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1 ndowing p53 mutants with thermostability and transcriptional activity.
2 eins YAP1, TAZ and TEAD4 and promoting their transcriptional activity.
3 ontaining factor, GhHOX3, and repressing its transcriptional activity.
4 enously interacts with GLI1 and enhances its transcriptional activity.
5 hibit LLPS of TFEB to negatively control its transcriptional activity.
6 ary contributor to the nuclear receptor (NR) transcriptional activity.
7 ri-infected tissues, and aligns with nuclear transcriptional activity.
8 timulate downstream NFkappaB, NFAT, and AP-1 transcriptional activity.
9 than a consensus-based method for predicting transcriptional activity.
10 s were able to repress AUXIN RESPONSE FACTOR transcriptional activity.
11 to the Fbxl2 promoter, resulting in reduced transcriptional activity.
12 require a bound ligand for folding or basal transcriptional activity.
13 inside the nucleus to coordinate with their transcriptional activity.
14 tream activation of NFkappaB, AP-1, and NFAT transcriptional activity.
15 alleles, correlating with parental-specific transcriptional activity.
16 differences in both cellular composition and transcriptional activity.
17 s 3'-untranslated region to downregulate its transcriptional activity.
18 beige adipocytes through inhibition of EBF2 transcriptional activity.
19 sically interacts with PARP-1 affecting E2F1 transcriptional activity.
20 f the FBP1 gene and negatively regulated its transcriptional activity.
21 s beta-catenin levels, protein half-life and transcriptional activity.
22 of promoter is as important as its level of transcriptional activity.
23 eration sequencing (NGS) assays that profile transcriptional activity.
24 alpha protein, ensuring HIF-2alpha-dependent transcriptional activity.
25 ive conformation was essential for caspase-3 transcriptional activity.
26 ation promotes its nuclear translocation and transcriptional activity.
27 pathways in a small motif to fine-tune FOXO1 transcriptional activity.
28 e unable to compensate for loss of HNF4alpha transcriptional activity.
29 nical inducer of the immune response and has transcriptional activity.
30 lity, nuclear localization, DNA binding, and transcriptional activity.
31 onical tyrosine phosphorylation and enhanced transcriptional activity.
32 known which Mediator subunit mediates SPL10 transcriptional activity.
33 ion and acetylation of MEF2D, increasing its transcriptional activity.
34 ly stage eggs possess little or no intrinsic transcriptional activity.
35 ning of DNA sequence variants for effects on transcriptional activity.
36 d FOXM1 in the regulation of FOXM1-dependent transcriptional activity.
37 i, by promoting TAZ nuclear localization and transcriptional activity.
38 HDAC4/5 and PRKD1 in the regulation of TBX5 transcriptional activity.
39 henotype severity and the reduction in KDM5C transcriptional activity.
40 also prevented Stat3 lysine methylation and transcriptional activity.
41 n an engineered cell line, reporting on Nrf1 transcriptional activity.
42 n of ligands capable of increasing RORgammat transcriptional activity.
43 coordinated with 3D genome organization and transcriptional activity.
44 ing the pleiotropic consequences of aberrant transcriptional activity.
45 hly homologous SMAD2 did not alter HIF2alpha transcriptional activity.
46 e AAA+ ATPase RUVBL1 is necessary for Nrf1's transcriptional activity.
47 phenotypes have largely been limited to its transcriptional activity.
48 f tyrosine phosphorylation, DNA binding, and transcriptional activity.
49 esis by binding to and suppressing PGC1alpha transcriptional activity.
50 nd this assembly mediates foci formation and transcriptional activity.
51 role in AR stability and is critical for its transcriptional activity.
52 vents its phosphorylation, and activates its transcriptional activity.
53 se orthologue (mG9a) potently stimulated p53 transcriptional activity.
54 cale TADs, whose boundaries are enriched for transcriptional activity.
55 mal region of the IL22 promoter and promotes transcriptional activity.
56 with greater inhibition of mTOR gene pathway transcriptional activity.
57 for cocaine reward memory and DRD1-mediated transcriptional activity.
58 sed K310 NF-kappaB acetylation and NF-kappaB transcriptional activity.
59 r regulation of cell spreading or MRTF-A/SRF transcriptional activity.
60 l cytotoxicity by impairing T-cell signaling transcriptional activity.
61 ally and post-translationally regulate Stat3 transcriptional activity.
62 TF-A and increased its nuclear retention and transcriptional activity.
63 endent (TEAD) and MRTF-A/B-dependent (SRE.L) transcriptional activity.
64 single cells according to the timing of past transcriptional activity.
65 idues is well characterized to inhibit Foxo1 transcriptional activity.
66 iptional complex to decrease DNA-binding and transcriptional activity.
67 omatin domains subclassified on the basis of transcriptional activity.
68 f chondrocyte maturation, and suppresses its transcriptional activity.
69 Myrf-V679A and Myrf-R695H do not exhibit any transcriptional activity.
70 abolism, ribosome biogenesis and E2F and MYC transcriptional activities.
71 artments that are characterized by differing transcriptional activities.
72 t play an important role in controlling gene transcriptional activities.
73 lethal resistance via its ligand-independent transcriptional activity?
74 Luciferase reporter assays showed higher transcriptional activity (1.4-fold) with the alternate G
75 nal variants from 14 loci displaying allelic transcriptional activity, a subset of which corroborates
76 physical consequences of the distribution of transcriptional activity across chromosomes should be ce
77 cells; ER "degraders" exhibit a spectrum of transcriptional activities and anti-proliferative potent
78 c gene sets-including those linked to low AR transcriptional activity and a stemness program-were act
79 d that B12/FA deficiency in mice induces AhR transcriptional activity and accumulation of erythroid p
80 bind to LDs, reducing their availability for transcriptional activity and attenuating the response to
82 rms a ternary complex to co-activate ERalpha transcriptional activity and concomitantly enhances ERal
83 ively, our data argue that DHX15 enhances AR transcriptional activity and contributes to PCa progress
85 O1 (forkhead box protein O1) suppressing its transcriptional activity and decreasing miR-145 expressi
87 sed the acetylation of c-Jun, increasing its transcriptional activity and enriching for an AP-1 gene
88 er151) is critical for RELB-DNA interaction, transcriptional activity and expression of the senescenc
89 weight forms of retinoid receptors that lack transcriptional activity and fail to be recognized by th
90 ia the modulation of forkhead box O1 (FoxO1) transcriptional activity and induces a tight junctional
91 PBRM1 BD4 mutant fails to fully support p53 transcriptional activity and is defective as a tumor sup
92 nd that TRIM27 alone is necessary for ZNF165 transcriptional activity and is required for TNBC tumor
94 des, evidenced by significantly enhanced p53 transcriptional activity and much more induced level of
95 TED2 deficiency elevate LPS-induced NFkappaB transcriptional activity and NFkappaB-p65 recruitment to
97 es NACA at specific residues, impacting cJUN transcriptional activity and osteoblast differentiation
98 /E7 oncogenes were abundantly expressed, and transcriptional activity and productive infection demons
99 ic Protease USP17 was shown to augment ELK-1 transcriptional activity and promote cell proliferation.
100 lation (pS) of STAT3 can augment its nuclear transcriptional activity and promote essential mitochond
101 Inhibition of Pvt1b increases Myc levels and transcriptional activity and promotes cellular prolifera
103 sociated with lower CRP levels and decreased transcriptional activity and protein binding in vitro, p
104 r1's ligand-binding domain and promoting its transcriptional activity and secondly by upregulation of
105 s ubiquitination of ELK-1 nor impacts on its transcriptional activity and suggest that an E3 ubiquiti
106 of expression thereby leads to increased AR transcriptional activity and survival in response to DNA
107 ll lines, we showed that INPP4B regulates AR transcriptional activity and the oncogenic signaling pat
108 p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function.
109 fer in chromosome numbers, sizes, functions, transcriptional activities, and cohesin complex location
110 compartments have distinct epigenetic marks, transcriptional activities, and transcription factor enr
111 pression through suppression of beta-catenin transcriptional activity, and also through activation of
112 quired for cell proliferation, enhanced AR's transcriptional activity, and colocated with AR at speci
114 liced isoforms of p53, known to modulate p53 transcriptional activity, are affected by IAV infection
116 romoter CpG density and, to a lesser extent, transcriptional activity, are key factors implicated in
117 nd mRNA expression, ultimately reducing LEF1 transcriptional activity, as judged by luciferase assay.
118 199 (miR-199-3p and miR-199-5p) and promoter transcriptional activity assays in mouse islets and mous
119 module containing Tox that exhibited higher transcriptional activity associated with more abundant a
121 he CLOCK protein to antagonize CREB-mediated transcriptional activity at the tyrosine hydroxylase (TH
123 lic community have different levels of total transcriptional activity, at the selected time-points, a
124 analysis has demonstrated that heterogeneous transcriptional activity attends molecular transition fr
125 rrogate marker of early replication or viral transcriptional activity before detection by routine per
126 1 We hypothesize that the regulation of NRF1 transcriptional activity by CDK2 may allow the modulatio
127 sphorylation at S811, for example, alters RB transcriptional activity by promoting its association wi
128 dephosphorylation, nuclear translocation and transcriptional activity by signalling through the recep
129 omatin structure-namely, cohesin binding and transcriptional activity-can be used to predict the kine
130 REBP1 variants exhibited significantly lower transcriptional activity compared to the wild-type, as d
131 cation conflicts (TRCs) occur when intensive transcriptional activity compromises replication fork st
133 indicate that targeting the effects of RUNX transcriptional activity could be relevant for clinical
134 some-mediated degradation, inhibition of MYC transcriptional activity, decreased cancer cell prolifer
136 mRNA transcripts dependent upon beta-catenin transcriptional activity during Ad5 infection, with earl
137 being driven by a Hh threshold, robust Gli3 transcriptional activity during skeletal and glossal dev
139 l consequences, including stimulation of p53 transcriptional activity, growth arrest, and cellular se
141 ent and interacting partners required for AR transcriptional activity has uncovered three pioneer fac
142 es carrying TP53 mutations with predicted 0% transcriptional activity (HR = 1.53, 95% CI: 1.21-1.94).
144 vities, contributes to various p53-dependent transcriptional activities in different cell types durin
145 B was subregion-specific, and that DeltaFosB transcriptional activity in both the dorsal and ventral
147 Here we show that insulin modulates YAP transcriptional activity in classic insulin target cells
149 ein (YAP) localization, phosphorylation, and transcriptional activity in human ECs challenged with Ab
151 NO2-OA inhibited TNFalpha-induced NF-kappaB transcriptional activity in human TNBC cells and suppres
152 gulates genome higher-order organization and transcriptional activity in living cells remains unclear
153 ed nuclear entry of p50 and showed decreased transcriptional activity in luciferase reporter assays.
154 PS-induced cytokine production and NF-kappaB transcriptional activity in mouse bone marrow-derived ma
156 cytotoxic therapy induced YAP expression and transcriptional activity in patient-derived xenografts t
157 ically interacts with TAZ, stimulating RunX2 transcriptional activity in pre-osteoblast cells in a TA
160 out or knockdown of CK5 ablated beta-catenin transcriptional activity in response to progestins and W
162 Tc3 nuclear accumulation and NFAT-luciferase transcriptional activity in skin microvessels, resulting
163 ER) alpha-gene (ESR1) result in constitutive transcriptional activity in the absence of estrogen and
164 and Y537C mutations resulted in increased ER transcriptional activity in the absence of estrogen comp
165 livers result from the dysregulation of YAP transcriptional activity in the bile duct-lining epithel
166 15 demonstrated substantial inhibition of GR transcriptional activity in the GR positive HCC1806 trip
169 regulated cytokine, cytolytic, and metabolic transcriptional activity in the psoriatic cells that dif
170 ity of nuclear myosin VI to bind DNA and its transcriptional activity in vitro We conclude that loss
173 tion, as evidenced by increased beta-catenin transcriptional activity, in breast cancer cells and tum
174 omatin occupancy and considerable changes in transcriptional activity, including increased expression
175 at3 phosphorylation, lysine methylation, and transcriptional activity increase before gastrulation an
177 wn halophilic viruses, many of which exhibit transcriptional activity indicative of host infection.
178 ay activation to test whether increased YAP1 transcriptional activity is a mechanism of MEK1/2 inhibi
180 a provide a greater understanding of how Myc transcriptional activity is determined and indicate modi
181 ur results suggest a mechanism in which MEF2 transcriptional activity is differentially recruited to
188 cea kluyveri Our findings indicate that Hsf1 transcriptional activity is tightly regulated to ensure
190 tion factor is activated and carries out its transcriptional activity, it also needs to be properly d
191 HK-2 genomic DNA resulted in a change in KL transcriptional activities, likely operating via long no
192 gulates the temporal expression of AR during transcriptional activity, MDM2 in CSCs promoted the cons
193 ibitors cause paradoxical activation of ERK5 transcriptional activity mediated through its unique C-t
194 p and miR-197 inhibitors markedly reduced AR transcriptional activity, mRNA and protein levels, incre
195 hat fulvestrant-like antagonists suppress ER transcriptional activity not by ER elimination, but by m
197 gnostic model and find correlations with the transcriptional activities of biological pathways.See re
198 uent storage at 4 degrees C; simultaneously, transcriptional activities of carotenoid biosynthetic ge
199 ompounds were evaluated for their effects on transcriptional activities of GATA4 and NKX2-5 individua
200 differential and overlapping DNA-binding and transcriptional activities of the NRFs has not yet been
202 Directing Aire to PML bodies impairs the transcriptional activity of Aire, while dispersing PML b
203 ication of mRNA and gene loci to measure the transcriptional activity of an endogenous gene in indivi
204 ed that homodimerization is required for the transcriptional activity of AR-V7 and that AR-V7 can als
205 ination with available oxygen to control the transcriptional activity of BbSre1, which in turn mediat
206 in another transgenic model with suppressed transcriptional activity of beta-catenin but preserved c
207 nts indicate that cf-mRNA levels reflect the transcriptional activity of bone marrow-resident hematop
208 nd results in reduced protein expression and transcriptional activity of both full-length AR (AR-FL)
209 sis of gene expression (CAGE), we quantified transcriptional activity of both host and pathogen over
214 vestigate how chromosome topology relates to transcriptional activity of clustered biosynthetic pathw
216 ular underpinnings of DMD, controlled by the transcriptional activity of different types of muscle an
217 contain a TATA consensus motif, support high transcriptional activity of downstream genes, and are li
218 ing sites by AR and negatively regulated the transcriptional activity of E2F1 on DNA replication gene
219 ing sites by AR and negatively regulates the transcriptional activity of E2F1 on DNA replication gene
224 erical restriction of flagella, in which the transcriptional activity of FlrA is down-regulated throu
226 anges in the plant methylome that impact the transcriptional activity of genes and transposable eleme
227 n organizational changes associated with the transcriptional activity of genes important for neuronal
228 irectly interacts with FIH1 and inhibits the transcriptional activity of HIF1alpha by upregulating FI
230 ce and time, and reveals how the coordinated transcriptional activity of individual nuclei shapes com
232 ogenic genes is dependent on ARID1A, whereas transcriptional activity of neurogenic genes is under co
233 gest that the absence of mu1 allows enhanced transcriptional activity of newly synthesized cores and
235 reased oxidative stress in diabetes, and the transcriptional activity of Nrf2, which is critical in r
237 Thiazolidinedione drugs (TZDs) target the transcriptional activity of peroxisome proliferator acti
238 as induced upon CR, leading to the increased transcriptional activity of peroxisome proliferator-acti
239 lity of this lncRNA to bind and regulate the transcriptional activity of Pit1 in conjunction with Zbt
240 that Yap and Taz differentially regulate the transcriptional activity of Runx2, and that the activity
244 ent gp130 (F/F) mice associated with reduced transcriptional activity of STAT3-regulated gene network
245 veral environmental pollutants modulated the transcriptional activity of tested nuclear receptors at
248 NACA and PP1A cooperatively potentiated cJUN transcriptional activity of the AP-1-responsive MMP9-luc
249 VEGFA rs1885657 and rs58159269 increased transcriptional activity of the constructs containing th
250 ncer cell nucleus, where it up-regulates the transcriptional activity of the glucocorticoid receptor
253 d knowledge of the cell type composition and transcriptional activity of the placenta and its compart
256 Cs was unaffected by the absence of Vpr, the transcriptional activity of the viral long terminal repe
257 tions than at diagnosis, including increased transcriptional activity of the Yes-associated protein (
262 s that OTUD5 depletion leads to the enhanced transcriptional activity of TRIM25 and the inhibited exp
263 n in the endoplasmic reticulum that controls transcriptional activity of various developmental progra
266 These findings suggest that axons regulate transcriptional activity of YAP/TAZ in adult SCs and tha
267 hese parameters provide access to a range of transcriptional activity, offering a new perspective for
268 f DNA strain arising from DNA compaction and transcriptional activity on initiation complex formation
270 T3 dependency by Helicobacter coincided with transcriptional activity on STAT3-regulated genes, rathe
271 to identify genes that regulate HIF2alpha's transcriptional activity on the promoter of the iron tra
273 IL15 and IL21 cooperatively increased their transcriptional activity, proliferation, and cytolytic p
274 negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell gro
275 A newly identified role for USP11 in ERalpha transcriptional activity represents a novel mechanism of
276 hese mutants, we show that induction of ERK5 transcriptional activity requires direct binding of the
277 he p53 protein involves altered or abrogated transcriptional activity resulting in a failure to media
278 first EAP1 mutations leading to reduced GnRH transcriptional activity resulting in a phenotype of sel
279 that GTAT haplotype exerts an increased DRB transcriptional activity, resulting in higher DRB expres
280 mice with beta cell-specific-deficient Notch transcriptional activity showed improved glucose toleran
284 er/Thr kinases is a primary factor for their transcriptional activity that incurs the formation of bo
285 Chromatin organizes DNA and regulates its transcriptional activity through epigenetic modification
286 regulates YAP1 nuclear localization and its transcriptional activity through the androgen receptor-S
287 function for NEK10 in the regulation of p53 transcriptional activity through tyrosine phosphorylatio
288 6 residue, which specifically modulates E2F1 transcriptional activity to enhance cell cycle arrest fo
289 icant impact on HIF expression or associated transcriptional activity under normoxic or hypoxic condi
290 anism by which chromatin parameters regulate transcriptional activity via the three-dimensional folde
292 upling is coordinating transcription or post-transcriptional activities we used stochastic switch mod
293 permatogenesis including cells that have low transcriptional activity, we apply a statistical tool th
294 of Zfp423 that cooperatively enhances Zfp423 transcriptional activity, which in turn affects myoblast
295 Loss of SHP reduces XBP1s protein level and transcriptional activity, which in turn attenuates the E
296 s identified USP11 as a regulator of ERalpha transcriptional activity, which was further validated by
297 me-as a surrogate measure of promoter-driven transcriptional activity-which is now known as a reporte
298 monstrate that inhibition of ERK5 kinase and transcriptional activity with a small molecule did not t
299 egulation of Hsf1 globally dysregulated Hsf1 transcriptional activity, with synergistic effects on bo
300 novel, sequence-dependent mechanism for Gli transcriptional activity within the craniofacial complex