ライフサイエンスコーパス: transactivation activity

1 more, HI-TOPK-032 decreased SSL-induced AP-1 transactivation activity.

2 The combinatory mutants had essentially no transactivation activity.

3 ic residue (e.g. Q56R) significantly reduced transactivation activity.

4 etinoic acid (RA), resulting in enhanced p53 transactivation activity.

5 i1 is translocated to the nucleus and it has transactivation activity.

6 cytoskeleton remodeling and Pak1-mediated ER transactivation activity.

7 ts sequence-specific DNA binding ability and transactivation activity.

8 tested sixteen analogues for TR binding and transactivation activity.

9 teraction between SIMPL and p65 enhances p65 transactivation activity.

10 ssociated with enhanced MEF2 DNA binding and transactivation activity.

11 cated in the regulation of its stability and transactivation activity.

12 acids region is critical in maintaining its transactivation activity.

13 ll transactivation domain showed very potent transactivation activity.

14 ent of cells with IGF-I has little effect on transactivation activity.

15 at the C-terminal region of GRF proteins has transactivation activity.

16 te, or inhibit but retains the LexA-mediated transactivation activity.

17 a-A at Ser-215 abrogates p53 DNA binding and transactivation activity.

18 wn that p34(SEI-1) possesses a LexA-mediated transactivation activity.

19 sion of PPFP and PPARgamma blocked PPARgamma transactivation activity.

20 and tested, the IGFBP-5 N-domain has strong transactivation activity.

21 greatly reduced cooperativity and decreased transactivation activity.

22 specifically augmented IL-1beta-induced RelA transactivation activity.

23 inding of PCAF to p73 is necessary for p73's transactivation activity.

24 tant protein demonstrated a 75% reduction in transactivation activity.

25 owever, phosphorylation is important in KLF5 transactivation activity.

26 yoD-myocyte enhancer binding factor-2 (MEF2) transactivation activity.

27 an increase in its stability and subsequent transactivation activity.

28 ve Cdk2 (Cdk2DN) substantially reduced B-Myb transactivation activity.

29 16 also results in significant inhibition of transactivation activity.

30 with p30 isoform, this peptide does modulate transactivation activity.

31 transforming activity while retaining strong transactivation activity.

32 ase kinase (MEK1) led to stimulation of PTTG transactivation activity.

33 n to exhibit reduced RAR/RXR transcriptional transactivation activity.

34 BHV-1 maturation and regulation of alphaBTIF transactivation activity.

35 o acids of Pitx2 specifically inhibits Pitx2 transactivation activity.

36 in these motifs decrease its GTP-binding and transactivation activity.

37 bited both basal and coactivator-mediated AR transactivation activity.

38 gene, encoded by two exons, which has potent transactivation activity.

39 matin recruitment of c-Myc, and enhances its transactivation activity.

40 o for DNA binding, protein dimerization, and transactivation activity.

41 xpression resulting from TLS-CHOP's putative transactivation activity.

42 pecially at serine 383, is important for its transactivation activity.

43 ed their focal accumulation as well as Runx2 transactivation activity.

44 a at K266, which is known to promote ERalpha transactivation activity.

45 ment, we concluded that AtERF53 has positive transactivation activity.

46 but not KRBDP4, possesses ligand-independent transactivation activity.

47 ng contact inhibition and thus inhibits YAP1 transactivation activity.

48 ression of ASB2 degrades MLL and reduces MLL transactivation activity.

49 identified herein to be a suppressor of GLI3 transactivation activity.

50 translocation, acetylation, DNA binding, and transactivation activity.

51 tein as well as for the Efl3 DNA binding and transactivation activity.

52 of IGFBP-5a are responsible for its lack of transactivation activity.

53 t with the ability of WWOX to suppress RUNX2 transactivation activity.

54 eas GABPbeta does not bind DNA but possesses transactivation activity.

55 nd in the nucleus of mammalian cells and has transactivation activity.

56 nd is an important negative regulator of its transactivation activity.

57 antagonizes AP-1 function by inhibiting its transactivation activity.

58 ) is essential for NF-kappaB DNA binding and transactivation activity.

59 vity of the c-fos promoter, followed by AP-1 transactivation activity.

60 acting protein kinase 2 greatly enhances its transactivation activity.

61 nuclear accumulation, but not its C-terminal transactivation activity.

62 iption factor CLOCK (CLK) and inhibiting its transactivation activity.

63 ound in the nuclei of cultured cells and has transactivation activity.

64 XIT had significant dose-dependent PPARgamma transactivation activities.

65 mparable affinities and exhibited comparable transactivation activities.

66 volves both up-regulation of DNA binding and transactivation activities.

67 teraction that inhibits both DNA binding and transactivation activities.

68 lter the Tax oncoprotein coding sequence and transactivation activities.

69 tepes (vlt), which abolishes DNA binding and transactivation activities.

70 with a unique combination of phosphatase and transactivation activities.

71 action, subcellular localization and ERalpha transactivation activity all increased in cells expressi

72 to induce transcription, with an independent transactivation activity also required.

73 Both cysteine-rich motifs exhibited transactivation activity, although the C1 activator was

74 There is a difference in the extent of transactivation activity among YAP isoforms: YAP2 is the

75 These mutants lacked TH binding and transactivation activities and exhibited potent dominant

76 y controlled by its specific DNA-binding and transactivation activities and that p63 is degraded in a

77 PAX6 (L46R, C52R, and V53L) exhibited lower transactivation activities and variable DNA binding abil

78 nactive, with essentially no DNA binding and transactivation activities and, unlike the wild type pro

79 functions by two means: (i) it blocks p53's transactivation activity and (ii) it targets p53 for deg

80 nd mutant ARs and efficiently inhibits their transactivation activity and ability to induce PSA gene

81 The ERRalpha-1 mutant F329A lost the transactivation activity and acted as a dominant negativ

82 /JNK signaling, leading to decreased Smad2/3 transactivation activity and alpha-smooth muscle actin e

83 phorylation also enhanced the SUMO-dependent transactivation activity and auto-repression activity of

84 bolishes its interaction with MtLUG, and its transactivation activity and biological function.

85 As a result, IKKepsilon induces ERalpha transactivation activity and enhances ERalpha binding to

86 er, AmphiSOXE is less efficient than SOX9 in transactivation activity and in the ability to preferent

87 levels, decreased E2F-1 phosphorylation and transactivation activity and increased cyclin A binding

88 nsfected MCF7 cells had increased basal AP-1 transactivation activity and increased expression of AP-

89 sed during adipogenesis, PPARgamma-dependent transactivation activity and induction of aP2 expression

90 defective in Rb interaction, stimulates E2F transactivation activity and inhibits Rb growth suppress

91 vation domain (AD) of CoCoA possesses strong transactivation activity and is required for the coactiv

92 The structural basis of this transactivation activity and its role in mediating IGF-i

93 the promoter region of ORF50, increasing its transactivation activity and KSHV spontaneous lytic gene

94 OXA2 at S107/S111, thereby suppressing FOXA2 transactivation activity and leading to decreased NUMB e

95 3, with one base-pair spacer reducing 90% of transactivation activity and longer spacers reducing tra

96 orter (40 kDa) protein (GATA1s) with altered transactivation activity and may lead to altered express

97 expressing an SM mutant allele defective for transactivation activity and nucleocytoplasmic shuttling

98 dition, MDM2 has been shown to stimulate E2F transactivation activity and promote S-phase entry indep

99 It exhibits the transactivation activity and regulates a number of genes

100 omain deletion mutant of TAp63gamma inhibits transactivation activity and stabilizes the wild-type TA

101 tumor suppressor protein by antagonizing p53 transactivation activity and targeting p53 for degradati

102 Cdk2 is directly involved in enhancing B-Myb transactivation activity and that levels of endogenous c

103 tetradecanoylphorbol-13-acetate-induced AP-1 transactivation activity and transactivation of c-Jun/c-

104 ion of Af4, Af9 and Enl which controls their transactivation activity and/or protein stability.

105 arget gene chromatin, stimulation of ERalpha transactivation activity, and enhanced expression of ERa

106 nd highly metastatic, exhibited minimal TP53 transactivation activity, and expressed genes with poten

107 a truncated ERalpha protein with detectable transactivation activity, and it is likely that this fun

108 h in turn heterodimerizes and suppresses FTF transactivation activity; and 2) it occupies the FTF/HNF

109 ns at Ser(213) and Ser(217) suppressed NFAT3 transactivation activity; and SP600125, a JNK inhibitor,

110 of the p21/Waf1 promoter) and sequester its transactivation activity, as seen in both in vivo and in

111 Transactivation activity assays performed in Arabidopsis

112 BPA mRNA and is commonly believed to have no transactivation activity, binds to the miR-181a-1 promot

113 ytoplasmic localization of CIITA and loss of transactivation activity, both of which can be rescued b

114 nd CBP not only resulted in complete loss of transactivation activity but also abolished transrepress

115 oregulator may lead to differential receptor transactivation activity but also provide a new way for

116 s, the P375Q mutant appears to have a normal transactivation activity but lower DNA binding through t

117 Ubc9 displays no intrinsic transactivation activity but modifies both the absolute

118 intraperitoneal metastasis, and reduced TP53 transactivation activity but retained responsiveness to

119 PAX6-5a-C52R, and -V53L showed lower transactivation activities, but PAX6-5a-L46R had greater

120 However, IFN-gamma abrogated IE62's transactivation activity by 16% in MeWo cells, indicatin

121 AKT, and also enhance cross-regulation of ER transactivation activity by growth factors.

122 nding factor, coregulates ER by enhancing ER transactivation activity by promoting the recruitment of

123 he same DNA element as Nur77, and that their transactivation activities can be blocked by a Nur77 dom

124 ifying the mechanisms by which wild type p53 transactivation activity can be abrogated may provide in

125 he p63 gene that abolish p63 DNA-binding and transactivation activities cause human diseases, includi

126 on isoform p32 did not greatly influence the transactivation activity compared with p30 isoform, this

127 of HNF1A isomers: HNF1A(A), with the lowest transactivation activity compared with the truncated iso

128 C-terminal domain of HBx, independent of its transactivation activity, complexes with p53 in the cyto

129 Only the intrinsic transactivation activity could be localized to a small r

130 s and the cells lacked beta-catenin-mediated transactivation activity, detectable using a reporter as

131 s impaired the ability of ATM to enhance VDR transactivation activity, diminishing 1,25-VD-mediated i

132 in vitro separation of transrepression from transactivation activity does not translate to an increa

133 We show that it has lost its transcriptional transactivation activity, fails to dimerize and bind DNA

134 Here, measuring transactivation activity for a large number of response

135 ZIP interacts with K-Rta and can repress its transactivation activity for some viral promoters.

136 cid substitution that results in the loss of transactivation activity for the HIV long terminal repea

137 Both RU24782 and RU24858 induced a transactivation activity highly dependent on the GR expr

138 Inhibition of RORalpha and RORgamma transactivation activities in a Tet-on CHO cell reporter

139 atives showed a strong inhibition of ERalpha transactivation activity in a luciferase reporter assay

140 Aurora-A induces AR transactivation activity in a phosphorylation-dependent

141 f TBP to HNF4alpha interferes with HNF4alpha transactivation activity in cells.

142 A/Cdk2 was found previously to enhance B-Myb transactivation activity in cotransfected cells.

143 l end of NFATx1 are required for its maximum transactivation activity in Jurkat T cells.

144 isolated NFATx isoforms, resulting in lower transactivation activity in Jurkat T cells.

145 is also required for both autoregulation and transactivation activity in mammalian cells.

146 ation of MEF2D protein and inhibition of its transactivation activity in mature cortical neurons.

147 RA enhances endogenous p53 transactivation activity in NT2/D1 but not NT2/D1-R1 cel

148 ion (435 amino acids) exhibited little or no transactivation activity in our assays.

149 tudies have revealed the involvement of AML1 transactivation activity in promoting cell cycle progres

150 transcription silencing domain restored CAR1 transactivation activity in reporter assays to approxima

151 BPbeta and inhibit C/EBPbeta DNA binding and transactivation activity in situ.

152 (C/EBPalpha) at serine 21 and increases its transactivation activity in the context of PEPCK gene tr

153 activity by either direct repression of p53 transactivation activity in the nucleus or promotion of

154 he elevated c-myc levels led to higher c-myc transactivation activity in the p53 wild-type cell line,

155 at ectopic expression of Aurora-A induces AR transactivation activity in the presence and absence of

156 ion and that IGFBP-2 and -3 also have strong transactivation activity in their N-domains.

157 Although androgen induced greater AR transactivation activity in this condition, it did not i

158 is conserved among alphaherpesvirus and has transactivation activity in transient transfections.

159 Reconstitution of the transactivation activity in vitro revealed that AR142-48

160 compassing HSsII harbors the majority of the transactivation activity in vitro, and electrophoretic m

161 Although HS II harbored much of the transactivation activity in vitro, it was not sufficient

162 of the coactivator TIF2 retaining intrinsic transactivation activity is a dominant negative inhibito

163 ERalpha transactivation activity is mediated by the synergistic

164 These results demonstrate that p73 transactivation activity is necessary for rapid p73 turn

165 This result indicates that functional transactivation activity is required for acute E2-mediat

166 sence of the AR, but not its transcriptional transactivation activity, is critical for hTGP transcrip

167 ure impaired NF-kappaB and adaptor protein 1 transactivation activity, leading to T cell unresponsive

168 In cancers harboring wild type p53, the p53 transactivation activity may be compromised by other mec

169 Trx-1 increased hypoxia-induced HIF-1 transactivation activity measured using a luciferase rep

170 The HLH domain is necessary for the transactivation activity observed, suggesting that inter

171 lyses demonstrated that both DNA binding and transactivation activities of AP-1 were induced by DCA i

172 owed synergistic stimulation with Raf on the transactivation activities of both the chimera Gal4-Nrf2

173 ty of Gal4-Nrf2-(113-251) and the diminished transactivation activities of chimera Gal4-Nrf2-(1-126)

174 EKK1, TAK1-DeltaN, and ASK1 up-regulated the transactivation activities of Gal4-Nrf2-(1-370) and Gal4

175 estrogen-dependent and estrogen-independent transactivation activities of hER-alpha66 and hER-beta.

176 chimeras and mutant derivatives thereof, and transactivation activities of original and mutant chimer

177 he DeltaNp63 isoforms seem to counteract the transactivation activities of p53 and TAp63 proteins, th

178 Both DNA binding and transactivation activities of p53 are required for Arf r

179 Finally, the transactivation activities of these mutants correlated w

180 Thus, differential transactivation activities of TR isoforms are mediated b

181 expression vector potentiated by 2-fold the transactivation activity of a chimeric transcriptional f

182 In addition, RA induces transactivation activity of a gal4-p53 fusion protein, s

183 PGC-1 also enhanced the transactivation activity of a PPARalpha-Gal4 DNA binding

184 conserved motif known to be critical for the transactivation activity of a related yeast SWI/SNF poly

185 he catalytic subunit of PKA (PKAc) increases transactivation activity of amino acids 548-1531 and act

186 rate that cyclin D3 negatively regulates the transactivation activity of AML1 in a dose-dependent man

187 acid (VPA) increase DNA binding activity and transactivation activity of AP-1 transcription factors,

188 ion demonstrated that vimentin inhibited the transactivation activity of ATF4 on osteocalcin by preve

189 also has an essential role in mediating the transactivation activity of beta-cat/Arm.

190 We used a functional assay that measures the transactivation activity of BRCA1 in combination with an

191 Sp100 represses the MAR-binding and transactivation activity of Bright.

192 rectly with CRX and that each diminishes the transactivation activity of CRX on the IRBP promoter.

193 n in E1A-CtBP2 fusion partially restored the transactivation activity of E1A.

194 Induction of T-ALL correlated with the transactivation activity of each Notch1 polypeptide when

195 assessed by serine 305 (S305) activation and transactivation activity of ER.

196 s mutation to glutamic acid (S305E) promoted transactivation activity of ER.

197 r affinity as wild-type ERalpha/HBD, and the transactivation activity of ERalpha/V376R was enhanced 5

198 ctivated transcription factor, and links the transactivation activity of estrogen receptor to the gro

199 The high transactivation activity of Gal4-Nrf2-(113-251) and the

200 EBP that involves specific inhibition of the transactivation activity of GRACE by LID under low gluco

201 luence the nucleocytoplasmic trafficking and transactivation activity of GRalpha, whereas introductio

202 The transactivation activity of HIF complexes requires the r

203 We demonstrate that regulation of the transactivation activity of HIF-1 alpha CAD also involve

204 We show that MAPK is required for the transactivation activity of HIF-1 alpha.

205 arate levels and increased the stability and transactivation activity of HIF-1alpha in cancer cells.

206 s human CYP8B1 transcription by reducing the transactivation activity of HNF4alpha through interactio

207 his was associated with up-regulation of the transactivation activity of HSF1 via increased HSF1 trim

208 on of HSBP1 in mammalian cells represses the transactivation activity of HSF1.

209 point of Hsp expression is regulation of the transactivation activity of HSF1.

210 hown that Tip110 functions to potentiate the transactivation activity of human immunodeficiency virus

211 Additionally, the transactivation activity of ICP0 was impaired in the S22

212 minus of the protein and that the C-terminal transactivation activity of ICP27 was not necessary.

213 er reporter plasmid, IFN-gamma abrogated the transactivation activity of IE62 by 95%, 97%, and 89% in

214 Intriguingly, the transactivation activity of IGFBP-5 is masked by negativ

215 GRIP1 also enhanced the hormone-dependent transactivation activity of intact glucocorticoid recept

216 rativity resulted from the regulation of the transactivation activity of IRF-7 by Smad3, and dominant

217 rolled by both the protein stability and the transactivation activity of its alpha subunit, HIF-1 alp

218 ding the p.E508K mutant demonstrated reduced transactivation activity of its target promoter compared

219 ccurs through Cu-dependent repression of the transactivation activity of Mac1p.

220 BMK1 dramatically enhances the transactivation activity of MEF2C by phosphorylating a s

221 We showed previously that the transactivation activity of MEF2C is stimulated by p38 m

222 d that in monocytic cells, LPS increases the transactivation activity of MEF2C through p38-catalysed

223 HepG2 cells were used to assess the transactivation activity of mERbeta isoforms with EDCs a

224 The transactivation activity of MLL was dependent on CBP, as

225 We suggest that the transactivation activity of MT1-MMP contributes to the p

226 repressed, in a dose-dependent fashion, the transactivation activity of myocyte enhancer factor 2 (M

227 Increased phosphorylation and transactivation activity of nuclear transcription factor

228 rylation of this residue is critical for the transactivation activity of Nur77, we investigated wheth

229 The transactivation activity of OsNIN-like3 needs to be furt

230 The transactivation activity of OsNIN-like3 was not possible

231 tion activity of wild-type p53, although the transactivation activity of p21 promoter by the A4 mutan

232 the HIF-p300 interaction and suppresses the transactivation activity of p300.

233 They inhibit the transactivation activity of p53 by binding separately or

234 ) promoter are responsible for the selective transactivation activity of p53 hinge domain mutant del3

235 nock down by RNA interference diminishes the transactivation activity of p53 without reducing the p53

236 een the N-termini of mdm2 and p53 blocks the transactivation activity of p53, the interaction between

237 33ING2 strongly enhances the transcriptional-transactivation activity of p53.

238 transformation, NASP expression reduced the transactivation activity of p53.

239 s in adipogenesis, by directly targeting the transactivation activity of PPAR-gamma.

240 on of BAG-1 expression plasmid inhibited the transactivation activity of RAR/RXR heterodimers but not

241 Examination of the transactivation activity of RaxL on a reporter construct

242 lymphomas by affecting an IKKalpha-regulated transactivation activity of REL.

243 nyl]-benzenesulfonamide (T0901317) inhibited transactivation activity of RORalpha and RORgamma but no

244 rs, although they did not show any effect on transactivation activity of RXR/RXR homodimers.

245 sed the expression, DNA binding activity and transactivation activity of Sp1 protein.

246 ther hand, coexpressed RB could activate the transactivation activity of the AR in an androgen-deplet

247 ed that intact pocket function of RB and the transactivation activity of the AR were required for RB

248 nhibitors of MCFA-CoA synthases increase the transactivation activity of the ARM repeat protein beta-

249 HL and hydroxylases in the regulation of the transactivation activity of the C-terminal activating do

250 d mutagenesis of these motifs suppressed the transactivation activity of the E1b proximal promoter, i

251 n the rice orthologue of HvABI5, reduces the transactivation activity of the factor by 50%.

252 distinguish between the transrepression and transactivation activity of the GR, the later thought to

253 Leu-678 appears to be critical for efficient transactivation activity of the hAhR and appears to disr

254 The transactivation activity of the p53 tumor suppressor pro

255 in the AR NTD, is implicated in constitutive transactivation activity of the receptor, and thus might

256 ize effects on the p160 coactivator-mediated transactivation activity of the receptor.

257 s the TCF binding site, and they also induce transactivation activity of the SRF.

258 acetyltransferase activity and represses the transactivation activity of transcription factor in S. c

259 e viral induction of apoptosis and (vii) the transactivation activity of VP16 is not necessary for th

260 a critical role of BCCIP in maintaining the transactivation activity of wild type p53 and further su

261 N1A-interacting protein, is required for the transactivation activity of wild type p53.

262 ated to alanine (the A4 mutant) retained the transactivation activity of wild-type p53, although the

263 Ciao 1 appears to specifically modulate the transactivation activity of WT1 and may function to regu

264 dent manner and exacerbates their respective transactivation activities on the RET promoter.

265 nscription activator (RTA) and represses its transactivation activity on several viral promoters.

266 ctivated protein (MAP) kinase augments ATF-2 transactivation activity on the PEPCK-C promoter, which

267 ction by affecting proper binding to DNA and transactivation activity or by altering the interaction

268 1) showed no significant effect on its basal transactivation activity or the fold of induction by Raf

269 ts to suppress recombination, independent of transactivation activity, raising the possibility that p

270 conserved to a high degree and that its full transactivation activity relies on the synergistic actio

271 Cdk5-dependent phosphorylation reduces MEF2 transactivation activity remained unknown.

272 K-Rta transactivation activity requires a protein degradation

273 tly increased AR mRNA and protein levels, AR transactivation activity, serum prostate-specific antige

274 pression of Gal4-p300HAT, which alone has no transactivation activity, stimulates the activity of the

275 that the Ser(16) locus mutants have abnormal transactivation activities, suggesting that the two alte

276 sically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1

277 ities to form homodimers and mediated higher transactivation activities than TRalpha1.

278 The Gal4/Mac1p hybrid exhibits transactivation activity that is repressed in cells cult

279 ome inhibition, GR is unique in its enhanced transactivation activity that results when proteasome fu

280 e data demonstrate that Tip110 regulates Tat transactivation activity through direct interaction, and

281 e conclude that the AR NTD contributes to AR transactivation activity via functional interactions wit

282 ear accumulation of EGFR to potentiate STAT3 transactivation activities, via activation of the nuclea

283 EGF-associated AP-1 transactivation activity was dramatically lower in H2AX-

284 bility or cellular localization, whereas its transactivation activity was hindered.

285 AP-1 transactivation activity was increased by the treatment

286 he effect of Aurora-A on p53 DNA binding and transactivation activity was not affected by phosphoryla

287 B-Myb transactivation activity was significantly reduced in a

288 NFAT3 transactivation activity was suppressed in JNK1(-/-) or

289 C1) was significantly decreased when the p53 transactivation activity was turned on, suggesting that

290 y, p73 deletion or point mutants that lacked transactivation activity were stable compared to wild-ty

291 Additionally, p53 transcription and its transactivation activity were suppressed by LANA express

292 protein (Delta500 - 1863 BRCA1), which lack transactivation activity, were unable to activate the GA

293 exon fragments can reconstitute substantial transactivation activity when fused to the DNA-binding d

294 expression of TRIM28 therefore inhibits IRF7 transactivation activity, whereas knockdown of TRIM28 ha

295 N-domains of IGFBP-2 and -3 also had strong transactivation activity, whereas those of IGFBP-1 and -

296 of Af4 encodes a region with transcriptional transactivation activity which is disrupted by the t(4;1

297 n function of p53 is mostly conferred by its transactivation activity, which is inactivated by p53 mu

298 ng pathways stimulated the Gal4-Nrf2-(1-370) transactivation activity while the p38 pathway played a

299 olog of MDM2, also binds to and inhibits p53 transactivation activity, yet it does not possess intrin

300 Although zebrafish IGFBP-5b possesses transactivation activity, zebrafish IGFBP-5a lacks this