ライフサイエンスコーパス: transcobalamin

1 wanted physiologic tissue uptake mediated by transcobalamin.

2 mentarity than those of intrinsic factor and transcobalamin.

3 proteins: haptocorrin, intrinsic factor, and transcobalamin.

4 oefficient, -0.11 [95% CI, -0.15 to -0.08]), transcobalamin-1 (TCN1; birth weight: coefficient, -208.

5 e reductase (MTHFR), Myosin IXB (MYO9B), and Transcobalamin 2 (TCN2) genes.

6 ely 20-25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is referred to as active

7 erum vitamin B12 into the fractions bound to transcobalamin and haptocorrin: two carrier proteins wit

8 wer and threefold faster, respectively, than transcobalamin binding to cyanocobalamin.

9 Transcobalamin binds cyanocobalamin-b-(5-aminopentylamid

10 Transcobalamin bound vitamin B12 (holoTC) was not influe

11 Bovine transcobalamin (bTC) stimulated the cellular accumulatio

12 The derivative shows no binding to transcobalamin but is recognized by haptocorrin, a prote

13 rphism of the vitamin B-12 transport protein transcobalamin gene (TCN2) (rs1801198; Pro259Arg) is ass

14 been hypothesized that the response of holo-transcobalamin (holo-TC) to oral vitamin B-12 may be use

15 -based biomarkers, like serum B(12) and holo-transcobalamin (HoloTc), or B(12)-associated metabolites

16 2 associated with the plasma binding protein transcobalamin (holotranscobalamin) have been developed.

17 ation, whereas B12 bound to non-glycosylated transcobalamin (i.e. holoTC) is not affected.

18 o CD320, the cellular receptor for cobalamin/transcobalamin II (Cbl/TCN2).

19 Transcobalamin II (TC II) receptor is expressed in the a

20 nesis of the 5'-flanking region of the human transcobalamin II (TC II) transfected in human intestina

21 Cobalamin attached to transcobalamin II (TC II), known as holo-TC II, is the a

22 75G>C) in the vitamin B12 transport protein, transcobalamin II (TCII), has been identified in which p

23 ptor, the transcobalamin II receptor and the transcobalamin II carrier protein.

24 (bp) (-581/-513) fragment derived from human transcobalamin II distal promoter constructed upstream o

25 t for 12 h also resulted in complete loss of transcobalamin II receptor (TC II-R) activity/protein le

26 Transcobalamin II receptor (TC II-R) exists as a monomer

27 esses the B12-intrinsic factor receptor, the transcobalamin II receptor and the transcobalamin II car

28 that the analogs could be effective in vivo transcobalamin II receptor imaging agents.

29 dly dividing cells up-regulate the number of transcobalamin II receptors during DNA replication.

30 cobalamin analogs for the purpose of imaging transcobalamin II receptors in malignant and nonmalignan

31 ysteine, methylmalonic acid, and the ligand, transcobalamin II, in their plasma.

32 Exogenously added transcobalamin II-[57Co]cyanocobalamin bound very poorly

33 Transcobalamin II-receptor (TC II-R) contains 10 half-cy

34 Rabbits injected with pure human placental transcobalamin II-receptor (TC II-R) failed to thrive wi

35 ort is mediated by three transport proteins: transcobalamin, intrinsic factor, and haptocorrin (HC).

36 ine the affinity of different cobalamins for transcobalamin, intrinsic factor, and nonintrinsic facto

37 irect binding assay, where recombinant human transcobalamin is conjugated to a biosensor chip, allows

38 n binding, shows that only recombinant human transcobalamin is sensitive to modification of the corri

39 ponse data for cyanocobalamin binding to the transcobalamin protein surface were globally fitted to a

40 In vitro binding of the analogs to the transcobalamin proteins was assessed by the unsaturated

41 respectively, as efficient in binding to the transcobalamin proteins when compared to cyanocobalamin.

42 we identified an autoantibody targeting the transcobalamin receptor (CD320) in a patient with progre

43 ulation bound to transcobalamin (TC) via the transcobalamin receptor (TC-R).

44 uptake of cobalamin (Cbl) is mediated by the transcobalamin receptor (TCblR) that binds and internali

45 Gene defects of transcobalamin (TC) and the transcobalamin receptor (TCblR), needed for cellular upt

46 The transcobalamin receptor-knockout mouse ( Cd320(-/-)) dev

47 A common genetic polymorphism [transcobalamin (TC) 776C-->G] may affect the function of

48 Gene defects of transcobalamin (TC) and the transcobalamin receptor (TCb

49 Transcobalamin (TC) has been cloned and used for studyin

50 Second, Cbl bound to plasma transcobalamin (TC) II is taken up from the circulation

51 receptor (TCblR) that binds and internalizes transcobalamin (TC) saturated with Cbl.

52 The membrane receptor TCblR/CD320 binds transcobalamin (TC) saturated with vitamin B12 [cobalami

53 the endocytosis of the B(12) carrier protein transcobalamin (TC) via its cognate cell surface recepto

54 they obtain it from the circulation bound to transcobalamin (TC) via the transcobalamin receptor (TC-

55 The membrane receptor (TCblR/CD320) for transcobalamin (TC)-bound cobalamin (Cbl) facilitates th

56 The transcobalamin (TC, TCII) receptor (TCblR) on the plasma

57 in (TC) 776C-->G] may affect the function of transcobalamin, the protein required for vitamin B-12 ce

58 Like haptocorrin and transcobalamin, the trout cobalamin-binding protein was

59 ment of cobalamin, holotranscobalamin, total transcobalamin, total haptocorrin, and methylmalonic aci

60 C--> G polymorphism on concentrations of the transcobalamin-vitamin B-12 complex (holo-TC) and to det

61 -transformed) B12, especially decreased holo-transcobalamin, was associated with visual evoked potent