ライフサイエンスコーパス: transcellular

1 racellular) or directly through the EC body (transcellular).

2 reduced the development of thrombin-induced transcellular actin stress fibers, cellular contractions

3 led to the secretion of group V PLA2 and its transcellular action on neighboring human neutrophils an

4 The transcellular activity of group V PLA2 was highly depend

5 whereas group IIA PLA2 exhibited much lower transcellular activity.

6 nducing intracellular aggregation and blocks transcellular aggregate propagation.

7 howed that albumin passage was predominantly transcellular and demonstrated colocalization of albumin

8 observed, suggesting that fluid leakage was transcellular and directly attributable to infecting vir

9 plicate WNK signaling in the coordination of transcellular and paracellular flux to achieve NaCl and

10 trations, epithelial membrane potential, and transcellular and paracellular fluxes.

11 Both transcellular and paracellular pathways of vascular solu

12 ntial physiological interactions between the transcellular and paracellular pathways of water transpo

13 ced pulmonary vascular hyperpermeability via transcellular and paracellular pathways.

14 HFg) mice were used to study cerebrovascular transcellular and paracellular permeability in vivo.

15 rimination with respect to the permeation of transcellular and paracellular probes, e.g. permeability

16 lecular mechanism involving AQP5 that allows transcellular and paracellular routes of water transport

17 ellularly, whereas sodium reabsorption takes transcellular and paracellular routes.

18 hin and between cells represent pathways for transcellular and paracellular transport of fluid.

19 the kidney, the proximal tubule allows both transcellular and paracellular transport, while the coll

20 demonstrates that the diffusion is primarily transcellular and the main barrier is located in the lip

21 paracellular) and through endothelial cells (transcellular) appear to be distinct processes.

22 ockout animals despite normal effects on the transcellular aquaporin-2-dependent pathway.

23 l convergence forces in the context of these transcellular arrays.

24 ced epithelial barriers in vitro, preventing transcellular bacteria dissemination.

25 d was associated with the restoration of the transcellular barrier and the re-establishment of apical

26 in endothelial cells form a paracellular and transcellular barrier to many blood-borne solutes via ti

27 thereby providing a mechanism for ameloblast transcellular bicarbonate secretion in the process of en

28 arious neural cells including neurons, their transcellular binding could be restricted to discrete si

29 not induce synapses, indicating that Kirrel3 transcellular binding is necessary but not sufficient fo

30 Two tested variants lack homophilic transcellular binding, which likely accounts for their r

31 n Kirrel3-expressing neurons via homophilic, transcellular binding.

32 bitory factor (Cif), can disrupt 15-epi LXA4 transcellular biosynthesis and function.

33 tions, namely RvTs, derived from n-3 DPA via transcellular biosynthesis and increased by atorvastatin

34 hydrolase-deficient mice, we show here that transcellular biosynthesis contributes to the production

35 providing unequivocal evidence of efficient transcellular biosynthesis of cysLTs.

36 o studies indicate that this process, termed transcellular biosynthesis, can lead to the production o

37 One intriguing aspect of LT production is transcellular biosynthesis: cells expressing 5-lipoxygen

38 t a pathogenic mechanism for FHHNC involving transcellular Ca(2+) pathway in the DCT and identify a m

39 Unexpectedly, proteins involved in transcellular Ca(2+) reabsorption in DCTs were not decre

40 potential vanilloid 5) is the gatekeeper of transcellular Ca(2+) reabsorption in the distal nephron.

41 mal models suggest may develop from impaired transcellular Ca(2+) reabsorption via TRPV5 in the dista

42 id type 5 (TRPV5) Ca(2+) channel facilitates transcellular Ca(2+) transport in the distal convoluted

43 l Ca(2+) channel TRPV6, which is involved in transcellular Ca(2+) transport in the intestine using th

44 ose or starch had higher rates of intestinal transcellular Ca(2+) transport, elevated intestinal and

45 riginate store-operated Ca(2+) entry-induced transcellular Ca(2+) waves that propagate glial excitati

46 activation of the basolateral CaR increases transcellular calcium transport independent of its effec

47 excavation requires both cellular energy and transcellular calcium transport, mediated by P-type ATPa

48 dels to account for the emerging concepts on transcellular calcium transport.

49 Transcellular chaperone signaling leads to the compensat

50 We propose that transcellular chaperone signaling provides a critical co

51 This transcellular chaperone signaling response maintains org

52 ecific sensory neurons and by the process of transcellular chaperone signaling.

53 Transcellular Cl(-) and HCO(3)(-) transport is a vital f

54 e that prostacyclin generation can arise via transcellular collaboration between platelets and fibrob

55 The proteostasis network is regulated by transcellular communication to promote health and fitnes

56 Our data indicate that transcellular competitive processes govern synapse forma

57 Mechanical stress (30-cm H(2)O transcellular compressive stress) applied for 3 h induce

58 the junctional line, forming an integrated, transcellular contractile network.

59 Inhibition of ROCK activity, which drives transcellular contractility, restored adhesion of TNCEGF

60 adhesion to endothelial cells and augmented transcellular conversion of leukotrienes, a disturbance

61 s cells invade the central nervous system by transcellular crossing of the endothelium of the BBB.

62 gated the contribution of platelet-dependent transcellular cysLT production in AERD.

63 We examined transcellular cysLT synthesis during zymosan-induced per

64 Due to the absence of a transcellular cytoskeleton, RBC shape is determined by t

65 6 microL/min per mm Hg/cm(2) with an average transcellular decrease in pressure of 3.33 +/- 0.16 mm H

66 This transcellular degradation of mitochondria, or transmitop

67 e requirements for developing novel CPPs for transcellular delivery of cargo.

68 Hence, efficient transcellular delivery of IgG-based drugs across human e

69 Transcellular delivery of LTA(4) from marrow-derived cel

70 naling in alveolar epithelial cells (ECs) by transcellular delivery of suppressor of cytokine signali

71 Secretion and transcellular delivery of vesicular SOCS proteins thus r

72 croparticles are generated and function as a transcellular delivery system will advance our basic und

73 Transcellular dendrites scanned the M-cell apical surfac

74 ial cells searching for areas permissive for transcellular diapedesis.

75 monstrate that virtually all, both para- and transcellular, diapedesis occurs in the context of a nov

76 absolute NL1 levels but instead depended on transcellular differences in the relative amounts of NL1

77 sis and effectively enhance paracellular and transcellular diffusion of drugs (e.g., adjudin) across

78 o hundreds of co-activated elements, and the transcellular DNase I sensitivity pattern at a given reg

79 ZO-1) and occludin and form a barrier with a transcellular electrical resistance (TCER) greater than

80 ut using diffusion of sodium fluorescein and transcellular electrical resistance (TER).

81 n, increased FITC dextran leakage, decreased transcellular electrical resistance and increased angiog

82 HC) electromotility was examined by means of transcellular electrical stimulation in a partitioning m

83 h kinase ligand, ephrinB1, and proposed that transcellular Eph/ephrin interactions made possible by t

84 results highlight the potential relevance of transcellular exchange of LTA(4) for the synthesis of LT

85 have shunted the PD, while at the same time transcellular fluid transport remained unaffected.

86 r and/or in surviving acinar cells, to drive transcellular flux of interstitial fluid into the labyri

87 n quality control mechanisms can promote the transcellular flux of these proteins in exosomes.

88 Therefore, stepwise impairment of transcellular followed by paracellular barrier mechanism

89 d with attenuated phosphorylation of the key transcellular glycoprotein (gp) 130.

90 Using a transcellular GPCR signaling platform, we report that EL

91 we demonstrate that IF stresses result in a transcellular gradient in beta1-integrin activation with

92 tive, tempering the alkaline pH generated by transcellular HCO(3) (-) secretion.

93 - exchanger in the apical membrane to affect transcellular HCO3- transport.

94 iabetes-associated myelopoiesis, whereas its transcellular hematostromal activation links myelopoiesi

95 We provide definitive evidence for transcellular (i.e., through individual endothelial cell

96 lation by approximately 60%, suggesting that transcellular ICl,swell largely mediates the increased c

97 ing limb of the loop of Henle, whereas it is transcellular in the distal convoluted tubule.

98 to M2, reduced Osm expression, and prevented transcellular induction of Cxcl12 In diabetic mice, piog

99 colonization initiates in root hairs through transcellular infection threads.

100 vectoral transport, and confocal imaging of transcellular insulin transport.

101 formation by providing evidence that Kirrel3 transcellular interactions mediate target recognition an

102 , and synaptogenesis, with less attention to transcellular interactions that coordinate neurodevelopm

103 oligin-2 on insulin secretion is mediated by transcellular interactions.

104 llular (extracellular) route as opposed to a transcellular (intracellular) route based on the finding

105 Many studies have shown acute regulation of transcellular ion transport in airway epithelia.

106 icrovilli, aberrant junctions, and losses in transcellular ion transport pathways, likely leading to

107 ect many epithelial cell functions including transcellular ion transport, secretion, and cell death.

108 tical nodule cells contained bacteroids, but transcellular ITs were rarely observed.

109 Latrophilin-3 binds to two transcellular ligands: fibronectin leucine-rich repeat t

110 yosin we also find evidence for formation of transcellular linear arrays incorporating these proteins

111 293 cells, group V and X PLA2s showed strong transcellular lipolytic activity, whereas group IIA PLA2

112 junctions (paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report

113 n to demonstrate the coexistence of seamless transcellular lumens and single or multicellular enclose

114 Transcellular magnesium (Mg(2+)) reabsorption in the dis

115 nism involving tight junctions and an active transcellular mechanism involving the type II sodium-dep

116 te lymph formation and suggest that LECs use transcellular mechanisms in parallel to the well-describ

117 y, yet the contributions of paracellular and transcellular mechanisms to this process in vivo are unk

118 ric oxide (NO) is an endogenous, diffusible, transcellular messenger shown to affect regulatory and s

119 further processed by endothelial enzymes via transcellular metabolism before the resulting products t

120 fficient levels of LTB(4) production through transcellular metabolism in K/BxN serum-induced arthriti

121 acid by two cell types expressing a combined transcellular metabolon.

122 6) epithelial Mg(2+) channels participate in transcellular Mg(2+) transport in the kidney and intesti

123 ks targeted trafficking of LBRC membrane and transcellular migration by >90%.

124 We show that transcellular migration likewise requires targeted traff

125 ts) in the cremaster muscle circulation, but transcellular migration may be more important at sites s

126 In the present study, we investigated the transcellular migration of HIV-1 as a cell-free virus th

127 Increased transcellular migration of Rap1b-deficient neutrophils i

128 s been demonstrated to utilize both para and transcellular migration routes facilitated by endothelia

129 The LBRC is also recruited to mediate transcellular migration when that occurs.

130 During transcellular migration, LBRC membrane invests the trans

131 adhesion molecule were recruited to sites of transcellular migration.

132 regulate paracellular migration also control transcellular migration.

133 ncy of a model blood-brain barrier to T-cell transcellular migration.

134 molecular mechanisms promote both para- and transcellular migration.

135 against PECAM or CD99, but not JAM-A, block transcellular migration.

136 enting cells (APC) and effector T cells form transcellular molecular complexes.

137 olateral membrane, and temperature-dependent transcellular movement from apical to basolateral media.

138 These processes involve transcellular movement of solutes across epithelial barr

139 vents such as cell entry, amplification, and transcellular movement.

140 intracellular actin/myosin cytoskeleton and transcellular N-cadherin adhesions.

141 ane (BLM) Na/K-ATPase provides the favorable transcellular Na gradient for BBM SGLT1 and NHE3.

142 al and conjunctival epithelia are capable of transcellular Na+ absorption and Cl- secretion, which dr

143 epletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick a

144 As in the synapse, transcellular neuroligin-2 interactions enhance the func

145 hese results indicate a significant role for transcellular neuroligin-2 interactions in the establish

146 lial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed

147 Advances in both paracellular and transcellular neutrophil migration through endothelial c

148 ers as a motile extracellular form that uses transcellular or paracellular migration, or by infecting

149 wed by firm adhesion, and ending with either transcellular or paracellular passage of the leukocyte a

150 Elucidation of epithelial transport across transcellular or paracellular pathways promises to advan

151 transport across epithelia can occur via the transcellular or paracellular pathways.

152 nsulin crosses the endothelium by a passive (transcellular or paracellular) or mediated process, accu

153 s promotes the neutrophil preference for the transcellular over the paracellular transmigration route

154 members of the SLC26 family that may mediate transcellular oxalate absorption.

155 Cftr(-/-) mice exhibited significantly less transcellular oxalate secretion than intestinal tissue o

156 ial basal membrane and transmigrated through transcellular passages formed by a ring of F-actin and c

157 Caveolin-1 expression appears to favor the transcellular path while down-regulation of caveolin-1 p

158 septic rats, indicating the blockade of the transcellular pathway by immunoglobulins administration.

159 Caveolae are thought to be the transcellular pathway by which plasma proteins cross nor

160 indicate that CFTR provides the predominant transcellular pathway for Cl and HCO in porcine airway e

161 ltrastructurally intact, suggesting that the transcellular pathway is responsible for the blood-brain

162 phosphate absorption by acting on the active transcellular pathway mostly mediated by NaPi-IIb while

163 e pf values of SGLT1 and aquaporin-1 makes a transcellular pathway plausible, it renders water pumpin

164 Our findings reveal a previously undescribed transcellular pathway that links the integrity of the de

165 Caveolae provide a possible, yet unproven, transcellular pathway to overcome such barriers.

166 and they crossed the HBMEC monolayers via a transcellular pathway without affecting the monolayer in

167 SPPs enhanced CsA skin penetration, via a transcellular pathway, enhancing its partitioning into k

168 se drug transport across the BBB through the transcellular pathway.

169 ted skin relative to untreated skin, and (3) transcellular pathways are present in the LTRs of US tre

170 molecules permeate via both paracellular and transcellular pathways in the presence of PPS.

171 s, raising the possibility that vesicular or transcellular pathways may be important in lymphatic sol

172 in solid tumors, including paracellular and transcellular pathways that enable passive or active tra

173 pothesized that shifting sodium transport to transcellular pathways would lead to increased whole-kid

174 r filtration coefficient of paracellular and transcellular pathways, and a decrease in the reflection

175 herens junctions (AJs) and caveolae-mediated transcellular pathways.

176 invasion, we have examined HIV-1 uptake and transcellular penetration in an in vitro BMVEC model.

177 Both LPA and S1P prevented increased transcellular permeabilities induced by PMA, and increas

178 ed paracellular, aqueous boundary layer, and transcellular permeabilities, and the villus-fold surfac

179 In active celiac disease, increases in transcellular permeability to intact gliadin peptides mi

180 ty by incubation with hepatoma cells and for transcellular permeability using Caco-2 cell monolayers.

181 maintain brain function in part via its low transcellular permeability(1-3).

182 Transcellular permeability, scaled by k(VF), was equated

183 ified as essential for both paracellular and transcellular PMN transmigration, and interfering with I

184 Mechanisms for transcellular pore formation in endothelium remain unkno

185 cellular calcium were required for efficient transcellular pore formation in response to podosomes.

186 palpate the surface of, and ultimately form transcellular pores through, the endothelium.

187 C extended dendrites through M-cell-specific transcellular pores to the gut lumen.

188 s are highly fenestrated cells; they contain transcellular pores with diameters between 50 to 200 nm.

189 n plasma potassium concentration by means of transcellular potassium redistribution and feedback cont

190 alidated by analyzing effects of TGFbeta2 on transcellular pressure changes and outflow facility.

191 3 microL/min per mm Hg/cm(2) with an average transcellular pressure decrease of 3.13 +/- 0.09 mm Hg.

192 P(i) reabsorption is a transcellular process that occurs along the proximal tub

193 ete and self-replicating amyloid structures, transcellular propagation of aggregation, and transmissi

194 Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregate

195 We and others have proposed that transcellular propagation of pathology is mediated by Ta

196 Recent studies have highlighted the transcellular propagation of protein aggregates in sever

197 vity-mediated regulation of proteostasis and transcellular propagation of protein aggregates in the n

198 Transcellular propagation of protein aggregates, or prot

199 seases, including ALS, might progress due to transcellular propagation of protein aggregation among n

200 Evidence indicates that transcellular propagation of protein aggregation, which

201 sses the contribution of prion phenomena and transcellular propagation to the progression of patholog

202 immunotherapy and small molecules, to block transcellular propagation, and new diagnostic tools to d

203 In the central nervous system, transcellular protein interactions (i.e. interactions be

204 Neuroligin-2 interactions are one of the few transcellular protein interactions thus far identified t

205 as an intermediary protein that facilitates transcellular receptor-ligand interactions.

206 LPA increases transcellular resistance across cultured rabbit corneal

207 stance, and DGPP (8:0) inhibited LPA-induced transcellular resistance in both the epithelium and endo

208 in-2, are postulated to decrease the overall transcellular resistance.

209 zed intestinal epithelial cells (IECs) via a transcellular route and remain biologically active.

210 dothelial cells using one of two pathways: a transcellular route directly through the cell or a parac

211 Together, these findings identify a transcellular route for intravascular maresin 1 biosynth

212 nd drug inhibitor data are consistent with a transcellular route in which internalized, basolateral-m

213 sorption of phosphate proceeds via an active/transcellular route mostly mediated by NaPi-IIb/Slc34a2

214 Unexpectedly, Rap1b deficiency promoted the transcellular route of diapedesis through endothelial ce

215 f podosome formation selectively blocked the transcellular route of diapedesis.

216 WAVE2 is needed for lymphocytes to follow a transcellular route through an EC.

217 s, could additionally breach the BBB via the transcellular route.

218 sported through the paracellular but not the transcellular route.

219 h as passive diffusion via a paracellular or transcellular route.

220 e found to cross the epithelium via only the transcellular route.

221 vidual microvascular endothelial cells (the "transcellular" route) or between them (the "paracellular

222 zing flow-activated, brush border-dependent, transcellular salt and water reabsorption.

223 tr(-/-) mice in Ussing chambers and measured transcellular secretion of [(14)C]oxalate.

224 sensitive to DIDS, and saturable, indicating transcellular secretion of oxalate.

225 nce between absorption and SLC26A6-dependent transcellular secretion.

226 e anterior end, suggesting that P4H1 enables transcellular signaling by the tip.

227 Major features of the transcellular signaling mechanism responsible for endoth

228 stasis in an organism and is facilitated via transcellular signaling molecules that orchestrate the a

229 We describe here a transcellular signaling pathway in embryonic hippocampal

230 ore, neuronal sff expression is dependent on transcellular signaling through a non-neural toll-like r

231 These microvesicles deliver transcellular signals across antigen-dependent synapses

232 men, as well as in coupling paracellular and transcellular sodium permeability.

233 ptive tight epithelium, coordination between transcellular sodium reabsorption and paracellular perme

234 To investigate whether transcellular sodium transport controls tight-junction c

235 ation enhances tau-HS binding and likely the transcellular spread of tau, providing a novel target fo

236 Prion-like transcellular spreading of tau in Alzheimer's Disease (A

237 e contractile forces are transmitted through transcellular structures.

238 We also used a transcellular Tat transactivation assay, where we expres

239 We observed robust transcellular TEM with TNF-alpha-activated HUVECs and IC

240 ell as endothelial cell shape contributed to transcellular TEM.

241 plasmic tail function preferentially reduced transcellular TEM.

242 f endothelial caveolae that is essential for transcellular trafficking of albumin and is also a criti

243 wever, the molecular pathways supporting the transcellular trafficking of divalent manganese ions wit

244 Subcellular and transcellular trafficking strategies now permit (1) opti

245 n stimulate Shiga toxin macropinocytosis and transcellular transcytosis alters current ideas concerni

246 nd a presumptive exocytosis component of the transcellular transcytosis route.

247 Collectively, these data suggest that the transcellular transduction pathway is both necessary and

248 onventional view of the disease by revealing transcellular transfer of mutated huntingtin proteins wh

249 Recent evidence supports transcellular transfer of tau misfolding (seeding) as th

250 nce (RNAi) specifically decreased lymphocyte transcellular transmigration.

251 id assembly and cytoplasmic envelopment, and transcellular transmission in differentiated neural prog

252 lt in overcoming this barrier and increasing transcellular transport across it.

253 n in mouse cortical collecting duct (CCD) by transcellular transport across type B intercalated cells

254 scytosis, which enables transendothelial and transcellular transport and a relatively uniform distrib

255 This protein is thought to function in the transcellular transport and enterohepatic circulation of

256 e examined whether TGF-beta(1) regulates the transcellular transport and metabolism of L-arginine by

257 ese include intracellular chain association, transcellular transport and secretion, proteolytic proce

258 METHODS AND We demonstrate that transcellular transport mechanisms substantially contrib

259 Here, we report on transcellular transport of a CPP, designated the CL pept

260 Transcellular transport of agonist-conjugated HAuNS was

261 as well as caveolae-mediated endocytosis and transcellular transport of albumin and uptake of cholera

262 Dental enamel formation depends upon the transcellular transport of Ca(2+) by ameloblasts, but li

263 diated cell association, internalization and transcellular transport of molecular IgG.

264 In summary, the transcellular transport of proteins across the podocyte

265 Moreover, in Caco-2 cells transcellular transport of the known OATP2B1 substrate a

266 ntisense radiopharmaceuticals, providing the transcellular transport of these molecules is enabled wi

267 ent abilities to facilitate paracellular and transcellular transport of water and solutes.

268 hin the embryo occur through a sophisticated transcellular transport pathway causing the proteolytic

269 The FcRn-IgG transcellular transport pathway may provide a general de

270 s on the cross-talk between paracellular and transcellular transport pathways.

271 cale pipet to differentiate paracellular and transcellular transport processes at high spatial resolu

272 ondrial metabolism and biogenesis as well as transcellular transport processes involved in countercur

273 e phosphate absorption in the gut, an active transcellular transport requiring the Na(+) /phosphate c

274 here are important differences in the Ca(2+) transcellular transport systems used by secretory- and m

275 f the passive flow of counter ions to active transcellular transport, thereby controlling net transep

276 known about the design of CPPs for efficient transcellular transport.

277 le the collecting duct primarily facilitates transcellular transport.

278 ugh epithelial tight junctions and protected transcellular transport.

279 h FcRn-independent paracellular, rather than transcellular, transport of antibodies.

280 Whereas WNK4 is known to regulate several transcellular transporters and channels involved in NaCl

281 Transcellular tubes called infection threads then develo

282 actin cytoskeleton is the primary barrier to transcellular tunnel formation using a combination of at

283 s both passive and active resistance against transcellular tunnel formation, serving as a mechanical

284 es are sufficient to induce the formation of transcellular tunnels in HUVECs.

285 ial toxin EDIN, which can induce spontaneous transcellular tunnels, less mechanical work is required

286 opening holes in endothelial cells, known as transcellular tunnels, which are formed by contact and s

287 left, and postsynaptic specialization form a transcellular unit to enable efficient transmission of i

288 NT also facilitated transcellular uptake of (3)H-glucose and (3)H-leucine an

289 ests that these cells mediate K(+) and water transcellular uptake until the initiation of phototransd

290 d tight junctions and extremely low rates of transcellular vesicular transport (transcytosis).

291 was to determine the relative importance of transcellular (vesicular) versus paracellular transport

292 dothelium involves two different routes: one transcellular, via caveolae-mediated vesicular transport

293 significant difference in the proportion of transcellular vs. paracellular transport between male an

294 In nontransfected NMCs, the transcellular water flow, P(f), value was relatively hig

295 ty in cell membranes is essential to control transcellular water flows.

296 ications on adaptational processes governing transcellular water flux and/or cell survival under extr

297 Thus, AQP4-mediated transcellular water movement is crucial for fluid cleara

298 alled aquaporins (AQPs) that are involved in transcellular water transport in mammals.

299 ed deletion of Aquaporin 5 (AQP5), the major transcellular water transporter in salivary acinar cells

300 racellular, which is energy independent, and transcellular, which is energy dependent-primarily focus