ライフサイエンスコーパス: transendothelial migration

1 n of Cdc42 activity, increased invasion, and transendothelial migration.

2 of CLL cell binding to PEX9, chemotaxis, and transendothelial migration.

3 catenins out of the junction at the site of transendothelial migration.

4 l ligands and support leukocyte adhesion and transendothelial migration.

5 ctins but impaired intraluminal crawling and transendothelial migration.

6 ls roll on the endothelium to initiate their transendothelial migration.

7 ty integrin activation and chemokine-induced transendothelial migration.

8 cruitment was assessed based on adhesion and transendothelial migration.

9 MMP-1 regulates endothelial permeability and transendothelial migration.

10 leukocyte rolling, adhesion, and ultimately transendothelial migration.

11 eir presentation to leukocytes and leukocyte transendothelial migration.

12 neutrophil adhesion to endothelial cells and transendothelial migration.

13 rins CD11b/CD18 (Mac-1), specifically during transendothelial migration.

14 ry signature with concomitant attenuation of transendothelial migration.

15 of calcium fluxes and Rac1 during leukocyte transendothelial migration.

16 , S730, or S737 were necessary for leukocyte transendothelial migration.

17 RNA completely blocked bradykinin-stimulated transendothelial migration.

18 ancer cell-endothelial cell interactions and transendothelial migration.

19 L-selectin, function to facilitate leukocyte transendothelial migration.

20 ing sequentially induce PECAM-1-mediated PMN transendothelial migration.

21 cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration.

22 tep 1) into firm adhesion (step 3), yielding transendothelial migration.

23 phosphorylation events are indispensable for transendothelial migration.

24 junction formation, leukocyte adhesion, and transendothelial migration.

25 f adhesion molecules, monocyte adhesion, and transendothelial migration.

26 ; and regulation of cellular recruitment via transendothelial migration.

27 necessary, but not sufficient for increased transendothelial migration.

28 resulted in increased E-cadherin and reduced transendothelial migration.

29 e endothelial surface for potential sites of transendothelial migration.

30 o the glomerular vasculature did not undergo transendothelial migration.

31 SIRPgamma, play an important role in T-cell transendothelial migration.

32 tion of early cellular processes involved in transendothelial migration.

33 esion molecule-1 (ICAM-1)-dependent monocyte transendothelial migration.

34 igration of PMN or evoke a role for JAM-C in transendothelial migration.

35 0.01) increase in IL-8-induced migration and transendothelial migration.

36 ssed ligand for PMN beta(2) integrins during transendothelial migration.

37 g monocyte adhesion to endothelial cells and transendothelial migration.

38 d the ability of CCL2 to stimulate monocytic transendothelial migration.

39 n molecule (JAM)-C plays a role in leukocyte transendothelial migration.

40 , compound 4 nonetheless inhibits lymphocyte transendothelial migration.

41 ells to endothelium from flow but also drove transendothelial migration.

42 s particularly important for steps involving transendothelial migration.

43 ial barrier function and reducing neutrophil transendothelial migration.

44 nt component in the regulation of neutrophil transendothelial migration.

45 eceptors that bind to chemokines and trigger transendothelial migration.

46 r transition to shear-resistant adhesion and transendothelial migration.

47 cell-cell contacts and facilitates leukocyte transendothelial migration.

48 n, epithelial-to-mesenchymal transition, and transendothelial migration.

49 t ~10% underwent spontaneous basal to apical transendothelial migration.

50 s a relevant negative regulator of leukocyte transendothelial migration.

51 hibited PMN adhesion, arrest under flow, and transendothelial migration.

52 ak through matrix barriers during tumor cell transendothelial migration.

53 ed human monocyte recruitment, adhesion, and transendothelial migration.

54 from the primary tumor, stromal invasion and transendothelial migration.

55 In contrast, during transendothelial migration, a form of active deformation

56 stimulatory effect of platelets on leukocyte transendothelial migration, a key mediator of atheroprog

57 (INV) expression are required for tumor cell transendothelial migration, a necessary step during intr

58 are not inherently toxic to neurons but that transendothelial migration across IL-1-stimulated brain

59 , we demonstrated that monocyte adhesion and transendothelial migration across inflamed endothelium w

60 In vitro, T lymphocyte transendothelial migration across PECAM-KO endothelial c

61 on the endothelial surface before undergoing transendothelial migration, also called diapedesis.

62 othelial cells and fibroblasts and prevented transendothelial migration, an effect rescued by the for

63 entation on endothelial cells and subsequent transendothelial migration, an essential step for lympho

64 Leukocyte transendothelial migration and adhesion to RA ST require

65 es that have been reported to play a role in transendothelial migration and asks why so many molecule

66 d to increased intravasation, the details of transendothelial migration and detachment into circulati

67 on of primary human monocytes promotes their transendothelial migration and differentiation into proi

68 60% of HIV-1-infected patients, to stimulate transendothelial migration and drive productively infect

69 early metastatic seeding, including arrest, transendothelial migration and early micrometastases for

70 il but endothelial LSP1 regulates neutrophil transendothelial migration and extravascular directional

71 sequential steps of lymphocyte adhesion and transendothelial migration and facilitates lymphocyte mi

72 ytoskeletal rearrangements abrogated CD34(+) transendothelial migration and impaired CD34(+) cell hom

73 ults extend the role of EMT in metastasis to transendothelial migration and implicate ZEB1 and N-cadh

74 regulates human polymorphonuclear leukocyte transendothelial migration and is anti-inflammatory.

75 Thus, transendothelial migration and lung metastasis developme

76 primary HCMV infection of monocytes induces transendothelial migration and monocyte-to-macrophage di

77 istration resulted in inhibition of monocyte transendothelial migration and monocyte/macrophage accum

78 These results implicate defects in both PMN transendothelial migration and PMN DAG kinase alpha sign

79 stop human polymorphonuclear leukocyte (PMN) transendothelial migration and PMN infiltration in sever

80 n the regulation of Mena(INV) expression and transendothelial migration and provide mechanistic infor

81 treatment can potentially decrease leukocyte transendothelial migration and reduce angiogenesis assoc

82 sions that interacted with leukocytes before transendothelial migration and removal of HS reduced thi

83 To this end, PMN transendothelial migration and superoxide anion generati

84 Mouse and human T cell transendothelial migration and T cell entry into LNs wer

85 sions, important for tumor cell invasion and transendothelial migration and tumor cell dissemination.

86 APCs in draining lymph nodes as well as for transendothelial migration and tumor cell recognition at

87 racterized by higher levels of inflammation, transendothelial migration, and coagulation.

88 foci formation, mechanotransduction, T cell transendothelial migration, and homing to lymph nodes, a

89 vage fluid cells, inhibited bone marrow cell transendothelial migration, and inhibited endothelial ce

90 le-1 expression, polymorphonuclear leukocyte transendothelial migration, and leukocyte sequestration

91 adhesion to microvascular endothelial cells, transendothelial migration, and metastatic retention in

92 activity including cell invasion, migration, transendothelial migration, and proliferation were incre

93 lly required for Axl-mediated cell invasion, transendothelial migration, and resistance against TGF-b

94 an occur without polymorphonuclear leukocyte transendothelial migration, and that polymorphonuclear l

95 bone marrow (BM) are recruited to tissues by transendothelial migration, and we found that CCL2 is ch

96 L-selectin; HEV expression of molecules for transendothelial migration; and metabolic programs for l

97 JAM-C has been implicated in leukocyte transendothelial migration, angiogenesis, cell adhesion,

98 integrin-mediated firm adhesion followed by transendothelial migration - are dependent on the activa

99 pecific cellular processes (phagocytosis and transendothelial migration) are enriched for transcripts

100 A transendothelial migration assay was used to determine t

101 Angiogenesis and transendothelial migration assays were performed in cons

102 12 both in transwell migration assays and in transendothelial migration assays.

103 alysis, inflammatory stimulation assays, and transendothelial migration assays.

104 genes and other genes involved in leukocyte transendothelial migration at the vaccine injection site

105 tubulin binding returned cell migration and transendothelial migration back to control levels, indic

106 onocyte ADAM17 facilitates the completion of transendothelial migration by accelerating the rate of d

107 ge in vivo, despite interruption of in vitro transendothelial migration by CD177 ligation.

108 We conclude that Trio promotes leukocyte transendothelial migration by inducing endothelial docki

109 data show that annexin A2 limits neutrophil transendothelial migration by organizing the spatial dis

110 nts in understanding regulation of leukocyte transendothelial migration by small GTPase signaling.

111 d chemokine receptor expression and enhanced transendothelial migration capacity in patients with CKD

112 a-forming cell (CAFC) capacity and augmented transendothelial migration capacity, which was abrogated

113 s firm adhesion to the vascular endothelium, transendothelial migration, chemotaxis, and phagocytosis

114 alis-stimulated monocytes displayed enhanced transendothelial migration compared with monocytes stimu

115 is factor alpha, and supported higher immune transendothelial migration compared with PAECs.

116 esulting increase in lymphocyte and monocyte transendothelial migration could be blocked with soluble

117 Intravital imaging demonstrated a transendothelial migration defect into DAP12-deficient l

118 endothelial R-Ras facilitates TNF-dependent transendothelial migration (diapedesis) of naive T cells

119 d diminished support for B16F10 adhesion and transendothelial migration, diminished B16F10-induced pe

120 smooth muscle cell activation and neutrophil transendothelial migration during AAA formation.

121 egrins have been shown to mediate neutrophil transendothelial migration during systemic and local inf

122 regulated markers associated with leukocyte transendothelial migration, extracellular matrix injury

123 by signaling through activating FcRs before transendothelial migration has occurred.

124 tigen processing and presentation, Leukocyte transendothelial migration, IL-17 signaling, Chemokine s

125 fficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependen

126 romoting the adhesion of monocytes and their transendothelial migration in a Mac-1-dependent manner.

127 e candidate targets for inhibiting leukocyte transendothelial migration in heart disease and chronic

128 Measurement of transendothelial migration in response to CCL5 demonstra

129 CR2 and CD62L levels and underwent efficient transendothelial migration in response to fractalkine (F

130 ng stathmin expression significantly reduced transendothelial migration in two different neuroblastom

131 Notably, transendothelial migration in vitro and extravasation in

132 ndothelial barrier and to support neutrophil transendothelial migration in vitro and in vivo in the s

133 y neutrophil arrest, adhesion, crawling, and transendothelial migration in vitro and in vivo.

134 ver, this mutant chemokine failed to promote transendothelial migration in vitro and inhibited the ha

135 Niflumic acid-treated PMNs also had impaired transendothelial migration in vitro, whereas migration i

136 d an increased chemotaxis, chemokinesis, and transendothelial migration in vitro.

137 priming impaired priming-enhanced eosinophil transendothelial migration in vitro.

138 mal cells and fibronectin along with reduced transendothelial migration in vitro.

139 ic interactions play a key role in leukocyte transendothelial migration, in allowing PECAM-1 to serve

140 ed permeability and increased naive monocyte transendothelial migration include the disruption of act

141 s have been shown to play a critical role in transendothelial migration including signals derived fro

142 Several mechanisms play a critical role in transendothelial migration, including signals derived fr

143 ICAM-1 is also involved in transendothelial migration, independently of its role in

144 ers, proportionally fewer MO-MDSCs underwent transendothelial migration, indicating that the final st

145 (1 unit/mL) tumor necrosis factor-alpha and transendothelial migration induced by high-dose (100 uni

146 contacts culminate in cooperative, step-wise transendothelial migration into bone is not known.

147 Leukocyte transendothelial migration involves the active participa

148 The process of intravasation involving transendothelial migration is a key step in metastatic s

149 d in cell-cell interactions during leukocyte transendothelial migration is a prerequisite for designi

150 of metastasis (TMEM), facilitates tumor cell transendothelial migration is not completely understood.

151 a separate step in leukocyte extravasation, transendothelial migration is regulated by molecules tha

152 Transendothelial migration itself can be dissected into

153 t resolvins directly act on PMN to attenuate transendothelial migration, less is known about the infl

154 Compared to PMN transendothelial migration, little is known about how PM

155 emained static before a proportion underwent transendothelial migration mediated by a combination of

156 migration, the effects of Pak1 knockdown on transendothelial migration (microinvasion), tumor growth

157 nd evidence suggests that initial neutrophil transendothelial migration modifies endothelial cell phe

158 ase-PI(3,4)P2 signaling axis while augmented transendothelial migration occurs in a vascular endothel

159 okine expression, proliferation, and delayed transendothelial migration of allogeneic memory, but not

160 ion that cognate recognition of ECs enhanced transendothelial migration of antigen-specific T lymphoc

161 ascular leakage in tumors, and inhibited the transendothelial migration of cancer cells.

162 igen was necessary for the firm adhesion and transendothelial migration of CD8+ effector T cells spec

163 Transendothelial migration of effector memory CD4 T cell

164 Bradykinin stimulated transendothelial migration of EPCs in a concentration-de

165 The ability of FNf to stimulate transendothelial migration of HIV-1-infected MNLs may he

166 reased endothelial permeability and elevated transendothelial migration of HIV-infected monocytes acr

167 -1 inhibition enhanced vitronectin-dependent transendothelial migration of human bone marrow-derived

168 -docosahexaenoic acid, and they both stopped transendothelial migration of human neutrophils (EC(50)

169 To study this process further, we analyzed transendothelial migration of human PC-3 prostate cancer

170 nce across the in vitro BBB and the enhanced transendothelial migration of immunocompetent cells acro

171 BBB permeability using TEER measurements and transendothelial migration of immunocompetent cells.

172 2 deficiency impaired the integrin-dependent transendothelial migration of innate leukocytes and rest

173 essed on the endothelial barrier can promote transendothelial migration of KSHV-infected cells.

174 lectin, and breakdown of the BRB, leading to transendothelial migration of leukocytes and recruitment

175 ressure, vascular permeability, clotting and transendothelial migration of leukocytes and tumor cells

176 on of blood-brain barrier (BBB) function and transendothelial migration of leukocytes are essential c

177 on endothelium and other cells as well as to transendothelial migration of leukocytes in the microcir

178 d flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed t

179 Transendothelial migration of leukocytes is a critical e

180 g the molecules and mechanisms that regulate transendothelial migration of leukocytes, or diapedesis,

181 alysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.

182 own that stanniocalcin-1 (STC1) inhibits the transendothelial migration of macrophages and T cells, s

183 was reduced by blocking WASP binding to WIP, transendothelial migration of macrophages, the most cruc

184 osome formation, thereby mediating efficient transendothelial migration of macrophages.

185 duced proliferation and superantigen-induced transendothelial migration of memory T cells, indicating

186 ivation, which led us to investigate whether transendothelial migration of monocytes across HSECs inf

187 These data point to a role of MMP-14 during transendothelial migration of monocytes and T-cell attra

188 We found that MCP-1-dependent transendothelial migration of monocytes markedly acceler

189 nocyte adhesion to ECs, EC migration and the transendothelial migration of monocytes, while the over-

190 al endothelial cells, facilitating increased transendothelial migration of monocytes.

191 endothelial barrier integrity and increased transendothelial migration of monocytes.

192 othelial cells increased the recruitment and transendothelial migration of monocytes.

193 thelial and BBB hyperpermeability as well as transendothelial migration of monocytic cells.

194 tactic Protein 1 (MCP-1), play a key role in transendothelial migration of mononuclear cells during t

195 ecruitment with a predominant enhancement of transendothelial migration of neutrophilic granulocytes.

196 is an adhesion molecule believed to mediate transendothelial migration of neutrophils and other leuk

197 9 regulate distinct, sequential steps in the transendothelial migration of neutrophils during inflamm

198 Transendothelial migration of neutrophils in postcapilla

199 se brain endothelial cells and supported the transendothelial migration of neutrophils in vitro.

200 Furthermore, RAP inhibited transendothelial migration of neutrophils induced by fib

201 Conditioned medium harvested after transendothelial migration of neutrophils or supernatant

202 own that TSG-6 inhibits chemokine-stimulated transendothelial migration of neutrophils via a direct i

203 that is needed to facilitate the early-onset transendothelial migration of PMN.

204 f TRPM2 expressed in ECs in the mechanism of transendothelial migration of PMNs.

205 lled F. tularensis LVS for 24 h promoted the transendothelial migration of subsequently added neutrop

206 Our results provide visualization of transendothelial migration of T cells into lymphatic sin

207 in reduced microvilli formation and impaired transendothelial migration of T cells.

208 xpress CXCR3 and reduced the IP-10-dependent transendothelial migration of T helper cells under condi

209 neutrophils would also modify the subsequent transendothelial migration of T lymphocytes across cytok

210 c G-protein-mediated signaling in supporting transendothelial migration of T lymphocytes.

211 pression of VLA-4 also resulted in increased transendothelial migration of Tck cells, which could be

212 pain as a critical driver of T. b. gambiense transendothelial migration of the human BBB.

213 as well as on endothelial cells promoted the transendothelial migration of the melanoma cells.

214 Transendothelial migration of these cells depended on ex

215 Monocytes promoted transendothelial migration of tumor cells through the in

216 Far less is known about the impact of transendothelial migration on eosinophil survival, in pa

217 /Rap1 GTPase signaling pathway, resulting in transendothelial migration on stimulated human umbilical

218 se VCAM-1 signals are required for leukocyte transendothelial migration on VCAM-1.

219 he subsets was studied in in vitro models of transendothelial migration or interstitial chemokinesis

220 ted that P5 peptide does not affect monocyte transendothelial migration or macrophage efflux from the

221 sion to HUVEC, but significantly reduced PMN transendothelial migration (P < 0.0001) and fMLP-induced

222 Here, we show that the leukocyte transendothelial migration pathway is activated in the o

223 resulting in enhanced monocyte motility and transendothelial migration, prolonged monocyte survival,

224 by expression of Rap1GAP increased leukocyte transendothelial migration, providing physiological rele

225 to the regulation of leukocyte adhesion and transendothelial migration remains poorly understood.

226 r, a complete mechanism governing tumor cell transendothelial migration remains unclear.

227 ell arrest on the EC surface, preventing the transendothelial migration response to IP-10.

228 cancer cell adhesion to the endothelium and transendothelial migration, resulting in reduced liver m

229 Ex vivo analyses of transendothelial migration revealed that Nef disrupted T

230 l chemoattractant, CXCL1, drove this reverse transendothelial migration (rTEM).

231 ost defense cell responsiveness to GM-CSF at transendothelial migration sites while suppressing it in

232 trafficking to alterations in the subsequent transendothelial migration step.

233 through a dense three-dimensional matrix and transendothelial migration, suggesting that tyrosine pho

234 In addition, we addressed the transendothelial migration (TEM) activity of bone marrow

235 lecule, is required for CLL cells to undergo transendothelial migration (TEM) and enter the prolifera

236 e and clustering) is required for lymphocyte transendothelial migration (TEM) and entry into lymph no

237 Leukocyte crawling and transendothelial migration (TEM) are potentiated by shea

238 trol efflux of small molecules and leukocyte transendothelial migration (TEM) between blood and tissu

239 previously reported that the TCR-stimulated transendothelial migration (TEM) depends on fractalkine

240 ar requirements of chemokine- and TCR-driven transendothelial migration (TEM) differ significantly.

241 Leukocyte transendothelial migration (TEM) has been modeled as a m

242 e EM CD4+ T cells, but fail to support their transendothelial migration (TEM) in response to TCR enga

243 Leukocyte transendothelial migration (TEM) is a critical event dur

244 Transendothelial migration (TEM) is a tightly regulated

245 Leukocyte transendothelial migration (TEM) is a tightly regulated,

246 Lymphocyte transendothelial migration (TEM) is critically dependent

247 In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial c

248 essential role in the CXCL12/CXCR4-mediated transendothelial migration (TEM) of CXCR4(+)CXCR7(+) hum

249 hat regulate the endothelial response during transendothelial migration (TEM) of invasive cancer cell

250 Transendothelial migration (TEM) of leukocytes across th

251 Transendothelial migration (TEM) of normal lymphocytes i

252 Transendothelial migration (TEM) of polymorphonuclear le

253 This rapid process, called transendothelial migration (TEM) or diapedesis, is compl

254 Leukocyte transendothelial migration (TEM) requires two major even

255 The transendothelial migration (TEM) step is poorly understo

256 distributed chemokines and their effects on transendothelial migration (TEM) under hydrodynamic shea

257 PECAM-1/CD31 is required for leukocyte transendothelial migration (TEM) under most inflammatory

258 Using neutrophil transendothelial migration (TEM) under physiological flo

259 helial cells (ECs) lining the venular lumen (transendothelial migration (TEM)) in a luminal-to-ablumi

260 designated as chemokine-driven or TCR-driven transendothelial migration (TEM), respectively.

261 adhesion, crawling towards EC junctions and transendothelial migration (TEM).

262 leukocytes and transmit signals required for transendothelial migration (TEM).

263 sion (TEP) by the T cell but fails to induce transendothelial migration (TEM).

264 tes subsequent signaling that promotes their transendothelial migration (TEM).

265 ecycling compartment (LBRC), is critical for transendothelial migration (TEM).

266 s primary human monocytes actively engage in transendothelial migration (TEM).

267 to form short-lived "gaps" during leukocyte transendothelial migration (TEM); however, whether these

268 ss endothelium [referred to as diapedesis or transendothelial migration (TEM)] is a critical step in

269 nocyte-to-myeloid fibroblast formation after transendothelial migration (TEM; 3-fold, P < 0.01).

270 cells were found to be independent of VEGF, transendothelial migration through CNS microvascular end

271 wice as many CD14++CD16+ monocytes underwent transendothelial migration through hepatic endothelial c

272 easured using in vitro chemotaxis assays and transendothelial migration through human umbilical vein

273 ma cells highlighted that stathmin regulates transendothelial migration through ROCK signaling.

274 ion pathways may lead to PECAM-1-independent transendothelial migration through the pulmonary or the

275 nderlying mechanisms that regulate leukocyte transendothelial migration through the vascular endothel

276 i showed that inflammation-induced leukocyte transendothelial migration to peritoneum or lungs was si

277 )CD28- T cells enhanced their chemotaxis and transendothelial migration toward the chemokine CCL5.

278 d for the induction of monocyte motility and transendothelial migration, two biological events requir

279 integrins, leading to defective adhesion and transendothelial migration under conditions of physiolog

280 n of CXCR 3 promotes lymphocyte adhesion and transendothelial migration under flow and that human hep

281 results in increased neutrophil adhesion and transendothelial migration under flow conditions and red

282 n the observed failure in firm adherence and transendothelial migration under flow conditions.

283 okines, promote mononuclear leukocytes (MNL) transendothelial migration, up-regulate monocyte CD11b a

284 diated both leukocyte adhesion and leukocyte transendothelial migration upon oxLDL treatment of endot

285 the lung, but acted by inhibiting neutrophil transendothelial migration upstream of interstitial migr

286 , which facilitates endothelial adhesion and transendothelial migration via an ICAM1-fibrinogen-ICAM1

287 cell proliferation, migration, adhesion, and transendothelial migration via increased expression of I

288 Furthermore, T lymphocyte transendothelial migration was inhibited by treatment of

289 Transendothelial migration was not observed in CD14(dim)

290 The reduction in T lymphocyte transendothelial migration was not observed using a diff

291 In vitro chemotaxis and transendothelial migration were examined in a Transwell

292 within endothelial cells decreased leukocyte transendothelial migration, whereas inhibiting Rap1 acti

293 and P3/P3a/P3b peptides inhibited B-CLL cell transendothelial migration, whereas the mutated peptide

294 hocytes, the malignant cells did not undergo transendothelial migration, which could explain why lymp

295 l gap formation, the first step during tumor transendothelial migration, which is mediated by both ad

296 ed breast cancer cell adhesion to HUVECs and transendothelial migration, which were repressed by ET-1

297 ing leaves open a possible role in leukocyte transendothelial migration, which would be consistent wi

298 resence of activated neutrophils and reduces transendothelial migration without affecting adhesion of

299 neutrophils, with alpha2-agonists decreased transendothelial migration, without affecting neutrophil

300 (SDF-1alpha [CXCL12])-mediated T lymphocyte transendothelial migration, without reducing accumulatio