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1 of epsilon(gamma-glutamyl)lysine crosslinks (transamidation).
2 ne, and that the cells thus are defective in transamidation.
3 glutamyl isomers as intermediate products of transamidation.
4 e to synthesize N-acyl pyrazoles followed by transamidation.
5  the kinetics of tRNA(Gln) glutamylation nor transamidation.
6  amide metathesis reactions that proceed via transamidation.
7 (< or =20 mol %) results in highly selective transamidation.
8 ether to form in high yields the products of transamidation.
9 ed high energy intermediate in Glu-tRNA(Gln) transamidation.
10 t glutamine hydrolysis is coupled tightly to transamidation.
11 s and aminolysis reactions during productive transamidation.
12  the protein in the endoplasmic reticulum by transamidation, a reaction in which a C-terminal GPI-att
13                                 Although the transamidation active site is similar to those of other
14  in cells exhibited enhanced GTP binding and transamidation activities and mimicked the survival adva
15         Moreover, both Gln-tRNA and Asn-tRNA transamidation activities are present.
16 I), which is capable of both GTP binding and transamidation activities, has been implicated in a vari
17                IL-1 beta and ATRA induced TG transamidation activity and calcification in wild-type b
18  activity of TGase-S is not dependent on its transamidation activity because the mutation of a cystei
19 drolyze GTP to GDP; binding GTP inhibits its transamidation activity but allows it to function in sig
20 uctural basis for the negative regulation of transamidation activity by bound nucleotide, and the pos
21                          Moreover, excessive transamidation activity did not appear to be detrimental
22 trate that the Ca(2+)-mediated regulation of transamidation activity is essential for the ability of
23 CXCR2 ligand GROalpha also induced increased transamidation activity of chondrocyte transglutaminases
24 ) from misacylated Glu-tRNA(Gln) through the transamidation activity of Glu-tRNA(Gln) amidotransferas
25 le inhibitors were identified that block the transamidation activity of hTG2 and allosterically aboli
26                   When assayed in vitro, the transamidation activity of TGase-II is Ca(2+)-dependent.
27       Recent studies have suggested that the transamidation activity of TGase-II is necessary for the
28 in a manner that does not require either TG2 transamidation activity or fibronectin binding.
29 is primarily known for its calcium-dependent transamidation activity that leads to formation of an is
30 ersible, noncompetitive inhibitor of TGase 3 transamidation activity, similar to GTPgammaS and GDP.
31                           In addition to its transamidation activity, TGase can bind guanosine 5'-tri
32 a2+ concentration reciprocally regulate TG's transamidation activity, with nucleotide binding being t
33 the Ca(2+)-mediated regulation of TGase-II's transamidation activity, with our goals being to identif
34 retains a wild-type level of NH(3)-dependent transamidation activity.
35  three sites inhibited the Ca(2+)-responsive transamidation activity.
36 nding/hydrolytic capability and an enzymatic transamidation activity.
37 yme that couples an ability to bind GTP with transamidation activity.
38                                          The transamidation (aminolysis) of phthalimide with primary
39 d expression/activation of TGase and in vivo transamidation and activation of RhoA.
40 ability of TGase to bind GTP and/or catalyze transamidation and found that GTP binding was sufficient
41 nctional protein with reciprocally regulated transamidation and purine nucleotide-binding activities,
42 ations to the plasma membrane by controlling transamidation and Rab4-GTP formation.
43 rt, formation, or usage in processes such as transamidation and translation.
44               Because bacteria primarily use transamidation, and the eukaryal cytoplasm uses glutamin
45 rter polymerization, we extended this direct transamidation approach to ultrahigh-molecular-weight (U
46            Competitive amidine formation and transamidation are observed with Cp*TiIV complexes, gene
47 iate filament proteins whose phosphorylation/transamidation associate with their aggregation in Mallo
48 minum(III) dimer Al2(NMe2)6 catalyzes facile transamidation between simple secondary carboxamides and
49 oester intermediate into an isopeptide bond (transamidation) but not in thioester hydrolysis (deamida
50  do not inhibit but instead activate TGase 3 transamidation by about 10-fold.
51 dation, intermolecular transpeptidation, and transamidation by added nucleophile.
52 al tail of FN are known to be susceptible to transamidation by both TG2 and activated blood coagulati
53 d nucleotide, and the positive regulation of transamidation by Ca2+.
54 ctivation of small GTPase RhoA via enzymatic transamidation by cytoplasmic tTG.
55 ases, substrate binding, Gln hydrolysis, and transamidation by Glu-AdT are tightly coordinated.
56 ctivity enabled a sequential, chemoselective transamidation by initially targeting the more reactive
57                             We conclude that transamidation by TG2 transforms S100A11 into a covalent
58                                              Transamidation catalytic activity of TG2 was not require
59 eover, S100A11 is covalently cross-linked by transamidation catalyzed by transglutaminase 2 (TG2), it
60 2 release modulates tissue repair, partly by transamidation-catalyzed covalent crosslinking of extrac
61 lymerizations, wherein side reactions (e.g., transamidation) compete with chain propagation, resultin
62  a nucleotide-bound closed conformation or a transamidation-competent open conformation.
63 ) and Gln-competitive, inhibition under full transamidation conditions mirrors the coupling between G
64 ertiary amides, which arises from successive transamidation cycles.
65 uble-mutants that were both GTP-binding- and transamidation-defective also stimulated cell death.
66 overexpression of wild-type tTG, but not its transamidation-defective counterpart, fully mimics the g
67       Microinjection of Rb(-/-) cells with a transamidation-defective TGase mutant and Rb afforded no
68 cts Rb from caspase-induced degradation in a transamidation-dependent manner.
69 different outcomes, amidine formation versus transamidation, depending on the identity of the TiIV co
70 on solution directly, as such intramolecular transamidation has been dramatically suppressed via kine
71 of primary amide substrates, secondary amide transamidation has remained elusive.
72 and catalyzes the cross-linking of proteins (transamidation), has been implicated both in the promoti
73 es were tolerated, showcasing the utility of transamidation in peptide modification and polymer degra
74 itu and, without isolation, are subjected to transamidation in the presence of zirconium chloride (0.
75 ation reactions and previously characterized transamidations involving secondary amides and primary a
76                                              Transamidation is a post-translational modification of p
77                 We hypothesized that protein transamidation is essential for MB formation.
78 n which its catalytic domain is exposed, but transamidation is not needed for the interaction.
79           This shows for the first time that transamidation is not only stabilizing the skin and the
80                       This demonstrates that transamidation is the only pathway to Gln-tRNAGln in B.
81 nd provide guidelines for the development of transamidation methods of the thioamide bond.
82 silient fertilization envelope: proteolysis, transamidation, NADPH-dependent oxidation and peroxidati
83 ransglutaminase (TG2, which is implicated in transamidation of 5-HT to Rac1) are observed in the mous
84 ulation of cells with high [5HT](ex) induces transamidation of a small GTPase, Rab4.
85            The scope of Lewis acid-catalyzed transamidation of acylated lactams was explored through
86 ge of amines in good to excellent yield, via transamidation of dimethylformamide.
87 anism we determined for gammaGTase-catalyzed transamidation of gammaGlu-AMC by Gly-Gly to form gammaG
88  uncompetitive inhibitor of Gly-Gly-promoted transamidation of gammaGlu-AMC.
89 glutaminylation of tRNAGln but by a specific transamidation of Glu-tRNAGln.
90 Through microbial transglutaminase-catalysed transamidation of gluten proteins using ethylamine as am
91               The alternative route involves transamidation of incorrectly charged tRNA.
92 of correctly charged Gln-tRNAGln through the transamidation of misacylated Glu-tRNAGln, functionally
93 de aminoacyl-tRNAs, Asn-tRNA or Gln-tRNA, by transamidation of mischarged Asp-tRNA(Asn) or Glu-tRNA(G
94                         (iii) Studies of the transamidation of N,N-dimethylated casein by Gly-OMe and
95 t a facile, highly chemoselective method for transamidation of N-tert-butoxycarbonylation (N-Boc) act
96 y, we unveil a novel approach for the direct transamidation of PDMA, leveraging recent advances in th
97 e advances have been made with regard to the transamidation of primary amide substrates, secondary am
98                        Two protocols for the transamidation of primary amides with primary and second
99 The activation of TGase results in increased transamidation of RhoA, which is inhibited by monodansyl
100 ling, which involves activation of TGase and transamidation of RhoA.
101                         The highly efficient transamidation of several primary, secondary, and tertia
102 osttranslational modification of proteins by transamidation of specific polypeptide-bound glutamine r
103 Me2)6, promote facile equilibrium-controlled transamidation of tertiary carboxamides with secondary a
104                                              Transamidation of the benzamide product is enabled by re
105 processed GPI-anchored proteins and identify transamidation of the GPI signal sequence as a step in P
106 port the first general method for the direct transamidation of thioamides by highly chemoselective N-
107      A long-standing challenge is the direct transamidation of thioamides, a process which would conv
108 modification strategies by pioneering direct transamidation of unactivated amides but also provides a
109 n of PDMA, leveraging recent advances in the transamidation of unactivated tertiary amide substrates.
110                              The challenging transamidation of unactivated tertiary amides has been a
111 of this study include: (i) gpTGase-catalyzed transamidation of Z-Gln-Gly by Gly-OMe proceeds essentia
112  by LipL, which catalyses the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-Gcv
113           Transglutaminase 2 (TG2) catalyzes transamidation or deamidation of its substrates and is o
114 oming the classic problem of secondary amide transamidation, our studies expand the growing repertoir
115 m and underlying protein dynamics that favor transamidation over deamidation, while revealing a cruci
116                We wondered whether a similar transamidation pathway also operates in the formation of
117 ctrum of bacteria rely on the tRNA-dependent transamidation pathway as the sole route to asparagine.
118                We demonstrate that an entire transamidation pathway composed of aspartyl-tRNA synthet
119 rly work suggested that mitochondria use the transamidation pathway for Gln-tRNA formation.
120 most surprising of these findings has been a transamidation pathway for the synthesis of asparaginyl-
121  the operon for the essential tRNA-dependent transamidation pathway harbors a SL with two potential o
122                                    Thus, the transamidation pathway operates only for Gin-tRNAGln for
123 cteria, archaea, and chloroplasts employ the transamidation pathway, in which a tRNA-dependent glutam
124          Instead, Gln-tRNA is formed via the transamidation pathway, the other route to this essentia
125 -tRNA(Asn) amidotransferase, employed by the transamidation pathway.
126 is made from aspartate in the tRNA-dependent transamidation pathway.
127 e expression and amino acid biosynthesis via transamidation pathways.
128                        In a number of cases, transamidation proceeds rapidly at room temperature.
129 mides and nucleophilic amines, affording the transamidation products in excellent yields through dire
130 [5]rotaxane synthesized using a dual-opening transamidation pump was structurally characterized by si
131  PCY1 S9A protease fold has been adapted for transamidation, rather than hydrolysis, of acyl-enzyme i
132               The approach involves a tandem transamidation reaction cascade that integrates intein-m
133 r parameters relating to the kinetics of the transamidation reaction in the context of rough microsom
134  the endoplasmic reticulum and consists of a transamidation reaction in which fully assembled GPI anc
135 oring of cell surface proteins consists of a transamidation reaction in which preassembled GPI donors
136  the proof that GPI anchoring proceeds via a transamidation reaction mechanism.
137 on of the lactam, and a lanthanide-catalyzed transamidation reaction of the Fmoc-protected lactam, us
138  proposed mechanism of the GPI transfer is a transamidation reaction that involves the formation of a
139 tributed the positive effect of CO(2) in the transamidation reaction to the stabilization of tetrahed
140 erazine unit occurring via an intermolecular transamidation reaction under mild condition, resulting
141 id requirements at the COOH terminus for the transamidation reaction using HDZ as the nucleophilic ac
142 ynthetic chemistry is the development of the transamidation reaction.
143  of these amino acids as amide donors in the transamidation reaction.
144 chanistic differences between these tertiary transamidation reactions and previously characterized tr
145                                              Transamidation reactions are often mediated by reactive
146 ficient catalysts for equilibrium-controlled transamidation reactions between secondary amines and te
147 ons and previous mechanistic suggestions for transamidation reactions catalyzed by transition metals
148 ies in the Suzuki-Miyaura cross-coupling and transamidation reactions provide insight into the reacti
149                                              Transamidation reactions represent a fundamental chemica
150  the presence of catalytic amounts of CO(2), transamidation reactions were accelerated with primary,
151                                 However, the transamidation route to Gln-tRNA formation is idled by t
152 tal-free domino hydroamination/isomerization/transamidation sequence, delivering trifluorinated-5-met
153 y on glutamines at either end of (1-5)F1 and transamidation specificity of both enzymes is achieved t
154                                          The transamidation step was performed without the need to pu
155 uble point mutant (K3R/Q102N) of S100A11 TG2 transamidation substrate sites.
156                               In addition to transamidation, TG2 also functions as a Galpha signaling
157                          In one protocol for transamidation, the N'-acyl-N,N-dialkylformamidine inter
158  to contemporary cells, or cenancestor, used transamidation to synthesize Gln-tRNA(Gln) and that both
159 t that the ability of TGase to modify Rb via transamidation underlies the ability of TGase to provide
160 es and amines are found to undergo efficient transamidation using the methods described.
161 a distinct reactivity in the CO(2)-catalyzed transamidation versus a N(2) atmosphere.
162                                        As no transamidation was observed, we searched for genes for a
163                                Inhibitors of transamidation were effective in blocking the hydrolysis
164           We expect that this new metal-free transamidation will have broad implications for the deve
165                                              Transamidation with a selected amine (isobutylamine or 2

 
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