ライフサイエンスコーパス: transcription factor 4

1 lear factor erythroid 2-related factor 2 and transcription factor 4.

2 ogen species and regulated by the activating-transcription factor-4.

3 eracting RNA clusters (3.6-fold) and curated transcription factors (4.1-fold), including zinc-finger

4 factor of activated T cells (NFAT) family of transcription factors [4, 5], we have quantified protein

5 hly expressed, enhancer-associated oncogenic transcription factors(4,5).

6 lases can also target other proteins such as transcription factors [4] [5] [6] [7].

7 acid deprivation did not require activating transcription factor 4, a critical component of the conv

8 These effects were mediated by activating transcription factor 4, a driver of exercise-induced ang

9 iolized cells stained with antibody to helix transcription factor 4, a factor associated with the cil

10 sitol-requiring enzyme 1alpha and activating transcription factor 4 abrogates autophagosome formation

11 nes (C/EBP homologous protein and activating transcription factor 4), accumulation of ceramide, loss

12 itol requiring kinase 1alpha, and activating transcription factor 4, all of which are featured change

13 factor 2alpha phosphorylation and activating transcription factor 4 and C/EBP homologous protein up-r

14 pha (eiF2alpha) and expression of activating transcription factor 4 and tribbles 3 were elevated in H

15 ted genes, including Phytochrome-Interacting Transcription Factors 4 and 5 (PIF4 and PIF5) and repres

16 Since ATF4 (activating transcription factor 4) and CCAAT/enhancer-binding prote

17 d increased recruitment of TEAD4 (TEA domain transcription factor 4) and its coactivator YAP1 (Yes-as

18 B, high mobility group AT-hook 2, spalt-like transcription factor 4, and alpha-fetoprotein expression

19 ly regulated interaction among Sox17, T-cell transcription factor 4, and beta-catenin proteins.

20 expression levels of NANOG, octamer-binding transcription factor 4, and sex-determining region Y-box

21 pseudokinase tribbles homolog 3, activating transcription factor 4, and transcription factor CCAAT/-

22 log 1) was regulated by the ATF4 (activating transcription factor 4) arm of the unfolded protein resp

23 iched for components of the ATF4 (activating transcription factor 4) arm of the unfolded protein resp

24 ite the increased recognition of TBX4 (T-BOX transcription factor 4)-associated pulmonary arterial hy

25 Inclusion of dominant-negative transcription factor 4 at the time of K-Ras-beta-catenin

26 stress/UPR genes, including BiP, activating transcription factor 4 (ATF-4), ATF-6, and a spliced for

27 stress response pathway regulator activating transcription factor 4 (ATF-4).

28 by demonstrating the induction of activating transcription factor-4 (ATF-4) and growth arrest DNA dam

29 stent eif2-alpha phosphorylation (activating transcription factor 4 [ATF-4], C/EBP homologous transcr

30 In this work, we found that the activating transcription factor 4 (ATF4) activates a mitochondrial

31 rd increasing downstream signals, activating transcription factor 4 (ATF4) and ATF6 indicating potent

32 ial translation of mRNAs, such as activating transcription factor 4 (ATF4) and C/EBP-homologous prote

33 ivated, as the expression of both activating transcription factor 4 (ATF4) and CHOP (DDIT3), critical

34 ed stress response (ISR) effector activating transcription factor 4 (Atf4) and induction of the ISR t

35 hesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolution

36 CM phenotypes was mediated by the activating transcription factor 4 (ATF4) and its downstream effecto

37 associated transcription factors: activating transcription factor 4 (ATF4) and nuclear factor of acti

38 from siRNA-mediated knockdown of activating transcription factor 4 (ATF4) and overexpression of exog

39 indicated by decreased levels of activating transcription factor 4 (ATF4) and phosphorylated eukaryo

40 n of the Keto diet, the levels of activating transcription factor 4 (ATF4) are markedly induced.

41 lood, Huang et al have identified activating transcription factor 4 (ATF4) as a novel regulator of fe

42 In silico analysis identified activating transcription factor 4 (ATF4) as a potential transcripti

43 We identified activating transcription factor 4 (ATF4) as a SKIP3-binding partner

44 ochondrial stressors, we identify activating transcription factor 4 (ATF4) as the main regulator of t

45 ranscription was conferred by two activating transcription factor 4 (ATF4) binding sites in the FGF21

46 es during EAE are not mediated by activating transcription factor 4 (ATF4) but are accompanied by act

47 production of the stress response activating transcription factor 4 (ATF4) by ineffective bypass of t

48 Here we show that activating transcription factor 4 (ATF4) exclusively activates gene

49 n of eIF2alpha, which upregulates activating transcription factor 4 (ATF4) expression.

50 s pathway, linked functionally to activating transcription factor 4 (ATF4) following treatment with o

51 response (UPR) and an increase in activating transcription factor 4 (ATF4) has been previously report

52 nvestigate the protective role of activating transcription factor 4 (ATF4) in controlling the hepatic

53 We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammal

54 ated protein stability by binding activating transcription factor 4 (ATF4) in nuclear speckles and pr

55 muscle atrophy via expression of activating transcription factor 4 (ATF4) in skeletal muscle fibers.

56 e we reveal an essential role for activating transcription factor 4 (ATF4) in survival following MYC

57 ling pathway of ER stress-induced activating transcription factor 4 (ATF4) in the regulation of Mulle

58 Activating transcription factor 4 (ATF4) is a critical transcriptio

59 Activating transcription factor 4 (Atf4) is a leucine-zipper-contai

60 Activating transcription factor 4 (ATF4) is a mediator of the UPR a

61 Activating transcription factor 4 (ATF4) is a transcription factor

62 Activating transcription factor 4 (ATF4) is a transcription factor

63 Activating transcription factor 4 (Atf4) is an essential effector o

64 Activating transcription factor 4 (ATF4) is an osteoblast-enriched

65 HRI also activates the eIF2alphaP-activating transcription factor 4 (ATF4) ISR in primary erythroid p

66 Activating transcription factor 4 (ATF4) mRNA and protein, C/EBP ho

67 ively enhances the translation of activating transcription factor 4 (ATF4) mRNA to induce stress resp

68 ively enhances the translation of activating transcription factor 4 (ATF4) mRNA to induce stress resp

69 ulting in enhanced translation of activating transcription factor 4 (ATF4) mRNA.

70 ongating ribosome and facilitates activating transcription factor 4 (ATF4) reinitiation.

71 trast, obese mice lacking hepatic activating transcription factor 4 (Atf4) showed an exaggerated ISR

72 ulated inhibitor kinase/eIF2alpha/activating transcription factor 4 (ATF4) signaling module.

73 nase RNA-like ER kinase (PERK) or activating transcription factor 4 (ATF4) significantly reduced the

74 -like ER kinase- (PERK)-eIF2alpha-activating transcription factor 4 (ATF4) stress pathway.

75 f AP20187 significantly increased activating transcription factor 4 (ATF4) translation and concomitan

76 are transcriptionally induced by activating transcription factor 4 (Atf4) via C/ebp-Atf-Response-Ele

77 of the bZip transcription factor activating transcription factor 4 (ATF4) was induced by glutathione

78 eIF2alpha phosphorylation induces activating transcription factor 4 (ATF4), a basic leucine zipper tr

79 Here we show that Activating Transcription Factor 4 (ATF4), a DISC1 binding partner,

80 by using targeted deletion of the activating transcription factor 4 (ATF4), a key downstream effector

81 ed cells stimulated expression of activating transcription factor 4 (ATF4), a master transcription fa

82 Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional

83 of triglyceride metabolism by the activating transcription factor 4 (ATF4), a member of the basic leu

84 important effector of the ISR is activating transcription factor 4 (ATF4), a transcription factor th

85 element binding protein 2 (CREB2)/activating transcription factor 4 (ATF4), a transcriptional repress

86 eases translation of the metazoan activating transcription factor 4 (ATF4), activating the integrated

87 rsenite, in a manner dependent on activating transcription factor 4 (ATF4), an important mediator of

88 ing protein-1 mRNA, expression of activating transcription factor 4 (ATF4), and cleavage of ATF6 were

89 rt-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target

90 ulator of amino acid homeostasis, activating transcription factor 4 (ATF4), is dysfunctional in HD be

91 transcriptional effectors of UPR, activating transcription factor 4 (ATF4), is essential for prostate

92 ch changes DISC1 interaction with activating transcription factor 4 (ATF4), modifies gene expression

93 rove the selective translation of activating transcription factor 4 (ATF4), potentiating YAP expressi

94 lectively increase translation of Activating Transcription Factor 4 (ATF4), resulting in the inductio

95 l that these compounds upregulate activating transcription factor 4 (ATF4), sensitizing cells to stre

96 We examined the contribution of activating transcription factor 4 (ATF4), the central node of the i

97 ions, increased the production of activating transcription factor 4 (ATF4), the transcriptional maste

98 PERK and its downstream factor, activating transcription factor 4 (ATF4), were crucial for this ind

99 mologous protein (Chop/Ddit3) and activating transcription factor 4 (Atf4), were upregulated in the c

100 ter system to detect induction of activating transcription factor 4 (ATF4), which controls expression

101 Increased expression of activating transcription factor 4 (Atf4), which indicates the activ

102 cts with the transcription factor Activating Transcription Factor 4 (ATF4), which is involved in the

103 ue (BAT) display induction of the activating transcription factor 4 (ATF4), which promotes fibroblast

104 rine synthesis were stimulated by activating transcription factor 4 (ATF4), which was activated by mT

105 rKO islets revealed activation of activating transcription factor 4 (ATF4), which was mediated by mam

106 rKO islets revealed activation of activating transcription factor 4 (ATF4), which was mediated by mam

107 or 21 (FGF21) as a BATokine in an activating transcription factor 4 (ATF4)-dependent manner.

108 as increased in coordination with activating transcription factor 4 (ATF4)-dependent REDD1 expression

109 e histone demethylase JMJD3 is an activating transcription factor 4 (ATF4)-dependent target gene.

110 protein 1 (CREB) and another with activating transcription factor 4 (ATF4).

111 f selected mRNAs such as that for activating transcription factor 4 (ATF4).

112 a (PPARalpha), and stress sensor, activating transcription factor 4 (ATF4).

113 ISR-dependent upregulation of the Activating Transcription Factor 4 (ATF4).

114 part through direct regulation of activating transcription factor 4 (Atf4).

115 uscle are positively regulated by activating transcription factor 4 (ATF4).

116 ress-related transcripts, such as activating transcription factor 4 (ATF4).

117 on by other stresses that involve activating transcription factor 4 (ATF4).

118 ion factor 2alpha (eIF2alpha) and activating transcription factor 4 (ATF4).

119 pact neuronal function, including activating transcription factor 4 (ATF4).

120 Here, we focused on activating transcription factor 4 (ATF4)/cAMP response element-bind

121 leucine zipper (bZIP) domains of activating transcription factor-4 (ATF4) and CCAAT box/enhancer-bin

122 addition, the CREB-related factor activating transcription factor-4 (ATF4) has been shown to interact

123 or 2 (eIF2alpha) phosphorylation, activating transcription factor-4 (ATF4) induction, and increased e

124 We show that activating transcription factor-4 (ATF4), which is paradoxically tr

125 nt redox states and expression of Activating Transcription Factor-4 (ATF4).

126 Activation of the ATF4 (activating transcription factor 4) branch of the ER stress pathway

127 of the transcriptional activators activating transcription factor 4, C/EBPalpha, Runx1, and Runx2.

128 on, particularly up-regulation of activating transcription factor-4, CHOP (C/EBP homologous protein),

129 The ER-stress element and the activating transcription factor 4 element in the CHOP promoter were

130 ound that a well-known oncogene, ETS variant transcription factor 4 (ETV4), serves as a molecular tra

131 Kruppel-like family of transcription factor 4 expression also decreases with ag

132 control nonderepressible 2 kinase-activating transcription factor 4 (GCN2-ATF4) pathway activation an

133 Alleles in the transcription factor 4 gene (TCF4), encoding a member of

134 by autosomal dominant mutations in the human transcription factor 4 gene (TCF4).

135 autistic spectrum caused by mutations in the Transcription Factor 4 gene.

136 Genetic variation in the TCF4 (transcription factor 4) gene is associated with risk for

137 t in BioTapestry, includes 22 genes encoding transcription factors, 4 genes encoding known signaling

138 ose-regulated protein-78 (GRP78), activating transcription factor 4, growth arrest and DNA damage-ind

139 alian vascular factor Kruppel-like family of transcription factor 4 has a conserved role in augmentin

140 We demonstrate that human activating transcription factor 4 (hATF4), a member of the activati

141 ion of WNT-dependent inhibitory Kruppel-like transcription factor 4 in miR-199a-5p-overexpressing cel

142 implication of the ISR-inducible activating transcription factor 4 in the process.

143 The role of ATF4 (activating transcription factor 4) in osteoblast differentiation an

144 e inhibitor bortezomib, levels of activating transcription factor-4 increase dramatically early in dr

145 aryotic initiation factor-2alpha, activating transcription factor 4, inositol requiring kinase 1, and

146 ATF4 (activating transcription factor 4) is an osteoblast-enriched transc

147 The transcription factor ATF4 (activating transcription factor 4) is induced by multiple PD-releva

148 nduced nuclear translocation of Kruppel-like transcription factor 4 (KLF4), a known repressor of SMC

149 r transcription factors, GR and Kruppel-like transcription factor 4 (KLF4), cooperatively transactiva

150 nscriptionally regulated by the Kruppel-like transcription factor 4 (KLF4), we determined the spatial

151 ap mesenchyme progenitors induced activating transcription factor 4-mediated nutritional stress respo

152 poorly translated mRNAs, notably activating transcription factor 4 mRNA, for reprogramming of gene e

153 with enhanced expression of octomer-binding transcription factor 4 (OCT-4) and several other genes c

154 s well as down-regulation of octamer-binding transcription factor 4 (Oct-4) expression and matrix met

155 Octamer-binding transcription factor 4 (OCT-4) is an important marker of

156 ve for alkaline phosphatase, octamer-binding transcription factor 4 (Oct-4), stage-specific embryonic

157 The octamer-binding transcription factor 4 (Oct3/4) is a master gene in the

158 are within binding sites of octamer-binding transcription factor 4 (OCT4) and signal transducer and

159 ed stem cell markers such as octamer binding transcription factor 4 (Oct4) and stage-specific embryon

160 ation of pluripotency marker Octamer-binding transcription factor 4 (OCT4) by at least 10% and increa

161 Octamer-binding transcription factor 4 (Oct4) has been shown to be an es

162 ly transcription factors and octamer-binding transcription factor 4 (OCT4), respectively, illuminatin

163 rt-term cyclic expression of octamer-binding transcription factor 4 (Oct4), sex-determining region Y-

164 lex inhibits Sox2 binding to octamer-binding transcription factor 4 (Oct4)/Sox2 enhancers.

165 nd POU5F1, the gene encoding octamer-binding transcription factor 4 (Oct4; also known as POU domain,

166 d eIF2alpha (p-eIF2alpha) but not activating transcription factor 4 or C/EBP homologous protein that

167 ivation of the PKR-like ER kinase/activating transcription factor 4 (PERK/ATF4) ER stress pathway, in

168 tral thermoregulator PHYTOCHROME INTERACTING transcription FACTOR 4 (PIF4), whose degradation is othe

169 y transcription factor Oct4 (octamer-binding transcription factor 4) plays an unappreciated role in t

170 We discovered that RUNT-related transcription factor 4 (RUNX4), the orthologue of Drosop

171 gnalling by activating mTORC2 via activating transcription factor 4/sestrin 2 activation whilst promo

172 e treatment and is independent of activating transcription factor 4 signaling and protein translation

173 ndoplasmic reticulum kinase)-ATF (activating transcription factor) 4 signaling axis in atherogenic ma

174 slation initiation factor 2-alpha/activating transcription factor-4 signaling pathway.

175 Here, we investigated the role of SRY-box transcription factor 4 (SOX4) in regulating TEC dediffer

176 lular reactive oxygen species and activating transcription factor 4 target gene expression precede ce

177 tivation mediated by beta-catenin and T cell transcription factor 4 (Tcf-4).

178 Transcription factor 4 (TCF4 also known as ITF2 or E2-2)

179 could physically interact with beta-catenin/transcription factor 4 (TCF4) and disrupt their complex

180 Variation in the transcription factor 4 (TCF4) gene has been identified a

181 aused by autosomal dominant mutations in the Transcription Factor 4 (TCF4) gene.

182 d by monoallelic mutation or deletion in the transcription factor 4 (TCF4) gene.

183 Transcription Factor 4 (TCF4) has been associated with a

184 Several polymorphisms of the transcription factor 4 (TCF4) have been shown to increas

185 Autoantibodies targeting transcription factor 4 (TCF4) in 1 patient who appeared

186 basic helix-loop-helix transcription factor transcription factor 4 (TCF4) in the nervous system is u

187 Transcription factor 4 (TCF4) is a basic helix-loop-heli

188 Transcription factor 4 (TCF4) is a basic helix-loop-heli

189 Transcription Factor 4 (TCF4) is a clinically pleiotropi

190 The psychiatric risk-associated transcription factor 4 (TCF4) is linked to schizophrenia

191 ain-of-function of the psychiatric risk gene transcription factor 4 (TCF4) severely disrupts the colu

192 ted as inhibitors of the beta-catenin/T cell transcription factor 4 (Tcf4) signaling pathway using a

193 ereas we observed early dysregulation of the transcription factor 4 (Tcf4) that may drive cortical ch

194 schizophrenia, SNPs in or in the vicinity of transcription factor 4 (TCF4), neurogranin (NRGN) and an

195 c chondrocytes showed that HIF1alpha lowered transcription factor 4 (TCF4)-beta-catenin transcription

196 eby activates the MYC gene by a beta-catenin/transcription factor 4 (TCF4)-mediated mechanism.

197 potential that is proactively suppressed by transcription factor 4 (Tcf4).

198 onal haploinsufficiency of the gene encoding transcription factor 4 (Tcf4).

199 gnaling pathway by directly interacting with transcription factor 4 (TCF4).

200 1.39 (1.24-1.55)] and at 18q21 [rs1452787 at transcription factor 4 (TCF4); P = 2.61 x 10(-8) , OR (9

201 This study identifies transcription factor 4 (TCF4; also known as ITF2) as a c

202 ally associated with CTG repeat expansion in Transcription factor-4 (TCF4) gene.

203 4 [Chrm4)], dopamine receptor D2 [Drd2], and transcription factor 4 [Tcf4]).

204 on factor AP-2 gamma (Tfap2c) and TEA domain transcription factor 4 (Tead4) expression in the presenc

205 hepatocytes and tumor cells, YAP/TEA domain transcription factor 4 (TEAD4)-dependent transcriptional

206 f the interaction between YAP and TEA domain transcription factor 4 [TEAD4]).

207 lity of the CFTR Y-box for sequence-specific transcription factors; 4) that trichostatin A, an inhibi

208 the HD-ZIP III proteins, well-known polarity transcription factors(4)-the expression of which is conc

209 h the transcription factor TEAD4 (TEA domain transcription factor 4) to regulate chromatin accessibil

210 he H5R gene product the name viral late gene transcription factor 4 (VLTF-4).

211 In contrast, Kruppel-like transcription factor 4 was induced in antimiR-expressing

212 in Stat4 (Signal Transducer and Activator of Transcription Factor 4) was the causative mutation.

213 protein kinase RNA-like ER kinase, activator transcription factor 4) were assessed in transgenic mice