ライフサイエンスコーパス: transitional B-cell

1 capacity to purge autoreactive immature and transitional B cells.

2 memory B cells and an increased frequency of transitional B cells.

3 BAFF-mediated survival of the Act1-deficient transitional B cells.

4 This was due to a decrease in naive and transitional B cells.

5 gnaling was reduced when compared to that in transitional B cells.

6 y have often been referred to as immature or transitional B cells.

7 B cells leave the bone marrow as transitional B cells.

8 ) spleen, there is an accumulation of type 1 transitional B cells.

9 ion of T and B cells and a mild expansion of transitional B cells.

10 d persistent numerical reduction in TREG and transitional B cells.

11 c CD8(+) T cells, and (iv) ISG(hi) naive and transitional B cells.

12 rtant in limiting the number of immature and transitional B cells.

13 secretion as was observed in healthy control transitional B cells.

14 B cells, as well as IL-10-producing CD27(+) transitional B cells.

15 ity via direct, TACI-dependent activation of transitional B cells.

16 biased by IS regimens, which also influenced transitional B cells.

17 enic B cells and a further pronounced one in transitional B cells.

18 FF promotes the expansion of TACI-expressing transitional B cells.

19 ance via positive selection of self-reactive transitional B cells.

20 ells were CD27(-)/CD10(+), characteristic of transitional B cells.

21 ated level of IRF8 promoted apoptosis in the transitional B cells.

22 ed and Notch hindered the differentiation of transitional B cells.

23 morphisms in BLK are restricted to naive and transitional B cells.

24 venting 2F5 V(H)/V(L) expression by immature/transitional B cells.

25 In the periphery transitional B cells accumulated under ERT, and the defe

26 In addition, both transitional B cell and plasmablast levels were signific

27 erapy was characterized by a predominance of transitional B cells and a lack of memory B cells.

28 nctionally immature, with a preponderance of transitional B cells and a paucity of memory B cells.

29 actin caused a decrease in the population of transitional B cells and an increase in mature follicula

30 A transient increase in transitional B cells and cells with phenotypic character

31 Both late splenic transitional B cells and cells within this uncharacteriz

32 t gene expression in BCR- and TLR-stimulated transitional B cells and development of the MZB cell com

33 d skewed B cell differentiation with loss of transitional B cells and expansion of plasmablasts.

34 Both cGVHD and L-aGVHD had decreased transitional B cells and increased cytolytic natural kil

35 igen-dependent negative selection of splenic transitional B cells and is required for activation of t

36 Both the percentage of immature/transitional B cells and levels of IL-7 were inversely c

37 tion was not evident in interactions between transitional B cells and preactivated CD4-expressing T c

38 se delta (PI3Kdelta) lead to accumulation of transitional B cells and senescent T cells, lymphadenopa

39 marrow of adult mice enter the periphery as transitional B cells and subsequently differentiate into

40 ctive immature B cells to differentiate into transitional B cells and to be positively selected into

41 ion of nonautoreactive immature B cells into transitional B cells and to promote their positive selec

42 ed with surface acquisition of CD73 on human transitional B cells and was augmented with the AMPK ago

43 4(high) B10 cells, CD24(hi)CD38(hi) immature transitional B cells, and CD73(-)CD25(+)CD71(+) BR1 cell

44 CD38-expressing plasmablasts, plasma cells, transitional B cells, and class-switch mBCs, ultimately

45 ecipients exhibit decreased plasmablasts and transitional B cells, and increased senescent T cells.

46 bodies, and increases in regulatory T cells, transitional B cells, and programmed cell death protein-

47 Follicular and transitional B cells are enriched in fetuses while CD69(

48 sinusoids, but above 90% of cloned apoptotic transitional B cells are not self-reactive/polyreactive.

49 pitope (SP62): in C57BL/6 mice, SP62-binding transitional B cells are readily identified in bone marr

50 In vitro, AID deficient immature/transitional B cells are significantly more resistant to

51 for WP ontogeny, and CXCL13-responsive late transitional B cells are the initiating subset.

52 In the absence of Rac1 and Rac2, transitional B cells are unable to migrate in response t

53 in A/WySnJ B cells decreased the turnover of transitional B cells, as determined by 5-bromo-2'-deoxyu

54 r, breakage of tolerance, increased immature/transitional B cells, B cell malignancies, as well as a

55 n receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or fol

56 the differentiation of CD23(-) into CD23(+) transitional B cells both in vitro and in vivo through a

57 We report that transitional B cells can process and present Ag as pepti

58 demonstrate that B cells, and in particular transitional B cells, can promote prolongation of graft

59 In contrast to early transitional B cells, CD21(int) T2 B cells exhibit augme

60 th increasingly elevated Flt3L, depletion of transitional B cells, CD56(bright) NK cells, naive T cel

61 effect against anti-IgM apoptotic signals on transitional B cell checkpoint, not observed with BAFF.

62 a trend for elevation in a CXCR5/CCR6(high) transitional B-cell cluster.

63 ese T-bet(+)CXCR5(+)TREG and T-bet(+)CD21(-) transitional B-cell clusters was correlated with increas

64 ing, as indicated by the increased number of transitional B cells coexpressing kappa/lambda light cha

65 Bregs were identified in both the naive and transitional B-cell compartments and suppressed T-cell p

66 t were selectively depleted in both TREG and transitional B-cell compartments in patients with ABMR.

67 od, and spleen in mice and humans shows that transitional B cells comprise a much smaller fraction in

68 The lack of dsDNA breaks in transitional B cells contrasts with their increased expr

69 In the phase 1b study, percentages of transitional B cells decreased, naive B cells increased,

70 In the current study, when transitional B cells developed in the presence of donor

71 appa recombination signal sequences, whereas transitional B cells did not.

72 for sustained p100 production emerged during transitional B cell differentiation, the stage at which

73 tory molecule CD86 (B7.2) and are activated, transitional B cells do not and undergo apoptosis.

74 d role in purging self-reactive immature and transitional B cells during their maturation in the bone

75 CD19(+)CD24(hi)CD38(hi) Immature/transitional B cells elevated in diabetic than non-diabe

76 the first time, the study reveals that human transitional B cells encompass not only transitional typ

77 pment is arrested at the same T0 stage, with transitional B cells excluded from the white pulp.

78 eased frequency of autoreactive new emigrant/transitional B cells exiting the BM, indicating that the

79 ty was associated with specific expansion of transitional B cells, extrafollicular IgG2c-producing pl

80 both LSD1-deficient and NF-kappaB-inhibited transitional B cells failed to undergo full MZB developm

81 ieu postreconstitution dominated by immature transitional B cells, favoring tolerance.

82 When modeled as a time-dependent covariate, transitional B cell frequencies (but not total B cells o

83 BAFF-mediated humoral autoimmunity, TACI(+) transitional B cells from BAFF-transgenic mice spontaneo

84 In addition, we found that transitional B cells from both healthy controls and IFN-

85 at IL-4 stimulated the generation of CD23(+) transitional B cells from CD23(-) B cells, and this effe

86 vity of antibodies expressed by new emigrant/transitional B cells from IPEX patients were similar to

87 ing immune response might rescue Ag-specific transitional B cells from negative selection.

88 We found that new emigrant/transitional B cells from patients with XLP were enriche

89 y, we examined the responses of immature and transitional B cells from V(H)12Vkappa1A Ig transgenic m

90 We found enrichment of transitional B cell genes in systemic lupus erythematosu

91 Whereas naive and transitional B cells have been associated with long-term

92 Human transitional B cells have previously been variably ident

93 Recent studies highlight transitional B-cell heterogeneity as a determinant of in

94 ry B cells and expansion of plasmablasts and transitional B cells; however, B-cell immune perturbatio

95 phocytes in blood: T regulatory (T(REG)) and transitional B cells in a cohort of 96 kidney transplant

96 nse, (2) transient preponderance of immature/transitional B cells in all lymphoid organs, (3) impaire

97 y low frequency of polyreactive new emigrant/transitional B cells in DOCK8-deficient patients.

98 on mature B cells, the expansion of immature/transitional B cells in patients with ICL occurred at th

99 Here, we report the expansion of immature/transitional B cells in patients with ICL, which is asso

100 number of regulatory CD19(+)CD24(++)CD38(++) transitional B cells in peripheral blood relative to tre

101 We identified transitional B cells in rabbits and classified them into

102 he bone marrow was obtained from analyses of transitional B cells in splenectomized lymphotoxin alpha

103 is dispensable for the generation of CD23(-) transitional B cells in the bone marrow, but it is impor

104 ns is maintained by continuous production of transitional B cells in the bone marrow.

105 the underpinning cause of apoptosis in most transitional B cells in the periphery.

106 cisely downmodulated upon culture of splenic transitional B cells in the presence of BAFF.

107 d for optimal survival and TLR7 responses of transitional B cells in the spleen and was overexpressed

108 Further, we show that transitional B cells in the spleen are latently infected

109 one marrow and a block in the progression of transitional B cells in the spleen from the T1 to the T2

110 at shares multiple characteristics with late transitional B cells in the spleen.

111 erventions to replenish and sustain TREG and transitional B cells in these patients.

112 evated numbers of peripheral blood naive and transitional B cells in tolerant participants compared w

113 l maturation to delineate refined subsets of transitional B cells, including a late transitional B ce

114 Later transitional B cells, including T2 and T3, are found at

115 Immature/transitional B cells increase remarkably in diabetic CHC

116 y damage, lymphopenia, increased circulating transitional B cells, increased immunoglobulin M, and re

117 ight on a new alternative mechanism by which transitional B-cells inhibit T-cell proliferation and cy

118 pt maturation and prevent differentiation of transitional B cells into marginal zone and follicular B

119 ts receptor BAFF-R are crucial for selecting transitional B cells into the mature B cell pool (Thomps

120 A substantial influx of CXCR5(+) transitional B cells into the spleen occurred 18 h befor

121 f naive follicular mature cells produced per transitional B cell is 3- to 6-fold higher across tissue

122 t that the gain of survival potential within transitional B cells is dependent on the ability to prod

123 Moreover, the fraction of transitional B cells is doubled in the cord blood of car

124 ells is reduced and the frequency of CD27(+) transitional B cells is increased in patients with autoi

125 the same signal induces receptor editing in transitional B cells is not clear.

126 Finally, we identified transitional B cells isolated from CV facilities as poss

127 Our results support the idea that transitional B cells lose the capacity to edit, but are

128 Transitional B cells mark the crucial link between bone-

129 cquisition of resistance to apoptosis during transitional B cell maturation is achieved by integratio

130 Additional studies demonstrate that transitional B cells mature across a developmental conti

131 lly resistant to apoptosis, whereas immature transitional B cells more commonly expressed Ki67, the l

132 Transitional B cells must actively undergo selection for

133 est at the T0 stage at least in part because transitional B cells need to migrate into the white pulp

134 What determines whether transitional B cells newly emerged from the bone marrow

135 B cells, with especially robust increases in transitional B cell number, marginal zone B cell prolife

136 Blood transitional B-cell numbers were normal, but naive matur

137 mory B cells, with a concomitant increase in transitional B-cell numbers.

138 a significant increase in naive, memory, and transitional B cells on day 30 after vaccination, wherea

139 ch that excess expression pushes the A/WySnJ transitional B cells past the apoptosis checkpoint to ce

140 lopment in the spleen abruptly halted at the transitional B cell population 1 to 2 stage, a block tha

141 Here we show that transitional B-cells produced more IL-10 and expressed h

142 An increased percentage of peripheral transitional B cells producing IL-10 has been observed i

143 No association between transitional B cell proportions and either de novo donor

144 A) formation was evident, although preserved transitional B cell proportions were associated with red

145 et of B-cell reconstitution characterized by transitional B-cell recovery occurred either early (mont

146 Transitional B cells represent a target of negative sele

147 CD24(high)CD38(high) transitional B cells represent cells at a key stage in t

148 We show that integrin beta1-deficient transitional B cells, representing the precursors of MZ

149 Transitional B cells required CK2a to maintain adequate

150 Estradiol enhances transitional B cell resistance to apoptosis and expands

151 The fundamental role of BLyS in transitional B cell selection, coupled with the relative

152 Moreover, enriched transitional B cells showed a cell-autonomous defect lea

153 were relatively unperturbed, WASp-deficient transitional B cells showed enhanced proliferation in vi

154 cells were rescued at both the immature and transitional B cell stage in E2-treated mice.

155 c B cells that differentiatively arrest at a transitional B cell stage in the spleen.

156 2, B cell development is arrested at an IgD- transitional B cell stage that we term transitional type

157 tive and negative selection occur within the transitional B cell stage.

158 of B cells that fail to progress beyond the transitional B cell stage.

159 tal block in B cells at the naive and type 1 transitional B-cell stage and impaired circulating T fol

160 Data point to the late transitional B-cell stage as a crucial juncture at which

161 s recent advances pointing to the peripheral transitional B-cell stage as a major juncture where tran

162 ed selective advantage beginning at the late transitional B-cell stage; and (3) a similar in vivo sel

163 were occupied by GPI, operated mainly at the transitional B cell stages in the spleen, preventing the

164 They arise from within the transitional B-cell subpopulation and are characterised

165 The characterization of multiple transitional B cell subpopulations provides important in

166 transplantation, the peripheral CD19CD24CD38 transitional B cell subset strongly declined, regardless

167 ts of transitional B cells, including a late transitional B cell subset with a phenotype intermediate

168 We have characterized a distinct, late transitional B cell subset, CD21(int) transitional 2 (T2

169 Flow cytometry analysis of the splenic transitional B cell subsets demonstrated that MZ B cell

170 late calcium mobilization in each of the two transitional B cell subsets.

171 study indicates that altered distribution of transitional B-cell subsets highlights different regulat

172 +)CD27(+) memory and CD19(+)CD24(hi)CD38(hi) transitional B-cell subsets in healthy human donors.

173 B-cell progenitors in the bone marrow and of transitional B-cell subsets in the spleen.

174 ides evidence for the existence of different transitional B-cell subsets, each displaying unique phen

175 ow levels of AID in bone marrow immature and transitional B cells suppress the development of autorea

176 1 plays a critical role in the regulation of transitional B cell survival and maturation.

177 TNFRSF13C gene, is critically important for transitional B cell survival to maturity.

178 Nonetheless, CD24(hi)CD38(hi) transitional B cells (TBs) and CD24(hi)CD27(+) B cells (

179 ation in the spleen and other IgD-expressing transitional B cells that express lower levels of CD21 a

180 We describe herein a population of immature/transitional B cells that is overly represented in the p

181 sic apoptosis was observed in CD10+ immature/transitional B cells that likely arise as a result of HI

182 s and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow,

183 ow and results in the generation of immature transitional B cells that transit to the spleen to compl

184 The process of maturation from immature transitional B cell through to mature naive B cell inclu

185 s underlying the differential sensitivity of transitional B cells to apoptosis remain unclear.

186 The ability of transitional B cells to process and present Ag to CD4 T

187 Despite the relatively small contribution of transitional B cells to the human nonmemory pool, the nu

188 prolonged expansion of functionally immature transitional B cells, tonsil biopsy tissues revealed act

189 Transitional B cells transiently increased 2 mo posttran

190 s and found that subsets of CD24(hi)CD38(hi) transitional B cells (TrBs), CD24(hi)CD27(+) memory B ce

191 Transitional B cells turn over rapidly in vivo and are s

192 Finally, type 1 transitional B cells uniquely produce MMP9 in response t

193 In addition, the number of 564Igi transitional B cells was increased in Rasgrp1-deficient

194 his stimulatory condition, CD86 expressed by transitional B-cells was down regulated and T-cell proli

195 at the down-regulation of CD86 expression by transitional B-cells was due to the autocrine effect of

196 BCR)-mediated apoptosis and proliferation of transitional B cells were analyzed by flow cytometry.

197 TREG and transitional B cells were both durably expanded in patie

198 TREG and transitional B cells were found to be potent suppressors

199 decreased IgD(+)CD27(+) memory B cells while transitional B cells were increased, likely contributing

200 sion, although the percentages of mature and transitional B cells were normal.

201 Splenic immature transitional B cells were significantly expanded both in

202 ations, namely mature activated and immature transitional B cells, which are overrepresented in untre

203 linical use markedly reduced bone marrow and transitional B cells, which has therapeutic implications

204 Furthermore, treatment of transitional B cells with high concentrations of anti-Ig

205 n of marginal zone B cells at the expense of transitional B cells, without changes in follicular B ce