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3 racellular cues by binding with cytokines to transduce a signaling cascade leading to gene transcript
4 preparations of AAV8 vectors can effectively transduce a variety of immune cell populations including
5 on in dim and bright light, respectively, by transducing absorbed photons into neural electrical sign
7 sensory receptors of the mammalian cochlea, transducing acoustic information into electrical signals
8 ion of the molecular determinants of signals transduced across the ligand binding and coregulator rec
10 h respect to protein interactions and signal-transducing activity of a panel of vIL-6 variants and ut
12 istance of the adaptor protein STAM1 (signal-transducing adaptor molecule 1) because disruption of th
13 localized on endosomes, we identified signal-transducing adaptor molecule-binding protein (STAMBP) an
14 olymer mechanochemistry, a mechanical force, transduced along polymer chains, is used to activate cov
15 nd a large-scale rearrangement of the signal-transducing alpha5-helix of Galpha away from its beta-sh
16 e, we present a general design strategy that transduces an aptamer-target binding event into a fluore
17 esonance Energy Transfer (FRET) strategy for transducing analyte recognition into real-time quantitat
18 in the intracellular signaling networks that transduce and amplify stress signals into physiological
19 proteins are the core upstream elements that transduce and amplify the cellular signals from G protei
24 treatments presently available, retrovirally transduced autologous epidermal grafts and intradermal l
25 ndscape associated with cAMP-binding signals transduced between the two CNB domains of protein kinase
27 s and high-throughput screening because they transduce biochemical signals into gene expression chang
30 xide memristors can be utilized for directly transducing biomarker concentration levels to discrete m
31 evolving primary sex-determining signals are transduced by a conserved regulatory module controlling
32 contrast, in sxc mutants, the Dpp signal is transduced by both Tkv and Sax, and elevated Dpp signali
34 TACSTD2(high) and TACSTD2(low) luminal cells transduced by constitutively activated AKT1 (caAKT1), an
35 Wnt signaling, an ancient signaling pathway transduced by Dishevelled, which assembles signalosomes
36 estigated the mechanisms by which forces are transduced by liver sinusoidal endothelial cells (LSECs)
39 es as a relay region for sensory information transduced by receptor neurons in the nose and ultimatel
40 ivo gene therapy using stem cells or T cells transduced by retroviral or lentiviral vectors has shown
44 s together lead to the modulation of signals transduced by the M(3) muscarinic receptor/G(q)/PLCbeta
45 l cues from the basement membrane, which are transduced by the Src tyrosine kinase to alter junctiona
48 scription and receptor signaling seems to be transduced by TK and PI-3K pathways and modulated by CRE
53 tent retroviruses, a routine safety test for transduced cell products in clinical studies, should be
54 packaged into viral particles and be used to transduce cells, allowing expression at physiological le
56 h the levels of syncytin 1 expression in the transduced cells and depended on the fusogenic activity
57 ed to the injected brain regions, AAV2.retro transduced cells in the striatum and in dozens of cortic
58 HSV1-TK enzyme can act as a suicide gene of transduced cells through treatment with the prodrug ganc
59 ta promoted cell killing in neighboring, non-transduced cells, thus revealing a bystander effect.
63 Molecular motors are diverse enzymes that transduce chemical energy into mechanical work and, in d
64 view highlights the advances in electrically-transduced chemical sensing that rely on 2D materials.
65 phorylation of Escherichia coli CheY protein transduces chemoreceptor stimulation to a highly coopera
68 embly complex (LUBAC) as an important signal transducing component of IL-17R, we established that IL-
70 olecular interactions within the active site transduce conformational changes to the active-site loop
71 s a conserved metazoan signaling system that transduces cues from extracellular cytokines into transc
72 phological measurements in membrane reporter-transduced D1- and D2-MSNs and astrocytes, and MMP-2,9 g
73 This shows that the machinery for visual transducing discs might still be present but not organiz
74 oupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state
78 problem, but previous methods(7-9) relied on transducing electric signals into magnetic fields via th
79 nterfaces with a sensing film in 3D with the transducing electronics is however difficult by conventi
80 idenced the possibility of using a DMFC as a transducing element in an electrochemical sensor, confir
83 MO) is emerging as an important mechanism to transduce environmental cues into cellular signaling.
84 ound growth factors instigate several signal transducing events that ultimately determine ASC differe
85 ed by pairs of guard cells that perceive and transduce external signals, leading to cellular volume c
86 receptors (GPCRs) are biologic switches that transduce extracellular stimuli into intracellular respo
87 ry pathways that optimize gene expression by transducing extracellular environmental signals to the c
90 matic cell reprogramming was investigated by transducing fibroblasts with the four reprogramming fact
92 ights into how HH signaling is generated and transduced from the cell surface into the intercellular
93 tress, which was genetically complemented by transducing genomic SVB SVB showed time-dependent induct
94 le uses a distinct mechanism for sensing and transducing germinant signals relative to previously cha
96 ting, Ca2(+) flux assays, differentiation of transduced HL-60 cells, in vitro differentiation of prim
97 owing engraftment into immunodeficient mice, transduced HSPCs give rise to human myeloid leukemia, wh
99 interferon-beta cDNA (hIFNbeta) was used to transduce human melanoma cell lines SK-MEL-05 and SK-MEL
101 t peridermal polarity, initiated by aPKC, is transduced in a stepwise manner by E-cadherin to the bas
102 no-associated virus (AAV) vector effectively transduced in the cerebrum, cerebellum, heart, liver and
103 1 (TAK1), are protein kinases essential for transducing inflammatory signals from interleukin recept
104 e receptors and serve as signal mediators to transduce information from extracellular signals such as
106 through Fcgamma receptors (FcgammaRs), which transduce interactions with immune complexes, leading to
107 phate (MEcPP) has emerged as a stress signal transduced into a diverse ensemble of response outputs.
108 ignal from a single plastidial metabolite is transduced into an ensemble of regulatory networks contr
111 H11 epitope-specific T cell receptors (TCRs) transduced into CD8+ T cells conferred antileukemic acti
113 ed to dynamic mechanical stimulation that is transduced into cellular responses by mechanotransductio
117 the working electrode can be quantitatively transduced into simultaneous emission of fluorescence.
119 that TREM2 regulates microglial function by transducing intracellular signals from aminophospholipid
120 o by facilitating force transmission, and by transducing key signals to cardiomyocytes, vascular cell
121 s to spindle microtubules to establish force-transducing kinetochore-microtubule attachments and 2) r
123 ng the existing material candidates that can transduce light energy into biologically relevant cues,
124 ir fluorescence, with the total intensity of transduced light being dependent on the optical path len
127 omising tool, even transplanted in vivo, for transducing light stimuli to non-functioning retinas.
129 in nuclei of sensory neuroendocrine cells to transduce low cellular energy charge into the mobilizati
131 he highest fluorescence activation in stably transduced mammalian cells upon DENV-2/ZIKV infection.
133 e to host defense across the animal kingdom, transducing many signals involved in both vertebrate and
135 e mechanisms through which endothelial cells transduce mechanical signals to cellular responses remai
136 anism for sensitivity and reversibility when transducing mechanical signals, in addition to the catch
137 s between subcellular structures involved in transducing mechanical signals, we combined experimental
138 iant provided functional insight into signal-transducing mechanisms of the engineered enzymes and hig
145 e earlier after transplantation than control-transduced Mpl(-/-) cells, and upregulated expression of
147 Instead of using a multitiered retina to transduce multiple simultaneous images, the sensor uses
149 serotype PHP.B in adult wild-type male mice transduced neurons and astrocytes throughout the brain m
150 effectively enters the brain parenchyma and transduces neurons at levels comparable to the level of
151 a central role in immune cell activation by transducing NF-kappaB signaling, and its proteolytic act
153 man immunodeficiency virus type 1 (HIV-1) to transduce nondividing cells is key to infecting terminal
157 ve poly(acrylamide-co-acrylic acid) hydrogel transduces optical energy into mechanical deformation of
158 switch on a trihelix transrepressor directly transduces osmotic stress to repress stomatal developmen
160 tion of the fast exocytotic component in the transduced Otof (-/-) IHCs was also associated with a re
161 ion and discuss what players are involved in transducing phosphoantigen-mediated signals to human Vga
164 Instead, we show that in DN thymocytes WNK1 transduces pre-TCR signals via OXSR1 and STK39 kinases,
166 are specialized postsynaptic structures that transduce presynaptic signals, are regulated by neural a
167 mniotic lentiviral injection can efficiently transduce progenitor cells of the adult mammary gland an
169 siderophore receptors, the TonB-ExbBD energy-transducing proteins coupling the outer and the inner me
170 m controlled molecules, in particular, could transduce quantum information across a wide range of qua
171 Our work demonstrates how molecules can transduce quantum information between qubits with differ
172 ransitions in quantum matter(10-12), and may transduce quantum information on the nano-femto scale(13
175 to activate all cells expressing the signal-transducing receptor chain glycoprotein 130 (gp130).
176 TIR-NLR receptors require NADase function to transduce recognition of pathogens into a cell death res
180 tors in adult male and female Th-Cre rats to transduce selectively RTN (Phox2b(+) /Nmb (+)) or C1 neu
183 cells provide the foundation for the gut to transduce sensory signals from the intestinal milieu to
185 electrical outputs can be readily used as a transducing signal to efficiently monitor bacterial grow
186 r proteins (YTHDF2 and YTHDF3) inhibit RIG-I-transduced signaling activated by viral RNAs by occupyin
187 Plexins are receptors for semaphorins that transduce signals for regulating neuronal development an
188 ellular matrix to the actin cytoskeleton and transduce signals in response to both chemical and mecha
190 iated by FcgammaRs, which upon cross-linking transduce signals that modulate the function of effector
191 ort that GPR56 is the platelet receptor that transduces signals from collagen and blood flow-induced
192 ds, Env binds to CD4 on key immune cells and transduces signals that can compromise their function.
193 a, Gbeta and Ggamma subunits, is involved in transducing signals from external stimuli to regulate do
194 G-protein-coupled receptors are essential in transducing signals from the microenvironment, and heter
195 e deficient in STAT1, a molecule involved in transducing signals from type I, II, and III IFN recepto
196 on construct]), up to 3 different gRNAs were transduced simultaneously to identify optimal conditions
197 crease in [(18)F]DASA-23 brain uptake in the transduced site of mice injected with the AAV mice over
199 We find that their decreased ability to transduce sound into electrical signals is, most probabl
201 ility, we evolved AAV capsids to efficiently transduce specific cell types in adult mouse brains.
203 , which localizes to the tips of the shorter transducing stereocilia in both inner and outer hair cel
204 protein required for the maintenance of the transducing stereocilia in mature cochlear hair cells.
205 tenance of the normal actin structure of the transducing stereocilia in mature mouse cochlear hair ce
206 localized to the tips of the shorter rows of transducing stereocilia in mouse cochlear hair cells.
208 lypyrrole platform, we demonstrated that the transducing system allowed the detection of 1 fM of DNA
210 high-avidity T cell clones and retrovirally transduced T cell populations that kill NPM1-mutated AML
211 of the alanine scan (X-scan) and testing TCR-transduced T cells against normal and tumor cells coveri
212 We have identified capsid variants that can transduce the central nervous system broadly, exhibit bi
215 nadal steroid hormones, enabling sirtuins to transduce the cognate signals through a conserved endocr
216 n residues T176 and Y226 that is critical to transduce the inhibitory effect of Ca(2+) and the stimul
217 ladium-benzoporphyrin by molecular oxygen to transduce the local oxygen concentration in the 3D tissu
219 t scAAV2-RPE65, specifically and efficiently transduced the RPE to increase active Rap1a protein in t
220 xpressed in renal proximal tubules, where it transduces the activity of eNOS in reprogramming interme
222 e electrochemical bubble nucleation and then transduces the change in nucleation condition to electro
224 ptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppresso
226 2)) amino-terminal cysteine dioxygenase that transduces the oxygen-regulated stability of proteins by
228 Pathway analysis is suggestive of integrins transducing the encapsulation effect into intracellular
230 lded protein response (UPR), is required for transducing the signal for activation of ERK1/2-RSK2 und
231 gesting that both high-affinity Ca(2+) sites transduce their effect, at least in part, through the al
232 s act as active optical microwaveguides that transduce their fluorescence, with the total intensity o
233 ical signals from their microenvironment and transduce them to the nucleus to regulate gene expressio
234 We investigated how plants generate and transduce these rapidly moving, long-distance signals re
235 owever, the parasite molecule for sensing or transducing these environmental signals to initiate game
237 tional viral vector strategy, we selectively transduced three different output pathways from the LHb
238 ic adeno-associated virus (AAV) serotypes to transduce thymocyte subsets and correct the T-cell immun
240 in which genome-wide methylation changes are transduced to differentiation skews through biases in Cp
241 ploration, the dynamic patterns of touch are transduced to electrical signals and transformed by the
242 lantation of hematopoietic stem cells (HSCs) transduced to express CARs could help to overcome this p
243 g neural stem cells (ReNcell VM NSCs) stably transduced to express exon 1 huntingtin (HTT) fragments
244 ction in expanded T cells to that in T cells transduced to express second-generation CARs and found t
245 ing components, are robustly and selectively transduced to mTOR to promote baseline translation of va
248 sed by plant phytochrome photoreceptors, are transduced to target genes through direct regulation of
249 generates an activating signal that must be transduced to the secretion machine by the needle filame
251 However, although voltage-sensing domains transduce transmembrane electric field changes by a comm
254 ration, we plated dissociated adult rat DRGs transduced using AAV5-shRNA-fidgetin on a laminin substr
257 Mechanosensitive Piezo1 and Piezo2 channels transduce various forms of mechanical forces into cellul
258 neutralizing antibody sequences, which were transduced via lentiviral vector into primary CD8+ T cel
259 ts weighing 50 kg or less or 0.1-2.5 x 10(8) transduced viable T cells for patients weighing more tha
260 nistration of a target dose of 0.2-5 x 10(6) transduced viable T cells per kg for patients weighing 5
261 ty of mechanically sensitive hair bundles to transduce vibrations into electrical signals that are fo
264 ne marrow or fetal liver cells that had been transduced with a Bcor sgRNA developed pro-B1 ALL, chara
268 e I study of autologous T cells lentivirally-transduced with a fully-human, BCMA-specific CAR contain
269 s showed that normal human CD34+ blood cells transduced with a lentiviral MYC vector and then transpl
273 ly infected epithelial and endothelial cells transduced with Ad-CC9-LANA underwent significant reduct
274 containing SaCas9 mRNA, compared with cells transduced with adeno-associated virus or lentivirus exp
275 endothelial cells (HUVECs) and SC cells were transduced with adenovirus containing eNOS promoter driv
276 islet cells from Atf6alpha (flox/flox) mice transduced with adenovirus expressing Cre recombinase.
281 ocytes (no Cre recombinase, PAM floxed) were transduced with Cre-GFP lentivirus, PAM protein levels d
283 fied/ER+ breast cancer cells and MCF-7 cells transduced with FGFR1 were resistant to fulvestrant +/-
284 hTERT-NHDFs, normal human dermal fibroblasts transduced with genes encoding human telomerase reverse
289 matopoietic stem/progenitor cells (HSPC) are transduced with lentiviruses expressing a mutated form o
290 n an orthotopic xenograft model, TICs stably transduced with LIMK1/2 shRNA were implanted intracrania
291 Lower off-target rates occurred in cells transduced with LVLPs containing SaCas9 mRNA, compared w
292 umor cells with neuroendocrine features when transduced with oncogenic signaling, the identity of the
293 anked by recombination signal sequences were transduced with retroviruses encoding either wild-type o
295 known to be enriched for PCFUs, and virally transduced with shRNAs to knock down GLIS3 and other pro
296 splantation of dental pulp stem cells stably transduced with small hairpin RNA (shRNA)-STAT3 into imm
297 involved infusion of autologous CD34+ cells transduced with the BCH-BB694 lentiviral vector, which e