ライフサイエンスコーパス: transcriptional activation domain

1 and by RP5, a viral strain lacking the VP16 transcriptional activation domain.

2 nding specificity, and is independent of the transcriptional activation domain.

3 at the C-terminus, encompassing the putative transcriptional activation domain.

4 of exon 8 and removes a majority of the Pax3 transcriptional activation domain.

5 to a previously mapped serine/threonine-rich transcriptional activation domain.

6 ect that is dependent on a C-terminal Notch1 transcriptional activation domain.

7 n bearing the DNA binding domain but not the transcriptional activation domain.

8 as the myogenin helix functions as a general transcriptional activation domain.

9 ting domain and, surprisingly, also a potent transcriptional activation domain.

10 her part of or all of the HD, but retain the transcriptional activation domain.

11 The DNA binding domain is linked to a VP16 transcriptional activation domain.

12 ino-terminal domain of CncB acts as a strong transcriptional activation domain.

13 that is likely to transmit the signal to the transcriptional activation domain.

14 nuclear matrix-targeting signal and the tau2 transcriptional activation domain.

15 s of LXR alpha or LXR beta that lack the AF2 transcriptional activation domain.

16 e N-terminal region of Myc which harbors its transcriptional activation domain.

17 vergence was most striking in the C-terminal transcriptional activation domain.

18 sor protein to mediate inhibition of the WT1 transcriptional activation domain.

19 ciated and transforming mutations within its transcriptional activation domain.

20 NA-binding domain and the COOH-terminal FKHR transcriptional activation domain.

21 egion linking the DNA-binding domain and the transcriptional activation domain.

22 is proposed to serve an essential role as a transcriptional activation domain.

23 he LIM domain of Lhx2 was shown to contain a transcriptional activation domain.

24 city, while the N terminus contains a potent transcriptional activation domain.

25 ved in the ETS DNA-binding domain and acidic transcriptional activation domain.

26 ted to the -137 to -130 bp region within the transcriptional activation domain.

27 khead (FKHR) sequences that contain a potent transcriptional activation domain.

28 3 lie an apoptotic domain as well as another transcriptional activation domain.

29 erminal part of BFCOL1 contained a potential transcriptional activation domain.

30 d by binding to SRF and in particular to its transcriptional activation domain.

31 p is a Ume6p-binding protein that provides a transcriptional activation domain.

32 l 125 amino acids function as an independent transcriptional activation domain.

33 tion of ARS 121 may occur independently of a transcriptional activation domain.

34 e compensated by a microsatellite-associated transcriptional activation domain.

35 p53 function by binding and masking the p53 transcriptional activation domain.

36 y domain (residues 41-110), and a C-terminal transcriptional activation domain.

37 nal region (residues 448 to 644) is a potent transcriptional activation domain.

38 3, and that this effect does not require its transcriptional activation domain.

39 Additionally, we show that DPC4 contains a transcriptional activation domain.

40 lian cells, indicating that GRIP1 contains a transcriptional activation domain.

41 gesting that it acts as a cell-type-specific transcriptional activation domain.

42 wild-type Sox2 but not a mutant lacking the transcriptional activation domain.

43 k4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain.

44 ect evidence that SIM in KLF4 functions as a transcriptional activation domain.

45 , NOC functions as a deadenylase but lacks a transcriptional activation domain.

46 ues 1-30) and conserved region 3 (CR3) - the transcriptional activation domain.

47 ediated phosphorylation at a site within the transcriptional activation domain.

48 r to ZXDC, containing ten zinc fingers and a transcriptional activation domain.

49 tral test protein, and a constant C-terminal transcriptional activation domain.

50 fers from other MAPKs in possessing a potent transcriptional activation domain.

51 ase CREB binding protein (CBP) to the FoxM1B transcriptional activation domain.

52 her mutations are at the amino-terminus in a transcriptional activation domain.

53 ns encoding the winged helix DNA binding and transcriptional activation domains.

54 gned to identify proteins that interact with transcriptional activation domains.

55 ment, we identified the Nmp4 DNA-binding and transcriptional activation domains.

56 A, but it is unaffected for interacting with transcriptional activation domains.

57 ch in Glu and Pro, a known characteristic of transcriptional activation domains.

58 st harbors both amino- and carboxyl-terminal transcriptional activation domains.

59 with Gal4 fusion proteins containing various transcriptional activation domains.

60 A168 to G222 were identified as independent transcriptional activation domains.

61 ion proteins, these LC sequences function as transcriptional activation domains.

62 ontains the human heat shock factor 1 (HSF1) transcriptional activation domains.

63 no detailed structures are yet available for transcriptional activation domains.

64 ependent transcription factor containing two transcriptional activation domains.

65 conserved DNA-binding domains and divergent transcriptional activation domains.

66 f HSF1 (CT) contains both the regulatory and transcriptional activation domains.

67 DP-dimerization, retinoblastoma-binding, and transcriptional activation domains.

68 nt of constituent side chains to function as transcriptional activation domains.

69 re often modular, with two or more separable transcriptional activation domains.

70 phorylated by p38 lie outside of the minimal transcriptional activation domains.

71 ion, HMR possesses an acidic nine-amino-acid transcriptional activation domain (9aaTAD) and a loss-of

72 ontains four domains including an N-terminal transcriptional activation domain, a C-terminal regulato

73 n that it contains a cytoplasmic DNA-binding-transcriptional activation domain, a transmembrane domai

74 Acidic or type IIB transcriptional activation domains (AADs) increase rates

75 he PAX3/PAX7 DNA binding domain and the FKHR transcriptional activation domain, activate transcriptio

76 exA DNA-binding domain and FKBP12 fused to a transcriptional activation domain activated reporter gen

77 nt fusion protein, containing a heterologous transcriptional activation domain activates Sex-lethal e

78 f galactose, Gal80 binds to and inhibits the transcriptional activation domain (AD) of the GAL gene a

79 by the Gal80 protein through masking of its transcriptional activation domain (AD).

80 the lexA DNA binding domain (LEXA-MSP) and a transcriptional activation domain (AD-MSP) interact to d

81 Transcriptional activation domains (ADs) are generally t

82 155, and (R)-UT-155) bind the amino-terminal transcriptional activation domain AF-1, which has not be

83 To investigate a potential ligand-dependent transcriptional activation domain (AF-2) in the C-termin

84 ontaining a mutation in the carboxy-terminal transcriptional activation domain, AF-2, retained elevat

85 the functional significance of the two major transcriptional activation domains, AF1 and AF2.

86 binding domain changes and mutations in the transcriptional activation domain, affected different se

87 AL4-NK-4 fusion constructs, we have mapped a transcriptional activation domain (amino acids 1-110) an

88 minus of the protein encodes two independent transcriptional Activation Domains (amino acids 1-74 and

89 functional domains, including a DNA-binding/transcriptional activation domain and a large extracellu

90 cidate its function have revealed a putative transcriptional activation domain and in vitro interacti

91 SREBP-1a has a longer transcriptional activation domain and is a more potent t

92 t, MyoD stimulates the function of the MEF2C transcriptional activation domain and the activity of en

93 Fusion of these zinc finger proteins to a transcriptional activation domain and to modified ligand

94 The N-terminal region of Hic-5 possesses a transcriptional activation domain and was essential for

95 usly defined CE2 site in the Hsf1 C-terminal transcriptional activation domain and with an additional

96 and fusion protein constructs that alter the transcriptional activation domains and the activities of

97 show that TGMV AL2, AL2(1-100) (lacking the transcriptional activation domain), and BCTV L2 can all

98 to amino acids 2829 to 2883 of MLL, a potent transcriptional activation domain, and amino acids 581 t

99 ter assays, identifying it as a proline-rich transcriptional activation domain, and indicating that t

100 TAp73 is a p73 isoform with a potent transcriptional activation domain, and loss of TAp73 pre

101 We show that an N-terminal transcriptional activation domain, and the bHLH region,

102 activity, but mutants of PU.1 that lack the transcriptional activation domain are nearly as efficien

103 Small molecule replacements of transcriptional activation domains are highly desirable

104 interaction, light-induced degradation, and transcriptional activation domains are located at the N-

105 t that individual functional elements in the transcriptional activation domains are responsible for a

106 interact with a region of p65 containing the transcriptional activation domain as demonstrated by mam

107 n analysis, it is shown that LKLF contains a transcriptional activation domain as well as a strong au

108 roline that was able to function as a potent transcriptional activation domain, as does the C terminu

109 of N-terminal truncations reveals a critical transcriptional activation domain at aa 31 to 185 and a

110 ing protein (CBP), resides in the C-terminal transcriptional activation domain at lysine 685.

111 It acts as an autonomous transcriptional activation domain at promoters containin

112 oncogene whose expression product contains a transcriptional activation domain at the C terminus.

113 at was sufficient to confer suppression of a transcriptional activation domain both in vivo and in vi

114 tein variant, MYC-S, which lacks part of the transcriptional activation domain but includes the conse

115 1 and USF2 proteins contain highly divergent transcriptional activation domains but share extensive h

116 Tax contains a transcriptional activation domain, but its ability to ac

117 onstruct (amino acid 691-750) containing the transcriptional activation domain, but not the DNA bindi

118 and the ability of TFIIB to interact with a transcriptional activation domain, but not with componen

119 Many AP-1 proteins contain defined transcriptional activation domains, but BATF and the clo

120 HIFalpha contains two transcriptional activation domains called the N-terminal

121 cated mutant of ORF50 lacking its C-terminal transcriptional activation domain, called ORF50DeltaSTAD

122 We show that the VP16 transcriptional activation domain can replace the C term

123 t a modified form of Pdx1, carrying the VP16 transcriptional activation domain, can cause conversion

124 region and a moderately conserved N-terminal transcriptional activation domain characterize the putat

125 inal 92 amino acids of LZIP contain a potent transcriptional activation domain composed of three elem

126 that CtBP1 also interacts directly with the transcriptional activation domain (conserved region 3 [C

127 IRS-4 interacts with both the transcriptional activation domain (conserved region 3) a

128 functions through the action of a conserved transcriptional activation domain, CR3.

129 lent linkage of LEF-1 to beta-catenin and to transcriptional activation domains derived from the estr

130 nuclear localization and that removal of the transcriptional activation domain did not eliminate Fish

131 regulates and small Maf proteins lacking the transcriptional activation domain down regulates ARE-med

132 58, which has been identified to be a second transcriptional activation domain, E2AD2.

133 The AZP fused to a transcriptional activation domain efficiently activated

134 enome regulation in human cells by tethering transcriptional activation domains either directly to a

135 Thus, through its kinase and transcriptional activation domains, ERK5 regulates trans

136 l, linker domain, Src homology 2 domain, and transcriptional activation domain failed to interact wit

137 s a loss-of-function D516N mutation in HMR's transcriptional activation domain, fails to induce the t

138 ncated Fli-1 protein, lacking the C-terminal transcriptional activation domain (Fli-1(DeltaCTA)).

139 minal acidic activation domain in YAP is the transcriptional activation domain for TEAD transcription

140 egradation of HIF-1alpha and that has a VP16 transcriptional activation domain from herpes simplex vi

141 ing the DNase I-hypersensitive site required transcriptional activation domains from TFE3 and PU.1, r

142 ion of HSF1 at serine residues distal to the transcriptional activation domain functions to repress t

143 hanced the activity of p53 or its N-terminal transcriptional activation domain fused to the DNA bindi

144 EWS/FLI, consists of an EWSR1-derived strong transcriptional activation domain fused, in-frame, to th

145 gene regulation, we also found that while a transcriptional activation domain fusion, CebpFlagWdr68,

146 rged as the human cDNA that, when fused to a transcriptional activation domain, gave the strongest 3D

147 and Runt derivatives containing heterologous transcriptional activation domains (HairyAct and RunAct)

148 d form of HSF in which the carboxyl-terminal transcriptional activation domain has been deleted [HSF(

149 A similar transcriptional activation domain has been identified in

150 PRC also contains a potent transcriptional activation domain in its amino terminus

151 ns and an acidic carboxyl terminus that is a transcriptional activation domain in maize and yeast cel

152 nalysis we show that HAND2 contains a strong transcriptional activation domain in the amino-terminal

153 , which was preceded by the acquisition of a transcriptional activation domain in the ancestral A-Myb

154 the Gal4 DNA binding domain has identified a transcriptional activation domain in the C terminus of E

155 4-Nkx2.2 fusion constructs to map a powerful transcriptional activation domain in the C-terminal regi

156 deletion mutants also provide evidence for a transcriptional activation domain in the N-terminal 19 a

157 l region for this function to a proline-rich transcriptional activation domain in the NH2-terminal 80

158 the role of c-Maf (large Maf) containing the transcriptional activation domain in the regulation of A

159 nkyrin repeat domain of Notch, and contain a transcriptional activation domain in their C termini.

160 screened a Jurkat cDNA library fused to the transcriptional activation domain in yeast expressing th

161 r enhanced Klotho's activation using p65-Rta transcriptional activation domains in addition to VP64.

162 ion with beta-catenin, and we delineated two transcriptional activation domains in beta-catenin whose

163 the Gal4 DNA-binding protein identified two transcriptional activation domains in C/EBPepsilon.

164 er (FRET) assay to monitor interactions with transcriptional activation domains in living cells.

165 We have identified potent classical transcriptional activation domains in the C termini of s

166 r receptor-binding properties and mapped the transcriptional activation domains in the two SRC1 isofo

167 All three OBP proteins contain transcriptional activation domains in their C-terminal r

168 either USF2 or GAL4 identified two distinct transcriptional activation domains in USF2, the USR and

169 expression, conservation of DNA binding, and transcriptional activation domains indicate that they ma

170 Phosphorylation of the C-terminal transcriptional activation domain induces a conformation

171 R deletion derivative lacking the N-terminal transcriptional activation domain, induction of CDI expr

172 Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances

173 Additionally, we find that the WT1 transcriptional activation domain interacts with the gen

174 The putative transcriptional activation domain is located in the C-te

175 The receptor's N-terminal transcriptional activation domain is not required for gr

176 The activity of the HSF1 transcriptional activation domains is modulated by a sep

177 ing that heat-induced phosphorylation of the transcriptional activation domains is not required for i

178 This isoform, which lacks a transcriptional activation domain, is generated by a pro

179 Aside from an N-terminal acidic transcriptional activation domain, little is known about

180 t transcription factor GAL4 revealed a major transcriptional activation domain located between aa 274

181 it duplication by dHAND requires neither the transcriptional activation domain nor the basic region,

182 g's sarcoma tumors, contains an NH2-terminal transcriptional activation domain (NTD) which resembles

183 lts are consistent with a model in which the transcriptional activation domain of activated Stat5 is

184 ate that the glutamine-rich subdomain of the transcriptional activation domain of AHR can interact wi

185 s insufficient and TGS reversal required the transcriptional activation domain of AL2.

186 In a broader sense, the transcriptional activation domain of avrXa10 may represe

187 ctivity; that the activity of the N-terminal transcriptional activation domain of Brn-3a is increased

188 Deletion of transcriptional activation domain of c-Maf (c-Maf) led t

189 To assess the role of the transcriptional activation domain of c-Rel in vivo, we g

190 ck a conserved sequence motif present in the transcriptional activation domain of class A-HSFs.

191 Elimination of the first transcriptional activation domain of E2A abolished both

192 ion involving a region within the N-terminal transcriptional activation domain of E2A-PBX1, termed th

193 ated reporter expression was mediated by the transcriptional activation domain of Elk-1.

194 The transcriptional activation domain of ERK5 is required fo

195 isolated as suppressors of a mutation in the transcriptional activation domain of GAL4.

196 ng experiments indicated that the C-terminal transcriptional activation domain of GLI1 and SMARCA2's

197 Heterologous fusion proteins linking the transcriptional activation domain of herpes simplex viru

198 The amino-terminal transcriptional activation domain of HNF3beta is essenti

199 howed that amino acids 1 to 43 of the acidic transcriptional activation domain of IE62 can bind recom

200 s from MEF2, and augments the potency of the transcriptional activation domain of MEF2 fused to a het

201 s are clustered within or close to the major transcriptional activation domain of MEF2A.

202 The complexation of KIX with the transcriptional activation domain of mixed-lineage leuke

203 gnals its destruction; this degron spans the transcriptional activation domain of Myc, and includes t

204 dimerization and DNA binding domains but not transcriptional activation domain of Nrf3.

205 ltured cells, the p90MDM2 protein blocks the transcriptional activation domain of p53 and also stimul

206 p90(MDM2) inhibits p53 by blocking the transcriptional activation domain of p53 as well as by s

207 that acts as a coregulator of the N-terminal transcriptional activation domain of progesterone recept

208 We further demonstrate that tethering the transcriptional activation domain of Rap1p to DNA is suf

209 The transcriptional activation domain of RelA(p65) interacte

210 The transcriptional activation domain of RelB, but not RelA,

211 ch disrupt the DNA binding domain or the AF2 transcriptional activation domain of SF-1 do not confer

212 between BRCA1 aa 502-802 and the C-terminal transcriptional activation domain of STAT1 including Ser

213 activity interacted with the C-terminal SH2 transcriptional activation domain of Stat1.

214 like activator by fusion with the C-terminal transcriptional activation domain of STAT2 or the acidic

215 to a cellular replication origin, the acidic transcriptional activation domain of the breast cancer p

216 The transcriptional activation domain of the herpesvirus pro

217 carcinoma translocated-1) and the C-terminal transcriptional activation domain of the Notch coactivat

218 enzoyl-L-phenylalanine (pBpa) throughout the transcriptional activation domain of the prototypical eu

219 This protein interacted mainly with the transcriptional activation domain of the SRF protein and

220 acetylated survivin binds to the N-terminal transcriptional activation domain of the STAT3 dimer and

221 he tetracycline repressor of E. coli and the transcriptional activation domain of the VP16 protein of

222 iochemical assays have shown that the potent transcriptional activation domain of VP16 can associate

223 P16 residues lying near the carboxy-terminal transcriptional activation domain of VP16 in associating

224 full length Hex to two copies of the minimal transcriptional activation domain of VP16 together with

225 essing a HMR22 mutant protein fused with the transcriptional activation domain of VP16, suggesting a

226 The transcriptional activation domain of WT1 is subject to r

227 In this study we localized the transcriptional activation domain of Xlim-1 to its carbo

228 of PML bodies by Z requires a portion of the transcriptional activation domain of Z but not the DNA-b

229 We map the transcriptional activation domain of ZLD to a central re

230 omains both interacted specifically with the transcriptional activation domain of Zta in an electroph

231 ted the previously described DNA binding and transcriptional activation domains of both Pit-1 and TR

232 ER-alpha36; the predicted protein lacks both transcriptional activation domains of hER-alpha66 but re

233 ly, we report that Hsp70 interacts with both transcriptional activation domains of Hsf1 in the relate

234 ate have been shown to affect DNA binding or transcriptional activation domains of MITF and act as do

235 id residues that exhibited homology with the transcriptional activation domains of several translocat

236 tion primarily by masking and inhibiting the transcriptional activation domains of the recruiting pro

237 (TGF-beta) activation and is mediated by the transcriptional activation domains of the Smad proteins.

238 ntains a limited region of homology with the transcriptional activation domains of three other genes

239 We have identified the transcriptional activation domains of Upc2p and Ecm22p a

240 Mutants in the transcriptional activation domain or DNA-binding domain

241 ric polypeptide composed of XSOX3 and a VP16 transcriptional activation domain or morpholino-induced

242 orm of MEF2C containing the Herpesvirus VP16 transcriptional activation domain partially bypasses the

243 atment caused a shift in the position of the transcriptional activation domain relative to the DNA bi

244 terminal phosphorylation sites or C-terminal transcriptional activation domain, restores positive sel

245 sion of a truncated form of CBF2 lacking its transcriptional activation domain resulted in a cold-sti

246 ession of a gene with Mcm1 fused to a strong transcriptional activation domain resulted in increased

247 Transcriptional activation domains share little sequence

248 ever, chromatin remodeling that depends on a transcriptional activation domain shows a considerable,

249 One class of transcriptional activation domains stimulates the concer

250 ve truncation or loss of the C-terminal BRCT transcriptional activation domain, suggesting that trans

251 y protein (IEP) lacking the essential acidic transcriptional activation domain (TAD) and serine-rich

252 ic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants.

253 Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the

254 the KIX domain of CBP/p300, and second, the transcriptional activation domain (TAD) of RelA binds to

255 ient mice, mice lacking the conserved Notch1 transcriptional activation domain (TAD) show attenuated

256 the following highly conserved regions: the transcriptional activation domain (TAD), MDM2 binding si

257 ivity mediated through its unique C-terminal transcriptional activation domain (TAD).

258 The COOH terminus of the STATs acts as a transcriptional activation domain (TAD).

259 ption and that this region contains a strong transcriptional activation domain (TAD).

260 r, IE62, contains a potent N-terminal acidic transcriptional activation domain (TAD).

261 The ability of transcriptional activation domains (TADs) to signal ubiq

262 oteins, including two experimentally defined transcriptional activation domains (TADs), fused to the

263 (amino acids 190-257), and assembly of their transcriptional activation domains (TADs).

264 Each of these factors contain a transcriptional activation domain that is activated by p

265 CBP was found to contain a signal-regulated transcriptional activation domain that is controlled by

266 yc that oppositely regulate its stability: a transcriptional activation domain that promotes Myc dest

267 FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conse

268 Among the transcriptional activation domains that can stimulate vi

269 sent a novel class of cofactors recruited by transcriptional activation domains that function in dive

270 These data indicate that, in addition to the transcriptional activation domain, the p53 proline-rich

271 man and bovine PROP1 proteins contain potent transcriptional activation domains, the amino termini an

272 ncodes a large protein with a defined acidic transcriptional activation domain; this protein does not

273 on factor by recruiting multiple copies of a transcriptional activation domain to a nuclease-deficien

274 tiple gRNAs can direct dCas9 fused to a VP64 transcriptional activation domain to increase expression

275 othesize that this region merely tethers the transcriptional activation domain to the cytoplasmic mem

276 ins to characterize the ability of different transcriptional activation domains to stimulate transcri

277 atalytically inactive Cpf1 nuclease fused to transcriptional activation domains to tune the expressio

278 zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the n

279 cDNA, or truncated mPax6Delta286 lacking the transcriptional activation domain was inserted into a te

280 ; aa, 1-683) that lacks tyrosine 699 and the transcriptional activation domain was introduced into Ba

281 ative Pitx2 isoforms in which the C-terminal transcriptional activation domain was replaced by the re

282 activity because of mutations in the acidic transcriptional activation domain was restored by additi

283 To identify independently functional transcriptional activation domains, we developed a heter

284 in tandem with specific features of the HSF1 transcriptional activation domains, we first used deleti

285 ed to different oligomerization motifs and a transcriptional activation domain were analyzed for olig

286 Candidate proteins fused to a transcriptional activation domain were tested for the ab

287 EBPepsilon isoforms, p32 and p30, possessing transcriptional activation domains were coexpressed in m

288 The transcriptional activation domains were separated by ami

289 ntrast, the position and interactions of the transcriptional activation domains were similar througho

290 s of USF-1 and -2 lacking the DNA binding or transcriptional activation domains were unable to stimul

291 These ZFPs, when fused to either VP16 or p65 transcriptional activation domains, were able to activat

292 observed that FoxA2 induces Arx through its transcriptional activation domain whereas Nkx2.2, induce

293 CHOP is found to contain a transcriptional activation domain which is inducible by

294 It provides a transcriptional activation domain which, unlike Oct-1, a

295 epresent a prokaryotic version of the acidic transcriptional activation domain, which heretofore has

296 identified at the amino-terminus of BRCA2 a transcriptional activation domain whose importance is hi

297 ependent association and disassociation of a transcriptional activation domain with a promoter.

298 f Ets domain proteins, contains a C-terminal transcriptional activation domain with multiple copies o

299 acterization of two evolutionarily conserved transcriptional Activation Domains within the GATA-4/5/6

300 We found that EAF2 and EAF1 both contain transcriptional activation domains within this region.