ライフサイエンスコーパス: transgenic rat

1 ion using a diphtheria toxin receptor (hDTR) transgenic rat.

2 the albumin-SV40 large T antigen (Alb-SV40) transgenic rat.

3 es isolated from an alb-SV40 large T-antigen transgenic rat.

4 load, and microgliosis compared to untreated transgenic rat.

5 in a model of retinitis pigmentosa, the P23H transgenic rat.

6 monary endothelial cells in vitro and in HIV-transgenic rats.

7 B27/human beta(2)-microglobulin (Hubeta(2)m)-transgenic rats.

8 ent receptor occupancy in the CNS of hBK B 1 transgenic rats.

9 stigated in INS-1 cells and human IAPP (HIP) transgenic rats.

10 reducing light-induced retinal damage in all transgenic rats.

11 ulation that became expanded in diseased B27 transgenic rats.

12 y prevented but did not treat colitis in B27 transgenic rats.

13 ry tissue from certain lines of mid-pregnant transgenic rats.

14 notypes are observed in female MMTV-TGFalpha transgenic rats.

15 estinal and systemic inflammation in HLA-B27 transgenic rats.

16 m inflammatory disease characteristic of B27 transgenic rats.

17 leasing (GRF) neurons in the hypothalamus of transgenic rats.

18 e pathways differentially in male and female transgenic rats.

19 ast-treated transgenic compared to untreated transgenic rats.

20 ar conditioning protocol and optogenetics in transgenic rats.

21 ce and orexin neuron-ablated orexin/ataxin-3 transgenic rats.

22 leted from the mesenteric lymph nodes of B27-transgenic rats.

23 ell differentiation would be aberrant in B27-transgenic rats.

24 tially reversible, at least in mutant TDP-43 transgenic rats.

25 w autoregulation, which were rescued in Add3 transgenic rats.

26 from the spinal cord of SOD1-overexpressing transgenic rats.

27 on in naive and cocaine-sensitized cfos-lacZ transgenic rats.

28 /human beta(2)-microglobulin-transgenic (B27-transgenic) rats.

29 SD) of parietal cells; in inflamed areas of transgenic rats 21 +/- 5.2% (P < 0.0001) of parietal cel

30 n 1) an experimental uveitis model, 2) SOCS1 transgenic rats, 3) insulin-deficient diabetic rats, 4)

31 For this purpose we used S334ter-line-3 transgenic rats, a transgenic model developed to express

32 ley (SD) and retinal degenerate S334Ter(+/-) transgenic rats aged 1 to 180 days.

33 Transgenic rats also displayed a low-level plasma viremi

34 The spinal cord of transgenic rats also exhibited a progressive depletion o

35 ecific expression of EGFP makes this line of transgenic rats an excellent novel tool to study germ ce

36 uman beta2-microglobulin transgenic (HLA-B27 transgenic) rats, an animal model of spondyloarthritis,

37 HLA-B27 transgenic rat and mouse models have provided a new tool

38 ion of EGFP in Prox1-expressing cells of the transgenic rats and allowed a convenient visualization o

39 e transgene was undetectable in the TGFalpha transgenic rats and could not be induced when the animal

40 nidazole significantly attenuated colitis in transgenic rats and DSS-treated mice, it had no therapeu

41 ers and cerebrospinal fluid (CSF) from BACHD transgenic rats and from human HD subjects can seed muta

42 s less abundant in beta-cells in both h-IAPP transgenic rats and humans with type 2 diabetes.

43 mooth muscle cells from cocaine injected HIV-transgenic rats and in total lung extracts from HIV infe

44 we selectively activated TH(VTA) neurons in transgenic rats and measured resulting changes in whole-

45 The authors generated SOCS1 transgenic rats and mice (SOCS1-Tg), induced experimenta

46 -in mice and Period1::luciferase (Per1::luc) transgenic rats and recorded bioluminescence as a real-t

47 etina, is validated in retina-specific SOCS1 transgenic rats and retinal cells overexpressing SOCS1/S

48 a way to silence gene expression in vivo in transgenic rats and shows a role of Nogo-A in regulating

49 ne in mammary carcinomas from the HrHr, HrKr transgenic rats and their non-transgenic littermates was

50 d NspA to cause invasive disease in human fH transgenic rats and to survive in wild-type infant rat s

51 t green fluorescent protein (GFP)-expressing transgenic rats and transplanted into a sciatic nerve cr

52 ssion SCI was induced in SOD1-overexpressing transgenic rats and wild-type littermates.

53 This study, the first to combine TRAP-seq, transgenic rats, and a cocaine self-administration parad

54 or human islet amyloid polypeptide (h-IAPP) transgenic rats, and pancreatic tissue from rats and hum

55 When two such lines of either type of transgenic rat are subjected to repeated cycles of pregn

56 disease manifestations in HLA-B27/Hubeta(2)m-transgenic rats arise in the absence of any functional C

57 Using the McGill-R-Thy1-APP transgenic rat as a model of selective Abeta pathology,

58 Our paper introduces the c-fos-GFP transgenic rat as a new tool to study unique synaptic ch

59 ression of ASBT in wild-type mice and in the transgenic rat ASBT promoter reporter, while paradoxical

60 adapted photoreceptors in all three lines of transgenic rats at advanced stages of retinal degenerati

61 this disease, we depleted these cells in B27 transgenic rats before the onset of disease by adult thy

62 not detectable in mammary tissue from virgin transgenic rats but is detected in mammary tissue from c

63 Injection of DT into transgenic rats but not wild-type rats resulted in dose-

64 /3 receptor ligand [(18)F]fallypride in aged transgenic rats carrying human pathogenic LRRK2 R1441C o

65 All three lines of transgenic rats carrying rhodopsin mutations show an inc

66 uman HLA-B27 and beta(2) -microglobulin (B27-transgenic rats), colitis and peripheral inflammation de

67 Only transgenic rats colonized with defined bacterial cocktai

68 the hypothalamus and brainstem of the renin transgenic rat compared with its normotensive control.

69 with HIV-1, lymphatic organs from hCD4/hCCR5 transgenic rats contained episomal 2-long terminal repea

70 od used allowed the generation of homozygous transgenic rats containing one copy of the transgene per

71 crease until late-stage disease in human and transgenic rat cortex, and p-tau was elevated in individ

72 e findings indicate that the orexin/ataxin-3 transgenic rat could provide a useful model of human nar

73 microglia, but not lymphocytes, from double-transgenic rats could be productively infected by variou

74 In the specific B27/hbeta(2) m-transgenic rat cross-strain (21-3 x 382-2)F(1) , only th

75 Using BAC transgenesis, our lab created a transgenic rat (Cx3cr1-CreERT2) that expresses a tamoxif

76 istological analysis of testes from neonatal transgenic rats demonstrated that gonocytes are the only

77 Light-induced retinal damage in transgenic rats depends on the time of day of exposure t

78 Transgenic rats designed to ubiquitously express either

79 B27 transgenic rats develop a spontaneous disease resembling

80 HLA-B27 transgenic rats develop chronic gastritis at age 3 month

81 Transgenic rats develop early changes in novelty-seeking

82 us lesions, and ulcers; however, whereas the transgenic rats died within 6 days, only very mild intes

83 BACHD transgenic rats display a robust, early onset and progre

84 (2 months) and aged (24-26 months) Per1-luc transgenic rats, entrained to light-dark cycles, were ki

85 HLA-B27 transgenic rats exhibit generalized, severe inflammatory

86 Aged (18-21 months) G2019S and R1441C mutant transgenic rats exhibit L-DOPA-responsive motor dysfunct

87 At 17 weeks of age, the transgenic rats exhibited postnatal loss of orexin-posit

88 The transgenic rats exhibited prominent schizophrenia-like b

89 Here, we report the generation of transgenic rats expressing a human ataxin-3 fragment wit

90 erated LRRK2 bacterial artificial chromosome transgenic rats expressing either G2019S or R1441C mutan

91 Through the use of donor cells from transgenic rats expressing GFP exclusively in the germli

92 Thus, transgenic rats expressing the appropriate human recepto

93 In this study, we explored transgenic rats expressing the HIV-1 receptor complex as

94 One line of transgenic rats expressing the PEPCK-TAg transgene devel

95 ines were established from the livers of two transgenic rats expressing the simian virus protein larg

96 Retinas from transgenic rats expressing truncated rhodopsin (Ser334te

97 Here, we examined Fmr1-targeted transgenic rats (Fmr1-KO rats) as an alternative preclin

98 We microinjected Daun02 in Fos-lacZ transgenic rats following a single extinction training e

99 Here, we used cFos-lacZ and pCAG-lacZ transgenic rats for activity-dependent or nonselective i

100 ypothesis, we validated the use of Per-1:LUC transgenic rats for continuous longitudinal assessment o

101 rhodopsin slow photoreceptor degeneration in transgenic rats for up to 3 months of age when injected

102 ransgenic tools, including viral vectors and transgenic rats, for targeted genome modification in spe

103 enerated for the first time, human SIRPA BAC transgenic rats, for which the gene is faithfully expres

104 Three lines of transgenic rats, GPR-2, -4, and -5, were established.

105 % of the NMU-induced carcinomas in these Ras transgenic rats had an activating ras mutation in their

106 The P23H transgenic rat has a slow rod degeneration with initiall

107 c strategies, difficulties of generating BAC transgenic rats have hindered progress.

108 Transgenic rats homozygous for the wild-type Rab38 BN al

109 Utilizing a transgenic rat in which an enhanced green fluorescent pr

110 By using anterograde tracing in a transgenic rat in which neurons express a dendritically-

111 Through use of a transgenic rat in which rhythmicity in transcription of

112 Raising Ser334ter transgenic rats in darkness resulted in minimal rescue f

113 techniques to monitor population activity in transgenic rats in vivo, we investigated the contributio

114 we report the creation of multiple lines of transgenic rats in which expression of ALS-associated mu

115 Heterozygous transgenic rats, including P23H sublines 2 and 3 and S33

116 In unmanipulated transgenic rats, inflammation was first evident in the d

117 We have generated transgenic rat insulin promotor (RIP)-CXCL10 mice expres

118 The inflammatory disease of B27 transgenic rats is thus T cell-dependent.

119 type 2 diabetes, isolated islets from h-IAPP transgenic rats, isolated human islets, and INS 832/13 c

120 etyl-D-mannosamine (ManNAc) to NPHS2-Angptl4 transgenic rats it increased the sialylation of Angptl4

121 ubretinal delivery of AAV5 expressing BiP to transgenic rats led to reduction in CHOP and photorecept

122 A transgenic rat line carrying the alb-SV40A transgene has

123 Breeding to homozygosity resulted in a novel transgenic rat line exclusively producing chimeric Abs w

124 and were observed in any of the HrHr or HrKr transgenic rat line heterozygotes.

125 mammalian circadian system, we constructed a transgenic rat line in which luciferase is rhythmically

126 We used a transgenic rat line, the GFAP-Tk, to selectively elimina

127 The advent of transgenic rat lines expressing Cre recombinase selectiv

128 pendent gRNA expression as well as three new transgenic rat lines to specifically target CRISPR-Cas9

129 d disease-prone and healthy HLA-B27/Hubeta2m-transgenic rat lines with a healthy line, 283-2, carryin

130 es also occurred in the respective CD8a(-/-)-transgenic rat lines.

131 a cell line, L25, derived from the Alb-SV40 transgenic rat liver tumors, whereas another cell line,

132 to enhanced green fluorescent protein (EGFP)-transgenic rat LTx with 18-hour cold preservation in Uni

133 Anti-H-Y CTL generated in cima B27 transgenic rats lysed male B27 cimb/b targets significan

134 of extracellular glutamate in the G93A SOD1 transgenic rat may account for a dampened effect of rilu

135 We demonstrate that ibudilast-treatment of transgenic rats mitigated hippocampal-dependent spatial

136 A previously developed novel transgenic rat model (rTg-D) expresses the human familia

137 re lowering effects in a hypertensive double-transgenic rat model after oral administration.

138 In this study, we created a transgenic rat model and investigated the transgeneratio

139 This transgenic rat model enables us to study physiological r

140 em brain tissue of patients with AD and in a transgenic rat model expressing human amyloid-beta plus

141 nvestigated the neuroanatomical changes in a transgenic rat model for a subset of sporadic chronic me

142 Overall, we have created a novel transgenic rat model for researchers to employ in unders

143 stating disease, we sought to create a first transgenic rat model for SCA17 that carries a full human

144 This transgenic rat model is unique as it exhibits hippocampa

145 s were compared between rTg-D HOM rats and a transgenic rat model of AD.

146 itro destruction of P23H mutant mRNAs from a transgenic rat model of ADRP.

147 e transport activity in a recently developed transgenic rat model of amyotrophic lateral sclerosis (A

148 Previous studies of the HLA-B27-transgenic rat model of ankylosing spondylitis (AS) sugg

149 proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.

150 e unlikely to serve as effector cells in the transgenic rat model of HLA-B27-associated disease, in o

151 matory agent, as demonstrated in the HLA-B27 transgenic rat model of inflammatory bowel disease.

152 y models) and yet were active in the HLA-B27 transgenic rat model of inflammatory bowel disease.

153 ion on retinal disease process in the P23H-1 transgenic rat model of retinal degeneration.

154 therapy for photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa.

155 so observed in the 2-year-old P23H rhodopsin transgenic rat model of retinitis pigmentosa.

156 rats with enhanced synaptic inhibition and a transgenic rat model of Rett syndrome (RTT).

157 In this study, we employed a transgenic rat model overexpressing human DISC1 (tgDISC1

158 r previously reported alpha-synuclein (SNCA) transgenic rat model support the idea that increased SNC

159 We evaluated the HIP rat, a human IAPP transgenic rat model that develops islet pathology compa

160 Here, we generated an HD transgenic rat model using a human bacterial artificial

161 We have generated a transgenic rat model using RNAi and used it to study the

162 We used a transgenic rat model whose tissues express luciferase in

163 We demonstrate that a novel transgenic rat model, modestly overexpressing the full-l

164 nd assessed their progression over time in a transgenic rat model, which allows for a finer spatial r

165 mammary carcinogenesis were examined using a transgenic rat model.

166 ood pressure lowering activity in the double-transgenic rat model.

167 These transgenic rat models confirm the conclusions reached in

168 ens opportunities for expansion of humanized transgenic rat models in the future to advance biomedica

169 testinal inflammation in gnotobiotic HLA-B27 transgenic rats monoassociated with either B. vulgatus o

170 f photo-switchable fluorescent mitoDendra in transgenic rat motor neurons expressing mutant or wild-t

171 hol intake by using Drd1a-iCre and Drd2-iCre transgenic rats of both sexes.

172 SMBs or BMCs derived from male GFP-transgenic rats, or PBS were injected intramyocardially

173 Using a newly generated line of transgenic rats (OTR-IRES-Cre), we determined that most

174 or mediated apoptotic pathway, as shown in a transgenic rat overexpressing tumor necrosis factor-alph

175 ined with varied approaches including use of transgenic rats overexpressing STPB-C which were studied

176 lands, extensive pathologies, whereas virgin transgenic rats produce no such abnormalities.

177 Therefore, B27-transgenic rats provide a model of spondylarthritis.

178 These transgenic rats provide a valuable resource to pursue ex

179 The GPR-4 line of transgenic rats provides a genetic model for the underst

180 expression of PDE4D1 (P) to GnRH neurons in transgenic rats (R) by using the GnRH gene promoterenhan

181 Retinal degeneration in transgenic rats raised in darkness was evaluated by quan

182 Gnotobiotic transgenic rats raised in Trexler isolators were selecti

183 The HIV-1 transgenic rat recapitulates many key features of human

184 HLA-B27 transgenic rats received antibiotics (ciprofloxacin, met

185 Cherry (control) and in experiment 2, D2-Cre transgenic rats received intra-NAcSh injections of Cre-d

186 Germfree transgenic rats reconstituted with enteric bacteria grow

187 enous renin-angiotensin system in Cyp1a1Ren2 transgenic rats reduced cortical tissue PO2.

188 ptor functional protection in P23H rhodopsin transgenic rat retina.

189 rs compacta dopamine neurons in R1441C LRRK2 transgenic rats reveal an age-dependent reduction in bur

190 In adult Fos-lacZ transgenic rats, selective inactivation of nicotine-cue-

191 In Fos-lacZ transgenic rats, selective inactivation of relapse test-

192 Add3 transgenic rats showed attenuation of proteinuria, glome

193 We generated a transgenic rat stably expressing the green fluorescent p

194 the generation and characterization of a new transgenic rat strain in which conditional expression of

195 podocyte depletion and glomerulosclerosis, a transgenic rat strain in which the human diphtheria toxi

196 stable fluorescence reporter from an inbred transgenic rat strain provides an important new resource

197 The transgenic rat system will be useful in further defining

198 smid construct used to generate two lines of transgenic rats, termed JP17 and JP59.

199 Here, a transgenic rat (TgF344-AD) expressing disease-causing mu

200 The HD transgenic rat (tgHD), which contains the human HD mutat

201 was administered by subretinal injection to transgenic rats (TgN S334ter-4) at postnatal day 15 (P15

202 of genetically engineered hypertension, the transgenic rat TGR (mREN2)27, provides a unique opportun

203 aggressive colitis and gastritis in HLA-B27 transgenic rats than did the other five bacteria without

204 introduce a CRISPR-based Oprm1-Cre knock-in transgenic rat that provides cell type-specific genetic

205 introduce a CRISPR-based Oprm1-Cre knock-in transgenic rat that provides cell type-specific genetic

206 eptor degeneration was examined in a line of transgenic rats that carry a rhodopsin mutation S334ter.

207 otrophin (CT)-1 on photoreceptor survival in transgenic rats that carry the rhodopsin mutation S334te

208 Here, we created novel lines of transgenic rats that express a mutant form of human TDP-

209 the activity of ERK1/2, in combination with transgenic rats that express Cre in tyrosine hydroxylase

210 We have also generated transgenic rats that express GFP at high levels, suggest

211 We created a line of transgenic rats that produce epitope-tagged human SREBP-

212 Using PV-Cre transgenic rats that went through a METH sensitization r

213 renal vascular smooth muscle cells from Add3 transgenic rats, those from FHH rats had elevated membra

214 aun02 inactivation procedure in male FosLacZ-transgenic rats to ablate selectively Fos-expressing PLC

215 We then used male FosGFP-transgenic rats to assess selective alterations of intri

216 al vectors (n = 7-8/group) were used in male transgenic rats to identify the contributions of D1- and

217 d light damage and the susceptibility of the transgenic rats to light damage.

218 sors revealed a defect in the ability of B27-transgenic rats to produce DCs of the migratory phenotyp

219 We trained c-fos-lacZ transgenic rats to self-administer cocaine in Context A

220 We trained c-fos-lacZ transgenic rats to self-administer heroin and 11 d later

221 We used transgenic rats to study each cell type and found that c

222 ral precision of optogenetics, together with transgenic rats, to probe contributions of a specific ci

223 We generated transgenic rats (TR) with targeted expression of IFN-gam

224 ls, we studied four additional groups of B27 transgenic rats treated with: 1) continuous anti-CD8alph

225 In FUS transgenic rats, ubiquitin aggregation and FUS mislocali

226 m is operative in photoreceptor death in the transgenic rats under investigation.

227 e that, like their human counterparts, HIV-1 transgenic rats undergo severe osteoclastic bone resorpt

228 fore, an efficient generation of human SIRPA transgenic rats using piggyBac opens opportunities for e

229 Using circuit perturbations in transgenic rats, we demonstrate that switching between s

230 neurons in prelimbic cortex (PLC) of FosGFP-transgenic rats, we found that operant food self-adminis

231 in choline acetyltransferase (ChAT)::Cre(+) transgenic rats, we selectively labeled cholinergic neur

232 In male HIV-1 transgenic rats, we show that 17aE2 treatment prevents t

233 ds isolated from hepatocellular neoplasms in transgenic rats were aneuploid.

234 Subsequently, germfree transgenic rats were colonized with groups of five to ei

235 Germfree transgenic rats were colonized with specific-pathogen-fr

236 Transgenic rats were created, wherein soluble OPG was ov

237 Five lines of PEPCK-TGFalpha transgenic rats were established, each genetic line cont

238 ollowing long-term treatment with ibudilast, transgenic rats were evaluated at 11 months of age for s

239 om preplaque amyloid precursor protein (APP) transgenic rats were found to produce a variety of poten

240 nic spinal cord of alkaline phosphatase (AP) transgenic rats were grafted acutely into a DC lesion at

241 , macrophages, and microglia from hCD4/hCCR5 transgenic rats were highly susceptible to infection by

242 Hepatocytes from transgenic rats were isolated by a two-step perfusion pr

243 c-fos-GFP transgenic rats were then used to assess glutamatergic s

244 Transgenic rats were trained on a heroin self-administra

245 Marked testis cells from transgenic rats were transplanted to the testes of immun

246 Opsin P23H transgenic rats were treated with light at P28 and analy

247 Next, male and female transgenic rats were used to selectively label D1 or D2

248 rmation of endogenous alpha-synuclein in non-transgenic rats, which leads to neurodegeneration in dis

249 nsformation of endogenous a-synuclein in non-transgenic rats, which leads to neurodegeneration in dis

250 Transgenic rats with a high level of expression of the h

251 By using transgenic rats with a luciferase (luc) reporter, we ass

252 common final cell death, apoptosis, we used transgenic rats with a P23H or S334ter rhodopsin mutatio

253 eking, we selectively transfected D1-MSNs in transgenic rats with an inhibitory Gi-coupled DREADD.

254 nfluenced by chromosomal context, leading to transgenic rats with different pigmentation that enabled

255 HLA-B7 and HLA-B27 transgenic rats with gut inflammation received EEN, CD-T

256 Transgenic rats with high expression of HLA-B27 develop

257 vation of macrophages from premorbid HLA-B27 transgenic rats with IFN-gamma increases HLA-B27 express

258 ages derived from the bone marrow of HLA-B27 transgenic rats with inflammatory disease.

259 s in bulb slices obtained from wild-type and transgenic rats with labelled GABAergic cells to test a

260 at lcn2 is induced in reactive astrocytes in transgenic rats with neuronal expression of mutant human

261 Our FUS transgenic rats would be useful to the mechanistic study