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1 e of electron delocalization in reactant and transition state stabilization.
2 dicating that all four groups have a role in transition state stabilization.
3 network of charged residues is essential for transition state stabilization.
4 be carefully investigated for their role in transition state stabilization.
5 l hydrogen bonding interaction necessary for transition state stabilization.
6 ion in a manner that allows it to assist in transition state stabilization.
7 indicating that this arginine is critical in transition state stabilization.
8 site can contribute to rate acceleration via transition state stabilization.
9 rm a network of hydrogen bonds necessary for transition state stabilization.
10 hanism that combines acid-base catalysis and transition state stabilization.
11 ns on the basis of fundamental principles of transition state stabilization.
12 be ground state destabilization rather than transition state stabilization.
13 and that Arg-131 and His-200 are involved in transition state stabilization.
14 more effective substrate preorganization and transition state stabilization.
15 n of dephosphorylation by nucleotide-induced transition state stabilization.
16 , indicating contributions to E2 binding and transition state stabilization.
17 induce enantioselectivity through selective transition state stabilization.
18 d reveals contacts that likely contribute to transition state stabilization.
19 Both of these residues might be involved in transition state stabilization.
20 ate discrimination results from differential transition state stabilization.
21 ontributed approximately 4.5 kcal/mol toward transition state stabilization.
22 ial catalytic groups for ubiquitin adenylate transition state stabilization.
23 alysis, and R92 plays a critical role in the transition state stabilization.
24 ns from a change in the solvation effect and transition state stabilization.
25 that the anionic backbone of DNA is used in transition state stabilization.
26 acid/base catalysis, substrate binding, and transition-state stabilization.
27 eaction and is likely to be a key residue in transition-state stabilization.
28 plexes may be good models of enzyme-mediated transition-state stabilization.
29 is probably involved in maltooligosaccharide transition-state stabilization.
30 ances are highlighted as key factors in MTAN transition-state stabilization.
31 ide chains to positions that provide optimal transition-state stabilization.
32 These changes buttress transition-state stabilization.
33 ase and oxyanion stabilizer, thus perfecting transition-state stabilization.
34 portant for high-affinity AdoMet binding and transition-state stabilization.
35 e conformations and in part by electrostatic transition-state stabilization.
36 ibutions to ground-state destabilization and transition-state stabilization.
37 idity and provides an overall 14-17 kcal/mol transition-state stabilization.
38 by creating a more favorable environment for transition-state stabilization.
39 mine makes a modest contribution to chemical transition state stabilization (1.0 kcal.mol-1 relative
40 Through protonation of the leaving group and transition-state stabilization, activated MKP3 catalyzes
41 arginine plays a key role by assisting with transition state stabilization and by reducing the pK(a)
42 ting alphaD335 to alphaS337 are important to transition state stabilization and catalytic function th
43 tentiates recruitment of RGS9 for hydrolytic transition state stabilization and concomitant signal te
44 ue of the hammerhead complex is critical for transition state stabilization and efficient cleavage ac
45 ribozyme/substrate complex are critical for transition state stabilization and efficient cleavage ac
46 We surmise that Arg-130 plays dual roles in transition state stabilization and general acid catalysi
47 us studies implicated Arg-223 and His-265 in transition state stabilization and Lys-167 in proton don
48 catalysis may be derived from electrostatic transition state stabilization and the opposing view tha
49 an oxyanion hole), which is crucial for the transition state stabilization and, therefore, on the en
50 of the active site permits us to suggest how transition-state stabilization and a general base may ca
51 on ( K m (D)) correlated with ATP hydrolysis transition-state stabilization and ATP occlusion (EC 50
52 se effects can be extended to ATP hydrolysis transition-state stabilization and ATP occlusion at a si
53 the previously proposed roles for Arg L96 in transition-state stabilization and for His L91 as the nu
54 binding energy) and are the key factors for transition-state stabilization and molecular recognition
55 central to the H-bond network that provides transition-state stabilization and tight binding of the
56 philic attack, provides direct electrostatic transition state stabilization, and facilitates leaving
57 oth metals participate in substrate binding, transition state stabilization, and the hydrolysis react
58 h as orientation and proximity of substrate, transition-state stabilization, and active-site incorpor
59 eighboring group electrostatic interactions, transition-state stabilization, and leaving group activa
60 xygen at C2 on the nucleobase contributes to transition-state stabilization, and thus acts as a posit
61 r these residues include nucleotide binding, transition-state stabilization, and triggering protein c
62 ation of charges (using differential product/transition state stabilization approach) followed by cal
64 implicated in phosphohydrolase chemistry via transition state stabilization (Arg308, Arg648, Gln275),
66 demonstration of stereoelectronic effects in transition state stabilization as well as a separation o
67 hich differ with respect to the mechanism of transition state stabilization, as dictated by differenc
68 ed S(N)2 pathway for the reaction with large transition state stabilization at relatively low OEEFs.
70 only is important for providing the optimal transition state stabilization but also ensures correct
71 in betaR246A caused almost complete loss of transition state stabilization, but partial rescue was a
72 t CTA gains catalytic efficiency from modest transition-state stabilization, but DTA and PTA catalyze
73 lfate on the alpha-phosphate of ATP involves transition state stabilization by Arg-248, Asn-249, His-
74 hat the 2'-OH may play an additional role in transition state stabilization by donating a hydrogen bo
75 arer understanding of the forces involved in transition state stabilization by Escherichia coli cytid
76 core a common catalytic mechanism, entailing transition state stabilization by manganese and the phos
77 The proposed catalytic mechanism implicates transition state stabilization by PPAT without involving
78 alysis are interpreted to be consistent with transition state stabilization by solvent being primaril
79 an allosteric effect, which includes a major transition state stabilization by the electrostatic effe
80 catalytic role of zinc ion, and improve the transition state stabilization by the enzyme environment
81 s of antibodies, catalyze hydrolysis through transition state stabilization by tyrosine or histidine
82 etal cofactor appears to be mediated through transition-state stabilization by outer-sphere complex f
83 the course of loop closure, as expected for transition-state stabilization by the side chain ammonio
84 up conformations are shown to be critical to transition-state stabilization (by up to 15 kcal/mol), a
86 oth substrate organization and electrostatic transition state stabilization contribute to catalysis.
88 ective enhancement effect are: (a) increased transition-state stabilization due to hydrogen bonding i
89 er alignment of sLys (downward orientation), transition-state stabilization (due to the protein envir
91 d residues involved in aspartate binding and transition state stabilization during the formation of b
92 rate and that, in this case, at least 70% of transition state stabilization energy can be achieved us
93 hich are important for substrate binding and transition state stabilization for both of the chemical
94 nalyses indicated roles for the arginines in transition state stabilization for catalysis but not in
95 nal reorganization while maintaining optimal transition state stabilization for every step during cat
96 esidue that is important in both binding and transition state stabilization for the activity with (S)
97 ity with (S)-mandelate, is also critical for transition state stabilization for the esters, but not f
98 sential activator, providing 3.2 kcal/mol of transition state stabilization for the truncated substra
100 of 3 x 10(10) M(-1), which corresponds to a transition-state stabilization for deuterium exchange of
101 nstrated the importance of charge balance in transition-state stabilization for phosphoryl transfer e
102 e conclude that a large portion of the total transition-state stabilization for the decarboxylation o
104 examined in this work, which enables strong transition state stabilization from enzyme-phosphodianio
105 abolishes both functions, R130K permits the transition state stabilization function (via contact of
106 test the contribution of this interaction to transition-state stabilization, Glu-91 was converted to
107 ous transition state inhibitors supports the transition state stabilization hypothesis for enzymatic
108 al residue involved in phosphate-binding and transition state stabilization in ATP synthase catalytic
109 otein structure is an important component of transition state stabilization in enzyme catalysis.
111 d active site mutants underscore the role of transition state stabilization in the evolution of this
113 pproach was used to examine the differential transition state stabilization in the papain mutant rela
115 contribute 10 to 20 kilocalories per mole to transition-state stabilization in enzymatic catalysis.
117 d through a mechanism that is similar to the transition-state stabilization in the general acid-base
118 ed by the results of experiments testing how transition state stabilization is affected by the trunca
119 rgues against the model in which substantial transition state stabilization is derived from a water m
121 eneral acid-base or electrostatic catalysis, transition state stabilization is likely to be an import
123 the positive charge is the main effector of transition state stabilization is shown by the construct
124 K25V the removal of the charge and resultant transition state stabilization is the main origin of the
126 190 in orienting the substrate for effective transition-state stabilization is consistent with rate r
127 e thermodynamic perturbation, in addition to transition-state stabilization, is required for the larg
128 42) hypothesized to be key for electrostatic transition state stabilization (K42A, K42Q, K42E, and K4
129 s favorable polar interactions important for transition state stabilization leading to efficient aden
130 ces is that catalysis occurs via a different transition state stabilization mechanism in HcTrpRS with
135 everal other arginines likely participate in transition state stabilization of the transferred phosph
136 anisms: pre-steady state bursts, significant transition-state stabilization of both amino acid activa
137 rmations in a manner reciprocal to enzymatic transition-state stabilization of reactions involving li
139 of protein side chain functional groups, and transition-state stabilization of the S(VI) exchange rea
140 ey suggest instead that something other than transition-state stabilization or tunneling is responsib
141 affect substrate carboxyl binding (R71N) and transition state stabilization (R63N) also yielded wild-
142 he SRL structure, which imparts 4.3 kcal/mol transition state stabilization relative to a single-stra
143 significantly, it accounts for 9kcal/mol of transition state stabilization relative to the reactant
144 combination with biochemical data, support a transition-state stabilization role for the P(1) residue
145 of KSHV Pr, (Ser114, His46, and His157) and transition-state stabilization site are arranged as in o
146 pling of substrate-dependent arch motions to transition-state stabilization suppresses inappropriate
147 binding interactions and through additional transition state stabilization that may arise from compl
148 ions of these side chains may play a role in transition state stabilization; the observed line broade
149 e ribofuranosyl contacts to ground state and transition state stabilization, Thr-100 and Asp-37 were
150 ion by the increase of a ring strain and the transition state stabilization through electronic effect
152 ons while leaving the ribose flexible, and a transition state stabilization through H-bond and electr
153 lts indicate that R277 plays a major role in transition state stabilization through its positive char
154 DeltaG(cat)()) for the CI mechanism involves transition-state stabilization through general-acid cata
155 he nucleophilicity of the alkene and provide transition-state stabilization through local electric fi
157 the enzyme works by providing electrostatic transition state stabilization (TSS), by applying steric
159 n bond (LBHB), may account for the "missing" transition state stabilization underlying the catalytic
161 cules rather that to the more common mode of transition state stabilization used by naturally evolved
162 atalysis, that Gly65 and Gln58 contribute to transition-state stabilization via hydrogen bond formati
163 ground state binding and the P4 position for transition state stabilization was identified through si
165 all catalytic effect is due to electrostatic transition state stabilization, which again reflects the
166 assembled beta-hairpin as a key template in transition state stabilization with the beta-turn playin
168 ribution of each substrate hydroxyl group to transition-state stabilization with the wild type and ea
169 y combining ground-state destabilization and transition-state stabilization within the cavity of an e
170 h is a rare case of enzyme-like catalysis by transition state stabilization without product inhibitio