ライフサイエンスコーパス: transamination

1 e protein synthesis (PS) and reduced leucine transamination.

2 nhancing AA-induced PS, and reducing leucine transamination.

3 P-dependent reactions in solution, including transamination.

4 turnover, suggesting a lower rate of leucine transamination.

5 Hyperglucagonemia did not affect leucine transamination.

6 hways, reversible dissociation and conjugate transamination.

7 ces to be highly reactive toward RS-mediated transamination.

8 of E1 toward dehydration, epimerization, and transamination.

9 etone body production, glucose synthesis and transamination.

10 Neither enantiomer is a substrate for transamination.

11 HF elimination than GABA is a substrate for transamination.

12 ced functional enzymes that catalyze alanine transamination.

13 me could not efficiently catalyze kynurenine transamination.

14 d rate of inactivation by substrate-mediated transamination.

15 for allosteric activation and glutamate from transaminations.

16 n biosynthesis(8-10) and aromatic amino acid transamination,(11) respectively, were required to initi

17 also presented that this substrate-mediated transamination accelerates normal degradation of S-adeno

18 residues critical for the dehydration versus transamination activity.

19 ne carbon flux, indicating increased leucine transamination (an important biochemical process for nit

20 aracterized metabolite produced by glutamine transamination and an unrecognized intermediate of endot

21 ized to monitor stereoselective biocatalytic transamination and assign the absolute configuration of

22 complish this by introducing three exogenous transamination and deamination cycles, which provide an

23 utilized for biosynthetic processes through transamination and deamination reactions.

24 lglycine decarboxylase, which catalyzes both transamination and decarboxylation half-reactions in its

25 r many important enzymatic reactions such as transamination and decarboxylation.

26 from the BCATc(-/-) mouse exhibit lower Leu transamination and higher intracellular Leu concentratio

27 imates of the in vivo rates of phenylalanine transamination and protein degradation.

28 es may also be common to pyridoxal-catalyzed transamination and related reactions in biological syste

29 ys performed with these mutants show that RS transamination and subsequent modification with alkoxyam

30 Transamination and the two decarboxylase systems (NADP-m

31 compartment model and assuming insignificant transamination and transmethylation in this tissue.

32 reactions typically proceed by electrophilic transamination and/or addition-elimination reaction mech

33 ecific activity with the serine : glyoxylate transamination, and apparent Km measurements indicate th

34 DMSP via three known pathways (methylation, transamination, and decarboxylation) and metabolize DMSP

35 involves a carboligation step, a subsequent transamination, and finally a Pictet-Spengler reaction w

36 thway intermediates revealed that methionine transamination, and not the transmethylation or transsul

37 into the hepatic vein, leucine oxidation and transamination, and synthesis and degradation of hepatic

38 d to undergo beta-elimination in addition to transamination, and the transamination product of N-term

39 nd introducing the nitrogen by oxidation and transamination at C-3.

40 ditions, they undergo catalyst-free, dynamic transamination at elevated temperatures, paving the way

41 tetrahydrohydroxyphenylpyruvate (H(4)HPP), a transamination away (via BacF) from 2S-H(4)Tyr.

42 to 3,5-dihydroxyphenylglyoxylate, which is a transamination away from Dpg.

43 boxylase-catalyzed decarboxylation-dependent transamination between 2-aminoisobutyrate (AIB) and pyru

44 notransferase (ALT) catalyzes the reversible transamination between alanine and 2-oxoglutarate to for

45 used radiochemical procedure, which measures transamination between alpha-ketoiso[1-14C]valerate and

46 Transamination between glutamine and alpha-keto-gamma-me

47 Transamination between L-glutamate (or L-phenylalanine)

48 The products resulting from transamination between L-phenylalanine and the alpha-ket

49 al phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto aci

50 notransferases were identified that catalyze transamination between several L-amino acids (e.g., phen

51 y to act as a substrate for GABA-AT, not for transamination, but for HF elimination.

52 ital to the 1,3-prototropic shift central to transamination, but not to reactions catalyzed by alanin

53 lases were inactivated by substrate-mediated transamination, but this reaction occurred much more fre

54 The hBCATm-catalyzed transamination can be described in molecular terms toget

55 including hydrazone formation and Katritzky transamination, can be monitored simultaneously without

56 al recombinant enzyme that catalyzes alanine transamination, confirming that the enzyme is an ALT.

57 t for alanine and glutamate, indicating that transamination contributes to the restoration of the met

58 The enzymatic transamination cycles that are key to modern biochemical

59 d (DP), whose formation involves consecutive transamination, cyclization, and isomerization steps.

60 The combined transamination-deoxygenation activity places ColD in a c

61 he putative contribution of two beta-alanine transamination enzymes, namely 4-aminobutyrate-2-oxoglut

62 4-amino-4,6-dideoxy-d-glucose that couples a transamination equilibrium to the thermodynamically favo

63 ism of inactivation most probably involves a transamination followed by aromatization to form an arom

64 The rate-determining step for transamination follows the formation of the quinonoid in

65 metabolism, linking carbohydrate metabolism, transamination, glycine, and folate-mediated one-carbon

66 m of DGD-PLP is 25 s(-1), while that for the transamination half-reaction between DGD-PMP and pyruvat

67 The primary [2-(2)H]-L-alanine KIE on the transamination half-reaction is unity.

68 The maximal rate constant for the transamination half-reaction of the potassium form of DG

69 the ketimine intermediate for the L-alanine transamination half-reaction.

70 ad-time of the stopped-flow in the L-alanine transamination half-reaction.

71 and breaking in both the decarboxylation and transamination half-reactions occurs at the "A" subsite,

72 The spectra for the first species in the transamination half-reactions of L-alanine and L-aminobu

73 osphate (PLP) catalyzed decarboxylations and transaminations have been revisited experimentally.

74 AAs also enhanced leucine transamination in both splanchnic and muscle beds.

75 zyme that catalyzes both decarboxylation and transamination in its normal catalytic cycle.

76 had no effect on protein dynamics or leucine transamination in splanchnic bed.

77 yzes two reaction types, decarboxylation and transamination, in the same active site.

78 The fact that a transamination initiates this pathway could help explain

79 oves the alpha-amino group of L-arginine via transamination instead of oxidative deamination by dehyd

80 city for beta-elimination/replacement versus transamination is dictated in part by the protonation st

81 e-determining step in the PL-metal-catalyzed transamination is different from metal-free and biologic

82 Ethylamine transamination is inhibited 4-fold by Al(3+) metalation,

83 d 4-fold by Al(3+) metalation, while alanine transamination is inhibited only 1.3-fold.

84 ucing bacteria, its catalysis of periplasmic transaminations is most likely a general tool for specif

85 tory T (iTreg) cells, we show that increased transamination, mainly catalysed by GOT1, leads to incre

86 that the enzyme metabolizes 1 according to a transamination mechanism.

87 the transmethylation, transsulfuration, and transamination metabolic pathways.

88 diastereo- and enantioselective biocatalytic transamination method to prepare a broad range of aromat

89 transaminase responsible for catalyzing the transamination of 3-hydroxykynurenine (3-HK) to xanthure

90 is primarily responsible for catalyzing the transamination of 3-hydroxykynurenine (3-HK) to xanthure

91 the pyridoxal phosphate-dependent equatorial transamination of 3-oxo-alpha-D-glucose 6-phosphate to f

92 catalyses the pyridoxal phosphate-dependent transamination of 7-keto-8-aminopelargonic acid to produ

93 ate from [alpha,delta-(15)N(2)]ornithine and transamination of [(15)N]glutamate to [(15)N]aspartate.

94 It catalyzes the transamination of a number of amino acids and uses many

95 no acids by decarboxylation or amination and transamination of aldehydes and ketones.

96 However, biology employs transamination of alpha-ketoacids to synthesize amino ac

97 eading to accelerated leucine catabolism and transamination of alpha-ketoglutarate to glutamate, with

98 , catalyzing the N-acetylornithine-dependent transamination of alpha-ketoglutarate.

99 cids were the preferred amino donors for the transamination of alpha-ketomethiobutyrate to methionine

100 ed asymmetric hydrogenation of an enamide or transamination of an arylketone that provided the corres

101 This enzyme catalyzed the transamination of aspartate, glutamate, phosphoserine, a

102 BCAT1 catalyzes the transamination of branched-chain amino acids while conve

103 ation was achieved via a bisulfite-catalyzed transamination of cytosine after endonuclease cleavage o

104 ary amides of iron(II), were obtained by the transamination of Fe{N(SiMe(3))(2)}(2), with HN(SiMe(3))

105 The (R)-enantiomer also inhibits the transamination of GABA 10 times more effectively than th

106 The best enzyme mimic accelerated the transamination of indole-3-pyruvic acid by a factor of 4

107 thionine decarboxylase by substrate-mediated transamination of its pyruvoyl cofactor.

108 These data indicate that KICSIS requires transamination of KIC and glutamate to leucine and alpha

109 erase II (hKAT-II) efficiently catalyzes the transamination of knunrenine to kynurenic acid (KYNA).

110 mKAT III is able to efficiently catalyze the transamination of kynurenine to KYNA and has optimum act

111 ased by d-amphetamine may interfere with the transamination of L-kynurenine to KYNA specifically in t

112 Transamination of L-leucine with alpha-ketoglutarate res

113 , including those formed by TATase-catalyzed transamination of l-phenylalanine, l-tyrosine, l-tryptop

114 chain aminotransferase) catalyzes reversible transamination of leucine and alpha-ketoglutarate to KIC

115 The kinetic parameters determined for the transamination of phenylalanine by TATase (kcat = 180 s-

116 rst step in phenyllactic acid synthesis, the transamination of phenylalanine to phenylpyruvate.

117 We elucidate the biochemistry underlying the transamination of phosphonopyruvate to PnAla, a new earl

118 sms, an aminotransferase is required for the transamination of prephenate into arogenate, but the ide

119 ry study we have also established the direct transamination of sugars to give acyclic aminopolyols.

120 Moreover, a novel reductive transamination of tertiary amides is also achievable whe

121 of UDP-glucuronic acid, followed by the C-4" transamination of the product to generate the novel suga

122 nvolve oxidation of the 5'-alcohol by Pac11, transamination of the resulting aldehyde by Pac5, and de

123 One plausible explanation is the transamination of the three acids to produce glutamic ac

124 Transamination of {(PEt(3))(2)RhN(SiMePh(2))(2)} (1a) or

125 or a range of protein substrates, N-terminal transamination offers a convenient way to install a reac

126 Neither compound can be oxidized by a transamination or addition/elimination mechanism, but bo

127 H positions with a stereoselective enzymatic transamination or carbonyl reduction step.

128 ntioselective reduction and enantioselective transamination, our systems exhibit long-term stability

129 ionine and derived-sulfur metabolites in the transamination pathway activate the GCN5 acetyltransfera

130 SP, probably using the same methionine (Met) transamination pathway as macroalgae and phytoplankton(1

131 to dopamine and suggest this may occur via a transamination pathway in which DHPPA is an intermediary

132 onal DMSP biosynthesis enzyme, DsyGD, in the transamination pathway of the rhizobacterium Gynuella su

133 The transamination product of leucine, alpha-ketoisocaproic

134 ation in addition to transamination, and the transamination product of N-terminal Gln was resistant t

135 matic ketoacids, including indolepyruvate, a transamination product of tryptophan.

136 ularly leucine, and can be reproduced by its transamination product, ketoisocaproic acid.

137 ed Delta(1)-piperideine-2-carboxylate as its transamination product.

138 were employed to detect the presence of the transamination products 2-ketoarginine and L-alanine, th

139 imulates PHAS-I phosphorylation although the transamination products of isoleucine and valine are ine

140 dapD and dapE mutants and to catalyze LL-DAP transamination, providing functional evidence for a role

141 treatment reduced leucine nitrogen flux and transamination rates in subjects with type 2 diabetes.

142 iabetic subjects, but leucine nitrogen flux, transamination rates, and plasma ketoisocaproate level w

143 capable of facilitating further steps of the transamination reaction after the formation of the exter

144 rcaptopyruvic acid (VI, formed by a Cys-APAP transamination reaction in kidney), 3,3'-biacetaminophen

145 This was followed by a bisulfite-catalyzed transamination reaction in order to biotinylate the dsDN

146 The transamination reaction of ethylamine is 75-fold slower

147 specific protein modification method using a transamination reaction that chemoselectively oxidizes t

148 usively catalyze a decarboxylation-dependent transamination reaction to form pyridoxamine 5-phosphate

149 no group of TM to a carbonyl group through a transamination reaction with glyoxylate produced a prote

150 The transamination reaction with l-alanine was coupled in th

151 (CH(3))(2)N)(4)Ti, TDMAT), which undergoes a transamination reaction with sufficiently nucleophilic a

152 ate at which the enzyme catalyses its normal transamination reaction.

153 stage of SGA biosynthesis through an unknown transamination reaction.

154 s) catalyze pyridoxal 5'-phosphate-dependent transamination reactions between amino donor and keto ac

155 o exhibit substantial cooperative effects in transamination reactions catalyzed by pyridoxal (PL), a

156 the block of its conversion to lactate, with transamination reactions converting pyruvate to form the

157 The one-pot transamination reactions on a zwitterionic benzoquinonem

158 auxotrophy either by producing glutamate via transamination reactions or by their conversion to gluta

159 We previously showed that in decarboxylative transamination reactions under credible prebiotic condit

160 xpressed in Escherichia coli catalyzed three transamination reactions using the following amino donor

161 somal photorespiratory enzyme that catalyzes transamination reactions with multiple substrates.

162 ozymes, the channeling of metabolic flow via transamination reactions, and active transport mechanism

163 ter 1) supplies glutamine, an amino donor in transamination reactions, to bacteriocytes (where Buchne

164 This finding establishes RS as a transamination reagent that is particularly well suited

165 lt, RS) was identified as a highly effective transamination reagent when paired with glutamate-termin

166 benzenesulfonate (Rapoport's salt, RS) as a transamination reagent, which oxidizes the N-terminal am

167 creening platform as a method to explore new transamination reagents while simultaneously identifying

168 From methionine, the steps are transamination, reduction and S-methylation to give the

169 This pathway involves an initial transamination step followed by tautomerization to form

170 ependent and its catalysis is initiated by a transamination step in which pyridoxal 5'-phosphate (PLP

171 organic synthesis, including the following: transamination substitution reactions with virtually any

172 was found to be 90-fold faster at catalyzing transamination than PL alone and 174-fold faster than Fe

173 ion, 6,8-dehydration, 4-epimerization, and 6-transamination that convert GDP-D-erythro-alpha-D-gluco-

174 Transamination, the biological process by which ammonia

175 nistic investigation demonstrates that, upon transamination, the lysine-derived ketone byproduct read

176 s a mitochondrial fuel source in neurons via transamination to alpha-ketoglutarate and subsequent red

177 uence of the need for increased reactions of transamination to cope with the liver metabolic derangem

178 sequent regio- and stereoselective enzymatic transamination to form densely functionalized homochiral

179 pha-ketobutyrate and ammonia) and L-alanine (transamination to form pyruvate), which have uncharged s

180 tein was proposed to catalyze the subsequent transamination to form UDP 2-acetamido-3-amino-2,3-dideo

181 alpha-(32)P]UDP-glucuronic acid, followed by transamination to generate [alpha-(32)P]UDP-l-Ara4N, whe

182 ual aspartate was liberated enzymatically by transamination to oxaloacetate with aspartate aminotrans

183 c acid is derived from phenylalanine via its transamination to phenylpyruvate, and mining of the tran

184 re, we investigate which metal ions catalyze transamination under conditions relevant to biology (pH

185 suppressed by hepatic and renal beta-alanine transamination upon oral beta-alanine intake.

186 Although leucine oxidation and KIC transamination were blocked in BCATm(-/-) islets, KIC ox

187 ction of BCATc correlates with increased Leu transamination, whereas T cells from the BCATc(-/-) mous

188 nates the pyridine nitrogen for catalysis of transamination, while both alanine racemase and O-acetyl

189 l-4-chloro-piperidine, were accomplished via transamination with a quaternary ammonium piperidone or

190 d dehydration of serine (Ser) coupled with a transamination with glycine (Gly), to produce both pyruv

191 al route for the synthesis of amino acids by transamination with glycine, paralleling the extant meta

192 ine in the reaction mixture is followed by a transamination with oleylamine, the solvent of the react

193 acid is a substrate for YwfG, which promotes transamination (with L-Phe as amino donor), to form tetr