ライフサイエンスコーパス: transcriptional initiation

1 ent means by which to probe the landscape of transcriptional initiation.

2 x act with this H3K36 HMT to prevent ectopic transcriptional initiation.

3 bryonic stem (ES) cells to prevent incorrect transcriptional initiation.

4 ors bound at target promoters and stimulates transcriptional initiation.

5 ltiple enzymatic activities are required for transcriptional initiation.

6 an increase in HBP1 mRNA stability, but not transcriptional initiation.

7 H3K4 trimethylation, a mark associated with transcriptional initiation.

8 c promoters is key to accurate and efficient transcriptional initiation.

9 impair recruitment of RNA polymerase II and transcriptional initiation.

10 ory element 0.1 kb upstream from the site of transcriptional initiation.

11 , suggesting that it acts via improvement of transcriptional initiation.

12 genes influence the location and kinetics of transcriptional initiation.

13 manner, consistent with a role in promoting transcriptional initiation.

14 precedes nuc-1 remodeling and, subsequently, transcriptional initiation.

15 ized within 412 nucleotides from the site of transcriptional initiation.

16 f these operons is regulated at the level of transcriptional initiation.

17 ted to transcriptional interference and even transcriptional initiation.

18 ns potential promoter elements essential for transcriptional initiation.

19 that amplify the hormone signal and mediate transcriptional initiation.

20 xpression is due to a defect at the level of transcriptional initiation.

21 le for TBP dimerization in the regulation of transcriptional initiation.

22 H4 within the reporter gene, and a block to transcriptional initiation.

23 licing factor, controls MLL complex-mediated transcriptional initiation.

24 ates with that mediating activated levels of transcriptional initiation.

25 iated abortive transcripts may down-regulate transcriptional initiation.

26 s or transcription factors lead to increased transcriptional initiation.

27 the inverse correlation seen at the site of transcriptional initiation.

28 kb transcript levels at a step subsequent to transcriptional initiation.

29 F dependence early in the process leading to transcriptional initiation.

30 re was a TPA-induced increase in the rate of transcriptional initiation.

31 nderstanding of the physical biochemistry of transcriptional initiation.

32 t observed in constructs lacking the zone of transcriptional initiation.

33 ciated with elevated baseline DNA damage and transcriptional initiation.

34 s, i.e. the number of rate-limiting steps in transcriptional initiation.

35 the promoters of ribosomal protein genes for transcriptional initiation.

36 the RNA polymerase-sigma(54) complex during transcriptional initiation.

37 IID dependency and become SAGA dependent for transcriptional initiation.

38 tion at other SAGA-dependent genes and hence transcriptional initiation.

39 ts at transcription start sites to attenuate transcriptional initiation.

40 PIC) at the core promoter and, consequently, transcriptional initiation.

41 sion in CD4+ T cells is mainly controlled at transcriptional initiation.

42 ana BZR1-BAM isoforms (BAM7 and BAM8) during transcriptional initiation.

43 of the RNA polymerase II-mediated PIC before transcriptional initiation.

44 These results support the role of Rad14p in transcriptional initiation.

45 II phosphorylated at a site associated with transcriptional initiation.

46 tes the recruitment of the TFIID complex for transcriptional initiation.

47 alternative polyadenylation and alternative transcriptional initiation.

48 to poise quiescent genes for activation and transcriptional initiation.

49 istone mark is confined to the regulation of transcriptional initiation.

50 its promoter complexes, and the mechanism of transcriptional initiation.

51 icate that ExsA facilitates an early step in transcriptional initiation.

52 diated H3K4 methylation in the regulation of transcriptional initiation.

53 ent conferred the essential cis promoter for transcriptional initiation.

54 riptional coactivators that are required for transcriptional initiation after xenobiotic or hypoxic c

55 The positioning of transcriptional initiation agrees with our current under

56 doderm morphogenesis thus emerges from local transcriptional initiation and a mechanically driven cyc

57 nositol 3-kinase (PI3K) pathway operating on transcriptional initiation and a Raf-1-mitogen-activated

58 nucleotides upstream from the start site of transcriptional initiation and an Sp1 site located 83 nu

59 ry evolution, such that variants influencing transcriptional initiation and decay have opposite effec

60 t arise through the use of a unique site for transcriptional initiation and differential splicing.

61 FIIIC specifies an orientation of TFIIIB for transcriptional initiation and directs integration to th

62 isms of RNA polymerase II (RNA Pol II)-based transcriptional initiation and discuss the ways in which

63 SUPT16H or SSRP1 protein affects both HIV-1 transcriptional initiation and elongation and spontaneou

64 The transition between transcriptional initiation and elongation by RNA polymer

65 likely by interaction with components of the transcriptional initiation and elongation complexes duri

66 By measuring the rates of transcriptional initiation and elongation directly in th

67 nome-wide analysis of the transition between transcriptional initiation and elongation in Escherichia

68 rent chromatin states coordinately influence transcriptional initiation and elongation rates and that

69 tightly regulated activator that stimulates transcriptional initiation and elongation using differen

70 ntegral role in regulating RNAPII occupancy, transcriptional initiation and elongation, and alternati

71 on by regulation of chromatin configuration, transcriptional initiation and elongation, and localizat

72 ection, suggesting their requirement in both transcriptional initiation and elongation.

73 eorganizes nucleosomes and functions in both transcriptional initiation and elongation.

74 of RNA polymerase II, facilitating efficient transcriptional initiation and elongation.

75 of RelB during differentiation by increased transcriptional initiation and elongation.

76 ntrolled by PKCbetaII-mediated regulation of transcriptional initiation and elongation.

77 n heat shock factor 1 (HSF1) stimulates both transcriptional initiation and elongation.

78 l dynamics predicted a tight coordination of transcriptional initiation and elongation.

79 created to include or exclude the regions of transcriptional initiation and elongation.

80 or redistribution causes momentous swings in transcriptional initiation and elongation.

81 ll survival upon osmostress by acting during transcriptional initiation and elongation.

82 putative coactivator proteins implicated in transcriptional initiation and elongation.

83 ational modification, which is essential for transcriptional initiation and elongation.

84 and contains regulatory elements needed for transcriptional initiation and elongation.

85 modifications to histones are important for transcriptional initiation and feedback inhibition servi

86 ng an unexpectedly significant delay between transcriptional initiation and mature mRNA production ea

87 effect of Snail on RKIP was on the level of transcriptional initiation and mediated by a proximal E-

88 We report here that alternative transcriptional initiation and mRNA splicing give rise t

89 egion stem-loop (RSL), has a small effect on transcriptional initiation and no effect on RNA polymera

90 letion of the R region had a small effect on transcriptional initiation and no effect on RNA polymera

91 d development was delayed despite normal Sry transcriptional initiation and overexpression.

92 upstream of genes, suggesting modulation of transcriptional initiation and polymerase-coupled spread

93 ' gene segment was used to identify sites of transcriptional initiation and promoter activity by RNas

94 tes Tax-dependent transcription by promoting transcriptional initiation and reinitiation.

95 some of the nucleotide elements involved in transcriptional initiation and sigma factor selection in

96 to other aspects of mRNA metabolism, such as transcriptional initiation and splicing, systematic info

97 Mechanistic analysis of transcriptional initiation and termination by RNA polyme

98 Positional effects of the transcriptional initiation and termination signals in th

99 uman PGE(2) EP2 receptor subtype, identified transcriptional initiation and termination sites in two

100 complexes that render chromatin insoluble at transcriptional initiation and termination sites.

101 e biological regulatory processes, including transcriptional initiation and termination, and the euka

102 The promoter activity of this zone of transcriptional initiation and the influence of gene seg

103 led that a nucleosome is positioned over the transcriptional initiation and the Sp1/3 binding sites.

104 lide (TPL), an XPB/TFIIH inhibitor, to block transcriptional initiation and then measured Pol II occu

105 ed region, suggesting an alternative site of transcriptional initiation and transcription through the

106 ter level in a region near the start site of transcriptional initiation and was independent of histon

107 y for viral replication and stimulates viral transcriptional initiation and/or elongation.

108 promoter DNA to form a complex required for transcriptional initiation, and many transcriptional reg

109 Deficient transcriptional initiation, and not elongation, is the m

110 lsE production is controlled at the level of transcriptional initiation, and regions of 5' DNA involv

111 tant sequence-based signals marking sites of transcriptional initiation at a large class of typical p

112 hat yFACT and Set2 oppose one another during transcriptional initiation at a step involving DNA bindi

113 s "active repression" complex, MerR prevents transcriptional initiation at merTPCAD until Hg(II) is a

114 Taken together, these results indicate that transcriptional initiation at the flhDC promoter by QseB

115 To understand how transcriptional initiation at these promoters is coordin

116 transcription complex assembly (and, hence, transcriptional initiation) at the promoter in vivo.

117 gistic effect on formation of PIC (and hence transcriptional initiation) at the promoter, revealing a

118 that Sus1p promotes PIC formation (and hence transcriptional initiation) at the SAGA-regulated genes

119 Alternative transcriptional initiation (ATI) refers to the frequent

120 s, were potentially based on the increase of transcriptional initiation, both in TAR-dependent and -i

121 tile regulatory agents, influencing not only transcriptional initiation but also elongation, splicing

122 berrant heterochromatin is incompatible with transcriptional initiation but does not inhibit elongati

123 ation of the circadian system has focused on transcriptional initiation, but it is now apparent that

124 calized to specific sequences, as it is with transcriptional initiation, but rather associates with t

125 Transcriptional initiation by a sigma factor responsible

126 ing protein (TBP) plays an important role in transcriptional initiation by all three nuclear RNA poly

127 ked RNA cannot be generated through aberrant transcriptional initiation by E. coli RNA polymerase in

128 indings expose a striking similarity between transcriptional initiation by pol II, pol III and bacter

129 in both organisms but is not as critical for transcriptional initiation by RpoS(Bb) as it is for RpoS

130 and also distorts the merO DNA to facilitate transcriptional initiation by sigma70 RNA polymerase.

131 se factors work with co-activators to direct transcriptional initiation by the RNA polymerase II appa

132 Moreover, the rate of transcriptional initiation can be determined for mRNAs w

133 TATA-binding protein (TBP) is a key step in transcriptional initiation complex assembly on TATA-box-

134 1 and SREBP-1c and disrupted assembly of the transcriptional initiation complex on the SREBP-1c promo

135 site suggested that MAP kinases regulate the transcriptional initiation complex.

136 characterization of the entire mitochondrial transcriptional initiation complex.

137 meaningful interpretation of how TE-derived transcriptional initiation contributes to the transcript

138 n studied most extensively in the context of transcriptional initiation control, cooperativity from o

139 hese results provide a mechanistic basis for transcriptional initiation directed by YY1 in the absenc

140 the Mediator protein complex that regulates transcriptional initiation during development.

141 trate that regulatory complexes that mediate transcriptional initiation (e.g., p220(NPAT)) and 3'-end

142 and its regulation working at the levels of transcriptional initiation, elongation and degradation.

143 litate the ordered assembly and functions of transcriptional initiation, elongation, and termination

144 degrees of progression through blocks to HIV transcriptional initiation, elongation, completion, and

145 zed here the role of Mdm30p in regulation of transcriptional initiation, elongation, mRNA processing,

146 ngation factor TFIIS, Med25 also facilitates transcriptional initiation-elongation coupling.

147 lar concentrations, dCA reduces Tat-mediated transcriptional initiation/elongation from the viral pro

148 In these offspring, we mapped transcription, transcriptional initiation, enhancer activity, non-methy

149 SpOtx(beta) mRNAs resulted from two separate transcriptional initiation events, and these transcripts

150 Nhp6b demonstrate that Nhp6 is required for transcriptional initiation fidelity of some but not all

151 protein in Saccharomyces cerevisiae restores transcriptional initiation fidelity to this highly purif

152 ks canonical TATA and CAAT boxes but directs transcriptional initiation from a single site.

153 is GC-rich and lacks a TATA box but directs transcriptional initiation from a single site.

154 the leader RNA switching are the results of transcriptional initiation from the 9-nt site.

155 ions to lacZ reporters, we demonstrated that transcriptional initiation from the ARE1 promoter is sig

156 to be the only polymerase capable of correct transcriptional initiation from the HTLV-1 promoter.

157 e enhancer regions also result in a shift in transcriptional initiation from the P2 promoter to P1 th

158 Furthermore, normal transcriptional initiation from the Pmga P1 start site a

159 Transcriptional initiation from two different promoters

160 tain chromatin structure and prevent cryptic transcriptional initiation from within transcribed regio

161 n mRNA stability, protein synthesis, and new transcriptional initiation, have been studied to determi

162 in addition to its various functions during transcriptional initiation, Hog1 behaves as a transcript

163 n assays, we demonstrate that Mta stimulates transcriptional initiation in 293 cells.

164 protein BRD2 generally functions to promote transcriptional initiation in a bromodomain-dependent ma

165 vivo correlate with chromatin remodeling and transcriptional initiation in activated T-cells.

166 nd our prior analysis to the common model of transcriptional initiation in bacteria in terms of two p

167 phosphorylation had no additional effect on transcriptional initiation in crude extracts.

168 There is also evidence for deficient transcriptional initiation in FRDA, but its relationship

169 ome analysis revealed a severe deficiency of transcriptional initiation in FRDA.

170 ssion of MDR1 mRNA is regulated by increased transcriptional initiation in HL60/VCR cells.

171 erexpression as a marker indicating aberrant transcriptional initiation in leukemia.

172 Methylation is associated with repression of transcriptional initiation in plants and animals, and is

173 The regulation of transcriptional initiation in the human genome is a crit

174 ence for transcriptional control elements or transcriptional initiation in the intergenic GPR40-GPR41

175 the promoters of ribosomal protein genes for transcriptional initiation in vivo.

176 the TFIID-dependent promoter for productive transcriptional initiation in vivo.

177 RNAPII degradation results in a shutdown of transcriptional initiation, in the absence of which cell

178 Prf1 cis-regulatory regions correlated with transcriptional initiation (increased recruitment of RNA

179 D::lacZ fusion strain, we now show that pilD transcriptional initiation increases progressively as L.

180 Transcriptional initiation invariably involves the trans

181 dies indicate that steroid receptor-mediated transcriptional initiation is a cyclical process involvi

182 est that the repeated helical opening due to transcriptional initiation is a significant contributor

183 Transcriptional initiation is activated by the T4 gene 4

184 Here, we show that sense transcriptional initiation is more efficient than in the

185 tion of Sus1p in promoting PIC formation and transcriptional initiation is not mediated via its role

186 A crucial step in eukaryotic transcriptional initiation is recognition of the promote

187 Indeed, deficient transcriptional initiation is the predominant cause of t

188 Although YY1 is not sufficient for transcriptional initiation, it is a required component o

189 with an active role in a subsequent step of transcriptional initiation leading to promoter opening.

190 A mutation that diminished transcriptional initiation led to twofold reductions in

191 ound hormone receptors and components of the transcriptional initiation machinery, including TATA-bin

192 omoter activity by interfering with the host transcriptional initiation machinery, potentially result

193 C2 targets are generally associated with the transcriptional initiation marker H3K4me3, but the signi

194 o gene transcription and that recruitment of transcriptional initiation markers also correlated with

195 the existence of a TAF1 (TFIID)-independent transcriptional initiation mechanism that may be used by

196 mplex displays two activities in redirecting transcriptional initiation of an S. pombe rDNA gene prom

197 Increased transcriptional initiation of c-myc induced by the short

198 class 2 flagellar gene, may be aiding in the transcriptional initiation of class 1 genes (flhDC) in E

199 Basal level transcriptional initiation of fission yeast ribosomal RN

200 Transcriptional initiation of mouse Cyp2s1 was found to

201 Transcriptional initiation of PbhuR mapped within the rh

202 elineate the molecular mechanisms underlying transcriptional initiation of rod-specific genes, we cha

203 In contrast, transcriptional initiation of Runx1 in nonpeptidergic no

204 lysine (K) acetyltransferase (KAT) promotes transcriptional initiation of TATA-binding protein (TBP)

205 nucleosome acetyltransferase of H4) promotes transcriptional initiation of TFIID (a complex of TBP an

206 ted that dimethylsulfoxide and HMBA enhanced transcriptional initiation of the reporter and p21/WAF1/

207 To better understand the mechanisms of transcriptional initiation of the X gene, we set out to

208 In flies, decreasing Pol III's transcriptional initiation on tRNA genes by a loss-of-fu

209 egulatory particle in controlling eukaryotic transcriptional initiation or activation independently o

210 ue to absolute blocks at the level of either transcriptional initiation or elongation but rather rela

211 thesis represents a critical juncture in the transcriptional initiation pathway when EC formation is

212 kinetic and compositional differences in the transcriptional initiation process among eukaryotic spec

213 3' end formation, and appearance of aberrant transcriptional initiation products.

214 n was accompanied by coordinate increases in transcriptional initiation rate and gene promoter activi

215 e elements act cooperatively to increase the transcriptional initiation rate approximately 100-fold i

216 e occupancy is inversely proportional to the transcriptional initiation rate at the promoter.

217 omoter derivatives suggests that the maximal transcriptional initiation rate in yeast cells is one mR

218 V) produced a time-dependent increase in the transcriptional initiation rate of the IL-8 gene.

219 occupancy of cis-regulatory target sites to transcriptional initiation rate, and thence to RNA and p

220 l p50 and p52 homodimers at sites within the transcriptional initiation region of HIV-1 provides for

221 DHPLC and identified a point mutation at the transcriptional initiation site (-1C-->A) with a carrier

222 l nuclear protein binding at the Bf upstream transcriptional initiation site (UIS).

223 ous Giant to repress when bound close to the transcriptional initiation site and found that Giant eff

224 Definition of the transcriptional initiation site and sequence analysis sh

225 oter within the first 223 bp upstream of the transcriptional initiation site and the possible presenc

226 ts using mouse liver mRNA indicate one major transcriptional initiation site and three minor sites.

227 this operon 226 base pairs downstream of the transcriptional initiation site between the attenuator a

228 We determined the transcriptional initiation site by primer extension.

229 A transcriptional initiation site in exon 1b (P1b) was pri

230 the substitution of C with A at the beta2GPI transcriptional initiation site is a causative mutation

231 The primary transcriptional initiation site is located 213 bp upstre

232 The transcriptional initiation site is located 22 nucleotide

233 The transcriptional initiation site of norA was unchanged in

234 ing of a stably positioned nucleosome at the transcriptional initiation site of ORF50 is a regulatory

235 The transcriptional initiation site of the ilvGMEDA operon i

236 pha (RXRalpha), is specifically bound at the transcriptional initiation site of the major late promot

237 oximately 85 base pairs (bp) upstream of the transcriptional initiation site served as the minimal DN

238 of the MAP kinase-responsive element to the transcriptional initiation site suggested that MAP kinas

239 immediately upstream from the most upstream transcriptional initiation site that led to increased tr

240 A transcriptional initiation site was detected 260 bp 5' o

241 The transcriptional initiation site was determined to be 636

242 The transcriptional initiation site was identified by 5' RAC

243 The transcriptional initiation site was identified by RNase

244 CAAT boxes immediately upstream of the major transcriptional initiation site, although CAAT boxes wer

245 d at approximately 860 bases upstream of the transcriptional initiation site, and it contains a typic

246 nce was found 24 bp upstream from the second transcriptional initiation site, and two inverted CCAAT

247 between -927 to -1181, upstream of the major transcriptional initiation site, followed by positive el

248 A transcriptional initiation site, located an appropriate

249 -acting domains: within 6 kb surrounding the transcriptional initiation site, separate sequences were

250 However, in the region upstream of the transcriptional initiation site, the cryptdin 4 gene con

251 tion of nucleotides -68/-316 relative to the transcriptional initiation site.

252 sites lie within very close proximity to the transcriptional initiation site.

253 present both upstream and downstream of the transcriptional initiation site.

254 found approximately 300 nucleotides from the transcriptional initiation site.

255 lude a PU.1 binding site upstream of the P1b transcriptional initiation site.

256 h sequence was identified flanking the major transcriptional initiation site.

257 -RACE independently identified the identical transcriptional initiation site.

258 are centered at -18 and -36 relative to the transcriptional initiation site.

259 factor-dependent footprint downstream of the transcriptional initiation site.

260 nalysis employing T. pallidum RNA revealed a transcriptional initiation site.

261 ) located 1.7 kb upstream of the presumptive transcriptional initiation site.

262 ment or the entire 1.7 kb fragment 5' of the transcriptional initiation site.

263 ivator protein)-binding site proximal to the transcriptional initiation site; both SRC-1 and c-Jun we

264 of 5' ends of rpoE mRNA identified five new transcriptional initiation sites (P1 to P5) located dist

265 ces at least eight transcripts by using four transcriptional initiation sites (TIS; resulting in thre

266 nit and found that the promoter has multiple transcriptional initiation sites and lacks a TATA box.

267 protection assays were used to identify two transcriptional initiation sites for algR within the alg

268 Distinct transcriptional initiation sites for CD45 were demonstra

269 Multiple putative transcriptional initiation sites for this gene were iden

270 ctive regions but is largely restricted from transcriptional initiation sites in active regions.

271 The presence of multiple transcriptional initiation sites is a typical feature of

272 SNP clusters were over-represented near the transcriptional initiation sites of immune response gene

273 species (-a, -b and -c in order) occurs with transcriptional initiation sites progressing 5' to 3' up

274 extension and RNase protection analyses, two transcriptional initiation sites were identified 59 and

275 sity in endothelial cells results from three transcriptional initiation sites within exon 1.

276 rimer extension identified multiple putative transcriptional initiation sites, including several site

277 segment, which encompasses hypothetical srp transcriptional initiation sites, is relatively less con

278 Two transcriptional initiation sites, spaced 35 nucleotides

279 nd RNase protection methods showed two major transcriptional initiation sites.

280 found 19 and 42 bp upstream from the second transcriptional initiation sites.

281 and that ATI arises primarily from imprecise transcriptional initiation that could be deleterious.

282 ures into our EM maps results in a model for transcriptional initiation that strongly correlates with

283 evealing a role for JARID1d in regulation of transcriptional initiation through H3K4 demethylation.

284 Thus, the transition from transcriptional initiation to elongation is highly varia

285 fidaxomicin was added at different stages of transcriptional initiation to identify the blocked step.

286 A 3'-terminal CCCA (3'-CCCA) directs transcriptional initiation to opposite the underlined C;

287 ciferase reporter gene, could confer correct transcriptional initiation to the reporter and could con

288 The rate-limiting step in transcriptional initiation typically is opening the prom

289 a fast inducible yeast gene, GAL1, following transcriptional initiation via histone H3 Lys(56) acetyl

290 Quantitative analysis of transcriptional initiation via metabolic labeling of nas

291 irectly measured by quantitative analysis of transcriptional initiation via metabolic labeling of new

292 n assay and RACE analysis, the major site of transcriptional initiation was identified at -56 nt.

293 The zone of transcriptional initiation was part of a larger GC-rich

294 orticoid receptor (GR) as a model factor for transcriptional initiation, we classified chromatin stru

295 Nucleosomes regulate transcriptional initiation when positioned in the promot

296 one of which is PI3K-dependent operating on transcriptional initiation, whereas the other is mitogen

297 Here we determine the sites of FGFR4 transcriptional initiation which show a pattern characte

298 sting a nearly global positive regulation of transcriptional initiation with transcriptional pausing.

299 brain total RNA indicated multiple sites of transcriptional initiation within a approximately 70-nt

300 G methylation functions to suppress spurious transcriptional initiation within infrequently transcrib