ライフサイエンスコーパス: transfuse

1 ntain 1.2 HCV RNA copies/mL (60 copies/50 mL transfused).

2 tify factors associated with the decision to transfuse.

3 d and 117 total units of blood products were transfused.

4 nd IFNgamma (P = 0.035) at 24 hours in those transfused.

5 in or hematocrit level below which RBCs were transfused.

6 fusion were compared with those who were not transfused.

7 nt years) were included, of which 58.8% were transfused.

8 the rebleeding rate, and the amount of blood transfused.

9 cquisition, after control for units of blood transfused.

10 s of plasma and platelets to red blood cells transfused.

11 s of plasma and platelets to red blood cells transfused.

12 No allogeneic blood was transfused.

13 ly separated hemoglobin levels and RBC units transfused.

14 A total of 7054 units blood were transfused.

15 n patients with blood group A and O who were transfused.

16 ient-specific Tregs are expanded ex vivo and transfused.

17 renal failure with dialysis, with less blood transfused.

18 tic events, and the amount of blood products transfused.

19 t mechanism, 47% severe TBI, 20.5% massively transfused.

20 Twenty of 51,440 platelet units transfused (0.004%; 389 per million) were bacterially co

21 sfusion events that occurred within 4 years, transfusing 16569 U of RBCs, 13933 U of FFP, 5228 U of c

22 in 9.6%, with increased transformation among transfused (24.6%; P < .001).

23 2 mm Hg; P < 0.05) but did not change after transfusing 3-day blood (17 +/- 2 to 18 +/- 2 mm Hg; P =

24 40-day plus nitric oxide blood but not after transfusing 3-day blood.

25 nsthoracic echocardiography, increased after transfusing 40-day blood (18 +/- 2 to 23 +/- 2 mm Hg; P

26 of storage), and the other "older" unit was transfused after 40 to 42 days of storage.

27 admission and titer of antibodies of plasma transfused allowed for analysis in specific matched coho

28 16.5]; P < .001), cumulative volume of blood transfused among the patients in each group who received

29 ulatory overload as they are more frequently transfused and associated with more comorbidities.

30 red aspiration, and volume of blood products transfused and fluids administered.

31 njury cases (n=16) were randomly assigned to transfused and nontransfused cardiac surgery controls in

32 inical outcomes of poor platelet recovery in transfused and nontransfused participants.

33 The plasma from transfused and nontransfused patients with severe sepsis

34 hemoglobin was 88 +/- 7 and 99 +/- 12 g/L in transfused and nontransfused patients.

35 ransplant antibodies was similar in patients transfused and not transfused, and only 1 of 12 patients

36 Exploratory subgroups included massively transfused and severe TBI patients.

37 gy to reduce the volume of allogeneic plasma transfused and to support storage following pathogen red

38 renal failure-free days, and blood products transfused) and compliance with each guideline, as well

39 resolution of base deficit, product volumes transfused, and INR after resuscitation.

40 s was similar in patients transfused and not transfused, and only 1 of 12 patients who received more

41 ile range 9-26]; 25% were in shock; 28% were transfused; and 6% died within 24 hours.

42 HbG-transfused animals also showed increased astrocytic glia

43 Two-photon microscopy in live transfused animals revealed that extracellular mitochond

44 Of the 15 million red blood cell components transfused annually in the United States, approximately

45 e approximately 2 million units of platelets transfused annually within the United States, if impleme

46 million units of red blood cells (RBCs) are transfused annually worldwide, transfusion practices var

47 than 81 million units of red blood cells are transfused annually.

48 tate to fall on ECLS and volume of platelets transfused are independent predictors of mortality.

49 efit assessment of the small volumes of RBCs transfused around delivery.

50 g/dL with 67%, 36%, 15%, and 5% of patients transfused at >7, >8, >9, and >10 g/dL, respectively.

51 enrolled in a randomized crossover study of transfusing autologous, leukoreduced blood stored for ei

52 mitant blockade of inhibitory FcgammaRIIB on transfused basophils further substantially increased bas

53 e 129 blood components, 62 of which had been transfused before identification of the infected donatio

54 nd that patients with both nontransfused and transfused beta-thalassemia have very high serum ERFE le

55 A widespread approach today is to transfuse bleeding trauma patients with RBC concentrates

56 a wide range of doses for the vCJD agent in transfused blood and plasma derivatives.

57 ed erythrocytes in a culture, distinguishing transfused blood cells from a patient's own blood, ident

58 ytomegalovirus nucleic acid testing (NAT) of transfused blood components and breast milk was performe

59 identical parasites in the recipient and the transfused blood confirmed transfusion-transmitted malar

60 Phenotypically matching transfused blood has been shown to decrease alloimmuniza

61 ESIGN, SETTING, AND PARTICIPANTS: The Age of Transfused Blood in Critically-Ill Children trial was an

62 uently demonstrated that Kell differences on transfused blood induce antibody responses and hemolytic

63 thesized that preimmunization to antigens on transfused blood may prime BMT rejection.

64 man neutrophil antigen antibodies present in transfused blood products, and predisposing factors such

65 nd packed red cells were the most frequently transfused blood products.

66 than 10 mg Fe/g dry weight, and more than 50 transfused blood units.

67 The prevalence of P. falciparum malaria in transfused blood was 4.7% (21/445) by microscopy, 13.7%

68 The mean age of transfused blood was 5.1 (SD, 2.0) days in the fresh RBC

69 om information about the storage duration of transfused blood was missing and one patient whose sex w

70 %) was the parasite identical to that in the transfused blood.

71 e genotyped and compared to parasites in the transfused blood.

72 isk of in-hospital mortality associated with transfusing blood stored longer than 35 days.

73 Fewer platelets were transfused but more frequent transfusions were required.

74 blood (treated) or whole blood prepared and transfused by standard local practice (untreated).

75 alent severity who are infrequently or never transfused can still develop serious complications of ir

76 gations to define the biological fate of the transfused cells in recipients.

77 A single transfusion in the chronically transfused cohort improved FMD.

78 of hospital stay was significantly longer in transfused compared with nontransfused patients (17.8 +/

79 ed time to hemostasis, blood product volumes transfused, complications, incidence of surgical procedu

80 a 28-day outcome and were matched to 251 non-transfused control COVID-19 patients.

81 sion-related acute lung injury compared with transfused controls.

82 ic medical centers enrolled 89 cases and 164 transfused controls.

83 window of 44 hours after hospitalization for transfusing COVID-19 patients with high-titer convalesce

84 The percentage of participants transfused did not differ (24.1% and 24.4% for the fixed

85 nts, and the total amount of red blood cells transfused did not differ between groups (1.80 U versus

86 number of units of blood products that were transfused during hospitalization was 4331 in the tranex

87 red significantly fewer platelet units to be transfused during the transplant procedure (median: 0 vs

88 ce to the foreign antigens on the surface of transfused erythrocytes if the animal has not been given

89 Adherence to a strict policy of transfusing exclusively ABO-identical platelets may lead

90 venous thromboembolism; (2) do not routinely transfuse for chronic anemia or uncomplicated pain crise

91 ation groups, ranging from 91.1% among those transfused for a malignant disease without surgery to 1.

92 A total of 5901 PRBC units were transfused for a median of 2 (interquartile range 2-4) u

93 sease without surgery to 1.7% among patients transfused for obstetrical bleeding.

94 infarcts occur among children with SCD being transfused for secondary stroke prevention.

95 The influence of transfusing fresh vs. stored blood on the liver has not

96 One unit was autologously transfused "fresh" (3-7 days of storage), and the other

97 he odds ratio (OR) for 10 years mortality in transfused group was 2.92 and after adjusting for preope

98 let Dose Study, which included 1272 platelet-transfused hematology-oncology patients who received 603

99 s from a 60-day follow-up of a cohort of 351 transfused hospitalized patients.

100 The AABB recommends transfusing hospitalized adult patients with a platelet

101 deletion was associated with engraftment of transfused HSPC without any toxic conditioning of the ho

102 restrictive red-cell transfusion threshold (transfuse if hemoglobin level was <7.5 g per deciliter,

103 or a liberal red-cell transfusion threshold (transfuse if hemoglobin level was <9.5 g per deciliter i

104 ve threshold for red blood cell transfusion (transfuse if hemoglobin<7.5 g/dl, intraoperatively and p

105 d postoperatively) with a liberal threshold (transfuse if hemoglobin<9.5 g/dl in the operating room o

106 Blood products were transfused in 72 (64%) patients within the first 24 hour

107 te with regard to number of blood components transfused in a 24-hour period post bypass.

108 ctive effects of fresh vs. stored blood when transfused in anemic rats after acute myocardial infarct

109 was an increased use of plasma and platelets transfused in the 1:1:1 group, no other safety differenc

110 These data demonstrate that RBCs transfused in the absence of inflammation can induce tol

111 ream infections occur in 15 (20.8%) of those transfused in the first 24 hours, compared with 1 patien

112 s of PRBCs (range, 0-167 units/patient) were transfused in the intraoperative (1581 units [39.5%]) an

113 A median of 2 units of red cells were transfused in the liberal-strategy group and none in the

114 s of anti-hGPA immunoglobulins, unlike those transfused in the presence of polyinosinic:polycytidylic

115 nor), although nonirradiated components were transfused in the vast majority of these (97.6%).

116 n burden (the total number of red-cell units transfused) in such patients.

117 Although many transfused incompatible RBCs are cleared, some remain in

118 ls did not reduce the proportion of patients transfused (interaction p = 0.01).

119 Of these, 16 RNA-positive units transfused into 16 susceptible recipients were identifie

120 C virus (HCV) RNA negative to positive were transfused into 2 chimpanzees to assess infectivity duri

121 Overall, 42 DENV RNA-positive units were transfused into 35 recipients.

122 from 105 donors (of 12 529 tested donations) transfused into a population of surgical patients with a

123 s from such mice were rapidly destroyed when transfused into C3-sufficient mice.

124 so exhibits markedly prolonged survival when transfused into FVIII-deficient mice, the cotransfused F

125 ovalbumin-human transmembrane Duffy(b)) were transfused into naive mice alone or together with select

126 sed into normal microvessels or systemically transfused into normal rats, MPs immediately adhered to

127 These antibodies, when transfused into patients infected with SARS-CoV-2, are t

128 pheresed red cells, divided and autologously transfused into the forearm brachial artery 5 and 42 day

129 fection among donors of the 8 blood products transfused into the organ donor or in products derived f

130 large numbers in vitro, and autologous MSCs transfused into tuberculosis patients have been found to

131 ng number of units of packed red blood cells transfused intraoperatively (odds ratio=1.2, 95% confide

132 injury of the right carotid artery and were transfused intravenously with ECs (total, 1.5x10(6) cell

133 is associated with iron overload due to both transfused iron and increased iron absorption, the latte

134 Mean (SD) pretransfusion HB of transfused LLDs was 11.7 g/dL (+/-1.2).

135 aracteristics of acute endothelial injury in transfused lungs in vivo.

136 ), and mortality was further increased among transfused MDS (P < .01).

137 CI -35 to 11]; p=0.23), with fewer RBC units transfused (mean 1.2 [SD 2.1] vs 1.9 [2.8]; difference -

138 -0.87 g/dL; P = .022), as were units of RBCs transfused (median [interquartile range (IQR)], 1 [0-2]

139 red blood cell sequestration in the lungs of transfused mice in vivo.

140 The recruitment of SF1670-pretreated transfused neutrophils to the inflamed peritoneal cavity

141 hosphatidylinositol (3,4,5)-trisphosphate in transfused neutrophils with PTEN inhibitor SF1670, provi

142 t with those derived from a risk analysis of transfused nonleukoreduced red blood cells in the United

143 n of blood component ratios in the massively transfused nontrauma demographic.

144 Among 601 massively transfused nontrauma patients, cardiothoracic surgery an

145 Massively transfused nontrauma patients.

146 S (HbS) containing red blood cells (RBCs) by transfusing normal blood units containing hemoglobin A (

147 V-C RNA acquisition increased with each unit transfused (odds ratio, 1.09; 95% confidence interval, 1

148 ) are lifesaving in neonatal intensive care, transfusing older RBCs may result in higher rates of org

149 n-bound iron derived from rapid clearance of transfused, older stored RBCs may enhance transfusion-re

150 Platelets were transfused on 68% of extracorporeal membrane oxygenation

151 tic, G6PD-deficient, anemic male patient was transfused on day 4.

152 Platelets were transfused on two third of the days on extracorporeal me

153 pido and colleagues evaluated the effects of transfusing one unit of blood close to the storage limit

154 24 hours, compared with 1 patient (2.5%) not transfused (OR = 10.3 [1.3-81], P = 0.008).

155 manage iron overload in children chronically transfused over 7 years before enrollment.

156 To evaluate the impact of transfused packed red blood cell (PRBC) age on periopera

157 th liberal practices were twice as likely to transfuse patients and had higher risk-adjusted mortalit

158 By day 5, 785 of 977 transfused patients (80.4%) had received at least one RB

159 y rates were 24.7% in bloodless and 24.5% in transfused patients (odds ratio, 1.01; 95% CI, 0.68-1.52

160 st common complications are iron overload in transfused patients and syndrome-specific malignancies i

161 comprehensive descriptions of the massively transfused patients and their outcomes.

162 All 6 previously transfused patients became transfusion-free during treat

163 ropathy, and graft loss was slightly more in transfused patients but the differences were not statist

164 Transfused patients frequently show iron overload that n

165 In comparison, 143 transfused patients had more severe injury, prolonged pr

166 Also, 50% of massively transfused patients in hemorrhagic shock demonstrated SD

167 n reaction, with an incidence close to 1% of transfused patients in the general adult population.

168 l, 71 (58%) chronic and 9 (15%) episodically transfused patients were alloimmunized.

169 lidated the 7 g/dL threshold, but previously transfused patients were excluded.

170 One-third of transfused patients were not bleeding and had no planned

171 Transfused patients were older, had higher hemoglobin le

172 -five (45%) chronic and 7 (12%) episodically transfused patients were Rh immunized.

173 We recruited 31 chronically transfused patients with beta-thalassemia major and coll

174 erasirox pharmacokinetics (PK), comparing 10 transfused patients with inadequate deferasirox response

175 s responsible for iron overload in minimally transfused patients with this disease.

176 Of the 316 transfused patients, 136 met a 28-day outcome and were m

177 Among transfused patients, 228 (46.7%) had died by day 90 when

178 less patients appeared to be comparable with transfused patients, albeit the latter group had older a

179 In 210 cases of monthly transfused patients, hepatic and myocardial iron overloa

180 Galacomannans were found in transfused patients, pooled platelet concentrates, fresh

181 racteristics, and the mortality of massively transfused patients.

182 the increased risk of ARDS in critically ill transfused patients.

183 anifestations, and cardiovascular events) in transfused patients.

184 nsfusion safety in severely ill or massively transfused patients.

185 efficient thymic entry of endogenous or i.v. transfused pDCs.

186 ed with lower 24-hour mortality in massively transfused pediatric trauma patients.

187 n, <10.0 g/dL; <4 red blood cell [RBC] units transfused per 8 weeks), and 31 were transfusion depende

188 The mean (+/-SD) total blood volume transfused per child was 314+/-228 ml in the immediate-t

189 The mean (+/-SD) volume of total blood transfused per child was 475+/-385 ml and 353+/-348 ml,

190 usion led to a decreased number of platelets transfused per patient but an increased number of transf

191 A mean (SD) of 0.5 (1.3) RBC unit was transfused per patient for the 500 OLTs, and 79.6% of th

192 The mean number of red blood cell transfused per patient was reduced from 1.21 +/- 0.05 to

193 median of 2 (interquartile range 2-4) units transfused per patient.

194 ntly reported in a murine model that mHAs on transfused platelet products induce subsequent BMT rejec

195 ell units (0.27 vs 0.29; P=.55) or number of transfused platelet units (0.26 vs 0.29; P=.31).

196 Transfused platelets have been shown to improve survival

197 rophages rapidly removed a large fraction of transfused platelets independent of their storage condit

198 ed bone marrow because, although immunity to transfused platelets is best characterized in relation t

199 However, some patients rapidly clear transfused platelets, preventing the desired therapeutic

200 only 2 of 10 (20%) recipients accepting the transfused platelets.

201 d in this analysis of a nontrauma, massively transfused population.

202 fewer patients in the restrictive group were transfused postrandomization (p<0.001) and received a me

203 Instead, transfused pRBCs remained in circulation longer in acute

204 fluid management or other components in the transfused product may enable the second hit.

205 The AABB recommends that platelets should be transfused prophylactically to reduce the risk for spont

206 aluated after exclusion of patients who were transfused proximate to the time of rejection.

207 uid balance, the number and type of products transfused, rate of transfusion, and cardiovascular and

208 immunized SCD CD16+ monocytes in response to transfused RBC breakdown products promote an anti-inflam

209 Trials comparing the effects of transfusing RBC units of different storage durations hav

210 o better assess when and how aggressively to transfuse RBCs in neurosurgical patients.

211 association between the length of storage of transfused RBCs and patient mortality.

212 association between the length of storage of transfused RBCs and patient mortality.

213 nts treated with immunoprophylaxis, with the transfused RBCs remaining in circulation having minimal

214 ion, serum cytokines, and consumption of the transfused RBCs were evaluated longitudinally.

215 Rapid clearance of essentially all transfused RBCs with detectable KEL glycoprotein antigen

216 fusions can trigger alloimmunization against transfused RBCs with serious clinical sequelae.

217 In contrast, transfused RBCs with the KEL glycoprotein antigen fully

218 cell subsets and participate in clearance of transfused RBCs, we tested the hypothesis that in respon

219 e to specific clinical questions; (2) do not transfuse red blood cells in hemodynamically stable, non

220 ces were noted in the median daily number of transfused red blood cell units (0.27 vs 0.29; P=.55) or

221 The number of transfused red blood cell units from female donors, prev

222 cy in adenosine-5'-triphosphate release from transfused red blood cells may promote or exacerbate mic

223 thologies, or studies using small volumes of transfused red blood cells.

224 key secondary end point was total number of transfused red blood cells.

225 The age of transfused red cells did not affect 90-day mortality amo

226 l monitoring for venous thromboembolism when transfusing red blood cells through multi-lumen PICCs se

227 '-triphosphate and adhesion in responses to (transfused) red blood cells.

228 into the possible mechanisms of clearance of transfused refrigerated platelets.

229 Transfusing sap supplemented with 12-OPDA or KODA increa

230 control study, DNA samples from 2 cohorts of transfused SCD patients were combined (France and The Ne

231 Th1 (IFN-gamma(+)) cytokines in chronically transfused SCD patients with alloantibodies as compared

232 TR jet, and FMD were measured in chronically transfused SCD pre- and posttransfusion (N = 25), in non

233 s study demonstrates that the persistence of transfused semiallogeneic donor cells mismatched at majo

234 These correlations improved for transfused, shocked or head injured patients.

235 ase of pulmonary artery pressure produced by transfusing stored blood.

236 been raised about the safety and efficacy of transfusing stored blood.

237 y and also the potential untoward effects of transfusing stored RBCs of different ages and storage co

238 Transfused subjects received a median of 5 transfusions.

239 Hemoglobin at randomization was lower in transfused than in nontransfused patients (94 vs 111 g/L

240 fusion according to the standard practice of transfusing the oldest available blood.

241 (1.09-2.95; p=0.022) compared with patients transfused through a peripheral intravenous line.

242 For every red blood cell unit transfused through a PICC, there was a significantly inc

243 Similarly, patients transfused through a right-sided PICC were more likely t

244 Platelets were transfused to 39% of patients.

245 RBC transfusion and the number of RBC units transfused to describe the effect of restrictive transfu

246 in the United States, approximately 40% are transfused to patients undergoing elective surgical proc

247 -NAT), and ID-NAT exclusively for components transfused to women of childbearing age.

248 ctive cohort study, we assembled data on 741 transfused trauma patients at a large trauma center.

249 s in the transfusion management of massively transfused trauma patients, focusing on the use of fixed

250 Hazard ratios for in-hospital mortality per transfused unit from female donors were 0.99 (95% CI, 0.

251 0.81 (95% CI, 0.44-1.49) in 2009 per 10 000 transfused units (P = .002).

252 phase, intraoperative blood loss, number of transfused units of blood, and postoperative morbidity.

253 Leukoreduced status of transfused units was not associated with GBV-C transmiss

254 led a median signal/cutoff ratio of 24.0 for transfused units, a value far exceeding the recent US Fo

255 ue to a failure to account for the timing of transfused units.

256 Because transfusing units of incompatible blood is potentially l

257 The AABB recommends transfusing up to a single apheresis unit or equivalent.

258 More than 1 in 10 units of PRBCs were transfused using a liberal Hb trigger.

259 ceived a transfusion, 456 units (11.4%) were transfused using a liberal trigger (intraoperative, 122

260 concentration-ie, the OR of death comparing transfused versus not transfused was less than 1 at all

261 mean age 61 + 0.4 yr and median RBCs volume transfused was 1700 mL (interquartile range 800-3150 mL)

262 92 (81.3%) vs 315/521 (60.5%); median volume transfused was 40 mL (IQR, 16-73 mL) vs 19 mL (IQR, 0-46

263 OR of death comparing transfused versus not transfused was less than 1 at all haemoglobin concentrat

264 The number of RBC units transfused was lower in the restrictive transfusion grou

265 The number of RBC units transfused was lower in the restrictive-strategy group t

266 fusion for each packed red blood cell (PRBC) transfused was recorded, in minutes, for all patients.

267 The amount of hemoderivatives transfused was significantly higher in the uDCD group.

268 The median number of platelets transfused was significantly lower in the low-dose group

269 n morning hemoglobin level and amount of RBC transfused were prospectively collected in the Randomize

270 ing HLA antibody if they had been previously transfused when compared with those who did not have a h

271 Sixty-three hospitals (70%) could transfuse whole blood but only 7 (7.4%) could separate a

272 subcapsular human islet allografts and were transfused with 1 x 10(7) of human spleen mononuclear ce

273 Volunteers were transfused with 3-day blood, 40-day blood, and 40-day bl

274 ased pulmonary artery pressure in volunteers transfused with 40-day blood (17 +/- 2 to 12 +/- 1 mm Hg

275 in one pretransfusion seropositive recipient transfused with a component containing greater than 10(1

276 In the TEG group, only 26.5% patients were transfused with all three blood components (fresh frozen

277 monstrated inferior haemostasis versus those transfused with ASO-FII following TT, LL, or ILI.

278 Mice transfused with ASO-FII mFFP demonstrated inferior haemo

279 Most patients transfused with contaminated platelets do not show immed

280 Patients were transfused with convalescent plasma, obtained from donor

281 phylococcus aureus pneumonia, were exchanged-transfused with either 7- or 42-day-old washed or unwash

282 Nearly one-half of patients transfused with FFP during the postoperative period had

283 tened FVIII survival in FVIII-deficient mice transfused with FVIII and VWF D'D3/D'D3-Fc is due to ine

284 Of 1092 recipients, 471 (43.1%) were transfused with HHV-8 antibody-positive blood.

285 STR occurred only in neutropenic patients transfused with high bacterial loads.

286 renal patients awaiting transplantation when transfused with HLA selected units of blood compared wit

287 of the recipient strain, because B10.BR mice transfused with membrane-bound hen egg lysozyme antigen-

288 Anesthetized mice were transfused with murine fresh-frozen plasma (mFFP), PCC,

289 of Rh alloimmunization in patients with SCD transfused with phenotypic Rh-matched African American R

290 a greater than twofold higher odds of being transfused with RBCs [adjusted odds ratio (AOR) = 2.41;

291 FVB mice transfused with RBCs expressing transgenic human glycoph

292 ients whose RBCs lacked the antigen and were transfused with Rh-matched RBCs.

293 All four deer transfused with the blood mononuclear cell fraction from

294 Mice transfused with these red blood cells are resistant to h

295 Wild-type (WT) recipients transfused with transgenic KEL2 RBCs generated anti-KEL

296 nts alloimmunization in wild-type recipients transfused with transgenic murine RBCs expressing the hu

297 Rats were transfused with trauma-sham shock (T/SS), or T/HS whole

298 hospital length of stay, and red blood cells transfused within 48 hours.

299 ity within 28 days, specifically in patients transfused within 72 hours of admission with plasma with

300 s associated with fewer red blood cell units transfused without adverse associations with mortality,