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1 e CBP interaction domain of KLF5 reduces its transactivation function.
2 e present study provide a mechanism for KLF5 transactivation function.
3 r kappaB (NFkappaB) DNA-binding activity and transactivation function.
4 is the critical step for FGF2-induced Runx2 transactivation function.
5 d N-terminal of p53 (p53TAD) and inhibit its transactivation function.
6 loss of ligand binding and ligand-dependent transactivation function.
7 y important roles in both ligand binding and transactivation function.
8 e hypothesis that cyclin D1 targets the AF-1 transactivation function.
9 These 'hot spot' mutations abrogate p53's transactivation function.
10 protein stability, nuclear localization and transactivation function.
11 cellular factors that may be involved in its transactivation function.
12 in that binds to HIF-1alpha and inhibits its transactivation function.
13 la (A) and Asp (D), both of which retain the transactivation function.
14 duplication regulatory pathways require its transactivation function.
15 nd that this interaction is crucial for PTTG transactivation function.
16 nase cascade plays a role in regulating PTTG transactivation function.
17 ylation site plays an essential role in PTTG transactivation function.
18 is novel role of E2F-1 is independent of its transactivation function.
19 ng that this interaction is critical for p53 transactivation function.
20 Furthermore, this motif is not critical for transactivation function.
21 occurs independently of its transcriptional transactivation function.
22 recruit CREB binding protein (CBP) for their transactivation function.
23 tly leads to an inhibitory effect on c-Jun's transactivation function.
24 1 protein can inhibit both GATA-1 and GATA-2 transactivation function.
25 modifying the cysteine thiols, inhibits Tat transactivation function.
26 nd demonstrate that HPV16 E6 can inhibit its transactivation function.
27 t TAK is a cellular factor that mediates Tat transactivation function.
28 e II, is a cofactor for Tat and mediates its transactivation function.
29 cell line results in an inhibition of p53's transactivation function.
30 ns of the PST domain are responsible for the transactivation function.
31 ed the mechanism of action of the N-terminal transactivation function.
32 to Glu-271 substitution potentiated the CREB transactivation function.
33 to inhibit cell growth is dependent upon its transactivation function.
34 n factor, Gal4 (residues 1 to 147), exhibits transactivation function.
35 uppression of senescence by p53 required its transactivation function.
36 t phosphorylation is not essential for Tat-2 transactivation function.
37 mechanisms by which ERalpha suppresses p53's transactivation function.
38 l cycle progression and also for optimal E2F transactivation function.
39 nd this modification is important in ERalpha transactivation function.
40 by directly binding Runx2 and repressing its transactivation function.
41 BP/p300 recruitment and KIX-independent CREB transactivation function.
42 H2 and COOH domains, known to be involved in transactivation function.
43 1 is involved in the regulation of NF-kappaB transactivation function.
44 at is responsible for the ligand-independent transactivation function.
45 ly non-redundant and indispensable for C-TAD transactivation function.
46 dly reduced the estrogen receptor-alpha (ER) transactivation functions.
47 s interaction is required for specific Ets-1 transactivation functions.
48 nction as a coactivator for both AF1 and AF2 transactivation functions.
49 y a role in the growth factor-mediated STAT3 transactivation functions.
50 d not require its replication initiation and transactivation functions.
51 nd participated in growth factor-mediated ER transactivation functions.
52 trogen receptor, modulates estrogen receptor transactivation functions.
53 gamma2 could not repress estrogen-induced ER transactivation functions.
54 s suggests a potential interplay between the transactivation function-1 and -2 domains of ERalpha and
55 A complementary mutant mouse lacking the transactivation function AF-2 of ERalpha (ERalpha-AF2(0)
56 ant-negative RXR alpha (dnRXR alpha) lacking transactivation function AF-2 to differentiated suprabas
57 rolaxifene antagonize one estrogen receptor transactivation function (AF-2) and agonize another (AF-
60 P-binding domain that reduce GTP-binding and transactivation function also reduce self-association.
61 horylation of p73 at serine235 abrogates its transactivation function and causes cytoplasmic sequestr
63 -mediated MED12 depletion enhanced, both MBD transactivation function and Gli3 target gene induction
64 ass II promoter, resulting in an increase in transactivation function and in the expression of MHC cl
65 s a dual function domain, mediating both its transactivation function and its direct mitochondrial ap
66 tumor-derived p53 mutants which retain MDM2 transactivation function and possess partial growth supp
67 n to an inactive, stable p73 mutant restored transactivation function and rendered the mutant protein
69 de novel insights into the regulation of p53 transactivation function and suggest that Hzf functions
70 AF2 domain of ERRalpha1 is essential for the transactivation function and that deletion or mutation a
71 protein with TFIIB is necessary for its full transactivation function and that the IE-TFIIB interacti
72 We also demonstrate that Z decreases CREB transactivation function and that this inhibitory effect
73 stimulates estrogen receptor-alpha (ERalpha) transactivation functions and associates with the endoge
74 both the levels of NF-kappaB DNA binding and transactivation function, and both phases are dependent
75 IF3 is an ER coactivator, hyperstimulated ER transactivation functions, and associated with the endog
76 es with other ER coactivators, stimulates ER-transactivation functions, and associates with the endog
78 beta that reduce or abolish ligand-dependent transactivation function are associated with resistance
79 lts illustrate that distinct DNA binding and transactivation functions are encoded within the structu
81 -p53 interaction appears to downmodulate p53 transactivation function as indicated by PBK/TOPK knockd
82 mechanistic role in conferring an optimal ER transactivation function as well as the proliferation of
83 MTA1s peptide effectively repressed ERalpha transactivation function, as evidenced by the estrogen r
84 V-induced serine 392 phosphorylation and p53 transactivation function at higher levels of DRB suggest
86 region, which contains a ligand-independent transactivation function; (b) dependent on RXR homodimer
87 oblastoma protein but was independent of its transactivation function because AHR mutants lacking DNA
88 at the I87R mutant protein not only lost the transactivation function but also failed to bind DNA by
89 key Pro(139) residue not only disrupted the transactivation function but also resulted in the loss o
90 ed speckle association did not depend on p53 transactivation functions but required an intact proline
91 that this activity was independent of B-Myb transactivation function, but correlated with its capaci
92 stically increases the RA-dependent RARalpha transactivation function by enhancing the interaction of
93 ified p53, implicating modification of p53's transactivation function by protein-protein interaction.
94 ptional corepressor that inhibits HIF-1alpha transactivation function by recruiting histone deacetyla
95 human breast cancers, repression of ERalpha transactivation functions by LMO4 might contribute to th
97 y, further analysis in yeast showed that the transactivation function could be retained even in the p
98 A-binding domain, while not compromising p53 transactivation function (D48H/D49H and W53S/F54S), did
99 loss of subnuclear targeting and associated transactivation functions encoded by the C-terminus of t
100 1(Waf1/Cip1) (Waf1), a major target of p53's transactivation function, has been shown to be one of th
101 e duplication in a manner independent of its transactivation function in addition to its transactivat
104 tiestrogenic action of tamoxifen upon the ER transactivation function in hormone-sensitive cells.
108 es loss of YAP1, implicating transcriptional transactivation function in mediating force-enhanced cel
109 as a coactivator of RXRalpha, increasing its transactivation function in response to 9-cis-RA as evid
113 everse the mdm2-mediated inhibition of p53's transactivation function in vivo would probably target M
114 er-containing p53 target gene, modulates p53 transactivation functions in an autoregulatory feedback
115 otion, LMO4 overexpression repressed ERalpha transactivation functions in an HDAC-dependent manner.
116 can serve as a coactivator, potentiating the transactivation functions in steroid receptor HBDs, poss
117 Ser-271 but not Ser-133, and activates CREB transactivation function including brain-derived neurotr
119 ese mutant proteins retained transcriptional transactivation functions, indicating that phosphorylati
121 s, we demonstrate that Tax inhibition of p53 transactivation function is independent of sequence-spec
125 of the Z(S186A) mutant form of ZEBRA, whose transactivation function is manifest only by coexpressio
127 h inhibition, suggesting that an E2-specific transactivation function is required for growth arrest.
128 a CDK inhibitor and a major target of p53's transactivation function, is an effector of p53-mediated
129 of Cdk2-cyclin E and a major target of p53's transactivation function, is involved in coordinating th
131 racellular domain of ErbB4, and inhibits its transactivation function mediated through Yes-associated
142 ion of the E2-Brd4 interaction abrogates the transactivation function of E2, indicating that Brd4 is
143 t transcriptional repression rather than the transactivation function of E2F1 may be involved in its
144 Activation of Notch interferes with the transactivation function of EBNA2, downregulates the exp
149 hese results suggest that STRAP inhibits the transactivation function of EWS by displacing p300 from
155 hway, we found that triptolide abrogates the transactivation function of HSF1 without interfering in
156 phorylation also dramatically stimulated the transactivation function of HSF1: exposure to calyculin
157 activity of CBP does not play a role in the transactivation function of KLF5 nor does it acetylate K
160 ine-dependent transrepressor to downregulate transactivation function of MEF2 factors and that altern
161 mbined defects in DNA binding activities and transactivation function of mutant 219InsGPAX9 likely al
163 activity in Rb(-/-) fibroblasts restores the transactivation function of MyoD and the expression of a
164 ion of PPXY-1, but not PPXY-2, inhibited the transactivation function of NF-E2, providing support for
165 Here we demonstrate that Akt targets the transactivation function of NF-kappaB by stimulating the
171 A double point mutation that destroys the transactivation function of p53 also abolishes its bindi
172 tration that c-Abl binds to p53, induces the transactivation function of p53 and activates p21 expres
173 Here, we show that Skp2 counteracts the transactivation function of p53 and suppresses apoptosis
174 rminal epitope in the region involved in the transactivation function of p53 and the binding of Mdm2.
175 monstrate here that both the DNA binding and transactivation function of p53 are required for ASPP1 a
176 phosphorylation of p53 at Ser20 enhances the transactivation function of p53 for p21 and mdm-2 in viv
177 sely, ectopic expression of p300 rescues the transactivation function of p53 in cells overexpressing
178 at p300 contributes to the stabilization and transactivation function of p53 in the cellular response
179 xpectedly, RA has been found to activate the transactivation function of p53 in the human embryonal c
181 The uncoupling of the apoptotic function and transactivation function of p53 will also be discussed.
182 TIRR causes an aberrant increase in the gene transactivation function of p53, affecting several p53-m
186 e ability of PTEN to inhibit the TNF-induced transactivation function of p65 is important, because ex
188 tivation signals regulate the expression and transactivation function of retinoid X receptor (RXR) al
189 promoters, it can dramatically decrease the transactivation function of RRV Orf50 (Rta), which is th
190 nt evidence that ellipticine can restore the transactivation function of several transfected p53 muta
191 tanding of mechanisms underlying the central transactivation function of SOXE proteins, these finding
192 inding to the promoter but involves enhanced transactivation function of Sp1 via p38 MAPK activation.
194 induction of apoptosis was separate from the transactivation function of Tat, required expression of
200 on of NF-kappaB as well as by increasing the transactivation function of the RelA/p65 subunit of NF-k
202 utated, thus suggesting that the synergistic transactivation function of the TEF-1-Max heterotypic co
203 in expression of p53 was used to examine the transactivation function of the toxic mutations when exp
205 -16 in mammalian cells, had no effect on the transactivation function of their functional orthologs G
208 tor, was found not to be able to enhance the transactivation function of this mutant, our results ind
210 at aa 3 and 9 are critical for an N-terminal transactivation function of v-Rel, and the analysis of s
213 TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for
215 nd provided new evidence to suggest that the transactivation functions of ER might be influenced by t
216 raction is mandatory for the recruitment and transactivation functions of ER or DLC1 to the target ch
217 protein 1 (MTA1) represses ligand-dependent transactivation functions of estrogen receptor-alpha in
219 r, UBCH7 showed no significant effect on the transactivation functions of p53 and VP-16 activation do
220 igh correlation between the transforming and transactivation functions of PTTG and also indicate that
222 ogen-activated protein kinase and stimulated transactivation functions of the ER and expression of en
223 lished the Pak1-mediated phosphorylation and transactivation functions of the ER, while its mutation
226 with the pADH vector unveiled the intrinsic transactivation functions of YY1 and SRF previously not
227 T and CDK9, two critical components for Tat transactivation function on HIV-1 long terminal repeat p
228 fic inhibitor, PP2, resulted in decreased AR transactivation function on two different reporters, mou
229 c-Rel is not sufficient to fully restore the transactivation function; other sequences in the N-termi
230 o acids and to correlate phosphorylation and transactivation function, phosphopeptide maps were produ
231 1 also interacts with RTA and inhibits RTA's transactivation function, preventing the expression of i
232 We found that S305 activation-linked ER transactivation function requires a functional S118, and
234 estrogen-dependent and estrogen-independent transactivation functions signaled through hER-alpha66 a
235 We previously identified a carboxy-terminal transactivation function termed AF-2 within the last 15
236 at PELP1 modulates transcription factor E2F1 transactivation functions, that PELP1 is recruited to pR
237 e regulatory effect on their transcriptional transactivation function, the C-terminal domain of B-Myb
238 Pin1 impacts both ERalpha protein levels and transactivation function, these data implicate Pin1 as a
239 as a regulator of nuclear receptor-mediated transactivation, functions through recruitment of C-term
241 t Nmo phosphorylation of Eya potentiates its transactivation function to enhance transcription of Eya
242 could be explained by recruitment of the Arm transactivation function to the promoters of Hh-target g
244 ties of various compounds, we analyzed these transactivation functions using AF-1-truncated and AF-2-
246 identify essential domains required for EKLF transactivation function, we cotransfected a human eryth
247 dy the importance of phosphorylation for p53 transactivation function, we generated mutations at each
248 of molecular mechanisms underlying the Aire transactivation function, we screened an AIRE-dependent
249 various lengths of KLF5 fusion protein, the transactivation functions were localized to 156 amino ac
250 econstituted with active ZAP 70 regained the transactivation function, whereas cells expressing kinas
251 LFS) mutant was found to be defective in its transactivation function, which correlated with its inab
252 criptional complex in which EYA provides the transactivation function while SO provides the DNA bindi