ライフサイエンスコーパス: transcription factor

1 ry for indelible expression of this critical transcription factor.

2 uronal dendritic growth mediated by the CREB transcription factor.

3 he androgen receptor (AR), a prostate master transcription factor.

4 This is regulated by the ExuR transcription factor.

5 we identified bHLH121 as an ILR3-interacting transcription factor.

6 53 is an intensely studied tumor-suppressive transcription factor.

7 X also dimerizes with MYC, an oncogenic bHLH transcription factor.

8 ell and are often controlled by pre-existing transcription factors.

9 r only a minority of the numerous associated transcription factors.

10 nd invasion, and transcriptional activity of transcription factors.

11 ed with specific chromatin modifications and transcription factors.

12 sport of FA, synthesis of triglycerides, and transcription factors.

13 patterned by the activities of Hh-regulated transcription factors.

14 al Notch ligand and other secretory-specific transcription factors.

15 rough the recruitment of proteins, including transcription factors.

16 Rs, a group of basic helix-loop-helix (bHLH) transcription factors.

17 atterns of paired box 2a (pax2a) and SRY-box transcription factor 10 (sox10) expression in the midbra

18 acts through the AUXIN RESPONSE FACTOR (ARF) transcription factors(2-4).

19 pecificity phosphatase 1 (DUSP1), activating transcription factor 3 (ATF3), and tribbles pseudokinase

20 lood, Huang et al have identified activating transcription factor 4 (ATF4) as a novel regulator of fe

21 es during EAE are not mediated by activating transcription factor 4 (ATF4) but are accompanied by act

22 ch changes DISC1 interaction with activating transcription factor 4 (ATF4), modifies gene expression

23 r transcription factors, GR and Kruppel-like transcription factor 4 (KLF4), cooperatively transactiva

24 nt redox states and expression of Activating Transcription Factor-4 (ATF4).

25 nts caused further declines of photoreceptor transcription factors accompanied by marked decreases of

26 Hyperphosphorylated RB releases E2F transcription factors, activating a transcriptional prog

27 f intracellular mediators that eventuates in transcription factor activation.

28 These data revealed time-resolved transcription factor activities and cell-state trajector

29 h and viability and activating p53-dependent transcription factor activity in a reporter cell assay.

30 cate that 5-HT potentiates the activity of a transcription factor (AhR) that regulates immune respons

31 een the islets with high levels of NF-kappaB transcription factor and control islet cells.

32 DSIF is a versatile transcription factor and has been implicated in both gen

33 ription factors, including myocardin-related transcription factor and Yes-associated protein/transcri

34 These comprise 171 transcription factors and 37 transcriptional cofactors a

35 IRT1 modulates its interactions with various transcription factors and a nodal cytosolic kinase invol

36 ADpred identifies known acidic ADs within transcription factors and accurately predicts the conseq

37 the C/EBPbeta (CREB-binding protein) and CBP transcription factors and activates ADGRB1 gene transcri

38 lve gene expression programs orchestrated by transcription factors and epigenetic regulators.

39 very of CD4(+) T cell subset-defining master transcription factors and framing of the Th1/Th2 paradig

40 in motifs belonging to PU.1, TCF3, and OCT2 transcription factors and involved elevated MYD88/TLR pa

41 tive enhancers that accompany the binding of transcription factors and local opening of chromatin.

42 ocessive RNA polymerases, allosteric protein transcription factors and synthetic DNA transcription te

43 lymphoid-enriched OCT2 and GC-specific MEF2B transcription factors and that this complex occupies and

44 Further, pNFkappaB p65, a key neuroimmune transcription factor, and IL-8, a chemokine, were signif

45 current catalogue of DNA sequence motifs for transcription factors, and describe motifs that correspo

46 plex interplay between chromatin remodeling, transcription factors, and signaling molecules.

47 nalling system; a high number of zinc finger transcription factors; and novel factors that previously

48 The signaling events activate the transcription factors AP-1 and NF-kappaB, leading to the

49 We show that transcription factor AP2 (Tfap2), a regulator of mammali

50 Kinases and transcription factors are also enriched among these cand

51 Transcription factors are attractive therapeutic targets

52 Members of the NF-kappaB family of transcription factors are key drivers of inflammation th

53 s a competitive reservoir in vivo from which transcription factors are released by mitogen-activated

54 mally repress the activity of auxin response transcription factors (ARFs).

55 otential host target is the ligand-activated transcription factor aryl hydrocarbon receptor (AhR), wh

56 We identify the SOX4 transcription factor as an important resistance mechanis

57 Our data show temporal transcription factors, as a group of molecules, are pote

58 RNA polymerase II (Pol II) and its general transcription factors assemble on the promoters of mRNA

59 pecifically, we observed enriched binding of transcription factors associated with chromatin structur

60 transcription requires assembly of cellular transcription factors at the HIV-1promoter.

61 The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for

62 ylation-mediated molecular clutch that tunes transcription factor availability via genome-wide redist

63 gulated transport of nuclear proteins (e.g., transcription factors) between myonuclei represents a po

64 Although it is well-established that transcription factors bind to specific DNA sequences usi

65 HIM integrates transcription factor binding and 3D genome structure to

66 xample, DNA methylation is known to regulate transcription factor binding but also to recruit methyl-

67 kews through biases in CpG enrichment of the transcription factor binding motif.

68 works, we developed a tool to analyze paired transcription factor binding motifs in the promoters of

69 sented in active gene regulatory regions and transcription factor binding sites.

70 rations, with multiple mutations overlapping transcription factor binding sites.

71 riants were also enriched for alterations in transcription factor binding sites.

72 leand is faithful to underlying chemistry of transcription factor binding to DNA.

73 ysis of tissue-specific regulatory elements, transcription factor binding, and gene expression progra

74 improved nucleosome positioning, heightened transcription factor binding, and increased expression o

75 nd ChIA-PET that generate coverage files for transcription factor binding, as well as DHS and ATAC-se

76 signatures of gene expression regulation or transcription factor binding, including a 6-fold differe

77 lleys exhibit elevated conservation and high transcription factor binding.

78 onship between the gain or disruption of TF (transcription factor)-binding motifs, inferred from alte

79 heparin/heparan sulfate assembly uncovered a transcription factor-binding motif for ZNF263, a C2H2 zi

80 The transcription factor BMAL1 is a principal driver of a mo

81 that long photoperiods induce the circadian transcription factor BMAL2, in the pars tuberalis of the

82 the BARLEY B RECOMBINANT/BASIC PENTACYSTEINE transcription factors BPC1/BPC2 positively regulate plan

83 ferentiation are critically dependent on the transcription factor c-Myc (Myc).

84 Multiple kinases converge on the transcription factor cAMP response element-binding prote

85 ulin-binding Transcription Activator (CAMTA) transcription factors CAMTA1, CAMTA2, and CAMTA3 (CAMTA1

86 ral genome, it is still unknown whether host transcription factors can repress viral genes more proxi

87 tress regulated in part by a BMPR2 dependent transcription factor complex between PPARgamma and p53.

88 on is abolished when the function of the FOS transcription factor complex is disrupted.

89 e window) respond in different ways to input transcription factor concentrations, suggesting that the

90 The p53 transcription factor confers its potent tumor suppressor

91 In the developing spinal cord, Onecut transcription factors control the diversification of mot

92 d HMG-box-containing (SOX) genes that encode transcription factors controlling cell fate and differen

93 These transcription factors cooperated to regulate expression

94 provides insights into how a spatiotemporal transcription factor coordinates heterochromatic silenci

95 is a lethal disease caused by mutations in a transcription factor critical for the function of thymus

96 ent downregulated expression of a network of transcription factors critical for chordoma survival and

97 f oxidative stress and the activation of the transcription factors DAF-16/FOXO and SKN-1/Nrf2.

98 at can subsequently bind lineage-determining transcription factors, depending upon what other externa

99 dopsis, the SHORT-ROOT (SHR)/SCARECROW (SCR) transcription factor dimer activates CYCLIND6;1 (CYCD6;1

100 onships between inherited epigenetic states, transcription factor-DNA binding affinity thresholds and

101 ted dominant negative form of the human TCF4 transcription factor (dnTCF4) that specifically abrogate

102 n the other hand, CpGs at sites not bound by transcription factors during the global re-methylation p

103 itors and their maintenance is driven by the transcription factor E2-2 and inhibited by its repressor

104 cyte development system, we identified eight transcription factors, each of which was essential for t

105 regulate autophagy via dephosphorylation of transcription factor EB (TFEB), a master regulator of ly

106 Here we show that transcription factor EB (TFEB), a master regulator of ly

107 upstream regulatory axis of FcepsilonRI) and transcription factors Elf-1 and YY1.

108 ion of emhABC was regulated by a TetR-family transcription factor EmhR, which was demonstrated to be

109 dentity through fine-tuned regulation of key transcription factors ensures beta-cell function.

110 turnover is further accelerated without the transcription factor Eomes.

111 The dual protein kinase-transcription factor, ERK5, is an emerging drug target i

112 antagonist of estrogen receptor (ERalpha), a transcription factor expressed in over 50% of breast can

113 SOX3 is a transcription factor expressed within the developing and

114 ns to stimulate increases in Oct-4 and other transcription factor expression in mouse fibroblasts.

115 The TFIIH general transcription factor facilitates transcription initiatio

116 a, the AT-hook motif nuclear-localized (AHL) transcription factor family has been implicated in restr

117 s to mammals, and yet they belong to a large transcription factor family that bind nearly identical D

118 mber of the ETHYLENE-INSENSITIVE3-LIKE (EIL) transcription factor family.

119 inating cells where it binds to Sox10, a key transcription factor for PNS and CNS myelination and rem

120 bon sources for shared transporters, between transcription factors for binding to communal regulatory

121 vious research has identified four conserved transcription factors, fos-1 (Fos), egl-43 (EVI1/MEL), h

122 activated by purified R. sphaeroides CarD, a transcription factor found in many bacterial species but

123 Mutations in the transcription factor FOXC2 are predominately associated

124 elium expression of repressive cldn5-related transcription factor foxo1 are associated with stress re

125 Transcription factor Foxp3 specifies and maintains regul

126 idopsis (Arabidopsis thaliana), the MADS-box transcription factor FRUITFULL induces GPA by directly r

127 mHtt) vis-a-vis the pathogenicity of mHtt on transcription factor function and cell survival.

128 , chemokine receptors CCR4 and CCR6, and the transcription factors GATA-3 and RORgammaT.

129 s necessary for activating the expression of transcription factor gene FIT in response to Fe deficien

130 ing the expression of doublesex (Dsx), a key transcription factor gene involved in the sex determinat

131 Loss-of-function of the transcription factor Gli3 is known to disrupt olfactory

132 Here, we demonstrate that transcription factors GLK1 and GLK2 interact with and ar

133 Two pioneer transcription factors, GR and Kruppel-like transcription

134 , we studied the highly conserved, essential transcription factor Grainy head (Grh).

135 The transcription factor GRHL3 regulates IFE differentiation

136 In each of these Th cell subsets, a single transcription factor has been identified as a critical r

137 Delivery of proangiogenic transcription factors has promise as a therapy for BPD i

138 ion, as well as transcription initiation and transcription factors, have detailed the mechanisms of t

139 A transcription factor helps young flies to sleep longer b

140 Hypoxia-inducible transcription factors (HIFs) directly dictate the expres

141 signalling in animals often involves direct transcription factor-hormone interactions that modulate

142 d by the maternally supplied SKN-1/Nrf2 bZIP transcription factor; however, the requirement for SKN-1

143 This transition relies on the transcription factor HY5 controlling a complex downstrea

144 xia have identified a prominent role for the transcription factor hypoxia-inducible factor (HIF) in t

145 ing a knockout mouse model, we show that the transcription factor hypoxia-inducible factor 2 alpha (H

146 When associated with the general transcription factor II H (TFIIH) it activates RNA polym

147 which the core DNA repair complex, including transcription factor IIH (TFIIH), is recruited are large

148 increased histone acetyltransferase general transcription factor IIIC subunit 4 and decreased histon

149 Gfi1 is a transcription factor important for HC development and su

150 PAX8 (P = 2x10-10), a known lineage-specific transcription factor in OC.

151 SReg provided better rankings of the correct transcription factors in 61.7% of cases, which is three

152 ters and enhancers are activated by the same transcription factors in different species.

153 as a key partner of TGF-beta-activated SMAD transcription factors in EMT.

154 gnificantly dysregulated genes, including 61 transcription factors in ethanol-exposed embryos.

155 e flexibility to cooperate with a variety of transcription factors in order to regulate CRE activity.

156 (PRC2) silences expression of developmental transcription factors in pluripotent stem cells by methy

157 text-dependent functions of lineage-defining transcription factors in regulating specification progra

158 filing shows differential expression of many transcription factors in response to 5,8-diHODE.

159 IDEA, PCF15 (TCP15), and related class-I TCP transcription factors in stamen filament elongation.

160 to epithelial-mesenchymal transition driver transcription factors in stem cell-specific accessible r

161 t in the co-expression of these antagonistic transcription factors in the majority of haematopoietic

162 R1 and variable members of the ETS-family of transcription factors (in 85% FLI1).

163 ng this cell type patterning is a network of transcription factors including a central MYB-basic heli

164 increased expression of a set of homeodomain transcription factors, including homeobox A9 (HOXA9) and

165 Also discussed are downstream transcription factors, including myocardin-related trans

166 an OCS pipeline focused on genes coding for transcription factors increases isoform detection by an

167 Levels of the transcription factor IRF4 control the magnitude of this

168 Nrf2 transcription factor is crucial for cytoprotective respo

169 hat aberrant expression of a testis-specific transcription factor is sufficient to co-opt somatic tra

170 The transcription factor JUN is highly expressed in pulmonar

171 ccessibility changes, we have implicated the transcription factor KLF5 in the transition from BO to O

172 This revealed that Myo6 and the transcription factor Knot regulate transient surges of m

173 with reduced expression of the key beta-cell transcription factor MAFA and abolished insulin secretio

174 Finally, we ran FloChIP for the transcription factor MEF2A in 32 distinct human lymphobl

175 Xanthine is a ligand for the transcription factor MftR that leads to attenuated DNA b

176 sets that were further characterized by the transcription factor motif codes of their promoters.

177 ze a land plant specific subgroup 9 R2R3 MYB transcription factor MpSBG9, in the early-diverging land

178 Transcription factor Mrr1, best known for its regulation

179 ence the ESR through general stress response transcription factors Msn2/4.

180 partially melted initiation complex (PmIC), transcription factor MTF1 makes base-specific interactio

181 actor 1 (PBX1) is an essential developmental transcription factor, mutations in which have recently b

182 ugh epigenetic repression of stemness master transcription factors NANOG and OCT4.

183 -opts binding sites of the essential meiotic transcription factor Ndt80 upstream of the integration s

184 bably associated with recruitment of general transcription factors, needed to assemble a transcriptio

185 MNT is a member of the MYC transcription factor network of proteins that must heter

186 A heterotrimeric transcription factor NF-Y is crucial for cell-cycle prog

187 in in single cells by sequencing defined the transcription factor NFE2L2/NRF2 as a critical driver of

188 ously identified a nuclear myocardin-related transcription factor (nMRTF) resistance pathway that amp

189 d an 'upstream' cascade of three consecutive transcription factor-nodes, which controls transfer comp

190 Tsc22d3 (GILZ), a glucocorticoid-responsive transcription factor not normally expressed in mature Tr

191 ng protein 4), a lineage-determining cardiac transcription factor not previously implicated in regula

192 N1 and GluN2A as well as KEAP1 (regulator of transcription factor NRF2).

193 duction by pharmacological activation of the transcription factor nuclear erythroid 2-related factor

194 Pioneer factors subsequently enable other transcription factors, nucleosome remodeling complexes,

195 nucleosomes demonstrate sufficiently stable transcription factor-nucleosome interaction to empower c

196 migatus and construction of a library of 484 transcription factor null mutants.

197 lity within 2,868 annotations of genome-wide transcription factor occupancy, and identified 378 signi

198 ysis identified FOXM1 and KDM4E as signature transcription factor of AF and NP respectively, which mi

199 udy, we show that SUMOylation of BZR1, a key transcription factor of BR signaling, provides a conduit

200 NR4A3 is a transcription factor of the orphan nuclear receptor fami

201 ted orphan receptor (ROR)-gammat, the master transcription factor of the Th17 subset of CD4(+) Th cel

202 affinity thresholds and influences of given transcription factors on the activities of other factors

203 y PfAP2-G requires interaction with a second transcription factor, PfAP2-I.

204 n the absence of four SPA genes, the pivotal transcription factor PIF4 fails to accumulate, indicatin

205 AP-1 transcription factors play an essential role in the card

206 iRNAs are transcriptionally regulated by the transcription factor Ppargamma and thus we identify a ro

207 s extensive epigenetic gene silencing of the transcription factor PRDM16 in renal cancer.

208 tive association between DWV-A infection and transcription factors previously associated with honey b

209 The Gsx2 homeodomain transcription factor promotes neural progenitor identity

210 ents, observe single-molecule nucleosome and transcription factor protection footprints, and quantify

211 ve-feedback regulator for multiple oncogenic transcription factors, provides insights into the functi

212 ity is modulated by genetic depletion of the transcription factor Prrx1.

213 Emerging evidence has linked the transcription factor RE1-silencing transcription factor

214 (Samd14-Enh), occupied by GATA2 and SCL/TAL1 transcription factors, reduces SAMD14 expression in bone

215 ssed endothelial and mesenchymal markers and transcription factors regulating endothelial-to-mesenchy

216 evant signaling pathways and functional TFs (transcription factors) regulating these processes is sti

217 Transcription factor regulatory networks control the lin

218 ific NFR were enriched for binding motifs of transcription factors related to tissue-specific functio

219 The Myc transcription factor represents an "undruggable" target

220 tegrative analyses revealed that the HOXA5-9 transcription factors repress the Ealpha enhancer at ear

221 IkappaBzeta, which is a key proinflammatory transcription factor required for cytokine synthesis in

222 inked the transcription factor RE1-silencing transcription factor (REST) to PD and also Alzheimer's d

223 We show that Hox5 transcription factors shape phrenic MN output by connect

224 dermis initials (CEI) by studying the mobile transcription factor SHORTROOT (SHR) and its binding par

225 cAMP response element-binding protein (CREB) transcription factor significantly slows Caenorhabditis

226 age the epithelial-to-mesenchymal transition transcription factor SLUG to directly repress pro-apopto

227 system, we found that high expression of the transcription factor SLUG was indispensable for the esta

228 aling pathway, causing downregulation of the transcription factor Sox17.

229 ere targeted to Ct-Smad2/3 and Ct-Smad1/5/8, transcription factors specific to the Activin/Nodal and

230 ding was enriched for motifs for key myeloid transcription factors such as CEBPA, PU.1, and RUNX1.

231 cells is reduced expression of key metabolic transcription factors, such as PPRC1.

232 Memory B cells (MBCs) expressing the transcription factor T-bet have been described in normal

233 at overexpression of two definitive endoderm transcription factors, T and Foxa2, results in changes t

234 t miR-17-92 forms a regulatory loop with the transcription factor TAL1.

235 umor suppressor protein p53 or the oncogenic transcription factor TAZ.

236 al consequences of reduced dosage of the CHD transcription factor, TBX5, in individual cells during c

237 c variation in regulatory elements can alter transcription factor (TF) binding by mutating a TF bindi

238 tinct positions of enrichment at the central transcription factor (TF) binding regions and at the fla

239 through association with the prohypertrophic transcription factor (TF) myocyte enhancer factor-2 (MEF

240 is difficult to reconcile the reported short transcription factor (TF) residence times on the DNA wit

241 r Factor of Activated T cells 5 (NFAT5) is a transcription factor (TF) that mediates protection from

242 ted with CCAAT/enhancer-binding protein beta transcription factor (TF), while the T allele did not sh

243 tify SCC25 enriched regulatory sequences and transcription factors (TF) motifs.

244 orchestrated by the core form of the general transcription factor TFIIH, containing the helicases XPB

245 ementing protein (XPB), a component of human transcription factor TFIIH, in both B lymphocytes and ep

246 nes have mostly focused on highly researched transcription factors (TFs) and cytokines, resulting in

247 tudy the regulatory interactions between the transcription factors (TFs) and the target genes.

248 ssue is modeling the complex crosstalk among transcription factors (TFs) and their target genes, with

249 entries from the most recent collections of transcription factors (TFs) from the JASPAR and UniPROBE

250 rate the activity of signaling effectors and transcription factors (TFs) on enhancers.

251 Stp1 and Stp2 are paralogous transcription factors (TFs) regulated by the Ssy1-Ptr3-S

252 Gene regulatory networks (GRNs) link transcription factors (TFs) to their target genes and re

253 , differentially expressed genes that encode transcription factors (TFs) were analysed.

254 trehalose metabolism and various families of transcription factors (TFs) were differentially expresse

255 ed by accessibility of regulatory regions to transcription factors (TFs).

256 y validate a CRC 'trio' constituted by three transcription factors (TFs): KLF15, TCF4 and NKX2-2, in

257 ce the bZIP60 mRNA that produces a truncated transcription factor that activates gene expression in t

258 p53 is a tetrameric transcription factor that binds DNA response elements to

259 Furthermore, we identified AP2IX-1 as a transcription factor that controls the switching from th

260 Kruppel-like factor 1 (KLF1/EKLF) is a transcription factor that globally activates genes invol

261 IFN regulatory factor 3 (IRF3) is a transcription factor that is activated by multiple patte

262 e-dimensional culture and expressed Hoxb7, a transcription factor that is part of a developmental reg

263 with the previously identified MLXIPL, is a transcription factor that may regulate serum urate via t

264 Runx1 is a transcription factor that plays a key role in determinin

265 and describe motifs that correspond to other transcription factors that are co-enriched with the prim

266 We also classified families of transcription factors that are increasingly enriched at

267 FOXO proteins are transcription factors that are involved in numerous phys

268 tional regulation is mediated by DNA-binding transcription factors that bind to regulatory gene regio

269 (PIFs) are a group of basic helix-loop-helix transcription factors that can physically interact with

270 bserved in plants expressing hyperactive MYC transcription factors that cannot bind JAZ repressors.

271 ation of the genetic regulatory elements and transcription factors that contribute toward GIN functio

272 identify transcription factors that define one subtype of neural

273 rane conductance regulator (CFTR) along with transcription factors that have binding sites 5' of SLC2

274 We also observed enrichment of transcription factors that implicated SMAD and JDP2 in B

275 s a complex multi-step process controlled by transcription factors that induce or suppress large dyna

276 ith known biological similarity and identify transcription factors that may mediate tissue-specific e

277 hlight PGC1alpha, SRF and the MEF2 family as transcription factors that may potentially mediate this

278 wth response genes 2 and 3 (EGR 2 and EGR3), transcription factors that negatively regulate T-cell ac

279 identify putative enhancer-gene linkages and transcription factors that regulate human corticogenesis

280 Finally, we identified transcription factors that regulate stimulation-dependen

281 the ERK serine/threonine kinase and the Fos transcription factor, thereby enhancing neurite outgrowt

282 y inform approaches targeting this oncogenic transcription factor to manage malignancies.

283 es engages conserved signalling pathways and transcription factors to coordinate the induction of inf

284 rks by linking enhancers and predicted bound transcription factors to their target promoters using a

285 he relevance of high-affinity binding of ARF transcription factors to uniquely spaced DNA elements in

286 Metazoan transcription factors typically regulate large numbers o

287 Nuclear receptor (NR) transcription factors use a conserved activation functio

288 to identify condition-specific functions of transcription factors using these data has become a majo

289 we found that APIP10 interacts with two rice transcription factors, VASCULAR PLANT ONE-ZINC FINGER 1

290 BF/MBF subunits in fixed cells revealed each transcription factor was organized into discrete cluster

291 ldlr), that are under the regulation of Foxo transcription factor were identified in Cx. pipiens.

292 Upregulation of Zn(II)-Cys6 transcription factors were uniquely induced in soybean a

293 ted the time-dependent functions of the Sim1 transcription factor, which is expressed in postmitotic

294 nt-binding proteins (SREBPs), membrane-bound transcription factors whose proteolytic activation requi

295 tors (LXRs)-a class of nuclear receptors and transcription factors with diverse functions in metaboli

296 program and identify it as a distinguishing transcription factor within islet cell subtype specifica

297 tein response (UPR) under the control of the transcription factor Xbp1.

298 nase-endoribonuclease module to activate the transcription factor XBP1s, which facilitates ER-mediate

299 found that ZIP4 increases expression of the transcription factor ZEB1, which activates expression of

300 The Arabidopsis thaliana zinc finger transcription factor (ZF-TF), S-nitrosothiol (SNO) Regul