ライフサイエンスコーパス: transactivation domain

1 ine-rich motif, a proline-rich domain, and a transactivation domain.

2 3 by binding separately or in concert to its transactivation domain.

3 the TIP60 acetyltransferase domain and c-Myb transactivation domain.

4 TNFalpha with a truncated HSF1 that lacked a transactivation domain.

5 original Nrf2 (now Nrf2a) but lacks the Neh4 transactivation domain.

6 ylates NFAT1 in Ser-32 within its N-terminal transactivation domain.

7 etains (TA) and the other lacks (DeltaN) the transactivation domain.

8 o a truncated isoform lacking the C-terminal transactivation domain.

9 ear hormone receptors through its N-terminal transactivation domain.

10 regulated neurotransmitter phenotype via its transactivation domain.

11 rminal proline-, serine-, and threonine-rich transactivation domain.

12 ough fusion to the Herpes Simplex Virus VP16 transactivation domain.

13 16) becomes well-defined upon binding of the transactivation domain.

14 and a STAT4beta isoform lacking a C-terminal transactivation domain.

15 n the C-terminus of Sox2, which contains its transactivation domain.

16 e Pyk2 phosphorylates tyrosine 131 in the E2 transactivation domain.

17 Tyr-267 and Tyr-363, both located within the transactivation domain.

18 Rather, WxxLF functioned as an autonomous transactivation domain.

19 nt on a key C-terminal domain located in its transactivation domain.

20 finger pair domain in Zap1 contains the AD2 transactivation domain.

21 vage sites were identified in the N-terminal transactivation domain.

22 (TCA) to proline (Pro) (CCA) within the REL transactivation domain.

23 nding domain to a highly potent EWS (or FUS) transactivation domain.

24 phosphoacceptor residue, Ser(64), within the transactivation domain.

25 ed with ERK5 or ERK5(1-740), which lacks the transactivation domain.

26 c p53 but not to a p53 mutant that lacks the transactivation domain.

27 n of Ser63/Ser73 located in the NH2-terminal transactivation domain.

28 YA is only a tyrosine phosphatase and has no transactivation domain.

29 for TAZ1 binding through its own disordered transactivation domain.

30 some processing but independent of NF-kappaB transactivation domain.

31 esidues regulates p107 affinity for the E2F4 transactivation domain.

32 n maps to a conserved site within the POU1F1 transactivation domain.

33 in reader module, and by employing an acidic transactivation domain.

34 eraction was determined to be near the FOXO3 transactivation domain.

35 MDMX that has sequence similarity to the p53 transactivation domain.

36 man cells, whereas the RRs were fused with a transactivation domain.

37 e variant of p63, which lacks the N-terminal transactivation domain.

38 minal Rel homology domain and the C-terminal transactivation domain.

39 dent phosphorylation within their respective transactivation domains.

40 ecruit coactivators via HIF-alpha C-terminal transactivation domains.

41 ides derived from the p63 and p73 N-terminal transactivation domains.

42 AT NH2-terminal modulatory and COOH-terminal transactivation domains.

43 the rel homology domain but not at its known transactivation domains.

44 he combined properties of amino terminal and transactivation domains.

45 elenoprotein, is proposed to carry redox and transactivation domains.

46 ains were tightly bound to the Neh4 and Neh5 transactivation domains.

47 evolution into v-Rel are deletion of c-Rel's transactivation domain 2 (cTAD2) and mutations in cTAD1.

48 nstrate direct binding of both ssDNA and the transactivation domain 2 of p53 (p53TAD2) to DBD-F, as w

49 /p300 (CBP/p300) that binds to the HIF-alpha transactivation domain, a new group of transcription coa

50 ontain a PST (Proline-Serine-Threonine)-rich transactivation domain, a threonine phosphatase motif (T

51 identified in the NH2-terminal region of the transactivation domain: a cluster of weak phosphorylatio

52 ion of target genes by GR is mediated by two transactivation domains: activation function 1 (AF1) in

53 the oncogenic chimera E2A-PBX1 contain three transactivation domains (ADs), with AD1 and AD2 having r

54 TAK1, predominantly via PPARalpha N-terminal transactivation domain (AF-1) thereby masking the TAK1 k

55 of breast cancers, contains an unstructured transactivation domain (AF1) in its N terminus that is a

56 tly as a recombinant peptide, the N-terminal transactivation domain (AF1) of the GR shows little stru

57 Expression of the Myc transactivation domain alone induces a transcription-ind

58 Loss of the RelB transactivation domain alters NF-kappaB-dependent transc

59 ng on the C-terminal ligand-binding and AF-2 transactivation domains, an assembly of an active transc

60 LX1 is a critical component of the transactivation domain and has been shown to mediate C/E

61 ssays identified that Stat3 binds to the p65 transactivation domain and is present in the NF-kappaB D

62 lass of isoforms, which lacks the N-terminal transactivation domain and is synthesized from an intern

63 8), located at the end of the amino-terminal transactivation domain and next to the Pit1-Oct-Unc86 (P

64 the presence of p50 homodimers, which lack a transactivation domain and rely on the transcriptional c

65 ta suggest that the Neh3 domain may act as a transactivation domain and that it is possibly involved

66 lar ATM kinase through its carboxyl-terminal transactivation domain and that this interaction blocked

67 cate that the interaction occurs via the p53 transactivation domain and the Aurora A catalytic domain

68 o1, an activity dependent on M303 in c-Myb's transactivation domain, and likely the recruitment of co

69 h required expression of both the N-terminal transactivation domain, and the C-terminal ligand bindin

70 nctional activity to serve as an independent transactivation domain, and the combination of three seq

71 However, mutants of E2F-1 that lack the transactivation domain are still able to induce cell dea

72 pression, we show that HOXA9 DNA binding and transactivation domains are essential.

73 d identified S118 within the N-terminal AF-1 transactivation domain as an additional element for regu

74 creen was performed using the p65 C-terminal transactivation domain as bait and identified the produc

75 and the S442D change increases activity in a transactivation domain assay.

76 addition, we demonstrate that transformation/transactivation domain-associated protein (TRRAP) and Ti

77 TAp63 isoforms possess a transactivation domain at the N terminus and are able to

78 We further show that the transactivation domain at the NH(2) terminus of p63 repr

79 d Chk1-dependent phosphorylation of the RelA transactivation domain at threonine 505, a site required

80 The acidic transactivation-domain-bearing (TA) isoforms of p63 and

81 cture, but an important pocket near the AF-2 transactivation domain becomes accessible only in struct

82 l half of the AhR, and the degeneracy in the transactivation domain between the mAhR and the hAhR res

83 The HIF-1alpha and CITED2 transactivation domains bind to TAZ1 through helical mot

84 A molecule of VH9 was located in each transactivation domain binding site, and the four non-MD

85 n of residues S650 and S975 weakens the E2F4 transactivation domain binding.

86 domain, which overlaps with the site of E2F transactivation domain binding.

87 The Myc transactivation domain binds to the transcription initia

88 The beta-catenin transactivation domain bound directly to isolated MED12

89 The transactivation domain but not the DNA binding domain of

90 5-37 kDa that retains intact DNA-binding and transactivation domains but lacks the 147 amino acids at

91 kDa that comprises the IRF dimerization and transactivation domains but lacks the DNA-binding domain

92 ation required a transcriptionally competent transactivation domain, but not the DNA binding function

93 phosphorylated at multiple sites within its transactivation domain by the JNKs, and c-Jun phosphoryl

94 the binding interface between the C-terminal transactivation domain (C-TAD) of hypoxia-inducible fact

95 roline hydroxylation motifs and a C-terminal transactivation domain (C-TAD) with an asparagine hydrox

96 hypoxic activation of HIF-1alpha C-terminal transactivation domain (C-TAD), but not HIF-1alpha-N-ter

97 g domain, dimerization domain, or C-terminal transactivation domain [C-TAD]) of HIF-2alpha with the a

98 xylation of residue Asn803 in the C-terminal transactivation domain (CAD) of hypoxia-inducible factor

99 -Cas9 proteins (dCas9) fused to heterologous transactivation domains can act as a potent guide RNA se

100 other P63 isoform which lacks the N-terminal transactivation domain compared to TAP63alpha, using the

101 of 20S (APIS), binds specifically to the E1A transactivation domain, conserved region 3 (CR3).

102 However, we found that a longer N-terminal transactivation domain construct p53(1-57) bound tightly

103 ts suggest that similar mutations in the REL transactivation domain contribute to the development of

104 s HIF-1alpha by hydroxylating the C-terminal transactivation domain (CTAD) of HIF-1alpha at HIF-Asn(8

105 sactivation domain (NTAD) and the C-terminal transactivation domain (CTAD).

106 Only STAT5A and its transactivation domain-deficient mutant STAT5ADelta749 s

107 element-controlled reporter through an Arnt transactivation domain-dependent mechanism.

108 erminal half of the receptor, containing the transactivation domain, determines the cellular localiza

109 of several other serine residues within the transactivation domain did not substantially affect REL'

110 However, the transactivation domain does not appear to play a role in

111 We propose that Myc transactivation domain-driven RNA Pol II CTD phosphoryla

112 bit the specific association between the E2F transactivation domain (E2F(TD)) and the Rb pocket domai

113 such that it mimics and directly blocks E2F transactivation domain (E2F(TD)) binding.

114 s MEF2C via three residues in the C-terminal transactivation domain, establishing MEF2C as a direct t

115 that either contain (TA) or lack (DeltaN) a transactivation domain, fail to develop stratified epith

116 Phosphorylation of a p53 transactivation domain fragment at Ser(20) by these enzy

117 ct sites on CLOCK and BMAL1 to sequester the transactivation domain from coactivators.

118 EWS-FLI1 harbors a strong transactivation domain from EWSR1 and the DNA-binding ET

119 t aspartic acid 137 separates the N-terminal transactivation domain from the C-terminal DNA binding a

120 scaffolds for the interaction of disordered transactivation domains from a wide variety of partners,

121 IF-1 transcriptional activity and HIF-1alpha transactivation domain function by oxygen-independent me

122 MCM3 inhibits transactivation domain function, whereas MCM7 enhances H

123 the AD2 interaction motif of the N-terminal transactivation domain functions as a phosphorylation-de

124 The fact that a dominant transactivation domain fused to Meis1 replaces the essen

125 eptides that display key residues of the p53 transactivation domain have emerged as bona fide clinica

126 ons of wild-type or mutant p53 with inactive transactivation domain I (p53(Q22/S23)) undergo apoptosi

127 and dimerization domains but differ in their transactivation domains, implying they may have unique t

128 In contrast, the transactivation domain in ELK1 was only required for act

129 and multiple site phosphorylation of the p53 transactivation domain in mediating its interaction with

130 partite transactivation mechanism, whereby a transactivation domain in the middle of the proteins (TA

131 rylates Thr90 of the Tal1 protein within its transactivation domain in vitro and in vivo.

132 Expression of the Myc transactivation domain increases CDK mRNA cap methylatio

133 N-terminal phosphorylation of the c-Jun transactivation domain increases target gene transcripti

134 ytokine production, in part by targeting the transactivation domain-induced recruitment of the histon

135 3alpha, a p63 isoform lacking the N-terminal transactivation domain, induces epithelial-mesenchymal t

136 y GSK3beta at three specific residues in its transactivation domain inhibits MEF2D transcriptional ac

137 The transactivation domain initiates with an extended region

138 Pax transactivation-domain interacting protein (PTIP) is a w

139 hy (SBMA), and the nuclear protein PTIP (Pax Transactivation-domain Interacting Protein), a protein w

140 on timing regulatory factor 1 (RIF1) and Pax transactivation domain-interacting protein (PTIP), in th

141 Pax transactivation domain-interacting protein (PTIP, or PAX

142 RCA1 C-terminal) domain-containing PTIP (Pax transactivation domain-interacting protein) chromatin re

143 oted by the BRCT domain-containing PTIP (Pax transactivation domain-interacting protein).

144 Pax2 transactivation domain interaction protein (PTIP), a pro

145 the recently described nuclear protein, Pax2 transactivation domain interaction protein (PTIP)-associ

146 -terminal region of Elf3, which contains the transactivation domain, interacts with its C terminus, w

147 ults indicate that precise folding of the E2 transactivation domain is crucial for its interaction wi

148 Although its C-terminal transactivation domain is dispensable for transcriptiona

149 ation, their relevance in the amino-terminal transactivation domain is unclear.

150 l for mammary gland development and contains transactivation domain isoforms, which have tumor-suppre

151 A key prediction is that the Tat transactivation domain makes modest contacts with the TA

152 tor both in vitro and in vivo through a Gli3 transactivation domain (MBD; MED12/Mediator-binding doma

153 Through binding to p53 at its N-terminal transactivation domain, mdm2 directly blocks the transcr

154 within the N-terminal 35 amino-acid minimal transactivation domain (MTD).

155 Importantly, replacement of the N-terminal transactivation domain (N-TAD) (but not the DNA binding

156 nal activation domains called the N-terminal transactivation domain (NTAD) and the C-terminal transac

157 The NH(2)-terminal transactivation domain, nuclear localization signal, and

158 ribed: (i) pocket protein binding blocks the transactivation domain of activator E2Fs, inhibiting E2F

159 KLF4 directly interacts with the C-terminal transactivation domain of beta-catenin and inhibits p300

160 n of Tax1BP1 interacting with the N-terminal transactivation domain of BPV1 E2.

161 Thus the transactivation domain of c-Jun recruits Mbd3/NuRD to AP

162 the folding of the intrinsically disordered transactivation domain of c-Myb (c-Myb) upon binding its

163 in-mutagenesis experiments revealed that the transactivation domain of c-Myb was necessary for restra

164 X domain of the CREB-binding protein and the transactivation domain of c-Myb.

165 tivated protein (MAP) kinase site within the transactivation domain of C/EBPepsilon, as being phospho

166 gamma fusion protein that is composed of the transactivation domain of CREB3L2 and all functional dom

167 The transactivation domain of E2 is crucial for interaction

168 The transactivation domain of E2 is required for each of the

169 cient cell lines and that the amino-terminal transactivation domain of E2 mediates association with t

170 om G1 to S phase, by directly binding to the transactivation domain of E2F and by binding to the prom

171 ciferase construct that was dependent on the transactivation domain of E2F1.

172 This amino acid lies in the transactivation domain of EBNA-2, and the S442D change i

173 l regulation of the intrinsically disordered transactivation domain of ERalpha.

174 pendently recruits one SRC-3 protein via the transactivation domain of ERalpha; the two SRC-3s in tur

175 l, Sp1-interactive domain and the C-terminal transactivation domain of FoxO4 are required for FoxO4-a

176 PTEN and FOXO3a regulate the transactivation domain of HIF-1alpha.

177 cetyltransferase activity, by the C-terminal transactivation domain of HIF-alpha (HIF-alphaCAD).

178 Using a series of deletion mutants, the transactivation domain of IGFBP-5 was mapped to its N-te

179 ing mutations were located in the C-terminal transactivation domain of KAT6A: NM_001099412.1: c.3116_

180 A PY motif in a transactivation domain of KLF5 is necessary for its inte

181 a 56-amino-acid sequence adjacent to a known transactivation domain of KLF5 significantly reduced its

182 typical point mutation in the amino-terminal transactivation domain of Myc(His), suggesting that most

183 r(893)), all of which are located within the transactivation domain of myocardin.

184 ajor satellite transcription, and the strong transactivation domain of NANOG is required for this org

185 -dependent) phosphorylation of Ser536 in the transactivation domain of NF-kappaB p65.

186 The transactivation domain of NFAT3 is found between amino a

187 a specific in vitro interaction between the transactivation domain of p53 (p53TAD) and a segment of

188 The interaction between the transactivation domain of p53 (p53TAD) and the N-termina

189 ns that have a higher affinity for the BOX-I transactivation domain of p53 and a reduced I(0.5) for p

190 The MDM2 N-terminal domain can bind to the transactivation domain of p53 and downregulate its abili

191 E1A efficiently competes with the N-terminal transactivation domain of p53 for binding to TAZ2 and th

192 The N-terminal transactivation domain of p53 interacts with several dom

193 We found that the transactivation domain of p53 made specific interactions

194 ve shown that Ser(20) phosphorylation in the transactivation domain of p53 mediates p300-catalyzed DN

195 HDM2 binds to an alpha-helical transactivation domain of p53, inhibiting its tumor supp

196 TFAM binds primarily to the N-terminal transactivation domain of p53, with a K(d) of 1.95 +/- 0

197 y MDM2 and/or MDMX binding to the N-terminal transactivation domain of p53.

198 clin/Cdk9 kinase complexes was mapped in the transactivation domain of p53.

199 f FAK directly interacts with the N-terminal transactivation domain of p53.

200 e N-terminal domain of MDM2 (MDM2N) with the transactivation domain of p53.

201 In addition, the N-terminal transactivation domain of p63 is indispensable for its p

202 involves phosphorylation of Ser(536) in the transactivation domain of RelA.

203 demonstrate that phosphorylation within the transactivation domain of RelA/p65(S536) displaces SMRT-

204 705)-STAT3 and indicated that the C-terminal transactivation domain of RTA was required for enhancing

205 induced phosphorylation at serine 754 in the transactivation domain of STAT3.

206 The 55-residue C-terminal transactivation domain of Stat3alpha is deleted in Stat3

207 ively active Stat5a, but did not require the transactivation domain of Stat5a.

208 udy demonstrates for the first time that the transactivation domain of the AhR influences important b

209 K directly interacts with the amino terminus transactivation domain of the AR to stabilise it thereby

210 The transactivation domain of the E2 protein is necessary an

211 led by Delta40p53, a p53 isoform lacking the transactivation domain of the full-length protein that m

212 The interaction between the acidic transactivation domain of the human tumor suppressor pro

213 cific RING-B-box E3 ligase and ligand of the transactivation domain of the serum response transcripti

214 minal domain of MDM4 binds to the N-terminal transactivation domain of the tumor suppressor p53 and i

215 and unambiguous assignment on the disordered transactivation domain of the tumor suppressor p53, alph

216 from the intrinsically disordered N-terminal transactivation domain of the tumor suppressor p53, both

217 ctrum of amino-acid substitutions within the transactivation domain of the v-maf avian musculoaponeur

218 f the IGF binding, nuclear localization, and transactivation domain of this multifunctional IGFBP.

219 F1 to the DNA binding domain of Gal4 and the transactivation domain of VP16, respectively, showing th

220 show that SHP physically interacts with the transactivation domain of XBP1s, thereby inhibiting the

221 edicted to result in the loss of part of the transactivation domain of YAP1, and sequencing of cDNA f

222 Here, we identify serine 118 in the transactivation domain of YY1 as the site of CK2alpha ph

223 ERGalt retains the DNA-binding and transactivation domains of ERG, but it inhibits wild-typ

224 mpact of the mutation on the DNA-binding and transactivation domains of FOXN1.

225 on factor sequences reveals that established transactivation domains of many transcription factors co

226 strated that the acidic domain, one of three transactivation domains of MTF-1, is required for recrui

227 genesis studies indicate that the C-terminal transactivation domains of Myocd and Smad3 are required

228 mplicated the RBPjk-association molecule and transactivation domains of Notch3 in generating choroida

229 apoptosis is reliant on the DNA-binding and transactivation domains of p53 but not on the acetylatio

230 ch four domains of p300 wrap around the four transactivation domains of p53.

231 3) Both zinc finger and glutamine-rich transactivation domains of Sp1 are involved in the Sp1-m

232 reas the DeltaN isoforms (lacking the acidic transactivation domain) of p63 and p73 are frequently ov

233 at select serine residues in the C-terminal transactivation domain on REL's transforming ability.

234 Two transactivation domains, one N-terminal and one C termin

235 -dependent degradation domain and C-terminal transactivation domain, our understanding of the contrib

236 A GATA4 mutation in the transactivation domain, p.G115W, was identified in famil

237 A well studied short sequence of the p53 transactivation domain, p53(15-29), binds weakly to four

238 dy, we probed the anticancer therapeutic p53 transactivation domain (p53TAD)/MDM2 interaction and its

239 Interestingly, disruption of the transactivation domain relieves the autoinhibition of El

240 L14 activates transcription in yeast, with a transactivation domain residing within the N-terminal re

241 It binds to the transactivation domain (residues 1-61) of p53 via an ext

242 rther delineate the functional region of the transactivation domain responsible for mitotic chromosom

243 Deletion of the transactivation domain retains the chromatin binding abi

244 cotransfection of an Rta mutant lacking its transactivation domain robustly restores transcriptional

245 mission EM, we noted that the p53 N-terminal transactivation domain significantly reduces aggregation

246 coding for proteins containing an N-terminal transactivation domain (TA isoforms) and for proteins la

247 horylated by IkappaB kinase (IKK) at S536 in transactivation domain (TAD) 1.

248 if3a blocked hyperosmotic increase of TonEBP-Transactivation Domain (TAD) activity, overall the knock

249 t lacks highly conserved residues within the transactivation domain (TAD) and has weak affinity for k

250 lly contain a DNA-binding domain (DBD) and a transactivation domain (TAD) and, although there are sev

251 In addition, the transactivation domain (TAD) appears to determine the pr

252 EZH2 harbors a hidden, partially disordered transactivation domain (TAD) capable of interacting with

253 eracted with six proteins of 35-152 kDa, its transactivation domain (TAD) interacted with four protei

254 The C-terminal transactivation domain (TAD) of BMAL1 (brain and muscle

255 ultiple residues within the carboxylterminal transactivation domain (TAD) of c-Fos, thus resulting in

256 ween the intrinsically disordered N-terminal transactivation domain (TAD) of p53 and the TAZ1 and TAZ

257 The transactivation domain (TAD) of p53 binds directly to se

258 binding interactions between the N-terminal transactivation domain (TAD) of p53, the TAZ1, TAZ2, KIX

259 ding of MDM2 to the intrinsically disordered transactivation domain (TAD) of p53.

260 le Ser/Thr residues that were located in the transactivation domain (TAD) of Stat3 and this in turn c

261 ivators on an alpha-helix located within the transactivation domain (TAD) of the BMAL1 C terminus.

262 interaction domain in the acidic C-terminal transactivation domain (TAD) of TRIP-Br2.

263 al ensembles of the intrinsically disordered transactivation domain (TAD) of tumor suppressor p53 and

264 ulated by interactions of BMAL1's C-terminal transactivation domain (TAD) with the KIX domain of CBP/

265 rix binding domain (SAPD) and the C/EBPdelta transactivation domain (TAD).

266 e Rel homology domain (RHD) and a C-terminal transactivation domain (TAD).

267 te that the latter residues constitute their transactivation domain (TAD).

268 h ligand-induced phosphorylation of the PRLr transactivation domain (TAD).

269 or, p53, requires direct binding between its transactivation domain (TAD, 1-57) and the transcription

270 family bind to the intrinsically disordered transactivation domain (TAD; residues 1-57) and C-termin

271 en-activated protein kinases (MAPK) in their transactivation domains (TAD) at so-called phosphoswitch

272 histone acetyltransferase (HAT) activity and transactivation domains (TAD) play essential roles for t

273 The p53 N terminus (NT) contains two transactivation domains (TAD1 and TAD2), a proline-rich

274 ntrinsically disordered transcription factor transactivation domains (TADs) function through structur

275 BP TAZ1 and TAZ2 domains in complex with the transactivation domains (TADs) of signal transducer and

276 amphioxus HIFalpha isoforms had 2 functional transactivation domains (TADs).

277 in the endoplasmic reticulum (ER) whilst its transactivation domains [TADs, including acidic domain 1

278 epithelial isoform containing the N-terminal transactivation domain (TAp63).

279 ingle amino acid substitutions within the E2 transactivation domain that are defective for both trans

280 influence Elf3 binding to DNA, including the transactivation domain that behaves as an autoinhibitory

281 roximity and orientation, and the C-terminal transactivation domain that interacts specifically with

282 pression, including a DNA binding domain and transactivation domains that are contained in the C-term

283 ic Notch protein (Notch1 ankyrin with Notch3 transactivation domain) that displayed superior signalin

284 f several functional domains: the N-terminal transactivation domain, the central sequence-specific DN

285 ted the phosphorylation of STAT1-S727 in the transactivation domain, thereby reducing recruitment of

286 ulatory motifs are located in the C-terminal transactivation domain, they are likely to be important

287 nted through direct recruitment of the NANOG transactivation domain to major satellites.

288 a more 'stand-alone' situation target Oct-4 transactivation domains to DNA using heterologous bindin

289 e relative contribution of the two HIF2alpha transactivation domains to hypoxic gene activation and r

290 xpressing dCas9 with the VPR transcriptional transactivation domains under the control of the Myh (my

291 et domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar re

292 f the bovine papillomavirus type 1 (BPV1) E2 transactivation domain was generated based on its homolo

293 ese functions were restored only when a VP16 transactivation domain was substituted.

294 e human papillomavirus type 16 E2 N-terminal transactivation domain, we found that amino acids requir

295 As Fra1 lacks transcriptional transactivation domains, we propose that Fra1 inhibits B

296 bstitutions in each conserved residue of the transactivation domain were tested for their ability to

297 active dead (d)Cas9 fused to transcriptional transactivation domains were developed for directing spe

298 e inhibitory domain (LID) that restrains the transactivation domain when glucose catabolism is minima

299 ous KLF7, we created a chimera with the VP16 transactivation domain, which displayed enhanced neurona

300 ough its intrinsically disordered C-terminal transactivation domain with the TAZ1 (also known as CH1)