ライフサイエンスコーパス: translatable

1 cortical NMDA function that is also robustly translatable.

2 d invertebrates, making any discovery easily translatable.

3 in vivo effects; hence, it may be clinically translatable.

4 not all treatments and outcomes are directly translatable.

5 are required to assess if these findings are translatable.

6 at the antioxidant effects may be clinically translatable.

7 pies have yet to find a way to be clinically translatable.

8 ogression in model bacteria are not directly translatable [1, 2, 6-8].

9 on did not increase expression of a directly translatable, 5'-proximal gene in RNA3, implying that 1a

10 on patterns of data in a form that is easily translatable across different imaging modalities.

11 easy-to-implement apparatus that is readily translatable across sites.

12 findings suggest that IMPs are a clinically translatable acute intervention for TBI with a well-defi

13 This clinically translatable agent could noninvasively detect inflammati

14 r a scaffold for the synthesis of clinically translatable agents.

15 erous novel oncogenic drivers and clinically translatable alterations.

16 ridine, making messenger RNAs (mRNAs) highly translatable and non-immunogenic is one such feature tha

17 to play a role in partitioning mRNAs between translatable and nontranslatable pools, and our results

18 s, which indicates that these biomarkers are translatable and relevant to human disease.

19 e recovery of 3' fragments revealed that the translatable and the AUG-deficient mRNAs are both degrad

20 al grade and hence this approach should be a translatable and universal modification of hydrogels.

21 e normal degradation of CYC1 mRNAs, and that translatable and untranslated mRNAs are degraded by the

22 es such as 3 mug/L or 20% are measurable and translatable and would substantially increase detection

23 A clear, translatable, and enforceable policy addressing perinata

24 ch infections is needed, as are relevant and translatable animal models to identify and test concepts

25 new pharmacological agents developed through translatable animal research over the past few decades h

26 eneficial in this mouse model and provides a translatable approach that could be feasible for treatin

27 A highly novel and translatable approach to assess the efficacy of cell the

28 e have the potential to provide feasible and translatable approach to creating complex tissues and or

29 ompatible, semi-quantitative, and clinically translatable approach to evaluate the tumor targeting of

30 tude of subsequent VWS and may provide a new translatable approach to identify individuals at risk fo

31 we propose that this drug might represent a translatable approach to limit organ injury in septic pa

32 with KGF represents a novel and potentially translatable approach to promote rapid and durable thymi

33 ms of action of alum and introduce a readily translatable approach to significantly improve humoral i

34 trating the therapeutic merit of this highly translatable approach.

35 autophagy and subsequent ASO activity using translatable approaches such as fasting or ketogenic die

36 rge open reading frame (ORF) of 3,494 codons translatable as a polyprotein and two embedded shorter O

37 V-1 transgenic (Tg) rats using cross-species translatable assays.

38 Viroids are non-translatable, autonomously replicating circular RNAs tha

39 findings to pathological mechanisms that are translatable back to the patient.

40 results from our studies appear to be highly translatable because we discerned an inverse relationshi

41 Fear extinction offers a tractable and translatable behavioral readout of individual difference

42 d we have endeavored to develop a clinically translatable, belatacept-based regimen that could obviat

43 rotein analysis showed that betah0 encodes a translatable beta-like globin protein that can pair with

44 suggest that gamma power abnormalities are a translatable biomarker among species and demonstrate the

45 These effects could serve as a translatable biomarker for future clinical investigation

46 A translatable biomarker of MMP activity would enable deve

47 this assay for nitrotyrosine as a clinically translatable biomarker was demonstrated by quantifying b

48 nce our understanding of EEG recordings as a translatable biomarker.

49 netic and pharmacodynamic analyses, discover translatable biomarkers and evaluate specific therapeuti

50 To identify translatable biomarkers for an off-the-shelf responsive

51 raphy (PET) in live animals using clinically translatable biomarkers for apoptosis ((18)F-ICMT-11) an

52 To identify clinically translatable biomarkers of SU11248 activity, expression

53 the use of electrophysiological measures as translatable biomarkers.

54 of preclinical models to identify clinically translatable biomarkers.

55 l trial design from FXLEARN, and incorporate translatable biomarkers.

56 e unlikely to be both condition-specific and translatable but consistent with the possibility of biol

57 formation in NHPs, and offers a potentially translatable calcineurin inhibitor-free protocol inclusi

58 ls for the development of potent, clinically translatable cancer therapies.

59 l transcript elongation capable of producing translatable carAB transcripts.

60 ncoding phenylalanine in position 508 of the translatable CFTR sequence (accompanied by a C to T repl

61 ing site II were investigated by introducing translatable chimeric minigenes containing sequence -20

62 We developed an approach called translatable components regression (TransComp-R) to over

63 Future pro-cognitive drug trials should use translatable cross-species cognitive tasks with biomarke

64 as a versatile method to prepare clinically translatable degradable polyesters.1 A variety of functi

65 tions offer the prospect of a novel, rapidly translatable, disease-modifying, and neuroprotective tre

66 r anatomical target for the development of a translatable drug treatment.

67 Accurate and clinically-translatable early-age diagnostics do not exist due to A

68 reduce research waste and provide clinically translatable evidence.

69 feasibility of this concept as a clinically translatable experimental therapeutic.

70 We report here four translatable findings: (i) losartan treatment enhances t

71 cal courses and response to therapy could be translatable for discerning patients appropriate for mor

72 d by ribosomes under conditions that are not translatable for most mRNAs.

73 s of current therapies and may be clinically translatable for patients with therapy-sensitive and the

74 and minimal sample preparation, making this translatable for point-of-care applications.

75 n vivo, and the defects are rescued by a non-translatable form of the transcript.

76 If translatable from mice to humans, these data have import

77 d for neuroimaging findings to be clinically translatable, future studies need to focus on a-priori h

78 ng a genome-based study, we showed in silico translatable genes encoding Vgamma9, Vdelta2, and BTN3 i

79 d here offers high potential as a clinically translatable genetic modification strategy for cell ther

80 Superinfecting BVDV failed to deliver a translatable genome into acutely infected cells, indicat

81 ats displayed a significant 60% reduction in translatable GLP1R mRNA.

82 ant HD protein by decreasing the quantity of translatable HD mRNA.

83 y lifestyles, but few studies have developed translatable health behavior change interventions.

84 that transcriptional induction of a readily translatable HuR mRNA may be driven by a mechanism known

85 uggest that HP DHA, a potentially clinically translatable imaging agent, holds special promise in ima

86 for the design of excretable and thus highly translatable imaging agents.

87 spectroscopic imaging (MRSI) is a clinically translatable imaging method that allows noninvasive moni

88 cardiography is a widely used and clinically translatable imaging modality for the evaluation of card

89 lthough clinically relevant, is not directly translatable in animal models.

90 Ex vivo results were translatable in vivo, confirming that intercellular adhe

91 As more translatable information about the larger adipokine-CV-l

92 vailable, this approach should be clinically translatable, insofar as it may assess the efficacy of i

93 system for developing potentially clinically translatable interventions for suppressing diabetogenic

94 two editing strategies that are potentially translatable into clinical application.

95 ing, identify interventions that are readily translatable into clinical practice, and cost less than

96 potential points on the endocardial surface translatable into electrograms or color-coded activation

97 evolutionarily conserved, our results may be translatable into new immunotherapies for the treatment

98 in full-scale N(2)O emission characteristics translatable into viable N(2)O control strategies and co

99 f-concept approach, we explored a clinically translatable intronic CRISPR (clustered regularly inters

100 All potentially translatable lncRNA ORFs had only a single peptide match

101 The translatable MALDI-IMS glycan profiling workflow describ

102 pletes cysteine and cystine, demonstrating a translatable means to induce ferroptosis in PDAC.

103 iferate and persist in vivo, demonstrating a translatable means to prevent ferroptosis in adoptive ce

104 osttranscriptionally into pre-mRNA to create translatable messages.

105 as genomes ((Cap)1G) or retained in cells as translatable messenger RNAs (mRNAs) ((Cap)2G and (Cap)3G

106 uridylate insertions and deletions, creates translatable messenger RNAs (mRNAs) out of nonsense pre-

107 which are not representative of the pool of translatable messenger RNAs.

108 pyruvate or alpha-ketoglutarate as potential translatable metabolic biomarkers of response to temozol

109 With the aim of improving the discovery of translatable metabolite biomarkers, we present search an

110 investigation as a cellular, nonchimeric and translatable method for inducing antigen-specific tolera

111 minimally invasive, nonviral and clinically translatable method of gene therapy.

112 signaling in DCs, suggesting an immediately translatable method to empower DC vaccination approaches

113 ER stress utilizing PBA can be a clinically translatable method to treat systemic cGVHD.

114 icular rate by adenosine might be clinically translatable methods for improving stem cell engraftment

115 y advantages offered by combining clinically translatable metronomic low-dose chemotherapy and IP pha

116 a strong Shine-Dalgarno element (SD2) and a translatable mini-ORF of six codons.

117 RNA (kRNA) editing is a process that creates translatable mitochondrial mRNA transcripts from cryptog

118 Our analysis presents a translatable model for the optimization of three-photon

119 LHM represent an interesting translatable model of human hepatic and lipoprotein meta

120 l mechanism(s), and to identify a clinically translatable model to assess the drug-drug interaction (

121 We have developed a clinically translatable model to separate and investigate strategie

122 tion, this has not been tested in clinically translatable models of hypoxia-reoxygenation injury.

123 this link is potentially targetable, robust translatable models to reliably quantify and track neuro

124 Thus, we report a translatable modular biomolecular approach with which to

125 This may provide a clinically translatable molecular imaging approach to characterize

126 an approach for the discovery of robust and translatable molecular signatures in GBM.

127 peutic agents with OVT, and using clinically translatable mouse tumor models to potentially translate

128 opment and validation of more predictive and translatable MR imaging protocols that can be used as cr

129 (ethical obligations precluded use of a non-translatable mRNA control) at randomized sites on the fo

130 ect of intron content on the rate of mature, translatable mRNA degradation has not been demonstrated.

131 They were similar in the ability to produce translatable mRNA except in the cases of NS1 and NS2, wh

132 l for mitochondrial respiration, but only if translatable mRNA for NRF-1 is available.

133 together as a recapping enzyme to regenerate translatable mRNA from decapped mRNA.

134 nding, and is proportional with the level of translatable mRNA.

135 ling ribosome recruitment to a fully edited, translatable mRNA.

136 ondria of kinetoplastid protists and creates translatable mRNAs by uridine insertion/deletion.

137 The mechanism by which ribosomes select translatable mRNAs from the complex mixture of incomplet

138 ucleotides in many preedited mRNAs to create translatable mRNAs in the mitochondria of the parasite T

139 ines from precursor-mRNAs to produce mature, translatable mRNAs.

140 s uridines from pre-mRNAs to produce mature, translatable mRNAs.

141 s and can be targeted by a novel, clinically translatable nanobioconjugate to inhibit glioma growth.

142 key consideration in the design of safe and translatable nanomedicines.

143 Given the translatable nature of the assays used, it is anticipate

144 c function and thus offers a more clinically translatable neovasculogenic therapy.

145 main effect of prenatal nutrition on highly translatable neurodevelopmental outcomes.

146 protein:polymer scaffolds provide a viable, translatable niche for hepatocytes and offers a solution

147 acting as a general anxiolytic, in a highly translatable nonhuman model, the rhesus monkey.

148 esults also provide the basis for clinically translatable noninvasive imaging markers for predicting

149 (11)C-PABA PET is an innovative, clinically translatable, noninvasive, bacteria-specific diagnostic

150 educing dietary BCAAs may represent a highly translatable option for the treatment of obesity and ins

151 ngineered flaps could represent a clinically translatable option that may circumvent issues related t

152 esistant transgenic plants expressing either translatable or nontranslatable versions of the coat pro

153 d >95% by induction of constructs for either translatable or untranslatable PLGA RNAs.

154 tial of BNPs as a biocompatible platform for translatable oral biofilm applications.

155 ading frame, arguing that only elements with translatable ORFs can be incorporated into the chromosom

156 the opportunity to answer the unmet need for translatable outcome measures for comparing treatment ef

157 This approach provides a translatable paradigm to investigate the mode and mechan

158 iers for inhalable RNA medicines and opens a translatable path for treating diverse pulmonary disease

159 ration microbubbles (SonoVue) and clinically translatable PEGylated VEGFR2-targeted microbubbles (BR5

160 perturbed with drugs to provide immediately translatable, personalized information to guide therapy.

161 e PET has potential to serve as a clinically translatable pharmacodynamic biomarker of GLSi.

162 xis as a target for a potentially clinically translatable pharmacological approach that can block T1D

163 r growth insofar as it offers a biologically translatable picture of how local and global action may

164 osclerotic lesions and suggests a clinically translatable platform for the detection of atherosclerot

165 DCs of highly potent toxins thus introduce a translatable platform that may be exploited to maximize

166 oustic imaging has evolved into a clinically translatable platform with the potential to complement e

167 ctivates this process, allowing synthesis of translatable polyadenylated TNF-alpha mRNA.

168 s in the localization of bound mRNA from the translatable pool to mRNA decay sites, such as processin

169 n of mRNAs temporarily removes them from the translatable pool; these repressed transcripts are stabi

170 300 as a novel regulator of endomitosis with translatable potential for therapeutic application.

171 in-wide fingerprints of alcohol effects with translatable potential.

172 rch and accelerate the generation of readily translatable preclinical data that could ultimately infl

173 ata of PDX tumors in developing a clinically translatable predictive cancer biomarkers for cancer pat

174 te-specific recombination system to create a translatable reading frame by excision of a blocking seq

175 1 cells cDNA library, a clone of most of the translatable region of HDGF was obtained and used to syn

176 uirements for transparent, reproducible, and translatable research are accelerated by the rapid growt

177 appropriate and a high-priority platform for translatable research in host-microbiome interactions.

178 empirical approaches without consistent and translatable results.

179 g signals but not to easily interpretable or translatable results.

180 ibosomes which are converted to cold-adapted translatable ribosomes by the association of cold-shock

181 e inducing signal for the cold-unadapted non-translatable ribosomes which are converted to cold-adapt

182 In cells, each targets translatable RNAs for cleavage and requires host Xrn1 to

183 confers tropism to bone and unveil a readily translatable roadmap for programming cellular traffickin

184 LT-1 possesses promising characteristics for translatable ROS detection and provide a general approac

185 ecular brush is expected to provide a highly translatable route for aptamer-based therapeutics.

186 ation of a fully functional solid organ at a translatable scale has not yet been achieved.

187 A transgene encoding a translatable sense-strand RNA from the 5' end of iaaM si

188 h methods can promote functional recovery in translatable settings.

189 Many tissues also produce translatable spliced transcript (SpORF2).

190 constructed around sense, antisense and non-translatable-stop strategies (pGRsensehph, pGRantihph an

191 OPC differentiation uncovered here suggest a translatable strategy for efficient de novo myelination

192 ineered porcine flaps as a novel, clinically-translatable strategy for future application in reconstr

193 ibrinolytic cotherapy is therefore a rapidly translatable strategy for improving therapeutic effectiv

194 Thus, our results demonstrate a potentially translatable strategy for restoring cortical dependent f

195 after transplantation and described a novel translatable strategy for targeted complement inhibition

196 sults may represent a potentially clinically translatable strategy for the development of protocols f

197 -target exposure and represents a clinically translatable strategy in myocardial regenerative therape

198 after transplantation and identify a readily translatable strategy of exceptional potency, which avoi

199 Such treatments provide a readily translatable strategy that warrants investigation in cli

200 stered human CAR T-cells, offering a readily translatable strategy to augment tissue delivery, thereb

201 Our findings also provide a rapidly translatable strategy to enhance the outcome of anti-VEG

202 tion in the niche, but also define a rapidly translatable strategy to enhance transplantation therape

203 reclinical validation of a novel and readily translatable strategy to improve cancer therapy.

204 vaccine effect presents a simple and readily translatable strategy to potentiate adaptive anti-tumor

205 med at augmenting ApoE may serve as a novel, translatable strategy to promote functional recovery in

206 on tumor immunity and propose a potentially translatable strategy to re-engineer the tumor-immune mi

207 Editing Machinery (STEM) LNPs may provide a translatable strategy to treat monogenic blood diseases

208 ress SHP-1-specific small interfering RNA, a translatable strategy, also exhibited enhanced antitumor

209 d represents a novel, potentially clinically translatable, strategy for the attenuation of GVHD.

210 In this clinically translatable study, we explored the critical role of zin

211 meric antigen receptors (CAR) are clinically translatable synthetic fusion proteins that can redirect

212 novel approach is the first truly clinically translatable system to unlock the therapeutic potential

213 ther diseases, motivating the development of translatable technologies for biological ROS imaging.

214 ific artificial microRNA is an effective and translatable therapeutic approach for ALS.

215 its safety profile, lactoferrin is a readily translatable therapeutic option for the management of CO

216 processes in adults and identify potentially translatable therapeutic strategies for ischemic heart d

217 Here, as a potentially translatable therapeutic strategy for human pathological

218 as a personalized and in our view clinically translatable therapeutic strategy to treat NS-associated

219 ckade of IL-12/23p40 may represent a readily translatable therapeutic strategy.

220 There is a need for developing clinically translatable therapy for preventing fetal origins of car

221 T: There is a need for developing clinically translatable therapy for preventing fetal origins of car

222 otor recovery and define CL-VNS as a readily translatable therapy to restore function after nerve dam

223 treat kidney disease and shows promise as a translatable therapy.

224 collagen hydrogel could produce a clinically translatable thermoresponsive hydrogel to attenuate post

225 ese magnetic resonance methods is clinically translatable, these markers could contribute to early di

226 The intervention is translatable through existing telephone cancer support a

227 this preclinical stage because it is readily translatable to a preformed implant product.

228 potential biomarkers and therapeutic targets translatable to all CKDs.

229 crystalline materials; this strategy is not translatable to biopolymers observed in nature.

230 -scale measurements, a response not directly translatable to canopies.

231 it has remained unclear if these effects are translatable to cells.

232 ll be used to illustrate how modeling can be translatable to clinical applications.

233 The lessons from NAT are translatable to clinical oncology and may help to promot

234 the recipient and is intended to be directly translatable to clinical use.

235 A mutation detection method should be easily translatable to electrophoretic analyses on microfluidic

236 structural tunability of these electrodes is translatable to functional tunability as the density of

237 ys and suggest that CR mechanisms are likely translatable to human health.

238 r vaccine kinetics in a needle-free platform translatable to human immunization.

239 scriptional changes in the macaque model are translatable to human M. tuberculosis infection and offe

240 e disease in an animal model and is directly translatable to human patients is critical.

241 These findings appear translatable to human patients with lupus nephritis, who

242 If these findings are translatable to human patients, they will have important

243 which often do not provide results that are translatable to human patients.

244 ro or in vivo, have been problematic and not translatable to human patients.

245 s on confirming that the rodent findings are translatable to human physiology and to diseases such as

246 These doses are scalable and translatable to humans and may provide the foundation fo

247 r imaging reporter gene labeling is directly translatable to humans and provides useful information o

248 However, the data gained are not always translatable to humans because of major species differen

249 se findings is limited by dosing that is not translatable to humans or is associated with off-target

250 If translatable to humans, a subset of migraine auras may b

251 of effort-related decision-making are highly translatable to humans, and an emerging body of evidence

252 Assuming our results are translatable to humans, they raise concerns that analges

253 ed protocol, make this technique potentially translatable to humans.

254 s that the behavior of CRLX101 in animals is translatable to humans.

255 observed ex vivo and in vivo in mice is also translatable to humans.

256 ar stress, these advantages seem not readily translatable to in vivo models.

257 The nanoparticles are readily translatable to in vivo studies on animals and ultimatel

258 on processes are rapid, straightforward, and translatable to industrial mass productions.

259 approach is environmentally friendly, fully translatable to industry and thus represents a significa

260 These findings may be particularly translatable to medical device applications.

261 ith the added advantage that the approach is translatable to MRI.

262 ression of Ube3a isoform 2 causes phenotypes translatable to neurodevelopmental disorders.

263 ommunicate with neighbouring cells, might be translatable to other acidifying epithelia.

264 od-production systems and these concepts are translatable to other built environments.

265 e approach we describe should prove directly translatable to other GPCRs, providing a new tool for li

266 hods and results presented herein are likely translatable to other mammalian cell systems.

267 ensure that these experiments are optimally translatable to patient care.

268 This transduction protocol may be directly translatable to patients with sickle cell disease who ca

269 If translatable to patients, these findings would improve t

270 d understand that not every AI innovation is translatable to renal pathology, while renal pathologist

271 on the crystalline samples are not obviously translatable to restrict the single-molecule conformatio

272 iption of such networks in a simple language translatable to Systems Biology Markup Language would al

273 s in cynomolgus monkeys (cynos) is generally translatable to that in humans.

274 This combination should be translatable to the clinic and other immunosuppressive c

275 Moreover, our device is easily translatable to the clinic, as the ergonomics, visual ou

276 c brain regions, this neuroimaging approach, translatable to the clinic, promises to be useful in exp

277 mor hypoxia noninvasively and is immediately translatable to the clinic.

278 hroughput, are expensive, and are not easily translatable to the clinic.

279 , with special emphasis on advances that are translatable to the clinic.

280 localized bacterial infections that could be translatable to the clinic.

281 n effective therapeutic approach potentially translatable to the clinic.

282 nt implications in understanding ICV and are translatable to the clinical setting.

283 These efforts are directly translatable to the development of sensitive detection o

284 This promise, however, is not directly translatable to the growing liver, where high rates of h

285 e to demonstrate so far that this finding is translatable to the human receptor.

286 y of purposes, these results are immediately translatable to the treatment of pancreatic cancer patie

287 Closed-loop optogenetic approaches may be translatable to therapeutic applications in humans.

288 in machine-readable formats that are readily translatable to various software.

289 Our findings are relevant, but not directly translatable, to human male infertility cases.

290 ing is a powerful new minimally invasive and translatable tool that can be used to track and quantify

291 burden in atheromata, providing a clinically translatable tool to identify inflamed plaques and to mo

292 to be effective, including the rational and translatable top hit of PARP plus topoisomerase I inhibi

293 In this article, we describe a clinically translatable topical, neuroprotective treatment (recombi

294 ed increased expression of the shorter, more translatable transcript and decreased expression of the

295 hronic HBV mouse model, offering a promising translatable vaccination strategy for the functional cur

296 der to establish fundamental, effective, and translatable vaccine design parameters, a highly modular

297 ltrasound molecular imaging using clinically translatable vascular endothelial growth factor receptor

298 geting myelinating Schwann cells that can be translatable, we delivered a lentiviral vector using a s

299 ered by rational design, but also clinically translatable, with robust function in primary human T ce

300 Furthermore, accumulation of translatable zygotic mRNAs is minimal in 1-cell embryos