ライフサイエンスコーパス: transcription factor PU.1

1 mphoid system is dependent on the Ets family transcription factor PU.1.

2 he hematopoietic cell-restricted, ets family transcription factor PU.1.

3 sion through heterodimerization with the ETS transcription factor PU.1.

4 n the H3.3 loading machinery and the pioneer transcription factor Pu.1.

5 enriched with binding motifs of the pioneer transcription factor PU.1.

6 l isoform usage by modulating binding of the transcription factor PU.1.

7 lls as well as aberrant induction of myeloid transcription factor PU.1.

8 activation of Irf8 that was dependent on the transcription factor PU.1.

9 on by modulating T(H)2 responses through the transcription factor PU.1.

10 driving the expression of the hematopoietic transcription factor PU.1.

11 olving induction of the erythroid-inhibitory transcription factor PU.1.

12 ve mechanistic role for the lineage-specific transcription factor PU.1.

13 re of these genes is their regulation by the transcription factor PU.1.

14 grin (DC-SIGN), after directly targeting the transcription factor PU.1.

15 esses nonphysiological levels of the myeloid transcription factor PU.1.

16 we found that the PF-2 gene was regulated by transcription factor PU.1.

17 is indirectly regulated by Meis1 through the transcription factor PU.1.

18 wnregulated expression of the Th9-associated transcription factor, PU.1.

19 osing the inhibitory functions of Id2 on the transcription factor PU.1, a master regulator of macroph

20 Furthermore, the transcription factor PU.1, a negative regulator of T(H)2

21 Notably, MEF2C cooperates with another transcription factor, PU.1, a central hub in the AD gene

22 ave been identified, we demonstrate that the transcription factor PU.1 acts upstream of these regulat

23 The transcription factor PU.1 (also known as Spi-1) plays a

24 tion dynamics of three key genes that encode transcription factors: PU.1 (also known as Spi1), Gata1

25 addition, mechanical deformation induced the transcription factor PU.1, an ets family member that is

26 155 is correlated with reduced expression of transcription factor PU.1 and CD10 in several B-lymphoma

27 tor Pgr by Notch1 overexpression through the transcription factor PU.1 and DNA methyltransferase 3b (

28 g of the macrophage- and the B cell-specific transcription factor PU.1 and exhibit histone modificati

29 DAR1 p150 promotes expression of the myeloid transcription factor PU.1 and induces malignant reprogra

30 Here we found more T cells expressing the transcription factor PU.1 and interleukin 9 (IL-9) in pa

31 we interrogated site-specific binding by the transcription factor PU.1 and its perturbation by DB270,

32 development is mediated via interacting with transcription factor PU.1 and modulating PU.1 and GATA-1

33 tudies we have investigated the roles of the transcription factor PU.1 and the coactivator OCA-B with

34 The transcription factors PU.1 and c-Myb are essential for h

35 regulated by the activation of CSF1R and the transcription factors PU.1 and C/EBPalpha as the molecul

36 erference experiments, we found that the Ets transcription factors PU.1 and GA-binding protein (GABP)

37 rn promoted expression of M-CSF receptor and transcription factors PU.1 and IRF8, thereby constitutin

38 associated with decreased expression of the transcription factors PU.1 and RelB.

39 Critical binding sites for the transcription factors PU.1 and Sp1 were identified in th

40 nes encoding the E26 transformation-specific transcription factors PU.1 and Spi-B in B cells (CD19-Cr

41 We also found that two transcription factors, PU.1 and C/EBPalpha, appear to sy

42 nes encoding the E26-transformation-specific transcription factors, PU.1 and Spi-B, in B cells (Delta

43 or binding motifs, was bound by an important transcription factor (PU.1), and was associated with hig

44 ne (F-gp55), aberrant over-expression of the transcription factor PU.1, and inactivating mutations in

45 CTSS and the Ets family transcription factor PU.1 are highly expressed in cells

46 lements of the CXCR1 gene and the ets family transcription factor PU.1 as a major regulator for activ

47 Here we identify the transcription factor PU.1 as an essential regulator of t

48 We identified the myeloid cell-specific transcription factor PU.1 as critical for regulating MRC

49 We have recently identified the ETS family transcription factor PU.1 as regulating heterogeneity in

50 UTX suppresses DPYD expression by inhibiting transcription factor PU.1 binding, leading to increased

51 e-nucleotide polymorphism rs10792832 reduced transcription factor (PU.1) binding and PICALM expressio

52 Although the ets transcription factor, PU.1, bound to this ets site, it o

53 regulate adenovirus clearance in AMs via the transcription factor PU.1 by redirecting virion traffick

54 quencing for a subset of motif corresponding transcription factors (PU.1, C/EBPbeta, and EGR2), confi

55 The transcription factors Pu.1, Cebpalpha, Cebpbeta, and Jun

56 We discovered that the hematopoietic transcription factor PU.1 conferred transcriptional acti

57 of Immunity, Carotta et al. reveal that the transcription factor PU.1 controls Flt3 expression in he

58 issect feedback mechanisms through which the transcription factor PU.1 controls lymphoid and myeloid

59 id leukemia 1 protein (AML1)- and Ets family transcription factor PU.1-dependent transcription.

60 microsomal PGES (mPGES)-1 and a myeloid cell transcription factor PU.1 did not appear until later pha

61 was a critical transcriptional target of the transcription factor PU.1 during lymphopoiesis.

62 AhR expression was coregulated with the transcription factor PU.1 during myeloid subset differen

63 Knockdown of the transcription factor PU.1 (encoded by Sfpi1) leads to ac

64 The transcription factor PU.1, encoded by the Sfpi1 gene, fu

65 ted through recent reports defining roles of transcription factors PU.1, GATA-3, and E2A, their inter

66 The overexpression of the myeloid-specific transcription factor PU.1 generates microglia-like cells

67 ghlights contributions of E2A, hematopoietic transcription factor PU.1, growth factor independence (G

68 The ETS transcription factor PU.1 has a potent ability to confer

69 d backbone dynamics of the ETS domain of the transcription factor PU.1 have been determined for the f

70 presumptive target genes for the Ets-family transcription factor PU.1 have been identified in the B

71 addressed the function of a group of key DC transcription factors-PU.1, ID2, IRF4, and IRF8-in the e

72 ment is activated by cooperation between the transcription factors PU.1, IFN regulatory factor 1 (IRF

73 These components include the transcription factors PU.1, Ikaros, Bcl11a, E2A, EBF, an

74 kine receptors Flk2 and IL-7R as well as the transcription factors PU.1, Ikaros, Bcl11a, E2A, EBF, an

75 dependent on the combinatorial action of the transcription factors PU.1, Ikaros, E2A, EBF, and Pax-5.

76 of GM-CSF in the lung, and expression of the transcription factor PU.1 in alveolar macrophages of GM(

77 PPARgamma colocalizes with the hematopoietic transcription factor PU.1 in areas of open chromatin and

78 und markedly heterogeneous expression of the transcription factor PU.1 in hematopoietic stem cells an

79 nalyses and validation studies implicate the transcription factor PU.1 in neutrophil to nAPC conversi

80 identified a requirement for the ETS family transcription factor PU.1 in Th9 development.

81 s or near-complete loss of the hematopoietic transcription factor PU.1 induces acute myeloid leukemia

82 otein complex, cross-immunoreactive with the transcription factors PU.1, interferon regulatory factor

83 ion demonstrated that the key haematopoietic transcription factor PU.1 is a major upstream regulator

84 The Ets transcription factor PU.1 is a master regulator for the

85 The transcription factor PU.1 is a master regulator of myelo

86 The B-lymphocyte- and macrophage-specific transcription factor PU.1 is a member of the ets family

87 We show that the transcription factor PU.1 is a target of the BSAP-mediat

88 The transcription factor PU.1 is an important regulator of h

89 The ets transcription factor PU.1 is an important regulator of t

90 The transcription factor PU.1 is critical for multiple hemat

91 r, we show that expression of the ETS domain transcription factor PU.1 is down-regulated in cells fol

92 The myeloid-specific transcription factor PU.1 is essential for expression of

93 and that the B cell and macrophage-specific transcription factor PU.1 is essential for regulating th

94 The ETS family transcription factor PU.1 is essential for the developme

95 The ets family transcription factor PU.1 is expressed in monocytes/macr

96 The essential hematopoietic transcription factor PU.1 is expressed in multipotent th

97 The ETS family transcription factor PU.1 is expressed in Th2 but not Th

98 The transcription factor PU.1 is found only in hematopoietic

99 The transcription factor PU.1 is involved in the decision to

100 uences of miR-142 specific promoter and that transcription factor PU.1 is necessary for its exclusive

101 The ETS domain transcription factor PU.1 is necessary for the developme

102 The transcription factor PU.1 is necessary for the developme

103 The transcription factor PU.1 is often impaired in patients

104 The transcription factor PU.1 is required for normal blood c

105 The ets family transcription factor PU.1 is required for the developmen

106 Transcription factor PU.1 is required for the developmen

107 The ets-family transcription factor PU.1 is required for the proper dev

108 The transcription factor PU.1 is shown to be required for th

109 Dysregulated expression of transcription factor PU.1 is strongly associated with Fr

110 The transcription factor Pu.1 is validated as a direct targe

111 Sfpi1, encoding the lineage-specific transcription factor PU.1, is indispensable for normal m

112 s for AP1 family and the macrophage-specific transcription factor, PU.1, is conserved from lizards to

113 Expression of transcription factor PU.1 may maintain some myeloid-like

114 es thus identified were found to bind to the transcription factors PU.1, NF-EM5, E2A, ATF-1, or CREM.

115 mic cells through the action of an oncogenic transcription factor (PU.1) on a key cell cycle regulato

116 genous expression of the lineage-determining transcription factor PU.1 or withdrawal of established d

117 IRF4 cobound with the transcription factors PU.1 or BATF to Ets or AP-1 compos

118 haploinsufficiency for the gene encoding the transcription factor PU.1 partially suppresses the neutr

119 However, mixture of multiple transcription factors (PU.1, PIP, c-Fos, and c-Jun) can

120 Our findings reveal that the ETS-family transcription factor PU.1 plays a crucial role in regula

121 The transcription factor PU.1 plays a key role in regulating

122 Transcription factor PU.1 positively regulates J chain g

123 ger RNA for the myeloid- and B-cell-specific transcription factor PU.1 progressively increases as mar

124 n receptor fusion of the macrophage-specific transcription factor PU.1 (PUER) show that BAF/PBAF recr

125 Whereas the transcription factor PU.1 regulates IL-7Ralpha expressio

126 The hematopoietic cell-specific ets family transcription factor PU.1 regulates many lymphoid and my

127 The transcription factor PU.1 regulates the generation of ly

128 Gene targeting of transcription factor PU.1 results in an early block to f

129 s deregulation of the hematopoietic-specific transcription factor PU.1 (Spi-1) by retroviral insertio

130 The transcription factor PU.1 (Spi-1) is a well-characterize

131 Regulation of the hematopoietic transcription factor PU.1 (Spi-1) plays a critical role

132 analyses revealed that FP I was bound by the transcription factor PU.1/Spi-1.

133 us studies have implicated the hematopoietic transcription factor PU.1 (SPI1) as an important target

134 o, null for the haemopoetic-lineage-specific transcription factor, PU.1, the task of phagocytosis is

135 These results elucidate how a single transcription factor, PU.1, through the cell context-spe

136 products down-regulates FcepsilonRI and its transcription factor PU.1, thus suggesting that Fcepsilo

137 Binding of the transcription factor PU.1 to its DNA binding motif regul

138 the deposition of histone variant H2A.Z and transcription factor PU.1 to key lymphoid fate regulator

139 ow that autophagy induces the degradation of transcription factor PU.1 to negatively modulate TH9 hom

140 R-203 established by the lineage-determining transcription factor PU.1, to achieve a differentiated p

141 ns specific binding sites for the Ets family transcription factor PU.1, transcription activating fact

142 In addition, the TH9 cell transcription factor, PU.1, undergoes K63 ubiquitination

143 The transcription factor PU.1 was markedly reduced in AMs of

144 We show that the ETS-family transcription factor PU.1 was required for the developme

145 neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased i

146 hybridization, mRNA expression levels of the transcription factor PU.1 were also found to be signific

147 generation of CNS macrophages relied on the transcription factor PU.1, whereas the MYB, BATF3 and NR

148 ive function of microglia is governed by the transcription factor PU.1, which becomes downregulated f

149 s because of inappropriate expression of the transcription factor PU.1, which binds to and represses

150 -response elements are primed by the pioneer transcription factor PU.1, which interacts with the gluc

151 ed that this kinase activated the ets family transcription factor PU.1, which is essential for macrop

152 itioned the critical haematopoietic-specific transcription factor PU.1 within a minimally deleted reg