ライフサイエンスコーパス: translation

1 s (DPRs) via repeat associated non-AUG (RAN) translation.

2 the rapidly growing field of local synaptic translation.

3 otes is RNA splicing, which readies mRNA for translation.

4 18S and 28S rRNA levels and elevated protein translation.

5 sm, ubiquitination, chromatin regulation and translation.

6 icles will result in more effective clinical translation.

7 therefore offer key advantages for clinical translation.

8 ordingly, it was blocked by an inhibition of translation.

9 kissing stem-loop interaction to facilitate translation.

10 the largest group being involved in protein translation.

11 iation factors that dampens synaptic protein translation.

12 electivity for the inhibition of prokaryotic translation.

13 uction, demonstrating potential for clinical translation.

14 rd interviews, and possible subtle errors in translation.

15 roplast thylakoids, vesicle trafficking, and translation.

16 hed on diverse sequence motifs known to slow translation.

17 ely charges leucine to tRNA(Leu) for protein translation.

18 - representing a further barrier to clinical translation.

19 re tissue-specific cis-regulators of protein translation.

20 ze candidate selection through discovery and translation.

21 research area, with an emphasis on clinical translation.

22 anning of ORFs outside periods of productive translation.

23 p depletion was simulated, confirming slowed translation.

24 t the growth defect stems from a shutdown of translation.

25 PAF1/2 dimer induces A/U-tailing to activate translation.

26 e uptake, and integrity of transcription and translation.

27 ool and thus presumed to not directly impact translation.

28 a, including genes involved in mitochondrial translation.

29 ad the highest upregulation in mitochondrial translation.

30 regulation to ensure proper mRNA export and translation.

31 arbons to support the bioenergetic demand of translation.

32 ing RNAs strongly positions it to act beyond translation.

33 y, centrality and antiquity are ingrained in translation.

34 icles for nanomedicine and eventual clinical translation.

35 associated, at least in part, with enhanced translation.

36 abundance estimation and infer mechanisms of translation.

37 ve challenges, and outlook on the pathway to translation.

38 evance of ex vivo activity assays to in vivo translation.

39 s in the inner ear sense both head tilts and translations.

40 l an unexpected high-degree of asynchrony in translation activity between mRNA molecules.

41 news translation in preserving text meaning (translation adequacy).

42 d consequently led to increased JNK2 protein translation and c-Jun activation.

43 ion of miR-1185-1 and further repressed CD24 translation and colorectal cancer stemness.

44 ement of protein dynamics, including protein translation and degradation.

45 t screenings combining coupled transcription/translation and droplet-based microfluidics.

46 es is the intimate interplay between protein translation and folding, and within this the ribosome pa

47 erential expression of host genes related to translation and innate immune response could contribute

48 o membraneless sites usually occurs prior to translation and involves specific sequences known as zip

49 iated cell signaling will hasten therapeutic translation and is reported herein.

50 RP) is an RNA binding protein that regulates translation and is required for normal cognition.

51 ion is a rate-limiting step in cap-dependent translation and is the main target of translational cont

52 a-catenin pathway by inhibiting beta-catenin translation and mTOR activity and thereby reduces HCC ce

53 4E (EIF-4E) protein, a key regulator of gene translation and protein function, is controlled by mTORC

54 ys which lead to adaptive regulation of mRNA translation and protein synthesis.

55 cells, we show that Ifit1b can modulate host translation and restrict WT mouse coronavirus infection.

56 scriptional program leading to enhanced mRNA translation and resulting in an increased PD-1 amount in

57 er hemi pelvises are symmetrical in terms of translation and rotation using 3D reconstruction, point

58 owing Noblit and Hare's seven-step method of translation and synthesis to generate a novel conceptual

59 Noblit and Hare's methodology for translation and synthesis was followed in developing a n

60 Our findings suggest that translation and tilt signals reach Purkinje cells via se

61 mutant is globally defective in chloroplast translation, and has varying deficiencies in the accumul

62 important roles in RNA stability, efficient translation, and immune evasion.

63 etic autism risk factor Nlgn3, regulation of translation, and oxytocinergic signalling.

64 nized role of Pdcd4 in controlling BDNF mRNA translation, and provided a new method that boosting BDN

65 t viral entry, endocytosis, genome assembly, translation, and replication.

66 ay, observed at cellular (eg, transcription, translation, and signaling), organ (eg, contractility an

67 this review, we discuss how OCM impacts the translation apparatus (composed of ribosome, tRNA, mRNA,

68 tides in tRNA are critical components of the translation apparatus, but their importance in the proce

69 tions and challenges for their discovery and translation are discussed.

70 nd potential avenues for future research and translation are discussed.

71 o steps of gene expression-transcription and translation-are spatially and temporally coupled.

72 Api-mediated translation arrest leads to the futile activation of the

73 ere used to validate MetAB transcription and translation as present in the IA3902 DeltaluxS::metAB mu

74 revealed eIF4G1, a protein for Cap-dependent translation, as a potential target of CUL3.

75 translation in both cell-based and in vitro translation assays.

76 Here, we show that TGFbeta promotes protein translation at least in part by increasing the mitochond

77 IFIT1 inhibits translation at the initiation stage by competing with th

78 luding cryptic sense/antisense promoters and translation, attenuation, incorrect start codons, and a

79 ne in the ribosome's P- or A-site slows down translation, but the effect of other pairs of amino acid

80 uromycin is a tyrosyl-tRNA mimic that blocks translation by labeling and releasing elongating polypep

81 elligence and deep learning to medical image translation, by employing a theoretical framework capabl

82 rgely unfolded, lacking the PK helix so that translation can be initiated at the ribosome binding sit

83 during slowed cell cycles by down-regulating translation capacity.

84 ein kinase C decreased and phase-shifted the translation component of Purkinje cell responses, but di

85 Among translation components, RNA association was most reduced

86 However, mechanistic insight and clinical translation continue to lag the pace of risk variant ide

87 nse-mediated mRNA decay (NMD) is a conserved translation-coupled quality control mechanism in all euk

88 How transcription-translation coupling mitigates these conflicts is unknow

89 iates NusG- and NusA-dependent transcription-translation coupling.

90 perturbation of RAB13 mRNA targeting-but not translation-depolarised filopodia dynamics in motile end

91 gulated at the level of messenger RNA (mRNA) translation during human hematopoietic development.

92 es of hibernation that suggests induction of translation during interbout arousals.

93 n near the LLO N terminus cause enhanced LLO translation during intracellular growth, leading to host

94 teria regulate translation of LLO to promote translation during starvation in a phagosome while repre

95 Examination of translation efficiency across the yeast membrane proteom

96 ults were further validated by assessing the translation efficiency of KRAS in cell lines that differ

97 amily to experimentally demonstrate that the translation efficiency of oncogenes that are preferentia

98 th translation, we also assessed its role in translation efficiency.

99 native to other methods to assess transcript translation efficiency.

100 of these two amino acids, leading to reduced translation efficiency.

101 ort that MCMV RNA contains a cap-independent translation element (CITE) in its 3' untranslated region

102 n important quality control mechanism during translation elongation and suggest that translational si

103 tein synthesis in a mouse liver by targeting translation elongation factor 2 (eEF2) with RNAi.

104 f Human Immunodeficiency Virus (HIV) perturb translation elongation.

105 principles surprisingly similar to canonical translation elongation.

106 logs, or release of mRNAs from ribosomes via translation elongation.

107 osome intersubunit rotation that accompanies translation elongation.

108 Translation-elongation speed is influenced by molecular

109 that SgrS forms a duplex with a uridine-rich translation-enhancing element in the manY 5' untranslate

110 y control (RQC) system that resolves stalled translation events is activated when ribosomes collide a

111 nthesis and that high expression of ABCE1, a translation factor directly upregulated by N-MYC, is its

112 es among cohorts, we introduced a horizontal translation factor to the dataset of each cohort.

113 ratus (composed of ribosome, tRNA, mRNA, and translation factors) and regulates crucial steps in prot

114 s of ARF include many ribosomal proteins and translation factors.

115 st radiographs after the cycle-GAN's texture translation (fake chest radiographs), showed decreased i

116 lizing the negative arm of the transcription/translation feedback loop without affecting period lengt

117 en by a functionally conserved transcription-translation feedback loop.

118 s are generated by interlocked transcription-translation feedback loops that establish cell-autonomou

119 amined in humans without success in clinical translation for infection imaging.

120 Protrusions act as hotspots of translation for RP-mRNAs, enhancing RP synthesis, riboso

121 harbor the potential to facilitate clinical translation for the treatment of both liquid and solid t

122 This study reports on a method translation from conventional one-dimensional (1D) GC to

123 ntly described system to visualize and track translation from individual HIV-1 RNA molecules in livin

124 effects in cellulo are unclear, delaying the translation from preclinical studies to clinical trials.

125 Translation from the laboratory to the field is likely t

126 ardiovascular diseases, attempts at clinical translation have shown mixed results.

127 individual domains in large proteins during translation helps to avoid otherwise prevalent inter-dom

128 rodent analog BC1 as negative regulators of translation in both cell-based and in vitro translation

129 of endoplasmic reticulum (ER)-targeted mRNA translation in DIS3L2-deficient cells.

130 To visualize the process of translation in human mitochondria, we report ~3.0 angstr

131 ence of mTOR, CDK1 activates eIF4E-dependent translation in MPs through phosphorylation of 4E-BP1.

132 ed professional-agency English-to-Czech news translation in preserving text meaning (translation adeq

133 onditioned-threat responses, whereas de novo translation in protein kinase Cdelta-expressing inhibito

134 roach to explore the timing of maternal mRNA translation in quiescent oocytes as well as in oocytes p

135 We show that de novo translation in somatostatin-expressing inhibitory neuron

136 ng revealed an uncharacterized complexity of translation in this archaeon with bacteria-like, eukarya

137 otein kinase C-dependent mechanisms regulate translation information processing in cerebellar cortex

138 sRNA-mRNA annealing, typically resulting in translation inhibition and RNA turnover.

139 Translation inhibition dissociated the expressome, where

140 The mechanism for translation inhibition involved the phosphorylation of e

141 r for both Ifit1 and Ifit1b, promoting their translation inhibition.

142 es recently identified several candidate RAN translation inhibitors from a high-throughput small-mole

143 ct the evolution and function of prokaryotic translation initiation and other RNA-mediated processes.

144 F2B to block eIF2 recycling, thereby halting translation initiation and reducing global protein synth

145 ion results in specific misregulation of the translation initiation and ribosome biogenesis machinery

146 sential for post-transcriptional processing, translation initiation and stability.

147 Modulation of the fidelity of translation initiation by OCM opens new avenues to under

148 or start codon and prevents formation of the translation initiation complex.

149 nase R [PKR]) that phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha), which

150 tein kinase R, phosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2alpha), t

151 the reversible polymerization of eukaryotic translation initiation factor 2B, an essential enzyme in

152 The eukaryotic translation initiation factor 4E (EIF-4E) protein, a key

153 e cap, inhibits interactions with eukaryotic translation initiation factor 4E, and resists decapping.

154 dditionally, expression levels of eukaryotic translation initiation factor 4GI (eIF4GI) and of its ho

155 the synthesis of proteins controlled by the translation initiation factor eIF2(11).

156 lation is supported by the localization of a translation initiation factor eIF4E and by ribosome-boun

157 s, including therapy resistance, require the translation initiation factor initiation elongation fact

158 tion of eIF2alpha (P-eIF2alpha), a conserved translation initiation factor, is clock controlled in Ne

159 report a neuron-specific microexon in eIF4G translation initiation factors that dampens synaptic pro

160 etabolites regulate the fidelity and rate of translation initiation in bacteria and eukaryotic organe

161 In G0 cells, canonical translation initiation is inhibited; yet we find that in

162 resistance strategies, we characterized the translation initiation mechanism of MCMV.

163 RISPR technology to mutate a single internal translation initiation site in Cx43 (M213L mutation), wh

164 d upstream of open reading frames facilitate translation initiation.

165 tial GTPase Initiation Factor 2 (IF2) during translation initiation.

166 ype level by a feedback mechanism increasing translation initiation.

167 S-box riboswitches is predicted to regulate translation initiation.

168 tRNA synthetases, tRNA-modification enzymes, translation-initiation and elongation factors, and ribos

169 ing gene circuits by cell-free transcription-translation into cell-sized compartments, such as liposo

170 lished methods are costly which limits their translation into clinical practice.

171 l decision making, with the aim to encourage translation into day-to-day practice.

172 DAZL binds to mRNAs whose translation is both repressed and activated during matur

173 Here, we argue that this limited translation is driven by a combination of intersubject h

174 Inhibiting mitochondrial translation is known to increase lifespan in C. elegans,

175 localization, we show that peripheral RAB13 translation is not important for the overall distributio

176 Here we show that, unlike replication, translation is not inhibited by arrested transcription e

177 Since bacterial translation is often modulated by enhancer-like elements

178 While human translation is still rated as more fluent, CUBBITT is sh

179 On-site translation is supported by the localization of a transl

180 We also found that JUND translation is unaffected by inhibition of mTOR, unless

181 RAB13 translation leads to a co-translational association of n

182 opens new avenues to understand alternative translation mechanisms involved in stress tolerance and

183 ia-like, eukarya-like, and potentially novel translation mechanisms.

184 ystems, including signaling, RNA processing, translation, metabolism, nuclear integrity, protein traf

185 ternative to state-of-the-art MR-to-CT image translation methods.(C) RSNA, 2020.

186 involves differential gene expressions, post-translation modifications, and signaling cascades.

187 ove in opposite directions along the genome, translation must be inhibited at a defined point followi

188 on with (35)S-labeled methionine resulted in translation of a 47 aa micropeptide.

189 ubjective and current techniques require the translation of a continuous variable to a categorical va

190 signal a promising step toward the clinical translation of a functional bioengineered ACL matrix.

191 nts, indicating that UPF1/NMD suppresses the translation of aberrant RNAs.

192 al changes in the active site, including the translation of an alpha-helix by 1 angstrom.

193 tes may be a significant barrier to clinical translation of cardiomyocyte cell therapies for heart di

194 y incomplete protein products resulting from translation of damaged or problematic mRNAs.

195 type, and environment will require extensive translation of data into a standard, computable form and

196 be made to increase the perception, use, and translation of directives of the neurocritically ill.

197 alyses, both of which will inform the future translation of E. faecium sequencing into routine outbre

198 We demonstrated that WDR77 regulated the translation of E2F1 and E2F3 mRNAs through the 5' untran

199 ionably the most critical step in the future translation of genome editing technologies.

200 As the development and translation of GTs gain pace, success can only ultimatel

201 ggregates, which was not linked to increased translation of IgG mRNA, but rather to impairment of aut

202 giography) provides an unrivaled way for the translation of images from one domain to the other.

203 To accelerate clinical translation of imaging techniques, we also describe exam

204 d molecular insights into prion biology, but translation of in vitro to in vivo findings is often dis

205 ndings suggest that m6A functions to enhance translation of key morphogenetic regulators, while also

206 inate the transport, localization, and local translation of key mRNAs in learning and memory and expa

207 target sites for microRNAs known to repress translation of LDLR.

208 chanism to explain how the bacteria regulate translation of LLO to promote translation during starvat

209 Our work highlights extensive translation of lncRNAs during hESC pancreatic differenti

210 provide a potential roadmap for accelerating translation of microbiome science toward microbiome-targ

211 1 and establishes a roadmap towards clinical translation of modulating miRs for various cancer types.

212 Translation of modulation of drug target activity to the

213 o that functional investigation and clinical translation of molecular research data are still inhibit

214 Up to now, however, translation of MS-based proteomics to the clinic has bee

215 However, translation of MSOT to the clinic is still in its prelim

216 ations must be carried out prior to clinical translation of nanomaterials-based formulations to avoid

217 s thought to be facilitated by the pervasive translation of non-genic transcripts, which exposes a re

218 cGAN-aided motion correction enables the translation of noninvasive clinical absolute quantificat

219 filtration function will be instrumental for translation of organoid technology for clinical applicat

220 The accurate translation of reads into the monomer alphabet turns the

221 reduces cell growth, polysome assembly, and translation of reporter mRNAs with structured 5'UTRs.

222 s associated with a specific decrease in the translation of ribosomal proteins.

223 FMRP, an RNA binding protein that represses translation of some of its target transcripts.

224 nthesis were unaffected by nsun-1 depletion, translation of specific mRNAs was remodeled leading to r

225 become an alternative to better balance the translation of spraying effort into impact, particularly

226 in complexes contributes to the preferential translation of stress-responsive gene transcripts during

227 y and present a conceptual framework for the translation of such findings into clinical practice, and

228 erial small RNAs (sRNAs) efficiently inhibit translation of target mRNAs by forming a duplex that seq

229 Similar to DNA replication, translation of the genetic code by the ribosome is hypot

230 will be unavoidably required for the further translation of these agents/approaches.

231 Translation of these mRNAs occurs during early seed germ

232 This poses a serious roadblock for clinical translation of this approach.

233 erspectives for future research and clinical translation of this new theranostic modality are also di

234 gations, arguing that the time is coming for translation of this work into clinical practice.

235 populations, and identifying ways to improve translation of trial results to general practice.

236 or self-renewal is driven by eIF2B5-mediated translation of ubiquitination genes.

237 r, fundamental discoveries and technological translations of chiral nanoceramics have received substa

238 For the Bengali and Urdu translations of the abstract see Supplementary Materials

239 inversion, time-reversal, and an additional translation operation.

240 f toxic protein aggregates that occur during translation or periods of stress.

241 escribe how unexpanded CGG repeats and their translation play conserved roles in regulating fragile X

242 ple binomial probability metric to ascertain translation probability.

243 opt native conformations early on during the translation process, with each subsequently translated r

244 revealing complex age-related changes in the translation process.

245 ations in cell cycle, metabolic, and protein translation processes.

246 Aborted translation produces large ribosomal subunits obstructed

247 most genes, one ORF represents the dominant translation product, but we also detect genes with trans

248 This two-tier functional redundancy for translation quality control breaks down during oxidative

249 erful technology for globally monitoring RNA translation; ranging from codon occupancy profiling, ide

250 lizes stimulus-induced and constitutive mRNA translation rate, decreases lactate and key glycolytic a

251 Protein translation rates serve as the integrator that proportio

252 isions would allow cells to dynamically tune translation rates while ensuring fidelity of the resulti

253 ce is the key to understand the mechanism of translation regulation and mRNA metabolism.

254 therefore important that the process of mRNA translation remains in excellent synchrony with cellular

255 mRNA translation represents the last step of genetic flow and

256 ion of the target mRNA and the efficiency of translation repression is the base pairing between the '

257 n of PDCD4 mRNA and prevents miR-21-mediated translation repression.

258 the PDCD4 mRNA and mitigate miR-21-mediated translation repression.

259 Filament formation transformed Orb2 from a translation repressor to an activator and "seed" for fur

260 sulting in predictions enriched for Ribo-seq translation signals.

261 These findings reveal key differences in translation, solubility, and protein aggregation of DPRs

262 t molecule (RBM3) whose manipulation affects translation specifically in synapses, and not at the who

263 he slow-moving to the fast-moving end of the translation-speed distribution in the future.

264 In Caenorhabditis elegans, RBPs control the translation, stability, or localization of maternal mess

265 uced ribosome stalling, which causes bias at translation start sites.

266 ociated with ribosomal synthesis and protein translation, suggesting the importance of protein synthe

267 Crystals having orientational and periodic translation symmetries are usually both short-range and

268 ow fluctuations spontaneously break the time-translation symmetry of a driven oscillator.

269 irst, we use an in vitro reconstituted yeast translation system to demonstrate that inhibitory codon

270 lthough HIV-1 RNA serves two functions, as a translation template and as a viral genome, individual R

271 apid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect

272 Using a global model of translation that included aaRS recharging, Gln4p depleti

273 ddition to GCN2 activation and reduced total translation, the reduced charging of tRNA(Gln) in amino-

274 stimulus-dependent ATP synthase beta subunit translation; this increases the ratio of ATP synthase en

275 n from initiation to the elongation phase of translation, thus blocking further initiation events.

276 nd 3) an immature phenotype which may impact translation to adult cardiac response.

277 of risk-modeling methods, considerations for translation to clinical practice, and considerations and

278 sed, but such a goal would require equitable translation to country-level contributions.

279 nd sepsis supported by clinical data and the translation to experimental models.

280 he Ts65Dn mouse model of Down syndrome (DS), translation to human clinical trials to improve cognitio

281 As such, we favor rapid translation to human patients as an antiscarring therapy

282 n dynamic nuclear polarization (DNP) and its translation to humans stimulated development of pH-sensi

283 mechanisms, implications of these findings, translation to humans, and future work, especially with

284 statin may be a candidate for human clinical translation to rescue fetal cardiovascular dysfunction i

285 protective agent in experimental stroke, but translation to the clinic is impeded by the large doses

286 successful preclinical therapies upon their translation to the clinic.

287 evaluation of immunogenicity to enable rapid translation to the clinic.

288 al frequency make this method attractive for translation to the clinical setting.

289 on of the contributions of transcription and translation to the reduced performance of some unnatural

290 Lu and are promising candidates for clinical translation to treat metastatic castration-resistant pro

291 Their translation toward biological applications is limited ow

292 are independently required for regulation of translation under cellular stress.

293 osome and leads to global inhibition of mRNA translation upon infection.

294 uR regulates autophagy by modulating ATG16L1 translation via interaction with circPABPN1 in the intes

295 surements to identify gene transcripts whose translation was up-regulated in response to the stress i

296 nslational mRNA decay is interconnected with translation, we also assessed its role in translation ef

297 Taking a cue from recent advances in machine translation, we train a recurrent neural network to enco

298 In vitro translation with (35)S-labeled methionine resulted in tr

299 fore, LNP uptake, endosomal escape, and mRNA translation with and without TLR4 activation are quantif

300 morphism that results in a premature stop in translation, yielding a truncated, nonfunctional enzyme.