ライフサイエンスコーパス: transcriptional elongation

1 ns across eukaryotes that are independent of transcriptional elongation.

2 sequence of the active GAL1 gene, and hence transcriptional elongation.

3 ukaemia (ELL) protein, as a key regulator of transcriptional elongation.

4 acting mechanism by which sequence modulates transcriptional elongation.

5 d H3K27 (H3K27me2), and proteins involved in transcriptional elongation.

6 tion by demethylating H3K27me3 and promoting transcriptional elongation.

7 nd results in suppression of hPAF1C-mediated transcriptional elongation.

8 lysine 120 (H2Bub) is associated with active transcriptional elongation.

9 m each burst of transcription by stimulating transcriptional elongation.

10 an H3K4me3 gradient important for productive transcriptional elongation.

11 -cells), as well as potential effects on HIV transcriptional elongation.

12 esolve DNA double-stranded breaks or promote transcriptional elongation.

13 ghly conserved non-coding RNA that regulates transcriptional elongation.

14 BRD4, and ELL coincides with termination of transcriptional elongation.

15 oint mutation in the IKBKAP gene involved in transcriptional elongation.

16 in (CTD) repeats of RNA polymerase II during transcriptional elongation.

17 acilitate the assembling process by stalling transcriptional elongation.

18 e or more factors involved in the process of transcriptional elongation.

19 presented here suggest an additional role in transcriptional elongation.

20 n elongation factor-b, leading to a block in transcriptional elongation.

21 tive elongation factors to stimulate general transcriptional elongation.

22 work links histone methylation by Set2 with transcriptional elongation.

23 essive chromatin structure is restored after transcriptional elongation.

24 arge complex and determine the inhibition of transcriptional elongation.

25 the coactivator function in regulating HIV-1 transcriptional elongation.

26 domain (CTD) of RNA polymerase II to promote transcriptional elongation.

27 hat is required for normal initiation and/or transcriptional elongation.

28 RNA polymerase II and is required for normal transcriptional elongation.

29 L1 expression is primarily due to inadequate transcriptional elongation.

30 at 6-AU sensitivity results from a defect in transcriptional elongation.

31 locking the transition from preinitiation to transcriptional elongation.

32 of RNA polymerase II, permitting productive transcriptional elongation.

33 logous to mammalian Cdk9, which functions in transcriptional elongation.

34 in both positively and negatively regulating transcriptional elongation.

35 ion is not required to maintain the speed of transcriptional elongation.

36 r 5 phosphorylation of RNA polymerase II and transcriptional elongation.

37 ers of the Paf1 complex, which also promotes transcriptional elongation.

38 omoter association and subsequent effects on transcriptional elongation.

39 -containing heptapeptide repeat and inhibits transcriptional elongation.

40 the RNA polymerase II complex and stimulates transcriptional elongation.

41 at the CCR4-NOT complex also plays a role in transcriptional elongation.

42 5-242 allele are factors involved in slowing transcriptional elongation.

43 e presented, implying a role for Bur1 during transcriptional elongation.

44 seful tool to identify factors important for transcriptional elongation.

45 t system for studying DRB-sensitive steps of transcriptional elongation.

46 IG-I, producing their enhanced expression by transcriptional elongation.

47 pre-mRNA splicing by chromatin structure and transcriptional elongation.

48 n downstream from SALL4 TSS influences SALL4 transcriptional elongation.

49 atin reader present in complexes stimulating transcriptional elongation.

50 pears to be a result of selective control of transcriptional elongation.

51 hromatin reassembly enhances the fidelity of transcriptional elongation.

52 P-TEFb), to target gene promoters, enhancing transcriptional elongation.

53 nduced latency reversal by suppressing HIV-1 transcriptional elongation.

54 ance of Spt16 in the absence of San1 impairs transcriptional elongation.

55 nd temperature stress releases the brakes on transcriptional elongation.

56 confirming that DDR signalling results from transcriptional elongation.

57 nhancer function and architectural models of transcriptional elongation.

58 ng splice machinery or indirectly modulating transcriptional elongation.

59 tion initiation independent of its effect on transcriptional elongation.

60 lated action mechanism of eRNAs during early transcriptional elongation.

61 elongation factor b (P-TEFb) and facilitated transcriptional elongation.

62 mosome segregation, protein homeostasis, and transcriptional elongation.

63 In contrast, a mutation that diminished transcriptional elongation abolished induction of full-l

64 Fusion with MLL preserves the transcriptional elongation activity of ELL but relocaliz

65 ncentration of ELL and EAF1 in CBs links the transcriptional elongation activity of ELL to the RNA pr

66 latter involves incremental increases in the transcriptional elongation activity of pol II that is pr

67 , an activity that is required for efficient transcriptional elongation and 3' RNA processing.

68 fusion proteins in leukemia induce aberrant transcriptional elongation and associated chromatin pert

69 d zebrafish; Spt5 may provide a link between transcriptional elongation and cell fate.

70 a series of features associated with active transcriptional elongation and chromatin 3D structure ar

71 role for these proteins in the regulation of transcriptional elongation and coordinated histone methy

72 ates for Bur1/Bur2, thus linking its role to transcriptional elongation and demonstrating a potential

73 usly unrecognized role of WHSC1, which links transcriptional elongation and H3.3 deposition into acti

74 S10 and H2Av phosphorylation is required for transcriptional elongation and heat shock-induced chroma

75 e Paf1 complex (PAF1C), which is involved in transcriptional elongation and histone modifications.

76 is directed to excellent existing reviews on transcriptional elongation and HIV transcription.

77 omain of RNA Pol II and stimulated efficient transcriptional elongation and HIV-1 expression in the a

78 ptualization of nucleosome remodeling during transcriptional elongation and in the development of his

79 ELL2 stimulates transcriptional elongation and is a subunit of the Super

80 We conclude that hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a prot

81 uction of PRGs is controlled at the level of transcriptional elongation and mRNA processing, through

82 Although these proteins control transcriptional elongation and perhaps modulate the effe

83 iption/export) complex that is important for transcriptional elongation and recruitment of mRNA expor

84 or of viral gene expression required for HIV transcriptional elongation and replication.

85 racted P-TEFb, thereby mobilizing downstream transcriptional elongation and splicing machineries.

86 nt introns, likely reflecting a link between transcriptional elongation and splicing.

87 Transcriptional elongation and termination by RNA polyme

88 ctive genes and influence, in opposing ways, transcriptional elongation and termination.

89 h these mRNA processing reactions throughout transcriptional elongation and termination.

90 ssion of sec2(ts) is not a result of reduced transcriptional elongation and that Elp1p physically ass

91 lation is normally associated with efficient transcriptional elongation and the recruitment of pre-mR

92 in C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination.

93 se data suggest a model whereby Hmt1 affects transcriptional elongation and, as a result, influences

94 o the histone 3 tail, play an active role in transcriptional elongation, and colocalize with genes th

95 coordinates nucleosome dis- and re-assembly, transcriptional elongation, and mRNA processing.

96 phosphorylated in a pattern consistent with transcriptional elongation, and only minimal levels of i

97 hibit characteristics of genes controlled by transcriptional elongation, and the SEC-P-TEFb complex i

98 initiation, leucine-specific tRNA regulates transcriptional elongation, and unknown factors differen

99 Bacterial regulators of transcriptional elongation are versatile units for build

100 lts in 2-fold higher ubH2B, and 2-fold lower transcriptional elongation at IRF1.

101 for the negative and positive regulation of transcriptional elongation at the HIV-1 promoter.

102 ts identify a new component of regulation in transcriptional elongation based on CK2-dependent tyrosi

103 In addition, progesterone bypasses the transcriptional elongation block resulting from Paf comp

104 polymerase to promoters or physically block transcriptional elongation, but at genes that it strongl

105 find that MeCP2 has no measurable effect on transcriptional elongation, but instead represses the ra

106 ses and facilitates DNA damage repair during transcriptional elongation, but its functional integrity

107 These results suggest transcriptional elongation, but not initiation, is block

108 primarily augment RNA polymerase II-mediated transcriptional elongation, but not initiation, of STAT3

109 that are potentially involved in regulating transcriptional elongation, but the mechanisms of action

110 that bacterial RNAP pauses frequently during transcriptional elongation, but the relationship of thes

111 ibility that genes are commonly regulated by transcriptional elongation, but this remains largely unt

112 istributed mobile element, the inhibition of transcriptional elongation by L1 might profoundly affect

113 a Cdk9-cyclin T1 heterodimer that stimulates transcriptional elongation by phosphorylating RNA polyme

114 mer, stimulates general and disease-specific transcriptional elongation by phosphorylating RNA polyme

115 P-TEFb positively regulates transcriptional elongation by phosphorylating the C-term

116 and is instead involved in the regulation of transcriptional elongation by phosphorylating the carbox

117 Cyclin-dependent kinase 12 (CDK12) promotes transcriptional elongation by phosphorylation of the RNA

118 II (Pol II) binding to the tim promoter and transcriptional elongation by Pol II that is constitutiv

119 gest that KIS-L facilitates an early step in transcriptional elongation by Pol II.

120 on that has been demonstrated to function in transcriptional elongation by recruiting the Rpd3S histo

121 human immunodeficiency virus type 1 (HIV-1) transcriptional elongation by recruitment of carboxyl-te

122 human immunodeficiency virus type 1 (HIV-1) transcriptional elongation by recruitment of the human t

123 Our results suggest control of transcriptional elongation by repressors contributes to

124 ), composed of CDK9 and cyclin T, stimulates transcriptional elongation by RNA polymerase (Pol) II an

125 drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, b

126 Transcriptional elongation by RNA polymerase II (Pol II)

127 or a direct role of AF4 in the regulation of transcriptional elongation by RNA polymerase II (Pol II)

128 ween these factors, chromatin structure, and transcriptional elongation by RNA polymerase II (pol II)

129 Biochemical experiments indicate that transcriptional elongation by RNA polymerase II (Pol II)

130 ycT1, CycT2, or CycK and Cdk9 and stimulates transcriptional elongation by RNA polymerase II (RNAPII)

131 Transcriptional elongation by RNA polymerase II (RNAPII)

132 ates viral gene expression through promoting transcriptional elongation by RNA polymerase II (RNAPII)

133 Transcriptional elongation by RNA polymerase II (RNAPII)

134 Transcriptional elongation by RNA polymerase II has been

135 ature linking the key biochemical process of transcriptional elongation by RNA polymerase II to histo

136 IM 1 and 2, is involved in the inhibition of transcriptional elongation by RNA polymerase II.

137 SPT5 and its binding partner SPT4 regulate transcriptional elongation by RNA polymerase II.

138 m-level resolution, which we used to monitor transcriptional elongation by single molecules of Escher

139 nd cyclin T1, is also critical in regulating transcriptional elongation by SPT4 and SPT5.

140 scriptional inhibition and the activation of transcriptional elongation by the human immunodeficiency

141 and trimethylation, histone acetylation, and transcriptional elongation can occur.

142 factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) sta

143 These results indicate the existence of a transcriptional elongation checkpoint that is associated

144 with a preponderance of factors that impact transcriptional elongation compared with initiation, in

145 ls, the Rtf1 and Paf1 components of the Paf1 transcriptional elongation complex are important for rec

146 ved decreased binding and recruitment of the transcriptional elongation complex containing cyclin dep

147 ecruited Super Elongation Complex (SEC), the transcriptional elongation complex essential for HIV-1 l

148 y for RNA polymerases I, II, and III, pol II transcriptional elongation complexes, and a variety of c

149 Transcriptional elongation control by RNA polymerase II

150 in modulating cell-fate determination and in transcriptional elongation control.

151 In addition, transcriptional elongation-coupled DDR signalling involv

152 d show that this correlates with a defect in transcriptional elongation-coupled histone acetylation.

153 chromatin immunoprecipitation evidence for a transcriptional elongation defect in which RNA polymeras

154 Depletion of hHpr1/p84/Thoc1 causes transcriptional elongation defects and associated cellul

155 nsitizes cells to 6-azauracil, a hallmark of transcriptional elongation defects.

156 ycophenolic acid sensitivities, hallmarks of transcriptional elongation defects.

157 plicing factors function directly to promote transcriptional elongation, demonstrating that transcrip

158 roles in different cellular pathways such as transcriptional elongation, differentiation and apoptosi

159 t the kinase CDK9, typically associated with transcriptional elongation, directly modulates translati

160 e H2B de-ubiquitylation and further controls transcriptional elongation, DNA repair and replication v

161 istone H2B ubiquitylation is associated with transcriptional elongation, DNA repair and replication.

162 S syndrome and CdLS caused by disturbance of transcriptional elongation due to alterations in genome-

163 MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development.

164 e introduces a chemical kinetic model of the transcriptional elongation dynamics of RNA polymerase.

165 ssor protein down-regulates transcription by transcriptional elongation enhanced by antagonizing elon

166 ciently tight to allow strong attenuation of transcriptional elongation, even at operators located ma

167 36 trimethylation (H3K36me3) associated with transcriptional elongation, even when highly transcribed

168 ramatically in the requirements for positive transcriptional elongation factor (P-TEF) b activity.

169 l elongation factors, including the positive transcriptional elongation factor (P-TEFb), the bromodom

170 ociation of RelA with the activated positive transcriptional elongation factor (PTEF-b) complex prote

171 main binding protein 5 (WBP5), also known as Transcriptional Elongation Factor A like 9 (TCEAL9) has

172 Spt6 is a transcriptional elongation factor and histone chaperone

173 By recruiting the positive transcriptional elongation factor b (P-TEFb) to paused R

174 Human positive transcriptional elongation factor b (P-TEFb), consisting

175 The positive transcriptional elongation factor b (P-TEFb), consisting

176 vents during initiation and P-TEFb (positive transcriptional elongation factor b) events during elong

177 ne activation might include recruitment of a transcriptional elongation factor by ubiquitinated activ

178 te myeloid leukemias fuses the gene encoding transcriptional elongation factor ELL to the MLL gene wi

179 of a chimeric protein that fuses MLL to the transcriptional elongation factor ELL.

180 ains casein kinase 2 (CK2) and the chromatin transcriptional elongation factor FACT (a heterodimer of

181 of CDK9 and a cyclin T subunit, is a global transcriptional elongation factor important for most RNA

182 presses KIT mRNA expression through positive transcriptional elongation factor inhibition and decreas

183 Amt-87 works by activating the human transcriptional elongation factor P-TEFb, a CDK9-cyclin

184 on of GATA-1 with components of the positive transcriptional elongation factor P-TEFb, a complex cont

185 ene containing a bromo-adjacent homology and transcriptional elongation factor S-II domain, which we

186 nse mutation (W049) in the gene encoding the transcriptional elongation factor Spt5 (reviewed in ) wh

187 ELL is an RNA Polymerase II (Pol II) transcriptional elongation factor that interacts with th

188 ranscriptional initiation, Hog1 behaves as a transcriptional elongation factor that is selective for

189 tracellular signal regulated kinase/positive transcriptional elongation factor-b and NF-kappaB.

190 ntial third biological function of p53: as a transcriptional elongation factor.

191 nism that is distinct from its function as a transcriptional elongation factor.

192 e was enriched in DNA damage repair factors, transcriptional elongation factors and E3 ubiquitin liga

193 innate response requires the recruitment of transcriptional elongation factors to rapidly induce inn

194 mplexes that also contain RNA polymerase II, transcriptional elongation factors, and general pre-mRNA

195 Here we identify multiple transcriptional elongation factors, including ELL2, TFII

196 ncing its interactions with coactivators and transcriptional elongation factors.

197 rentiation of KG1 by an early enhancement of transcriptional elongation, followed by an increase in t

198 imulated both basal and tat-induced in vitro transcriptional elongation from the HIV-1 LTR.

199 Tat and other cellular factors to stimulate transcriptional elongation from the viral long terminal

200 cation that is involved in regulating P-TEFb transcriptional elongation function.

201 hHSF1 residues responsible for activation of transcriptional elongation has the most severe effect on

202 CDK9/cyclin T) to suppress RNA polymerase II transcriptional elongation in a process that specificall

203 or Spt4, Spt5, and Spt6 in the regulation of transcriptional elongation in both yeast and humans.

204 We examine the role of transcriptional elongation in control of IRF3-dependent

205 not required for chromatin decondensation or transcriptional elongation in Drosophila.

206 translational initiation into regulators of transcriptional elongation in Escherichia coli.

207 regulation of c-myb mRNA and increased c-myb transcriptional elongation in HMBA-induced MEL cells.

208 NA 3'-end processing in chicken cells and in transcriptional elongation in human cells.

209 tivation of downstream inflammatory genes by transcriptional elongation in RSV infection.

210 eaks and DDR signalling in the mechanisms of transcriptional elongation in stimulus-inducible genes i

211 Transcriptional elongation in the C. elegans germline th

212 we analyze the domains of SPT5 that regulate transcriptional elongation in the presence of either DRB

213 ated factor that has been shown to stimulate transcriptional elongation in vitro.

214 Here, we designed a specific assay for transcriptional elongation in vivo that involves an arti

215 nduced pausing represents a major barrier to transcriptional elongation in vivo.

216 r-associated pausing and of Spt5 and Spt6 in transcriptional elongation in vivo.

217 ting the factors that regulate RNA decay and transcriptional elongation in vivo.

218 yeast or inhibition of CK2 activity impairs transcriptional elongation in yeast as well as in mammal

219 ymerase II and was thought to have a role in transcriptional elongation in yeast.

220 RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of th

221 eptual advance that PRL3-mediated control of transcriptional elongation is a differentiation checkpoi

222 unctional studies demonstrated inhibition of transcriptional elongation is a dominant pathway blockin

223 ngly suggests that developmentally regulated transcriptional elongation is central to the process of

224 Transcriptional elongation is critical for gene expressi

225 The ability of Tat to stimulate transcriptional elongation is dependent on its binding t

226 NIPBL occupancy at enhancers and that active transcriptional elongation is essential to maintain H3K2

227 dent manner, and domains are maintained when transcriptional elongation is inhibited.

228 Extended transcriptional elongation is not required for Av, since

229 hese results suggest that an optimal rate of transcriptional elongation is required for normal cotran

230 equently reduces the engagement of Pol II in transcriptional elongation, leading to promoter-proximal

231 Emerging studies implicate DNA methylation, transcriptional elongation, long noncoding RNAs (lncRNAs

232 lers, general transcription factors, and the transcriptional elongation machinery are primarily invol

233 Genome-wide maps of the transcriptional elongation mark H3K36me3 were generated

234 suggest that the ability of Tat to increase transcriptional elongation may be due to its ability to

235 methylation at lysine 4, in conjunction with transcriptional elongation, may function in a negative f

236 is necessary for licensing Pol II to enter a transcriptional elongation mode.

237 HPR1 loss compromises transcriptional elongation, nuclear RNA export, and geno

238 rease in our understanding of how productive transcriptional elongation occurs.

239 ic pattern of Ubx expression by facilitating transcriptional elongation of bxd ncRNAs, which represse

240 omide exerts these effects by inhibiting the transcriptional elongation of genes that are required fo

241 gation Complex (SEC) that strongly activates transcriptional elongation of HIV-1 and cellular genes.

242 To stimulate transcriptional elongation of HIV-1 genes, the transacti

243 Thus, transcriptional elongation of HSV IE genes is a key limi

244 The transcriptional elongation of human immunodeficiency vir

245 yptic intragenic transcription, and inhibits transcriptional elongation of KDM5B target genes.

246 Transcriptional elongation of most eukaryotic genes by R

247 also show that SNW1 is indispensable for the transcriptional elongation of NF-kappaB target genes suc

248 is dependent on the p38 MAPK, which promotes transcriptional elongation of p21 by RNA Pol II.

249 ining protein 4 (BRD4) stimulates productive transcriptional elongation of pluripotency genes by diss

250 P-TEFb promotes transcriptional elongation of RNA polymerase II by using

251 o the NF-kappaB-p-TEFb complex to facilitate transcriptional elongation of some NF-kappaB target gene

252 ubunit, distinct P-TEFb species regulate the transcriptional elongation of specific genes that play c

253 utilizes TFIIS.h to selectively promote the transcriptional elongation of the bax gene, upsurging ce

254 ed downstream of PKCepsilon to derepress the transcriptional elongation of the c-myc gene.

255 ion of the tumor suppressor Rb, derepressess transcriptional elongation of the c-myc oncogene, and pr

256 merase II, the transactivator Tat stimulates transcriptional elongation of the human immunodeficiency

257 cal studies have identified major players of transcriptional elongation, our understanding of the imp

258 evisiae COMPASS complex, is regulated by the transcriptional elongation Paf1-Rtf1 and histone ubiquit

259 F-kappaB activation and binds to NF-kappaB's transcriptional elongation partner p-TEFb.

260 NusA is a key regulator of bacterial transcriptional elongation, pausing, termination and ant

261 target region, consistent with an effect on transcriptional elongation/pausing.

262 During transcriptional elongation, phosphoryl-Ser(5) (pSer(5))

263 The inhibition of transcriptional elongation plays an important role in ge

264 mt1 is recruited during the beginning of the transcriptional elongation process.

265 A polymerase II (RNAPII) postrecruitment and transcriptional elongation processes, is required for BR

266 ly promotes cell cycle arrest but also halts transcriptional elongation, promotes apoptosis, induces

267 ification that is involved in regulating its transcriptional elongation properties in response to vir

268 osphorylation and function in modulating its transcriptional elongation properties.

269 hyperacetylation leads to an increased local transcriptional elongation rate and decreased inclusion

270 modifications and subsequent changes in the transcriptional elongation rate and exon skipping.

271 gating form of RNAPII We show that a reduced transcriptional elongation rate results in early embryon

272 monstrate the requirement for an appropriate transcriptional elongation rate to ensure proper gene ex

273 roteins, which are involved in regulation of transcriptional elongation rate.

274 Inhibition of transcriptional elongation resulted in the loss of SNAPC

275 ity, was efficiently abrogated by a block to transcriptional elongation, resulting in decreased c-myc

276 onent of TREX, and loss of Hpr1p compromises transcriptional elongation, RNA export, and genome stabi

277 complex that can specifically interfere with transcriptional elongation, RNA polymerase binding, or t

278 stribution of Pol II, proteins important for transcriptional elongation (Spt5, Spt16), or RNA process

279 diated transcriptional activation involves a transcriptional elongation step, like HIV Tat, and const

280 n, genes involved in histone acetylation and transcriptional elongation, such as TRRAP and BRD4, were

281 ation complex (SEC), a critical regulator of transcriptional elongation, suggesting that aberrant con

282 Here we report a new layer of regulation in transcriptional elongation that is conserved from yeast

283 hat is essential for Tat activation of HIV-1 transcriptional elongation, the CAK kinase associated wi

284 nt understanding of the relationship between transcriptional elongation through a chromatin template

285 uired for effective Pol II pause release and transcriptional elongation through a novel mechanism inv

286 P-TEFb) (CDK9/cyclin T (CycT)) promotes mRNA transcriptional elongation through phosphorylation of el

287 replication and activates RNA polymerase II transcriptional elongation through the association with

288 Here we show that blockade of transcriptional elongation through the mouse T cell rece

289 ivity in facilitating Pol II's engagement in transcriptional elongation, thus deciphering a novel reg

290 the wake of elongating RNA polymerase II and transcriptional elongation, thus revealing novel regulat

291 been proposed that the MSL complex regulates transcriptional elongation to control dosage compensatio

292 e ASRs and suggest that these ASRs allow the transcriptional elongation to proceed through the silenc

293 e-9 (CDK9; a kinase necessary for triggering transcriptional elongation) to promoters of NF-kappaB-de

294 that enhances the engagement of Pol II into transcriptional elongation) to the coding sequence of an

295 homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the elev

296 However, transcriptional elongation was not affected under antibi

297 mal level of Spt16 is required for efficient transcriptional elongation, which is maintained by San1

298 ratus with a novel two-bead assay to monitor transcriptional elongation with near-base-pair precision

299 Hence, assembly of TREX physically couples transcriptional elongation with RNA processing factors.

300 Suggestive of a role in transcriptional elongation, Yta7 localized to the ORFs o