectively released IL-6, but did not u

12 The biological significance of trans-sialidase expression on this subset, termed TS+, a

13 his study, the effectiveness of the T. cruzi trans-sialidase family (ts) genes ASP-1, ASP-2, and TSA-

14 on a few immunodominant peptides encoded in trans-sialidase family genes.

15 e epitopes from the large and highly diverse trans-sialidase family of surface proteins.

16 Intramolecular trans-sialidase from leech (Macrobdella decora) is the f

17 (ANYKFTLV) and subdominant TSKB74 (VNYDFTLV) trans-sialidase gene (TS)-encoded epitopes with up to 40

18 encoded by members of the T. cruzi sialidase/trans-sialidase gene superfamily.

19 CD8+ T cells recognizing the immunodominant trans-sialidase gene-encoded peptide TSKB20 (ANYKFTLV) a

20 cruzi expresses a developmentally regulated trans-sialidase implicated in the pathogenesis of Chagas

21 The critical role of the trans-sialidase in invasion was underscored by the obser

22 ing this observation, we found that purified trans-sialidase induces the selective release of biologi

23 , introduction of small amounts of exogenous trans-sialidase into suspensions of nonpenetrating TS- p

24 unique findings presented here suggest that trans-sialidase is a major inducer of IL-6 secretion in

25 trans-Sialidase is an essential enzyme for Trypanosoma c

26 ATCC 29149 strain produces an intramolecular trans-sialidase (IT-sialidase) that cleaves off terminal

27 art trypomastigote population expressing low trans-sialidase levels.

28 tegories and up-regulation of genes encoding trans-sialidase-like and ribosomal proteins.

29 hat the T. cruzi gp83 ligand, a cell surface trans-sialidase-like molecule that the parasite uses to

30 sion with a synthetic peptide epitope of the trans-sialidase monoclonal antibody.

31 families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel famil

32 s demonstrated with a genetically engineered trans-sialidase mutant, an enzymatically active polypept

33 iferative forms expresses proteins including trans-sialidases, normally restricted to infective and n

34 Trans-sialidases of parasites transfer alpha2,3-linked s

35 itation and competition assays show that the trans-sialidase/parasite-derived neurotrophic factor (PD

36 We recently identified two T. cruzi trans-sialidase peptides that are targets of approximate

37 NanB is an intramolecular trans-sialidase producing 2,7-anhydro-Neu5Ac selectively

38 ch sialidase, NanB acts as an intramolecular trans-sialidase releasing Neu2,7-anhydro5Ac.

39 rade mucins is mediated by an intramolecular trans-sialidase (RgNanH).

40 ucins; however, in order to be substrates of trans-sialidase, some of the galactose residues should b

41 ost cells >20 hr earlier than immunodominant trans-sialidase-specific T cells.

42 of the CD4 cells are stimulated by a single trans-sialidase superfamily epitope and suggest that a c

43 g T. cruzi infection the CD4 response to the trans-sialidase superfamily is critical to the protectiv

44 ly epitope and suggest that a combination of trans-sialidase superfamily proteins combines to stimula

45 ultaneously expresses variant members of the trans-sialidase superfamily.

46 soma cruzi, the agent of Chagas disease: the trans-sialidase (TcTS) catalyzes the transfer of sialic

47 Trypanosoma cruzi trans-sialidase (TcTS) is a key target protein for Chaga

48 Therefore, T. cruzi trans-sialidase (TcTS) presents a potential and appealin

49 T. cruzi supergene family comprising active trans-sialidase (TS) and TS-like proteins.

50 nasal immunizations with the unique T. cruzi trans-sialidase (TS) antigen protect against gastric and

51 ease trypanosomiasis, in which the action of trans-sialidase (TS) enzymes harbored on their surface i

52 onately target epitopes encoded in the large trans-sialidase (TS) gene family.

53 ponses targeting epitopes encoded by variant trans-sialidase (TS) genes.

54 The Trypanosoma cruzi trans-sialidase (TS) is a unique enzyme with neuraminida

55 The trans-sialidase (TS) of T. cruzi and the Cys-rich domain

56 ed that mice primed for a few hours with the trans-sialidase (TS) of Trypanosoma cruzi, the agent of

57 evant to this observation, we found that the trans-sialidase (TS) of Trypanosoma cruzi, the etiologic

58 is largely comprised of T cells recognizing trans-sialidase (TS)- and mucin-encoded epitopes.

59 Strong trans-sialidase TSKB18- and TSKB20-specific CD8+ T-cell

60 fter mucosal T. cruzi infection and T. cruzi trans-sialidase vaccination.

61 ted with the expression of an intramolecular trans-sialidase, which releases 2,7-anhydro-Neu5Ac, rath

62 parasite-derived neurotrophic factor (PDNF)/trans-sialidase with neurotrophic receptors TrkA and Trk