ライフサイエンスコーパス: transduction

1 ot fully characterized (e.g., potential gene transduction).

2 nal transduction, led to induction of signal transduction.

3 em not to be directly responsible for signal transduction.

4 rtmentation of Ca(2+) and calcineurin signal transduction.

5 , for perception and initiation of signaling transduction.

6 or heterodimerization) is central to signal transduction.

7 in protein folding, trafficking, and signal transduction.

8 brane proteins implicated in cellular signal transduction.

9 t require TYK2 and Janus kinase 1 for signal transduction.

10 around axons to facilitate electrical signal transduction.

11 e test (POCT) to measure PT using electrical transduction.

12 od requires cells to be susceptible to viral transduction.

13 transcriptional reporter of G protein signal transduction.

14 alterations were also restored by lenti-Wnt6 transduction.

15 and vimentin directly participate in signal transduction.

16 nsory neurobiology-that of gut-brain sensory transduction.

17 eptor endocytosis is required for Wnt signal transduction.

18 1-induced inhibition of the human TCR signal transduction.

19 production yields, virion stability, and CNS transduction.

20 has been done to explore their role in taste transduction.

21 a function for ribosome collisions in signal transduction.

22 which disrupts calcium gradients, blocks AAV transduction.

23 eraction with CD63 and the subsequent signal transduction.

24 nabling robust ABA and osmotic stress signal transduction.

25 tive affinity reagents that block Ras signal transduction.

26 ntaining cellular calcium homeostasis on AAV transduction.

27 of the catalytic dwells influence the energy transduction.

28 etabolism and inhibits MyD88-directed signal transduction.

29 ticularly in neurons associated with sensory transduction.

30 ocytosis is not a requirement for Wnt signal transduction.

31 tream intracellular calcium-dependent signal transduction.

32 cells in sensory systems function in sensory transduction.

33 organelle in cellular metabolism and signal transduction.

34 ting the principal features of photoreceptor transduction.

35 col (~1 h) and disposable electrodes for the transduction.

36 ls is the site of auditory mechanoelectrical transduction.

37 SPR-linked genes, often implicated in signal transduction.

38 anonical AUX/IAA proteins in auxin signaling transduction.

39 , resulting from MI-triggered R-PersL signal transductions.

40 ane proteins responsible for cellular signal transductions.

41 in transitions suited to quantum storage and transduction(11-15), but only recently have single rare-

42 requirement for G-proteins to mediate signal transduction, a situation similar, but not identical, to

43 ovector demonstrates a 200-fold reduction in transduction ability in the OFF state compared to AAV9,

44 90 variants but had no major impact on their transduction ability or immunoreactivity.

45 d to low charge transfer resistance and high transduction activity towards the co-enzyme NADH, delive

46 ly been reported to enable long-range signal transduction also in asymmetric dimers containing only o

47 L)-6/IL-6 receptor-alpha (IL-6Ralpha)/signal transduction and activation of the transcription 3 (STAT

48 n AuNP-antibody conjugate serves as a signal transduction and amplification agent by promoting the re

49 f the fly's molecular machinery for auditory transduction and amplification.

50 imerization is essential for internal signal transduction and autophosphorylation in this protein.

51 predictions to guide further study of signal transduction and cell behavior that affect mesenchymal c

52 and optical resonators will enable efficient transduction and create opportunities toward multi-platf

53 ks trypanosome environmental sensing, signal transduction and developmental gene expression in a cohe

54 ell as assessment of hematopoietic stem cell transduction and engraftment.

55 eoretical and experimental studies on signal transduction and gene regulation.

56 so directly binds DNA to facilitate cellular transduction and intracellular inflammatory signaling.

57 ptors (GPCRs) plays a central role in signal transduction and is uniquely positioned to sense both th

58 of the molecular events of the IL-17 signal transduction and its regulation.

59 gnized importance of PPIn species for signal transduction and membrane homeostasis, there is still a

60 nging from genetics and biophysics to signal transduction and physiology.

61 and sucrose metabolism, plant hormone signal transduction and plant-pathogen interaction pathways, wh

62 e have a limited understanding of the energy transduction and product distribution in tandem mechanoc

63 ht on the role of GAD65(+) TBCs in gustatory transduction and taste-mediated behavior.

64 Cilia are essential for Shh signal transduction and the ciliary phosphatidylinositol phosph

65 unclear how GPR52 and G(s) couple for signal transduction and whether a native ligand or other activa

66 ce, a Chd23 mutant with no mechanoelectrical transduction, and deafness before p56.

67 ell division, DNA replication/repair, signal transduction, and glutathione metabolism.

68 our mechanistic understanding of Wnt signal transduction, and have implications for harnessing Wnt a

69 ner retina involved in signal processing and transduction, and that the evolution of this pathway was

70 ting the regulatory mechanisms of ABA signal transduction, and the physiological importance of basal

71 ine-dependent cellular proliferation, signal transduction, and transcriptome analysis.

72 r functions, including cell motility, signal transduction, and virus replication.

73 d Raman scattering (SERS) probes for sensing transduction; and a functionalized filter membrane assem

74 Some targets of Hh signal transduction are common to the disc, ASP and myoblasts,

75 nfirm that effects following DREADD receptor transduction are not owing to the actuator drug itself.

76 turnover of Wnt receptors, and the signaling transduction are tightly regulated and fine-tuned to kee

77 eins that bind the molecule to effect signal transduction are unknown.

78 on, protein phosphorylation, cellular signal transduction, as well as mechanical roles.

79 onstrates efficiency in lung epithelial cell transduction based on imaging and flow cytometry analysi

80 The switchable transduction behavior was found to be a direct result of

81 ies, we investigated the mechanism of energy transduction between the ATP and RNA binding pockets usi

82 g a distinctive approach to realizing energy transduction beyond the conventional limitation imposed

83 To specifically study signal transduction by CARs, we developed a cell-free, ligand-b

84 ISPR-based knockout (KO) of ATP2C1 decreases transduction by different AAV serotypes.

85 hlear potential, the driving force for sound transduction by inner ear hair cells.

86 lding transition commonly observed in signal transduction by intrinsically disordered proteins in bio

87 with CusR likely ensure an efficient signal transduction by providing proper conformation and avoidi

88 receptors, but they may also modulate signal transduction by several other mechanisms.

89 e expression of genes involved in the signal transduction by the p53 class mediator, which is a repli

90 ified several residues that are critical for transduction, capsid assembly, or DNA packaging.

91 Inhibition of the taste transduction cascade abolished the increase in [Ca(2+)](

92 A signal transduction cascade regulates this process, a component

93 twork (MEN), a budding yeast Ras-like signal transduction cascade, translates nuclear position into a

94 plementary coreceptor and initiates a signal transduction cascade, which leads to a variety of respon

95 flecting a reduction in amplification of the transduction cascade; an increase in the rate of turnove

96 ortant implications for intracellular signal transduction, cell migration, and differentiation.

97 PIEZO2 is the essential transduction channel for touch discrimination, vibration

98 ansduction mutants were mimicked by block of transduction channels of cochlear explants in culture.

99 x, which conveys force to open the inner-ear transduction channels that mediate sensory perception.

100 Transduction channels thus specify and maintain row iden

101 ension gates the hair cell mechanoelectrical transduction channels.

102 cardiomyocytes that include mechano-electro-transduction (commonly referred to as mechano-electric c

103 3, the provector shows a 95-fold increase in transduction compared to the OFF state.

104 l maturation, including mitochondrial energy transduction, contractile function, and ion transport.

105 pairs based on ligand binding and/or signal transduction could advance hormone-based physiology and

106 es diverse cellular processes such as signal transduction, cytoskeletal organization and cell polarit

107 l Elkin1 exhibit defective mechanoelectrical transduction, decreased motility and increased dissociat

108 ority of the cells within the tissue, making transduction difficult.

109 While the signal transduction downstream of EGFR has been extensively inv

110 tase SHP2, a critical mediator of RAS signal transduction downstream of multiple RTK, represented an

111 the JAK kinase family that regulates signal transduction downstream of receptors for the IL-23/IL-12

112 Vector engineering can increase AAV transduction efficiency (by optimizing the transgene cas

113 ation are the two key factors that influence transduction efficiency and outline a "gold standard" ap

114 We do not find differences in transduction efficiency nor in any other parameter in ou

115 scence staining and western blot to test the transduction efficiency of this vector.

116 comprehensively improve AAV tissue tropism, transduction efficiency, and antibody evasion.

117 s with respect to specific tissue targeting, transduction efficiency, antigenicity, or receptor retar

118 Evidence is emerging that signal transduction elements are activated in a-nucleated eryth

119 Transduction elements are discussed in terms of electrod

120 n detection are broadly reviewed in terms of transduction elements, biorecognition elements, electroc

121 ad, AAV6 or AAV9-binding antibodies showed a transduction-enhancing effect.

122 sion was safe and resulted in enhanced liver transduction, even in the setting of vector readministra

123 ession kinetics, and biologic markers of AAV transduction for up to 3 years.

124 However, the regulation of the signal transduction from the IL-17 receptor (IL-17R) remained e

125 es between rods and cones are: (1) decreased transduction gain, reflecting smaller amplification in t

126 e precursors through expression of different transduction genes or the same genes at different expres

127 ecursors through the expression of different transduction genes or the same genes at different levels

128 that extensive recovery of mechanoelectrical transduction, hair bundle stiffness, and spontaneous bun

129 y of operation, unique versatility of signal transduction (i.e. average or discrete signals), and pot

130 Further, AAVhum.8 displays robust transduction in a human liver xenograft mouse model with

131 ternal structures are compressed, leading to transduction in an internal sensory neuron.

132 ly implicated as master regulators of signal transduction in cancer, where raft compartmentalization

133 ptamer RCAs significantly induced the signal transduction in chicken HD11 macrophage cell line (p < 0

134 primarily responsible for the attenuation of transduction in human and mouse cell lines through type

135 gentle touch and sound by amplifying signal transduction in low-threshold mechanoreceptors (Scholz e

136 l for understanding the principles of energy transduction in mammalian complex I.

137 ological functions of CD36 in insulin signal transduction in mice fed a low-fat diet.

138 s with quantitative assessment of Wnt signal transduction in mouse embryonic stem cells (mESCs).

139 VSDs) are important tools for probing signal transduction in neurons and other excitable cells.

140 involved in developmental control and signal transduction in plants.

141 and bone morphogenetic protein (BMP) signal transduction in postnatal mice, with BMP signaling being

142 We also analyzed signal transduction in T cells expressing BCR or B cells expres

143 rs that mediate rapid electrochemical signal transduction in the animal nervous system through the op

144 dies have elucidated the mechanism of signal transduction in the cGAS pathway at the atomic resolutio

145 K, do not contribute to inhibition of signal transduction in the insulin signaling pathway.

146 d decreased mechano- and chemosensory signal transduction in uninjured bystander neurons.

147 es the defective ATP2C1 KO phenotype and AAV transduction in vitro Conversely, the calcium ionophore

148 tion with a second-generation retroviral CAR transduction including a 4-1BB costimulatory domain in p

149 ellular compartment that orchestrates signal transduction independent from the cell body.

150 IL-22 SyCyRs phenocopied native IL-22 signal transduction, indicated by induction of cytokine-depende

151 Mechanoelectrical transduction is a cellular signalling pathway where phys

152 ndodermally derived epithelium, while signal transduction is confined to the mesenchymal compartment,

153 Specificity in signal transduction is determined by the ability of cells to "e

154 anism by which proteoglycans regulate signal transduction is largely unknown.

155 How TARK1 participates in immune signal transduction is not well understood.

156 Pre-T-cell receptor (TCR) signal transduction is required for developing thymocytes to di

157 t factors that influence AAV trafficking and transduction is still evolving.

158 aying critical roles in intracellular signal transduction, is essential for epidermal barrier integri

159 opy specifically localized PHIP to the force transduction layer, together with TLN1 and VCL.

160 ined in its normal position within the force transduction layer.

161 eviously was considered not to induce signal transduction, led to induction of signal transduction.

162 ntly shown that the SE functions as a signal transduction ligand that activates a cell surface calret

163 ain, unraveling features critical for signal transduction, ligand binding, and voltage sensing.

164 asmic calcium, a novel finding for OR signal transduction, likely because of cell lineage.

165 no-electric coupling, MEC) and mechano-chemo-transduction (MCT) mechanisms at cell and molecular leve

166 Here we present a versatile and compliant transduction mechanism for high-sensitivity strain detec

167 be used in these wireless transponders as a transduction mechanism of proteolytic activity.

168 BBs) have been developed, depending on their transduction mechanism, namely electrochemical, optical

169 signaling cascades that rely on calcium as a transduction mechanism.

170 Yet, signal transduction mechanisms for salty taste have remained ob

171 A detailed understanding of the signal transduction mechanisms in heme-containing sensor protei

172 as been obtained and inactivation and signal transduction mechanisms indicate that RAF dimerization i

173 al induce homeostatic reactions and modulate transduction mechanisms that amplify cellular response t

174 any bendable surface and can possess diverse transduction mechanisms.

175 orms without affecting core cue detection or transduction mechanisms.

176 ensors that are disconnected from endogenous transduction mechanisms.

177 to decipher the mechanistic modes of signal transduction mediated by GABA(B) dimers, and have import

178 and head movement requires mechanoelectrical transduction (MET) channels at tips of hair-cell stereoc

179 e have also shown that the mechanoelectrical transduction (MET) current from OHCs of mice harbouring

180 , we introduce BEHRT: A deep neural sequence transduction model for electronic health records (EHR),

181 protein signaling (RGS) proteins are signal transduction modulators, expressed widely in various tis

182 to many biological processes, such as signal transduction, molecule translocation, and ion transport,

183 e altered distribution of marker proteins in transduction mutants was accompanied by increased variab

184 dimensions and in EPS8 distribution seen in transduction mutants were mimicked by block of transduct

185 tallest row), lost their row exclusivity in transduction mutants.

186 2 tips were also distributed differently in transduction mutants; the heterodimeric capping protein

187 In order to analyze how a signal transduction network converts cellular inputs into cellu

188 us measurement of multiple nodes of a signal transduction network within single cells.

189 smotic-stress and abscisic acid (ABA) signal transduction network.

190 genes that confer ASD risk operate in signal transduction networks critical for both cortical develop

191 l retrograde metabolite in orchestrating the transduction of a repertoire of signaling cascades.

192 Unintentional transduction of B-cell acute lymphoblastic leukemia blas

193 Adeno-associated virus-based transduction of Dnase1l3 into Dnase1l3-deficient mice re

194 ns ABSTRACT: Haemoglobin (Hb) may impact the transduction of endothelium-dependent and nitric oxide (

195 Furthermore, this opto-chemo-mechanical transduction of energy mediated by the 3D cross-linked h

196 Transduction of I/LnJ BMDMs with C57BL/6J CD300LF made t

197 Mammalian Piezo2 channels are essential for transduction of innocuous mechanical forces by proprioce

198 orneal trigeminal neurons and contributes to transduction of mechanical forces by corneal nociceptors

199 nel is Piezo1, which plays a key role in the transduction of mechanical stimuli in humans and is impl

200 Transduction of N-MYLK domain (amino acids 1-919 devoid

201 We demonstrated that in vitro transduction of normal human CD4+ T lymphocytes with NPM

202 Thus, iRFP transduction of primary patient-derived glioblastoma cel

203 rogression that can be rescued by lentiviral transduction of RAD50.

204 t interferon response was detected following transduction of T cell lines with VSV-G-pseudotyped lent

205 2) is correlated with optical reporter gene transduction of the brain.

206 te subsets after in situ gene transfer, with transduction of up to 5% of cells.

207 n profile was restored in patient cells upon transduction of wild-type MAN2B2.

208 rganization of keratin is initiated by force transduction on cell-cell contacts mediated by C-cadheri

209 inhibitors targeting either oncogenic signal transduction or epigenetic regulation can alter specific

210 al roles in apoptosis, cell adhesion, signal transduction, or metabolite homeostasis.

211 athway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid re

212 ports a PIEZO1-independent mechanoelectrical transduction pathway and modulates cellular adhesions an

213 ese data uncover a previously unknown signal transduction pathway by which the SE facilitates protein

214 Serotonin acts through a signal transduction pathway conserved between C. elegans and ma

215 oth species, including multiple r-opsins and transduction pathway constituents, congruent with immuno

216 The pooled prevalence indices of signal transduction pathway mutations in gastric cancer, liver

217 ental Cell, Ho and Treisman uncover a signal transduction pathway that coordinates muscle growth and

218 ested this hypothesis by perturbing a signal transduction pathway that plays a major role in controll

219 itric oxide/S-nitrosylation-dependent signal transduction pathway that regulates the growth cone cyto

220 the cJun NH(2)-terminal kinase (JNK) signal transduction pathway.

221 he Toll-like receptor 4 (TLR4) immune signal transduction pathway.

222 otential "communication hub" for this energy transduction pathway.

223 Many signal transduction pathways activate RhoA-for instance, Galpha

224 Integrating changes in signal transduction pathways and cellular metabolism is essenti

225 Uncovering the missing elements of signal transduction pathways and psbA gene expression could ope

226 In normal cells, signal transduction pathways control core cellular functions, i

227 However, the downstream signal transduction pathways involved are poorly characterised.

228 cisely highlight the main biochemical signal-transduction pathways involved in the biocompatibility c

229 e opening and that shared Ca(2+) and voltage transduction pathways involving the alphaB helix may be

230 s, and compounds able to modulate the signal transduction pathways of the cannabinoid type-2 receptor

231 standing of the protein complexes and signal transduction pathways regulated by RGS proteins in addic

232 Identifying the important signal transduction pathways that control monocyte chemotaxis c

233 essed in many cancers and involved in signal transduction pathways that promote cancer cell prolifera

234 scovery and characterization of novel signal transduction pathways to exploring the molecular underpi

235 to induce cardioprotection, and their signal transduction pathways, are discussed.

236 ons abrogated established FGF-induced signal transduction pathways, yet FGF functions such as cell-ma

237 key regulator of protein function in signal transduction pathways.

238 ternal stimuli to regulate downstream signal transduction pathways.

239 rt mechanical integrity and influence signal transduction pathways.

240 ized by their involvement in critical signal transduction pathways.

241 versible, PTMs serve as regulators of signal transduction pathways.

242 Treg cell outcomes through 2 distinct signal transduction pathways: one Smad3 dependent and the other

243 embrane trafficking and to control signaling transductions pathways.

244 ese genes were mainly associated with signal transduction, photosynthesis, regulation and response to

245 uch as transcription and translation, signal transduction, post-translational modification cascades,

246 Biosensor development exploiting various transduction principles is characterized by a strong com

247 y OSNs as a cascade consisting of an odorant transduction process (OTP) and a biophysical spike gener

248 nly partially characterized, and the odorant transduction process and the axon hillock spiking mechan

249 Detailed molecular models of the odorant transduction process are, however, scarce for fruit flie

250 pace of odorants, are encoded by the odorant transduction process.

251 of the spatiotemporal coordination of signal transduction processes in Arabidopsis.

252 ed because of its essential role for mechano-transduction processes in multiple body organs.

253 d play essential roles in an array of signal transduction processes.

254 genome, MiST 3.0 provides a complete signal transduction profile, thus facilitating theoretical and

255 with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relati

256 o-B-cell stage (via activation of the signal-transduction protein STAT5)(2-4) or pre-B-cell receptors

257 ny of the enzymes involved, including signal transduction proteins, O(2) homeostasis systems, and nit

258 was validated by using HL-60 cells, in which transduction reduced differentiation into CD11b(+)CD16(+

259 ligand binding, receptor activation, signal transduction, regulation by accessory proteins, and cros

260 In bacteria, signal transduction relies on two-component systems (TCS) which

261 tis elegans, the molecular mechanisms behind transduction remain poorly understood.

262 studied, their role in mechanosignaling and transduction remains largely unexplored.

263 of the vertebrate Hh pathway is that signal transduction requires the primary cilium (PC) where majo

264 Hh signal transduction requires the primary cilium for several ste

265 ce of IL-7, this augmented downstream signal transduction, resulting in increased STAT5 transcription

266 gnals downstream of Fc receptors and plays a transduction role in antibody expression following B cel

267 odifications (PTMs) are key events in signal transduction since they affect protein function by regul

268 or outflow, termed sympathetic neurovascular transduction (sNVT), accompanied changes in blood pressu

269 whether IH alters sympathetic neurovascular transduction (sNVT), measured as the relationship betwee

270 ects of DREADD actuators prior to any DREADD transduction, so that effects of DREADDs can be attribut

271 scovered that the BumSR two-component signal transduction system (TCS) directs a response to butyrate

272 , the BumSR TCS is the only bacterial signal transduction system identified so far that mediates resp

273 is occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic sentinel lectins

274 Bacteria and archaea employ dedicated signal transduction systems that modulate gene expression, seco

275 Electrochemiluminescence (ECL) is a powerful transduction technique with a leading role in the biosen

276 9, but hu.32 mediated substantially greater transduction than the others throughout the mouse brain.

277 in chains is a key regulatory step in signal transduction that impacts cell death and inflammatory si

278 scriptional control, endocytosis, and signal transduction that is important for ESC proliferation and

279 We provide direct evidence of T cell transduction through the detection of AAV genomes and tr

280 ses the specificity and efficiency of signal transduction through the ERK pathway.

281 Signal transduction through the RAF-MEK-ERK pathway, the first

282 fibers to length changes requires mechanical transduction through titin's intact polypeptide chain.

283 desmin or vimentin was induced by adenoviral transduction to examine the sufficiency of increased IF

284 ung EC (HPMEC-im) line was generated by SV40 transduction to facilitate mechanistic studies.

285 has weak constitutive activity, it triggers transduction to produce electrical noise even in darknes

286 tro culture system that is amenable to viral transduction to simultaneously profile lineage and ident

287 tial delayed response task before any DREADD transduction took place.

288 The IL-17A signal transduction triggers two broad, TRAF6- and TRAF5-depend

289 transpiration, root development, and signal transduction underlie these putative CT loci.

290 o investigate CLEC-2-induced platelet signal transduction using computational modeling in combination

291 D3, which likely impact initiation of signal transduction via TCR.

292 range of biological events including signal transduction, viral infection and membrane curvature ind

293 While AAV2 transduction was primarily limited to the injected brain

294 (LIMK2), an essential molecule in p21 signal transduction, was significantly upregulated and represen

295 isms and consequences of TLR-mediated signal transduction with a focus on themes identified in the TL

296 In vivo HSPC transduction with a GFP-expressing vector and subsequent

297 riment 2, male Long-Evans rats received NAcc transduction with halorhodopsin (Halo) or a control fluo

298 differentiation with phorbol ester (PMA) and transduction with the full-length cDNA of GLS2.

299 press a complex I deficiency, and lentiviral transduction with wild-type NDUFAF8-cDNA ameliorated bot

300 findings reveal a potential route of signal transduction within the CRISPR-Cas9 HNH nuclease, advanc