ライフサイエンスコーパス: transcriptional response

1 ributions to the production of an estrogenic transcriptional response.

2 ypomorph, causing an attenuated p53-mediated transcriptional response.

3 ial co-regulators of the estrogen receptor's transcriptional response.

4 erminant governing the host cell's antiviral transcriptional response.

5 tion, followed by a slower, more traditional transcriptional response.

6 we observed changes to the magnitude of the transcriptional response.

7 d time of day (ZT1 or ZT6) occurrence of the transcriptional response.

8 atory state and gave rise to a new, specific transcriptional response.

9 he architecture of the nucleus modulates the transcriptional response.

10 cells to ER stressors and measured the early transcriptional response.

11 t be sufficiently sustained to ensure robust transcriptional response.

12 latory sequences acting together to elicit a transcriptional response.

13 h a dedicated MED subunit to induce specific transcriptional responses.

14 ver, they were unable to trigger UPR-related transcriptional responses.

15 application produced similar phenotypic and transcriptional responses.

16 ments abrogates the ability to activate both transcriptional responses.

17 hypoxic survival and limited proinflammatory transcriptional responses.

18 ional, yet associated with relatively narrow transcriptional responses.

19 echanism for the control of cytokine-induced transcriptional responses.

20 cardiomyocytes and interrogated whole genome transcriptional responses.

21 ed for ZIKV NS5 to regulate hBMEC cell cycle transcriptional responses.

22 level, less is known about bat IFN-mediated transcriptional responses.

23 chanisms in addition to its well-established transcriptional responses.

24 as an important regulator of hypoxia-induced transcriptional responses.

25 uct, which traffics to the nucleus to effect transcriptional responses.

26 injury until complete recovery, in terms of transcriptional responses.

27 ty of accessibility associated with additive transcriptional responses.

28 d-messenger generation, and JAK/STAT or NFAT transcriptional responses.

29 antly influences ligand-dependent, ER-driven transcriptional responses, also of the ESR1 gene itself.

30 ons leads to a decreased HIF-1alpha mediated transcriptional response and correlates with a reduction

31 Here, we explore the transcriptional response and gene networks active in adi

32 lacking on the relationship between the host transcriptional response and HIV latency reversal.

33 ibers, but not Matrigel, trigger a conserved transcriptional response and subsequent motility switch

34 th GIV mount a more tolerant (hypo-reactive) transcriptional response and suppress proinflammatory cy

35 show that cellular stress responses-the p53 transcriptional response and the integrated stress respo

36 tween these metabolic modes requires a rapid transcriptional response and this is orchestrated by Sur

37 ared mce3R-regulated genes with baseline INH transcriptional responses and implicated the gene ctpD (

38 ty of membrane-associated antigens to induce transcriptional responses and proliferation.

39 show that Notch signaling produces "bursty" transcriptional responses and that variance in these res

40 ata can disentangle key aspects of a complex transcriptional response, and it provides new insights i

41 tes TGF-beta-induced R-Smad phosphorylation, transcriptional responses, and subsequent physiological

42 ng to chromatin often underlies how adaptive transcriptional responses are controlled.

43 he Hippo signaling pathway, and YAP1-induced transcriptional responses are essential in cancer cell p

44 terogeneity of GPCR signaling and downstream transcriptional responses are not understood.

45 way activation(2,7), the mechanisms by which transcriptional responses are regulated remain largely u

46 ivity, pDCs from infected host have distinct transcriptional response associated with activation of i

47 olomics of the conditioned media, as well as transcriptional responses associated with the longevity

48 The mucosal transcriptional response at 24 hr revealed the involveme

49 alysis showed that romidepsin altered early, transcriptional responses at 3 and 6-hour post-amputatio

50 iption factor gradients trigger differential transcriptional responses based on concentration.

51 st plant root exudates resulted in different transcriptional response between species.

52 eatures that might explain the difference in transcriptional response between subclasses is the local

53 involves a number of signaling pathways and transcriptional responses between both partners.

54 s by regulating cyclic-di-GMP levels, global transcriptional responses, biofilm production, and polys

55 All these stimuli induce not only a specific transcriptional response but also interact extensively,

56 ses in myocyte Ca(2+) transients and nuclear transcriptional responses but that chronic progression o

57 F1 is the master regulator of the heat shock transcriptional response, but the heat shock response pa

58 revious work has shown that Notch can induce transcriptional responses by binding to promoters but mo

59 We also summarize how specific changes in transcriptional responses can modulate infection or dise

60 cases, it is natural to ask how the combined transcriptional response compares to the individual resp

61 seq reveals both shared and context-specific transcriptional response components that can identify dr

62 t, is characterized by a rapid and transient transcriptional response composed of large, oppositely r

63 dered the master regulator of stress-induced transcriptional responses, controls the expression of cy

64 d apoptosis of TR-APhi and reorganization of transcriptional responses, could collectively contribute

65 is with nitric oxide we found that the rapid transcriptional responses, detectable within minutes of

66 Interestingly, the host transcriptional response did not predict induction of ce

67 in mice primary macrophages, showed that the transcriptional response downstream of TLR4 was intact i

68 e there are much data to support the role of transcriptional responses downstream of pattern recognit

69 er layer of control that serves to fine-tune transcriptional responses downstream of TLR activation.

70 r ATF3 as a key regulator of the acinar cell transcriptional response during injury and may provide a

71 examined the impact of RA on the genome-wide transcriptional response during Th differentiation to mu

72 e assay to probe pathway fluxes through five transcriptional response elements against a control cons

73 uggests that drug synergy may ensue when the transcriptional responses elicited by two unrelated indi

74 induces a HIF2alpha-associated hypoxia-like transcriptional response followed by an increase in neur

75 re we show that Myc activation induces rapid transcriptional responses followed by proliferation in s

76 Transcriptional responses following stimulation were pro

77 Comparison of the ex vivo transcriptional response from the primary podocyte cultu

78 ion is well-studied, the key elements of the transcriptional response governing IGF1's actions are no

79 ast, two enhancers with full EREs produced a transcriptional response greater than the wild-type locu

80 downstream coactivators that coordinate the transcriptional response have not been fully illustrated

81 bridging purinergic receptor activation with transcriptional responses have been probed in great deta

82 etic mechanisms contribute to signal-induced transcriptional responses, here we manipulate the signal

83 to the nucleus but did not induce a Wnt-like transcriptional response, i.e., TCF/LEF dependent.

84 We show that KT and SD elicit common transcriptional responses implicating distinct elements

85 we describe a role for DRH-1 in directing a transcriptional response in C. elegans called the intrac

86 cell-cell interactome and induced a specific transcriptional response in glia cells.

87 use of PRO-seq to characterize the immediate transcriptional response in human cells to celastrol, a

88 r Typhimurium initiates an anti-inflammatory transcriptional response in macrophages through its effe

89 The hepatic transcriptional response in mice on high-fat diet treate

90 Here we show that the transcriptional response in neurons is exquisitely sensi

91 tions improve understanding of the ER stress transcriptional response in pancreatic islets.

92 Here, we examine the upper airway host transcriptional response in patients with COVID-19 (n =

93 duction, leading to part of the SA-dependent transcriptional response in plant cells.

94 e wide transcriptional analysis identified a transcriptional response in podocytes to elevated [Ca(2+

95 rved protein in eutherian mammals, elicits a transcriptional response in the endometrial epithelium i

96 lood-meal following mating induced a greater transcriptional response in the spermathecae than mating

97 revealed a dysregulation of the ER-dependent transcriptional response in tumors carrying neoGATA3-gen

98 nses to VOR and examine the longevity of the transcriptional response in various cellular models.

99 In this study, we examined the whole-genome transcriptional response in visceral WAT to T and WSD, a

100 provides a comprehensive profile of the p53 transcriptional response in vivo, revealing both tissue-

101 riptome sequencing study examining pulmonary transcriptional responses in B. pertussis-infected mice

102 associated EVs elicit potent proinflammatory transcriptional responses in cells that line the genital

103 udy, we have comprehensively profiled global transcriptional responses in crowns of field-grown sprin

104 ical investigation in PDAC, induces distinct transcriptional responses in each PDAC subtype, with aug

105 for EVs from HIV-infected men induces potent transcriptional responses in epithelial and stromal cell

106 brane are important regulators of downstream transcriptional responses in reactive glia.

107 tudy is among the first to measure lung cell transcriptional responses in relation to real-world, gas

108 and XBP1 direct overlapping transcriptional responses in some cell types.

109 ling activation to coordinate the downstream transcriptional responses in the immediate wound vicinit

110 uired for all of the colonization-associated transcriptional responses in the juvenile eye.

111 scription factors that appear to drive these transcriptional responses, including members of the E2F

112 (-/-) mice showed reduced hepatic ATZ and a transcriptional response indicative of decreased ER stre

113 ed D1 (PsbA) protein levels, and an enhanced transcriptional response indicative of PSII repair activ

114 We identified signatures of tissue-specific transcriptional responses indicative of tropism in the c

115 published article and reevaluated lung cell transcriptional response induced by outdoor atmospheric

116 ence of regulatory mechanisms in addition to transcriptional responses involving de novo gene express

117 omics data sets to illustrate that a similar transcriptional response is identifiable in Halobacteriu

118 Our current understanding of this transcriptional response is largely informed from analys

119 In larger eukaryotes, the stress-induced transcriptional response is mediated by a family of heat

120 orphogen regulate SMO to promote switch-like transcriptional responses is a central unsolved issue.

121 er, the manner in which TAZ orchestrates the transcriptional responses is poorly defined.

122 flux, how these modifications contribute to transcriptional responses is poorly understood.

123 How YAP coordinates these transcriptional responses is unknown.

124 species persistence and impairs anti-oxidant transcriptional responses, leading to elevated DNA break

125 at are less well understood, DSBs also alter transcriptional responses locally, which may be importan

126 immunity and mucosal hypoxia with a focus on transcriptional responses mediated by HIF.

127 RNA-Seq indicated distinct transcriptional responses: nitrogen affects transport of

128 This transcriptional response occurred in two major waves, on

129 The majority of initial transcriptional responses occurred within a rapid window

130 Here, we assessed the transcriptional response of a primary 3D airway model ac

131 The transcriptional response of AM roots under K(+) deficien

132 Here, we systematically integrate the transcriptional response of B-ALL to GCs with a next-gen

133 The transcriptional response of BECs was inflammation indepe

134 In this study, the dynamic transcriptional response of both the reference strain an

135 Here, we interrogated the epigenetic and transcriptional response of endothelial cells to VEGFA t

136 Here the metabolic and transcriptional response of exogenous melatonin was asse

137 Here, we analyzed the transcriptional response of human MCF-7 cells to retinoi

138 We have examined the CNS transcriptional response of Locusta migratoria manilensi

139 Growth on glucomannan led to a transcriptional response of many genes, in particular a

140 over transcription factors that regulate the transcriptional response of oncogenic KRAS in pancreatic

141 Here, we used RNA sequencing to study the transcriptional response of ovine lung tissue to infecti

142 While the transcriptional response of PCGs to HS has been comprehe

143 our results newly elucidate the heterogenous transcriptional response of single-cell peritoneal macro

144 The transcriptional response of the border zone was much str

145 e molecular features underlying the impaired transcriptional response of this mutant (ERalpha-Q375H)

146 art by insufficient understanding of how the transcriptional response of two monotherapies results in

147 Instead, Zn simulated the transcriptional response of typical Fe-regulated genes,

148 The transcriptional responses of all 757 genes identified af

149 ted phenotypes similar to that of bkdE1alpha Transcriptional responses of BCKDH to different N status

150 Transcriptional responses of human cell lines to 15 ART

151 Transcriptional responses of human esophageal cells to I

152 In this study, we analyzed the transcriptional responses of human monocytes, macrophage

153 The combined transcriptional responses of induced genes exhibited a r

154 We here examined the comparative transcriptional responses of innate immune genes to NDV

155 erance to imposed drought stress and altered transcriptional responses of markers of mitochondrial re

156 sent a comparative study of variation in the transcriptional responses of peripheral blood mononuclea

157 Here, we examined the transcriptional responses of populations of E. huxleyi i

158 characterize the human regulome and test the transcriptional responses of putative regulatory element

159 The initial legitimate transcriptional responses of TFs to OSKM reprogramming w

160 Understanding the transcriptional responses of the host midgut to viral in

161 The tissue-specific and time-specific transcriptional responses of the lncRNA genes under some

162 In this study, we examined the transcriptional responses of the T. ni midgut to infecti

163 nfected with AcMNPV occlusion bodies and the transcriptional responses of the T. ni midgut were analy

164 othesis using RNA sequencing to quantify the transcriptional responses of wild grapevine (Vitis ripar

165 in different omics-profiles, and overlay the transcriptional response on a metabolic network.

166 Transcriptional responses partially reproduced in vivo s

167 Overall, our findings are consistent with transcriptional responses participating mostly in late-s

168 s for goblet cell metaplasia, we studied the transcriptional response profile of IL-13-exposed primar

169 spectrum of REs, each coding for a distinct transcriptional response profile.

170 systems consisting of a sensor kinase and a transcriptional response regulator to detect environment

171 This dynamic transcriptional response relies on the activities of tis

172 TLR activation influence the quality of the transcriptional responses remains unknown.

173 We find that long term modulation of the transcriptional responses requires continued NODAL/Activ

174 M(2.5) exposure on the nature/time course of transcriptional responses, self-renewal of APhi, and the

175 cultured cells to hypoxia predict the cell's transcriptional response several hours later.

176 e a comprehensive new data set measuring the transcriptional response shortly after inducing overexpr

177 e two compounds, which we use to measure the transcriptional response similarity of the two compounds

178 embedding vector of a chemical compound in a transcriptional response space.

179 hat CF macrophages had intact reparative and transcriptional responses, suggesting that macrophage co

180 Hdac2 knockout resulted in a substantial transcriptional response that included modification of t

181 pause release, which enables a pro-survival transcriptional response that is crucial for cell fate u

182 s proliferate locally and provide a distinct transcriptional response that is linked to tissue regene

183 n of transcription factors, which primes the transcriptional response that underlies elongation growt

184 cal stimuli, such as denervation, can induce transcriptional responses that are propagated along the

185 Importantly, it contributes to early transcriptional responses that are suppressed by PiSFI3.

186 flowing blood to stimulate cytoskeletal and transcriptional responses that form a highly efficient v

187 ortant for triggering root growth, the early transcriptional responses that stimulate primary root el

188 or the first time, the monocyte and parasite transcriptional responses that underpin human monocyte-T

189 e regulatory mechanisms of the plant spatial transcriptional response through cis-regulatory codes bu

190 it is positioned to coordinate the adaptive transcriptional response to a cell's most abundant energ

191 dback mechanism by which the duration of the transcriptional response to a developmental signal is li

192 ere associated with a significantly enhanced transcriptional response to a second acute GC challenge.

193 fer which transcription factors can regulate transcriptional response to a stimulus, or identify sequ

194 ng to RNA polymerase II to promote immediate transcriptional response to ABA and drought signals.

195 obtail squid, we characterized the bacterial transcriptional response to acidic pH experienced during

196 We found that the global transcriptional response to acute hypoxia is tissue-spec

197 l conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulat

198 n health and a need to examine the conserved transcriptional response to adversity alongside other pr

199 related to increased expression of conserved transcriptional response to adversity genes and distinct

200 of chronic adolescent stress influenced the transcriptional response to an acute novel stressor in a

201 chronic adolescent stress modifies the adult transcriptional response to an acute stressor in males a

202 nd activating AP1 complexes may permit rapid transcriptional response to and resolution from stress s

203 for anautogenous mosquito reproduction, the transcriptional response to blood-ingestion remains unde

204 study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the

205 This transcriptional response to cholestatic liver injury lik

206 edicted E2F3 as an upstream regulator of the transcriptional response to cocaine self-administration

207 ed several candidate drivers of the observed transcriptional response to CYP2J2 silencing; these mast

208 HY5 was found to mediate a subset of the transcriptional response to cytokinin.

209 in vitro approaches to characterize the SOS transcriptional response to DNA damage in the Patescibac

210 DSM639 showed that while both share a strong transcriptional response to elemental sulphur, S. acidoc

211 novel target in beta-cells that coordinates transcriptional response to elevated glucose levels.

212 A homeostatic transcriptional response to ferroptotic stimuli is unkno

213 Our results suggest that the plant organ transcriptional response to high salinity is regulated b

214 tor-1alpha (HIF-1alpha) promotes an adaptive transcriptional response to hypoxia and as such is a maj

215 The transcriptional response to hypoxia is generally conserv

216 way, but still shows robust survivorship and transcriptional response to hypoxia.

217 ding question why cell types differ in their transcriptional response to hypoxia.

218 These findings are based on analysis of the transcriptional response to infection by the intracellul

219 The transcriptional response to infection in Brachypodium wa

220 In this study, we measured the host transcriptional response to infection in multiple DENV t

221 frequencies of immune cell subsets, and the transcriptional response to infection in peripheral bloo

222 genes contribute to shaping the host cell's transcriptional response to infection is largely unclear

223 6 plays in modulating the host cell's global transcriptional response to infection is not clear.

224 Here, we evaluated the host transcriptional response to infection with murine corona

225 in the human lung, coinciding with a robust transcriptional response to infection, including a role

226 e of tail amputation to regulate the initial transcriptional response to injury and regeneration.

227 st epigenomic map providing insight into the transcriptional response to injury and the differential

228 We established that a chloroplast transcriptional response to light intensity was mediated

229 n is critical for both the translational and transcriptional response to metformin.

230 FtsH1/3 leads to a drastic reduction in the transcriptional response to nutrient stress of not only

231 ize the regulatory mechanisms underlying the transcriptional response to oncogenic KRAS and provide a

232 f Hog1, a kinase important for signaling the transcriptional response to osmotic stress.

233 Analysis of the transcriptional response to pdcA mutation indicates that

234 osensory neuronal subtypes undergo a similar transcriptional response to peripheral nerve injury that

235 ss this question, we investigated the global transcriptional response to perturbations in O-GlcNAcyla

236 4A2 and NR4A3 are components of a downstream transcriptional response to PKA activation in the neutro

237 The transcriptional response to PPIs was partially mediated

238 may be responsible for triggering a stronger transcriptional response to promote submergence survival

239 al-time PCR analysis were used to assess the transcriptional response to rbCAPG (Control, vehicle, CA

240 Here, we uncovered an ATR- and CHK1-mediated transcriptional response to replication stress (RS) in m

241 Further, EDF1 regulates an immediate-early transcriptional response to ribosomal collisions.

242 d negative correlation, suggesting a complex transcriptional response to SAM.

243 Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with oth

244 ecreased, and we observed a reduction in the transcriptional response to Shh pathway activation.

245 f all mAtg8s or GABARAPs affected the global transcriptional response to starvation and downregulated

246 Here we show that the transcriptional response to stress signaling is supporte

247 pport of this, F. oxysporum showed almost no transcriptional response to T. guizhouense Deltanox1 str

248 ntensity was mediated by SIG5; a chloroplast transcriptional response to the relative proportions of

249 his animal model of IUGR links the placental transcriptional response to the stressor of gestational

250 ulates is associated with an altered cardiac transcriptional response to transverse aortic constricti

251 High-throughput screening of the host transcriptional response to various viral infections pro

252 -gatherers and agriculturalists in the early transcriptional response to viruses compared with that f

253 tably, transplanted microglia exhibit robust transcriptional responses to Abeta-plaques that only par

254 uced IL-6, IL-1beta, CXCL1, CXCL2 and CXCL10 transcriptional responses to bacteria, and increased sus

255 a reference dataset of the intestinal mucosa transcriptional responses to chronic EtOH exposure for f

256 Gas5 may serve as an important regulator of transcriptional responses to cocaine.

257 gene pairs is species specific, the initial transcriptional responses to cold appear to be more cons

258 maize, the promoters of genes with conserved transcriptional responses to cold tend to contain more m

259 n serially collected fecal samples and their transcriptional responses to different histories of colo

260 cies-specific differences in the kinetics of transcriptional responses to differentiation signals.

261 of evidence are TF binding locations and the transcriptional responses to direct TF perturbations.

262 of the cis-regulatory code of plant spatial transcriptional responses to environmental stress.

263 ulted in altered ER binding and differential transcriptional responses to estrogen stimulation.

264 Here, we examined intestinal transcriptional responses to EtOH in WT and transgenic f

265 Transcriptional responses to external stimuli remain poo

266 A wide range of transcriptional responses to FGF1 was observed across di

267 widely studied, but there are few studies of transcriptional responses to hours of hypoxia in vivo, e

268 ), a key transcription factor that regulates transcriptional responses to hypoxia.

269 By analyzing host and bacterial transcriptional responses to infection, together with Vi

270 nd NRF1 transcription factors in determining transcriptional responses to ischemia.

271 ed a dose-dependent shift in the kinetics of transcriptional responses to LPS.

272 tion followed by M. gallisepticum R(low) The transcriptional responses to monoinfection and coinfecti

273 Transcriptional responses to optogenetically delivered h

274 Transcriptional responses to oxidative and osmotic stres

275 The aim of this study was to define transcriptional responses to PKA activation and to delin

276 everal intestinal antiviral and inflammatory transcriptional responses to RV.

277 Whereas CD8(+) transcriptional responses to sICB and cICB involve a sha

278 We identified significant and divergent transcriptional responses to stimulation in each of the

279 re to GCs can change the set point of future transcriptional responses to stress by inducing lasting

280 ch uses "nuclear hashing" to quantify global transcriptional responses to thousands of independent pe

281 of long-term cell viability from short-term transcriptional responses to treatment.

282 The priming of chromatin enabled robust transcriptional responses to weak upstream signals.

283 However, how pyruvate controls the transcriptional responses underlying the metabolic switc

284 d that JA is required for regulating several transcriptional responses unique to the stress combinati

285 enhancer landscape, permitting an immediate transcriptional response upon bacterial exposure.

286 egulates cell proliferation, we analyzed the transcriptional responses upon simultaneous induction of

287 tified with the largest amount of associated transcriptional response was benzene.

288 d by the strength and reproducibility of the transcriptional response, was not significantly associat

289 In accordance with transcriptional responses, we found persistent degradati

290 When we examined these transcriptional responses, we uncovered novel night-resp

291 kg, IP) and innate immune signaling, and the transcriptional response were assessed (1 and 5 hours),

292 Putative toxins with the strongest transcriptional response were found to have low conserva

293 our previous classifications, and show that transcriptional responses were largely equivalent betwee

294 lopmental responses, fungal colonization and transcriptional responses were monitored in two independ

295 Portions of these transcriptional responses were not associated with time

296 disease-associated subpopulations, and that transcriptional responses were substantially different b

297 ting DNA methylation marks into a downstream transcriptional response, which has implications for bot

298 tiplicative or super-multiplicative combined transcriptional responses, while sub-additivity of acces

299 ncing transcriptome profiling to compare the transcriptional response with both modes of precondition

300 h it is clear that ecdysone elicits distinct transcriptional responses within its different target ti