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1 ed Jagged1 using osteoblast-specific Jagged1 transgenic mouse model.
2 n-target/off-tumor toxicity in a human CD147 transgenic mouse model.
3 stemic anaphylaxis in human FcepsilonRIalpha transgenic mouse model.
4 ase (SCD) in a NRF2 knockout (SCD/NRF2(-/-)) transgenic mouse model.
5 apoptosis mediated by the p53 pathway in our transgenic mouse model.
6 cells, using a unique T cell receptor (TCR) transgenic mouse model.
7 impaired decidualization in both women and a transgenic mouse model.
8 progression of retinal pathology in a PD/DLB transgenic mouse model.
9 was further demonstrated in vivo using a CLL transgenic mouse model.
10 different EAE models, including the 2D2 TCR-transgenic mouse model.
11 and elicit functional improvement in an aged transgenic mouse model.
12 ing breast cancer progression in a MMTV-PyMT transgenic mouse model.
13 etworks and inhibited tumor progression in a transgenic mouse model.
14 U2AF1 mutation using a doxycycline-inducible transgenic mouse model.
15 epox/ectromelia virus (ECTV)-infection, B7.2 transgenic mouse model.
16 intracerebroventricular infusion in an aged transgenic mouse model.
17 eractions to induce leukemia in the Emu-TCL1 transgenic mouse model.
18 anied by visual deficits in a tie2-TNF-alpha transgenic mouse model.
19 on of USP6 enhances learning and memory in a transgenic mouse model.
20 modifier identified by the screen-in an APP transgenic mouse model.
21 with cognitive improvements in an AD APP/PS1 transgenic mouse model.
22 attenuate acute colitis in a humanized IL-26 transgenic mouse model.
23 tau protein aggregation both in vitro and in transgenic mouse models.
24 ed this hypothesis, using highly replicative transgenic mouse models.
25 using tetracycline- and tamoxifen-inducible transgenic mouse models.
26 of Interleukin (IL)-10 in the brains of APP transgenic mouse models.
27 ain and in Abeta precursor protein (AbetaPP) transgenic mouse models.
28 ical alternative to conditional knockout and transgenic mouse models.
29 etic screen were fulfilled in our studies of transgenic mouse models.
30 kout mouse lines in addition to the existing transgenic mouse models.
31 ty and the formation of amyloid plaques in a transgenic mouse model (5xFAD) of early amyloid depositi
33 diomyocyte-specific, doxycycline-regulatable transgenic mouse model aggravated cardiac hypertrophy, f
34 in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of front
35 riggers, could prevent disease symptoms in a transgenic mouse model and a knockin mouse model of the
36 urther generated a corresponding betaH1-eGFP transgenic mouse model and demonstrated the presence of
38 interstitial fluid (ISF) and CSF from an AD transgenic mouse model and postmortem ventricular and an
40 We generated a cardiomyocyte-targeted Nox2-transgenic mouse model and studied the effects of in viv
41 Using various inducible and site-specific transgenic mouse models and pharmacological validation e
42 overcome these limitations, we combined here transgenic mouse models and proteomic analyses in order
43 tissue; CC cell xenografts; a p53-deficient transgenic mouse model; and a non-transgenic, chemically
44 s decreased in the brains of AD patients and transgenic mouse model, as well as Abeta-treated cells.
46 dividual B cell clones from two distinct BCR transgenic mouse models but is dispensable for all of th
48 fects of soticlestat were characterized in a transgenic mouse model carrying mutated human amyloid pr
50 sphoribosyltransferase locus, we generated a transgenic mouse model containing the human renin (hREN)
51 st time Pcdh10 up-regulation in tissues from transgenic mouse models, cultured Schwann cells, and hum
52 tution of bone marrow cells into a TGF-alpha transgenic mouse model demonstrated that fibrocytes do n
55 ire breadth to a non-self-antigen, a TCRbeta transgenic mouse model (EF4.1) expressing a limited, yet
57 first report of a newly generated humanized transgenic mouse model engineered to express human NRG1-
64 c alleviated S. pyogenes-induced sepsis in a transgenic mouse model expressing human FH (S. pyogenes
66 er mammals and humans, but not in rodents, a transgenic mouse model expressing the complete human MOG
69 anamide, was investigated in the brain of AD transgenic mouse models (FAD) on an APOE4 or APOE3 genet
70 ntration in vivo, we developed a conditional transgenic mouse model (Flpo/Frt system) expressing bioa
72 blockade in the K14cre;Cdh1(F/F);Trp53(F/F) transgenic mouse model for breast cancer stimulates intr
74 he advantages and limitations of the HLA-DR4 transgenic mouse model for evaluating human C. trachomat
79 t composition in the skin, we have generated transgenic mouse models for tamoxifen-inducible de novo
80 ) and previously undescribed (G2-Gata4(Cre)) transgenic mouse models for the study of coronary vascul
81 ue expression in Tg32, a human FcRn knock-in transgenic mouse model, for which a strong correlation o
83 of IR-induced DSBs to GBM development using transgenic mouse models harboring brain-targeted deletio
85 f the problem with AD drug discovery is that transgenic mouse models have been poor predictors of pot
86 n the majority of Rett Syndrome (RTT) cases, transgenic mouse models have played a critical role in o
88 ine phosphatases Shp1 and Shp2, knockout and transgenic mouse models have revealed distinct phenotype
89 el, Hi-Myc mice, with a liver-specific IGF-1 transgenic mouse model (HIT) to increase their circulati
91 severative behaviors, we characterized a new transgenic mouse model in which inducible ablation of SC
92 o address this gap, we developed a new IL-33 transgenic mouse model in which overexpression of full-l
93 cted CC, a toxin-driven model in rats, and a transgenic mouse model in which p53 deletion is targeted
95 V-induced skin carcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter
100 injury pharmacologically and genetically in transgenic mouse models in which microglia and systemic
102 ation and improves survival in a calcineurin transgenic mouse model, indicating that COUP-TFII may se
105 ow for the first time that, unlike other tau transgenic mouse models, minimal expression of a human d
110 to investigate brain copper trafficking in a transgenic mouse model of AD by PET imaging with (64)Cu,
111 that reducing endogenous alpha-syn in an APP transgenic mouse model of AD prevented the degeneration
112 of Western diet (WD) on female EFAD mice, a transgenic mouse model of AD that includes human APOE al
120 Mechanistic analysis was undertaken in a transgenic mouse model of ALS, where we find similar mar
121 genous alpha-synuclein (alpha-syn) in an APP transgenic mouse model of Alzheimer's disease (AD) preve
122 S)-induced microglia activation in vivo in a transgenic mouse model of Alzheimer's disease (APP/PS1)
123 subsequent fluorescent amyloid staining in a transgenic mouse model of Alzheimer's disease (tgSwe).
125 d in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis
129 are antipruritic against acute itch and in a transgenic mouse model of atopic dermatitis produced by
130 D8+ T cells are implicated as effectors in a transgenic mouse model of autoimmune GFAP meningoencepha
132 of CaSR-PTHrP interactions in the MMTV-PymT transgenic mouse model of breast cancer and in human bre
137 igated the impact of gammadelta T cells in a transgenic mouse model of carcinogenesis induced by HPV1
139 th plaque deposition and neuronal death in a transgenic mouse model of cerebral beta-amyloidosis.
143 vivo relevance of this pathway in our IL-15 transgenic mouse model of CTCL by showing that interfere
145 logical approaches, we have shown that, in a transgenic mouse model of dementia, the functional prope
147 GMP signaling.SIGNIFICANCE STATEMENT In DYT1 transgenic mouse model of dystonia, PDE10A, a key enzyme
148 ion and cardiac metabolism are affected in a transgenic mouse model of enhanced cardiac glycolysis (G
155 ilin degradation and rescued phenotypes in a transgenic mouse model of hereditary primary open-angle
158 Here we report novel findings in the R6/2 transgenic mouse model of Huntington's disease (HD) by d
159 duced in striatal output neurons of the R6/2 transgenic mouse model of Huntington's disease, at an ag
161 ing required Bcl2-mediated autophagy using a transgenic mouse model of impaired inducible autophagy (
162 Using a human islet amyloid polypeptide transgenic mouse model of islet amyloidosis, we show ARC
166 ymal transition and metastasis, an MMTV-PyMT transgenic mouse model of mammary tumour progression and
167 Here, we further characterized a lethal transgenic mouse model of MERS-CoV infection and disease
169 non of reduced OEMVs was again observed in a transgenic mouse model of multiple system atrophy and in
176 our results show in an aggressively growing transgenic mouse model of PDAC that the coordinated acti
178 se hypotheses were tested using cells from a transgenic mouse model of prostate cancer infected with
184 mtDNA genomes on the background of the PyMT transgenic mouse model of spontaneous mammary carcinoma.
186 emporal structure of SWRs was disrupted in a transgenic mouse model of tauopathy (one of the major ha
189 endritic metaplasticity is dysregulated in a transgenic mouse model of the disease, either before or
193 To test this, we used a previously described transgenic mouse model of wound-induced skin tumorigenes
196 ortem brain tissue samples from AD patients, transgenic mouse models of AD, and neuronal cells were u
197 was activated in reactive astrocytes in two transgenic mouse models of Alzheimer's disease and in a
200 tigated behavioral and pathologic changes in transgenic mouse models of amyotrophic lateral sclerosis
202 derived tumor xenograft (PDX) and MYC-driven transgenic mouse models of breast cancer by inhibiting t
203 a result of tumor formation in two different transgenic mouse models of cancer (RIP1-Tag2 model of in
207 odeled acquired resistance to osimertinib in transgenic mouse models of EGFR(L858R) -induced lung ade
208 olysis events observed in vivo, we generated transgenic mouse models of HD representing five distinct
209 Here, we use bacterial artificial chromosome transgenic mouse models of LRRK2 to explore potential no
210 breast cancer metastasis in two conditional transgenic mouse models of PyMT-induced breast cancer.
211 emonstrate a significant analgesic effect in transgenic mouse models of SCD and cancer as well as com
213 oters, and disruption of endogenous genes in transgenic mouse models of tauopathy make it difficult t
214 Disappointingly, the initial enthusiasm for transgenic mouse models of the disease has not been foll
217 t the generation of Alzheimer's disease (AD) transgenic mouse models on a panel of 28 background stra
220 in DIV7 cortical cultures of either from E18 transgenic mouse model or from rat E18 embryos that were
224 l cognitive assessment (water maze) in an AD transgenic mouse model (PS2APP) from 8 to 13 mo of age,
225 in LTP/LTD magnitude seen across ages in AD transgenic mouse models reflect the inability to undergo
226 nfection model and a lethal model makes this transgenic mouse model relevant for advancing MERS resea
227 udied the contribution of REST to MB using a transgenic mouse model (RESTTG ) wherein conditional Neu
228 ified a beneficial taxonomic repertoire in a transgenic mouse model (RIP140mvarphiKD) which resists t
235 riven tumor progression, we generated triple-transgenic mouse model (tetO-EGFR(L858R); CCSP-rtTA; Mal
236 e therapeutic profile of CpG ODN in a triple transgenic mouse model, Tg-SwDI, with abundant vascular
237 o brain slice culture model for CWD, using a transgenic mouse model (Tg12) that expresses the elk (Ce
240 Previous studies described a TDP-43(A315T) transgenic mouse model that develops progressive motor d
241 In the current studies, we identified a transgenic mouse model that exhibited a dysplastic coron
242 on in vivo, we generated and characterized a transgenic mouse model that expresses a non-glycosylated
249 g electrophysiology, cellular markers, and a transgenic mouse model that specifically labels GABA cel
252 Here, we used the Vav1 promoter to generate transgenic mouse models that expressed either human STAT
257 In this issue of the JCI, Pham et al. use a transgenic mouse model to demonstrate that STAT5BN642H i
258 gionally restricted and temporally regulated transgenic mouse model to investigate the behavioral, mo
262 s neuron population, and employed additional transgenic mouse models to assess the role of one specif
264 ell type-specific loss- and gain-of-function transgenic mouse models to investigate the physiologic r
268 eloped bacterial artificial chromosome (BAC)-transgenic mouse model, we demonstrate that Lgr5 express
269 d precursor protein (APP)/presenilin 1 (PS1) transgenic mouse model, we found that inhibition of RIPK
271 imeric cell-cell fusion assays, and a Sema3a transgenic mouse model, we identify Sema3a-Nrp1 signalin
280 y and cognition in novel genetically matched transgenic mouse models, we surprisingly found that nonm
286 ectrophysiological recordings in the rTg4510 transgenic mouse model, which overexpresses a mutant for
288 ediated skin cancer by interbreeding an HPV8 transgenic mouse model with a conditional disruption of
289 of TRAF3IP2 in heart disease, we generated a transgenic mouse model with cardiomyocyte-specific TRAF3
290 ere, we report the generation of a claudin-1 transgenic mouse model with doxycycline-inducible transg
292 s phenomenon, we have developed an inducible transgenic mouse model with expression of the most commo
293 p52 expression in vivo, we generated a novel transgenic mouse model with inducible expression of p52
294 e, we studied retroviral susceptibility in a transgenic mouse model with lifelong innate immune syste
297 ional effects of TMPRSS2:ERG expression in a transgenic mouse model with those of ERG knockdown in a
298 er-induced choroidal neovascularization, and transgenic mouse models with deficient or spontaneous re