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1 conversion among mature resident cell types (transdifferentiation).
2 ression of lineage master regulators induces transdifferentiation.
3 RG1 significantly enhanced the efficiency of transdifferentiation.
4 ugh vascular mimicry (VM) and/or endothelial transdifferentiation.
5 nt for AR, often through neuroendocrine (NE) transdifferentiation.
6 regulated upon fenretinide (FR)-mediated RPE transdifferentiation.
7 king the nitrosylation site almost abrogated transdifferentiation.
8 OS-generated nitric oxide (NO) might enhance transdifferentiation.
9 sylation of RING1A is critical for effective transdifferentiation.
10 per cell type to another, a process known as transdifferentiation.
11 establishes a model for Notch regulation of transdifferentiation.
12 can develop drug resistance through squamous transdifferentiation.
13 meeting a conservative definition of direct transdifferentiation.
14 nking impaired Wnt signaling with hepatocyte transdifferentiation.
15 nerate HCs via both proliferation and direct transdifferentiation.
16 gh a Notch-dependent process of plasmatocyte transdifferentiation.
17 ived by both mitotic regeneration and direct transdifferentiation.
18 e activation of these genes can drive sexual transdifferentiation.
19 ues the inhibitory effect of YAP on squamous transdifferentiation.
20 unction postnatally as a barrier to cellular transdifferentiation.
21 ressively resistant to Dlx2-induced neuronal transdifferentiation.
22 is remarkably stable and resists direct cell transdifferentiation.
23 hat mechanism DMRT1 prevents from triggering transdifferentiation.
24 romote adipogenesis in preadipocytes, in HSC transdifferentiation.
25 rging roles of mTOR in T-cell exhaustion and transdifferentiation.
26 nk between iPS cell reprogramming and B-cell transdifferentiation.
27 genes potentially involved in neuroendocrine transdifferentiation.
28 , suggesting that classical PKCs regulate CF transdifferentiation.
29 on or called iPSC transcription factor-based transdifferentiation.
30 pithelial cells (BHPrEs) promotes urothelial transdifferentiation.
31 st glycoprotein M6a, undergo myofibroblastic transdifferentiation.
32 nt, direct reprogramming to pluripotency and transdifferentiation.
33 n HSCs to determine if metabolism influenced transdifferentiation.
34 cineurin, which itself induced myofibroblast transdifferentiation.
35 peutic approach for inhibiting myofibroblast transdifferentiation.
36 boxypeptidase A1, Amylase2a) on day 4 of the transdifferentiation.
37 ed with increased histone acetylation during transdifferentiation.
38 antigen receptor locus assembly, and program transdifferentiation.
39 e that triggers luminal to basal/mesenchymal transdifferentiation.
40 a membrane, thereby increasing myofibroblast transdifferentiation.
41 ts that enable the inhibition of endothelial transdifferentiation.
42 ween metabolism and epigenetic modulation in transdifferentiation.
43 lasma membrane recruitment and myofibroblast transdifferentiation.
44 eta signaling led to alpha-cell to beta-cell transdifferentiation.
45 icts the transcription factors used in known transdifferentiations.
46 d SOX2 and induced epithelial-to-mesenchymal transdifferentiation accompanied by increased TKI tolera
47 age, mutant disc cells displayed chondrocyte transdifferentiation, accompanied by strong expression o
48 terminally differentiated, remain plastic to transdifferentiation across germ layer lineage boundarie
49 ontroversial phenomenon, as it would require transdifferentiation across the mesoderm-ectoderm barrie
50 tellate cells (HSCs) undergo myofibroblastic transdifferentiation (activation) to participate in live
52 (in BJ fibroblasts) of iNOS nearly abolished transdifferentiation, an effect that could be reversed b
56 w concept of iPSC transcription factor-based transdifferentiation and discuss its application in gene
57 the role of epithelial plasticity, including transdifferentiation and epithelial-to-mesenchymal trans
58 ited transforming growth factor-beta-induced transdifferentiation and fibrotic signaling in WT BM-FPC
59 a/Arf is a potent barrier to direct neuronal transdifferentiation and further suggest that this locus
60 PV4) is a critical mediator of myofibroblast transdifferentiation and in vivo fibrosis through its me
61 y altered expression as a consequence of HSC transdifferentiation and of these 104 were modulated ear
62 ify Rev-erbalpha as a novel regulator of HSC transdifferentiation and offers exciting new insights on
63 ure, and it interfered with ATII-to-ATI cell transdifferentiation and organoid formation, which were
64 veal distinct PKC-dependent regulation of CF transdifferentiation and proliferation and suggest that
65 forms distinctly regulate cardiac fibroblast transdifferentiation and proliferation, the two central
66 kappaB (NF-kappaB) induces mesenchymal (MES) transdifferentiation and radioresistance in glioma stem
67 inistration of FR induced neuronal-like cell transdifferentiation and reduced expression of Wnt-relat
69 ng downstream of Org-1 in this first step of transdifferentiation and show that alary muscle lineage-
70 ivo evidence for smooth muscle-to-macrophage transdifferentiation and supports an important role of S
71 , the exact molecular events accompanying NE transdifferentiation and their plasticity remain poorly
72 vascular regeneration, with its emphasis on 'Transdifferentiation and Tissue Plasticity in Cardiovasc
73 iew mechanisms of BE pathogenesis, including transdifferentiation and transcommitment, and discuss po
74 1 activity and gene expression abrogated GSC transdifferentiation and vascularization in vitro, and i
75 sure to FR, with cell cycle arrest, neuronal transdifferentiation, and concomitant up-regulation of t
76 broblasts proliferate, undergo myofibroblast transdifferentiation, and deposit large amounts of extra
78 ossible implications of GBM-endothelial cell transdifferentiation; and vasoformative responses, inclu
80 nd PI3Kgamma were required for myofibroblast transdifferentiation as assessed by the increased produc
81 dings including iPS reprogramming and direct transdifferentiation as well as gene editing have gradua
85 tes a glycolytic switch that is required for transdifferentiation, both processes being attenuated by
86 ate ECM accumulation and modulate fibroblast transdifferentiation; both are critical events in advers
87 ndent acquisition may involve neuroendocrine transdifferentiation, but there is little knowledge abou
88 trated to induce fibroblast-to-myofibroblast transdifferentiation by activation of p38 mitogen-activa
90 l of potency of these iMSCs and assess their transdifferentiation capacities into functional odontobl
91 Hep3B and HepG2, induced primary mouse HSCs transdifferentiation, characterized by profibrotic prope
93 how varying parameters of cell delivery and transdifferentiation could result in three mechanisms of
94 ion of new hematopoietic differentiation and transdifferentiation data to foster our understanding of
95 order to bypass inducing pluripotent stage, transdifferentiation/direct conversion technologies have
96 LPCs and pluripotent stem cells, findings of transdifferentiation, disease-specific considerations fo
98 is responsible for myocyte-to-Purkinje fiber transdifferentiation during avian heart development.
99 itor-like tumor cells with basal/mesenchymal transdifferentiation during murine BRCA1 BLBC developmen
100 nate immunity may play a fundamental role in transdifferentiation during wound healing and regenerati
102 that the efficiency of a naturally occurring transdifferentiation event in Caenorhabditis elegans is
108 r diagnostics, whereas myotubes generated by transdifferentiation from an individual's fibroblasts ac
109 r adult stem cells via differentiation or by transdifferentiation from other cell types with the aid
110 podocytes onto Bowman's capsule, rather than transdifferentiation from PECs to parietal podocytes.
111 man's capsule via the vascular stalk; direct transdifferentiation from PECs to podocytes was not obse
115 nique referred to as direct reprogramming or transdifferentiation has proven to be a rapid, robust, a
117 em cell biology and direct reprogramming, or transdifferentiation, have produced powerful new tools t
119 support for the concept that neuroendocrine transdifferentiation in prostate cancer cell populations
120 n melanoma, treatment-induced neuroendocrine transdifferentiation in prostate cancer, and sarcomas, w
121 omatic cells comprises dedifferentiation and transdifferentiation in the context of tissue regenerati
122 inhibition in FSGS mice increased RFP(+)CoRL transdifferentiation in the IGC to phenotypes, consisten
123 ility of Myt1l (Myt1-like) to drive neuronal transdifferentiation in vitro in vertebrate systems.
124 used to measure the metabolic changes during transdifferentiation in vitro, and Matrigel plug assay w
127 s a developmental barrier to direct neuronal transdifferentiation induced by transcription factor ove
130 generation and expansion of alpha-cells for transdifferentiation into beta-cells and the treatment o
131 ication and proliferation, and in hepatocyte transdifferentiation into cholangiocytes during liver re
133 ablation does not impair SC proliferation or transdifferentiation into growth promoting repair SCs.
134 cluding the first-in-field model of complete transdifferentiation into lethal neuroendocrine prostate
140 RBP-Jkappa in forming beta-cells led to the transdifferentiation into the other endocrine cells type
141 induced pluripotent stem cells, facilitated transdifferentiation into trophoblast stem cells, and im
142 The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regen
143 Immunofluorescence showed that myofibroblast transdifferentiation is attenuated and appearance of fib
144 e predicted miRNA target genes confirmed the transdifferentiation is closely related to neuronal diff
147 eta cell conversion was not, suggesting that transdifferentiation is not mediated by glucagon/GLP-1 c
149 rafts causes enhanced tumor progression, EMT-transdifferentiation, metastatic dissemination, and chem
150 Recent reports have proposed an alternative transdifferentiation method in which fibroblasts are dir
151 thereby allowing the execution of hepatocyte transdifferentiation; moreover, they highlight HOTAIR as
152 vidence of pregranulosa cell-to-Sertoli cell transdifferentiation near birth, following a severe decl
154 tures, supporting histological evidence that transdifferentiation occurs adjacent to the vasculature.
155 OXA1 cooperate with PPAR activation to drive transdifferentiation of a basal bladder cancer cells to
156 of human disease, which was associated with transdifferentiation of a subset of contractile SMCs int
157 Synthetic androgen (R1881) prevented NE transdifferentiation of AD LNCaP cells and markedly supp
158 pathogenesis of many diseases including the transdifferentiation of adipocytes (fat cells) into myof
159 ent cells-leucophores-one of which arises by transdifferentiation of adult melanophores and another o
160 suggest that neogenesis from duct cells and transdifferentiation of alpha-cells are potential contri
161 r binding protein-alpha (C/EBPalpha) induces transdifferentiation of B cells into macrophages at high
162 Gs) maintain BeAT in infants and prevent the transdifferentiation of BeAT into lipid-storing white ad
163 premise of heart muscle regeneration by the transdifferentiation of bone marrow cells or putative ad
164 vein clearing is caused by pathogen-induced transdifferentiation of chloroplast-containing bundle sh
165 es to produce functional beta-cells include: transdifferentiation of closely related cell types (for
166 ver, the loss of wild-type Braf also induces transdifferentiation of club cells, which leads to the r
167 Xenopus had been described as one involving transdifferentiation of cornea epithelial cells (i.e., o
168 aling can be activated in SCs but not impede transdifferentiation of denervated SCs to regeneration-p
169 ial-mesenchymal transition (EMT), defined as transdifferentiation of epithelial cells into mesenchyma
171 specification, might be sufficient to induce transdifferentiation of fibroblasts into ECs (induced EC
172 mous innate immune signaling facilitates the transdifferentiation of fibroblasts into induced endothe
174 ducing signals, has been reported to trigger transdifferentiation of fibroblasts into other cell type
175 shown that innate immunity is necessary for transdifferentiation of fibroblasts to endothelial cells
176 munity, has been previously described in the transdifferentiation of fibroblasts to endothelial cells
177 however, it failed to rescue TGFbeta-driven transdifferentiation of fibroblasts to myofibroblasts in
178 sume an immature replicating cell phenotype; transdifferentiation of hematopoietic stem cells into ca
179 and progenitor cells (HSPCs) arise from the transdifferentiation of hemogenic endothelial cells (hem
180 rtebrate embryos, HSCs arise from the unique transdifferentiation of hemogenic endothelium comprising
182 ells (HSCs), but the mechanisms that control transdifferentiation of HSCs are poorly understood.
185 Here, we showed that TRPV4 promoted the transdifferentiation of human and mouse lung fibroblasts
187 Overall, we describe a method for achieving transdifferentiation of human dermal fibroblasts into in
189 ockdown studies, we found that the effective transdifferentiation of human fibroblasts to ECs require
190 ent, markedly increase the efficiency in the transdifferentiation of human fibroblasts to iDA neurons
192 indicated remodeling of vitreous cortex and transdifferentiation of hyalocytes into myofibroblasts.
195 TGF-beta-Slug-EMT signaling reactivated the transdifferentiation of keratinocytes, reviving their mi
196 ific interests because it is associated with transdifferentiation of liver cells and may play an impo
197 tively, our findings demonstrate the de novo transdifferentiation of lung ADC to SCC in mice and prov
198 Here we provide in vivo evidence showing the transdifferentiation of lung cancer from ADC to SCC in m
200 F acts redundantly with ThPOK to prevent the transdifferentiation of mature CD4(+) T cells into CD8(+
203 otch signaling or use of lithium can trigger transdifferentiation of mature principal cells to interc
205 t suggests that forskolin and IBMX result in transdifferentiation of MSCs into a neural lineage.
206 ion, resistance to apoptosis, and subsequent transdifferentiation of PAH-PASMCs into osteoblast-like
209 tabilized TbetaRII and potentiated TGF-beta1 transdifferentiation of pericytes into myofibroblasts in
210 ss a detailed time course of culture-induced transdifferentiation of primary human HSC, this a key ev
213 the tumor microenvironment, TGF-beta induces transdifferentiation of quiescent pericytes and related
214 162 microRNAs changed in expression during transdifferentiation of rat HSC, however only 17 underwe
215 s both necessary and sufficient for neuronal transdifferentiation of RPE cells and reveal an essentia
221 e show that loss of TP53 leads to adrenergic transdifferentiation of tumour-associated sensory nerves
222 Because microRNAs (miRs) are involved in the transdifferentiation of vascular smooth muscle cells int
223 he latter's reduced binding to TWIST1 during transdifferentiation of Wharton jelly-derived MSC (WJ-MS
224 st that reinitiation of cambial activity and transdifferentiation of xylem parenchyma cells results i
225 production of fate-specific cells by in vivo transdifferentiation offers a targeted method for tissue
226 and characterize the efficiency of cellular transdifferentiation on a genome-wide scale can be appli
227 on factors used in iPSC generation to induce transdifferentiation or called iPSC transcription factor
228 without ectopic hepatocyte-to-cholangiocyte transdifferentiation or long-term liver abnormalities.
230 presenting biomolecular events, such as cell transdifferentiation or the presence of an amplicon.
231 re have been no reports of cartilage to bone transdifferentiation or vasculature in human-relevant TM
232 f glucagon to secretion of insulin and back (transdifferentiation) or from an active secretory state
233 ls, represent intermediates during Treg/Th17 transdifferentiation, or constitute a distinct cell line
234 hes might include stem cell differentiation, transdifferentiation, or expansion of cadaver islets or
235 le strategies including stem cell expansion, transdifferentiation, or proliferation of differentiated
237 ined from mouse fibroblasts by OSKM-induced 'transdifferentiation' pass through a transient pluripote
239 taining, we detected c-kit (a marker of cell transdifferentiation) positive ductal cells co-expressin
240 tributors to fibrotic lesions because of the transdifferentiation potential of these cells into myofi
242 tem cells (HSCs) are generated via a natural transdifferentiation process known as endothelial to hem
243 ation of agents that selectively inhibit the transdifferentiation process leading to the formation of
245 thelial-to-mesenchymal transition (EMT) is a transdifferentiation process that converts epithelial ce
246 pithelial-to-mesenchymal transition (EMT), a transdifferentiation process triggering metastasis.
247 inted out CD25 as a key molecule during this transdifferentiation process, however molecules that all
251 mesenchymal transition (EndMT) is a cellular transdifferentiation program in which endothelial cells
252 mal transition (EMT), a reversible embryonic transdifferentiation program that allows partial or comp
253 ung cancers as well as incidences of subtype transdifferentiation raise the question of to what exten
257 cancer development, stem cell induction and transdifferentiation requires the modulation of multiple
258 rea by paracrine activity rather than active transdifferentiation, resulting into cardioprotection as
259 itions for terms such as plasticity, de- and transdifferentiation, reversion, and paligenosis were di
260 issue-specific cell types via a conventional transdifferentiation strategy typically uses overexpress
261 5 expression during alveolar epithelial cell transdifferentiation, suggesting that HDAC inhibitors ma
265 m cell and induced fibroblast-to-neuron (iN) transdifferentiation technologies has revolutionized our
267 active strategy for regenerative medicine is transdifferentiation-the direct conversion of one somati
269 alistic representations of cell delivery and transdifferentiation therapy modalities as well as repre
271 as cell-fate specification, cell death, and transdifferentiation throughout post-embryonic developme
272 e tested if pancreatic metaplasia represents transdifferentiation to a biliary phenotype and what eff
273 ia (ADM), a reprogramming event that induces transdifferentiation to a ductlike phenotype and, in the
274 Unrepaired ICL damage results in aberrant transdifferentiation to a mesenchymal state of cultured,
275 s during atrial-to-ventricular cardiomyocyte transdifferentiation to define intermediate cardiac repr
276 Here we conferred fusogenic activity without transdifferentiation to multiple non-muscle cell types a
277 investigated its potential role in adipocyte transdifferentiation to myofibroblast in dermal fibrosis
278 gested that the FIZZ1 induction of adipocyte transdifferentiation to myofibroblast might be a key pat
279 ced homing of BM-FPCs to the heart and their transdifferentiation to myofibroblasts and thus attenuat
280 suggest that IL10 inhibits BM-FPC homing and transdifferentiation to myofibroblasts in pressure-overl
281 ext at key target genes is determinative for transdifferentiation to neurons and likely other cell ty
283 lls, and a developmental arrest in the T(H)1 transdifferentiation trajectory upon loss of mTORC1 acti
285 e putative vasculature and cartilage to bone transdifferentiation using healthy and diseased TMJ tiss
286 Recent studies revealed a new paradigm of transdifferentiation: using transcription factors used i
287 ly differentiated cell type into another (or transdifferentiation) usually requires the forced expres
290 by increasing CoRL number, migration, and/or transdifferentiation, we administered tamoxifen to Ren1c
291 ransition significantly accelerates squamous transdifferentiation, whereas constitutive YAP activatio
292 Pharmacological Lox inhibition promotes the transdifferentiation, whereas ectopic Lox expression sig
293 whether its loss can trigger principal cell transdifferentiation (which could explain acquired diabe
295 pled with cells undergoing cartilage to bone transdifferentiation, which may contribute to TMJ pathog
296 eceptor (AR) signaling during neuroendocrine transdifferentiation, which results in resistance to AR-
297 1(Deltabeta)) caused beta-to-delta-like cell transdifferentiation, which was delayed until postnatal