ライフサイエンスコーパス: translation initiation factor

1 S, a decapping pyrophosphatase, and eIF4E, a translation initiation factor.

2 on has not been previously described for any translation initiation factor.

3 nhances translation through eIF4B, a general translation initiation factor.

4 t of a 5' cap and some/all of the associated translation initiation factors.

5 that the W73V mutant could not interact with translation initiation factors.

6 oskeletal organization, and the abundance of translation initiation factors.

7 the viral RNAs, using different sets of host translation initiation factors.

8 pendent and autophagy-related processes, and translation initiation factors.

9 fold, which was not observed before in other translation initiation factors.

10 example is EIF1AY, which encodes eukaryotic translation initiation factor 1A Y-linked, together with

11 of the host cell; therefore, the eukaryotic translation initiation factor 2 (eIF2) gene family is a

12 Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimer

13 The eukaryotic translation initiation factor 2 (eIF2) is central to the

14 phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2alpha) in an AR-dep

15 d PERK specifically phosphorylate eukaryotic translation initiation factor 2 (eIF2alpha) on Ser51 to

16 nse in the liver, including alpha subunit of translation initiation factor 2 (eIF2alpha) phosphorylat

17 ntly increases phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in

18 Dephosphorylation of translation initiation factor 2 (eIF2alpha) terminates s

19 hosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) to activate

20 orylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) was decrease

21 orylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), is an impor

22 osphorylates the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2alpha), resulting i

23 Translation initiation factor 2 (IF2) promotes 30S initi

24 te (MMS), absence of the full-length form of Translation Initiation Factor 2 (IF2-1) or deficiency in

25 hat, translational control by the eukaryotic translation initiation factor 2 alpha (eIF2alpha) bidire

26 gulated inhibitor kinase (HRI), a eukaryotic translation initiation factor 2 alpha (eIF2alpha) kinase

27 interacts with and can methylate eukaryotic translation initiation factor 2 alpha (eIF2alpha), in vi

28 nase R [PKR]) that phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha), which

29 kinase R (PKR) and its substrate eukaryotic translation initiation factor 2 alpha (eIF2alpha).

30 process is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha).

31 and EIF2AK2 encode members of the eukaryotic translation initiation factor 2 alpha kinase (EIF2AK) fa

32 nt, c.388G>A, p.Gly130Arg, in the eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2)

33 d activation (phosphorylation) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3,

34 hereas biallelic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF

35 tein kinase R, phosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2alpha), t

36 EIF2AKs phosphorylate eukaryotic translation initiation factor 2 subunit 1 (EIF2S1, also

37 hen phosphorylates its substrate, eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha

38 result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or

39 ated stress response (ISR) by phosphorylated translation initiation factor 2, eIF2(alphaP).

40 mmaTE treatment increased phosphorylation of translation initiation factor 2, IkappaBalpha, and JNK,

41 otein translation mediated by the eukaryotic translation initiation factor 2-alpha kinase 2/eukaryoti

42 determined that activation of the eukaryotic translation initiation factor 2-alpha kinase 2/eukaryoti

43 protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2-alpha/activating transcr

44 Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protei

45 nitiation factor 2-alpha kinase 2/eukaryotic translation initiation factor 2alpha (EIF2AK2/eIF2alpha)

46 nitiation factor 2-alpha kinase 2/eukaryotic translation initiation factor 2alpha (Eif2ak2/Eif2alpha)

47 ding increased phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) and reg

48 lum stress and phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) are ass

49 Phosphorylation of translation initiation factor 2alpha (eIF2alpha) attenua

50 tein levels in the heme-regulated eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase

51 The eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase

52 out (PERK-KO) or phosphodeficient eukaryotic translation initiation factor 2alpha (eIF2alpha) mouse e

53 Ppp1r15b, a regulatory subunit of eukaryotic translation initiation factor 2alpha (eIF2alpha) phospha

54 The eukaryotic translation initiation factor 2alpha (eIF2alpha) phospho

55 , in which the phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) results

56 ase 1alpha (PP1alpha) to dephosphorylate the translation initiation factor 2alpha (eIF2alpha) to prev

57 Ralpha and phosphorylation of the eukaryotic translation initiation factor 2alpha (eIF2alpha).

58 edly increased phosphorylation of eukaryotic translation initiation factor 2alpha (p-eIF2alpha), an a

59 -dependent phosphorylation of the eukaryotic translation initiation factor 2alpha and enhanced transl

60 d that the PKR-like, ER-localized eukaryotic translation initiation factor 2alpha kinase branch of th

61 h activating pancreatic ER kinase/eukaryotic translation initiation factor 2alpha signaling.

62 s both the phosphorylation of the eukaryotic translation initiation factor 2alpha subunit and the spl

63 inding protein and phosphorylated eukaryotic translation initiation factor 2alpha unchanged.

64 he latter of which phosphorylates eukaryotic translation initiation factor-2alpha (eIF2alpha).

65 slation initiation factor complex eukaryotic translation initiation factor 2B (eIF2B) and the very-lo

66 ons in genes encoding subunits of eukaryotic translation initiation factor 2B (eIF2B).

67 ng disease caused by mutations in eukaryotic translation initiation factor 2B (eIF2B).

68 the reversible polymerization of eukaryotic translation initiation factor 2B, an essential enzyme in

69 nce 03 (retr03), an allele of the eukaryotic translation initiation factor 2B-beta (eIF2Bbeta).

70 Here, we show that human eukaryotic translation initiation factor 3 (eIF3) acts as a distinc

71 h encodes a core component of the eukaryotic translation initiation factor 3 (eIF3) complex, as a key

72 nitiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access o

73 Eukaryotic translation initiation factor 3 (eIF3) is a central play

74 Eukaryotic translation initiation factor 3 (eIF3) plays a central r

75 epatitis C virus (HCV) IRES binds eukaryotic translation initiation factor 3 (eIF3), but the exact fu

76 nslation, a process that involved eukaryotic translation initiation factor 3 subunit b as a P311 bind

77 addition, mTOR co-localised with Eukaryotic translation initiation factor 3 subunit F (eIF3F) at the

78 Eukaryotic translation initiation factor 3 subunit I (eIF3I) with t

79 eIF3a (eukaryotic translation initiation factor 3a), one of the core subun

80 exerted at initiation through the eukaryotic translation initiation factor 4 F (eIF4F).

81 dase E (CPE) by inhibition of the eukaryotic translation initiation factor 4 gamma 1 translation init

82 the canonical translation factor eukaryotic translation initiation factor 4 gamma I (eIF4GI) is clea

83 DEAD-box RNA helicases eukaryotic translation initiation factor 4A (eIF4A) and Ded1 promot

84 tured 5' UTRs by interacting with eukaryotic translation initiation factor 4A (eIF4A) and inhibiting

85 ts antitumor activity by clamping eukaryotic translation initiation factor 4A (eIF4A) onto polypurine

86 d4(157-469), a deletion mutant that binds to translation initiation factor 4A (eIF4A), sufficiently i

87 -, beta-, and gamma-subunits) and eukaryotic translation initiation factor 4A (three isoforms), altho

88 In cells depleted of CDK12 or eukaryotic translation initiation factor 4A3 (eIF4A3) from the EJC,

89 rary profiling, we identified the eukaryotic translation initiation factor 4B (eIF4B) as a MELK-inter

90 Eukaryotic translation initiation factor 4B (eIF4B) is a cofactor f

91 Further, we found that eukaryotic translation initiation factor 4B (eIF4B) played a key ro

92 e found that the protein level of eukaryotic translation initiation factor 4B (eIF4B), an integral co

93 phorylation of the S6K1-dependent eukaryotic translation initiation factor 4B.

94 tion factor 4E-binding protein 1/ eukaryotic translation initiation factor 4E (4EBP1/eIF4E) cascades.

95 The eukaryotic translation initiation factor 4E (EIF-4E) protein, a key

96 loid leukemia (AML) by regulating eukaryotic translation initiation factor 4E (eIF4E) activation.

97 Dysregulation of translation initiation factor 4E (eIF4E) activity occurs

98 d to be based on mutations in the eukaryotic translation initiation factor 4E (eIF4E) and its isoform

99 Here, we show that eukaryotic translation initiation factor 4E (eIF4E) binding protein

100 Eukaryotic translation initiation factor 4E (eIF4E) binds the m7GTP

101 ift assays (EMSAs) indicated that eukaryotic translation initiation factor 4E (eIF4E) binds the MTE d

102 Here, we show that mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosp

103 ess p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to

104 etically increasing the levels of eukaryotic translation initiation factor 4E (eIF4E) in mice results

105 translation, and indicate that activation of translation initiation factor 4E (eIF4E) is involved in

106 Eukaryotic translation initiation factor 4E (eIF4E) is overexpresse

107 Eukaryotic translation initiation factor 4E (eIF4E) selectively pro

108 Association of eukaryotic translation initiation factor 4E (eIF4E) with eIF4E-bind

109 iation of the cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) with eIF4G is a

110 Here, we focus on eukaryotic translation initiation factor 4E (eIF4E), a prooncogenic

111 Phosphorylation and activation of eukaryotic translation initiation factor 4E (eIF4E), eIF4E-binding

112 Here, we discovered that eukaryotic translation initiation factor 4E (eIF4E), itself a cap-b

113 lated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing bin

114 K-interacting kinase 1 (MNK1) and eukaryotic translation initiation factor 4E (eIF4E), resulting in e

115 imiting factor for translation is eukaryotic translation initiation factor 4E (eIF4E), which is negat

116 e analogues were bound tightly to eukaryotic translation initiation factor 4E (eIF4E), with CCl2-subs

117 o target a specific oncogene, the eukaryotic translation initiation factor 4E (eIF4E), with its inhib

118 Moreover, eukaryotic translation initiation factor 4E (EIF4E)-associated prot

119 d translation of MTFP1, which is mediated by translation initiation factor 4E (eIF4E)-binding protein

120 inhibited phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E)-binding protein

121 ed expression of the translational repressor translation initiation factor 4E (eIF4E)-binding protein

122 Eukaryotic translation initiation factor 4E (eIF4E)-binding protein

123 mice, we investigated the role of eukaryotic translation initiation factor 4E (eIF4E)-eIF4G interacti

124 ignaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-d

125 ain, which displays similarity to eukaryotic translation initiation factor 4E (eIF4E).

126 eIF4E1b, closely related to the canonical translation initiation factor 4E (eIF4E1a), cap-binding

127 ockade of its downstream effector eukaryotic translation initiation factor 4E activity equally reduce

128 achinery, decreases expression of eukaryotic translation initiation factor 4E and cyclin D1, and indu

129 ate the importance of the p38-MNK-eukaryotic translation initiation factor 4E axis in TNF production

130 gy by activating mTORC1 effectors eukaryotic translation initiation factor 4E binding protein 1 and U

131 educe the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues.

132 lates the alternative splicing of eukaryotic translation initiation factor 4E nuclear import factor 1

133 ammalian target of rapamycin, and eukaryotic translation initiation factor 4E phosphorylation seen in

134 A trend for an increase of eukaryotic translation initiation factor 4E phosphorylation was obs

135 r 1 (Eif4enif1), which encodes an eukaryotic translation initiation factor 4E transporter (4E-T) prot

136 ), a protein that binds to eIF4E (eukaryotic translation initiation factor 4E) and prevents mRNA deca

137 e cap, inhibits interactions with eukaryotic translation initiation factor 4E, and resists decapping.

138 rget of rapamycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-bind

139 APK-interacting kinase (MNK), and eukaryotic translation initiation factor 4E, which is a critical re

140 A-RNA interaction and an adjacent eukaryotic translation initiation factor 4E-binding 3'CITE.

141 p T-shaped structure (kl-TSS) and eukaryotic translation initiation factor 4E-binding Panicum mosaic

142 mTORC1 activation inhibits eukaryotic translation initiation factor 4E-binding protein (4E-BP)

143 ted with increased recruitment of eukaryotic translation initiation factor 4E-binding protein (4E-BP)

144 rget of rapamycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

145 revealed hyperphosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

146 first, it preferentially targets eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

147 Eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

148 n, measured by phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

149 and protein synthesis, including eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

150 mTORC1) and its downstream target eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

151 ibosomal protein S6 kinase 1, and eukaryotic translation initiation factor 4E-binding protein 1 durin

152 K/ribosomal protein S6 (RPS6) and eukaryotic translation initiation factor 4E-binding protein 1/ euka

153 Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-B

154 the translation repressor, 4E-BP (eukaryotic translation initiation factor 4E-binding protein).

155 NCBP3 and RHA substitutes for the eukaryotic translation initiation factors 4E and 4G and activates m

156 malian target of rapamycin (mTOR)-eukaryotic translation initiation factor 4F (eIF4F) and eIF2alpha p

157 Disrupting the eukaryotic translation initiation factor 4F (eIF4F) complex offers

158 (eIF4G), the scaffold subunit of eukaryotic translation initiation factor 4F (eIF4F), preferentially

159 are required for formation of the eukaryotic translation initiation factor 4F complex (eIF4F) and ini

160 MNK binds eukaryotic translation initiation factor 4G (eIF4G) and phosphoryla

161 Remarkably, depleting eukaryotic translation initiation factor 4G (eIF4G), the scaffold s

162 on initiation by interaction with eukaryotic translation initiation factor 4G (eIF4G), we investigate

163 nding partners containing a middle domain of translation initiation factor 4G (MIF4G) are emerging as

164 to bind the poly(A) tail of mRNA, as well as translation initiation factor 4G and eukaryotic release

165 ip between the O-GlcNAcylation of eukaryotic translation initiation factor 4gamma1 (eIF4G1) and carbo

166 dditionally, expression levels of eukaryotic translation initiation factor 4GI (eIF4GI) and of its ho

167 6 deletion disrupted the putative eukaryotic translation initiation factor 4GI-binding domain and pro

168 , we have shown downregulation of eukaryotic translation initiation factor 5 A (elF5A), expressed onl

169 Mechanistically, Klf5 activates eukaryotic translation initiation factor 5a (eIF5a) transcription t

170 for deoxyhypusine modification of eukaryotic translation initiation factor 5A (eIF5A).

171 rently known hypusinated protein, eukaryotic translation initiation factor 5A.

172 und in a single cellular protein, eukaryotic translation initiation factor-5A (eIF5A), and its homolo

173 Two of these proteins, are eukaryotic translation initiation factor 5A1 (eIF5A1) that is invol

174 ta reveal a transient increase of eukaryotic translation initiation factor 5B (eIF5B), the eukaryotic

175 anslation initiation via an interaction with translation initiation factor 5B (eIF5B).

176 ng is controlled by the G-protein eukaryotic translation initiation factor 5B (eIF5B).

177 Eukaryotic translation initiation factor 6 (eIF6) is essential for

178 nduced protein kinase R (PKR) and eukaryotic translation initiation factor alpha (eIF2alpha) phosphor

179 doplasmic reticulum kinase (PERK)-eukaryotic translation initiation factor alpha (eIF2alpha)-CEBP hom

180 omitant with elevated phosphorylation of the translation initiation factor alpha subunit of eukaryoti

181 acids led to significant down-regulation in translation initiation factors, amino acid metabolism, a

182 has also been detected on several eukaryotic translation initiation factors and ribosomal proteins.

183 g mRNA-binding proteins, ribosomal proteins, translation initiation factors and translation elongatio

184 election by 5' upstream open reading frames, translation initiation factors, and primary and secondar

185 Notably, detection of translation initiation factors at the RTC was instrument

186 ing proteins (PABPs) link mRNA 3' termini to translation initiation factors, but they also play key r

187 udies suggest that the reduced activity of a translation initiation factor called eIF2alpha might be

188 tion between the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmar

189 assays, we show the Saccharomyces cerevisiae translation initiation factor complex eukaryotic transla

190 to identify the components of the norovirus translation initiation factor complex.

191 c RNA-binding proteins but none of the major translation initiation factors, consistent with a functi

192 Deregulation of translation initiation factors contributes to many patho

193 Yet, no signals specifically targeting translation initiation factors during mitosis have been

194 factors such as ribosomal protein RPS-1 and translation initiation factor EIF-3.J to reduce infectio

195 The heterotrimeric eukaryotic translation initiation factor (eIF) 2 plays critical rol

196 SG formation is triggered by both eukaryotic translation initiation factor (eIF) 2alpha phosphorylati

197 BYDV-like CITE or BTE) that binds eukaryotic translation initiation factor (eIF) 4F and recruits 40S

198 thways convergently signal to the eukaryotic translation initiation factor (eIF) 4F complex to regula

199 The eukaryotic translation initiation factor (eIF) 4G is a scaffold pro

200 The eukaryotic translation initiation factor (eIF) 4G is required durin

201 Here we report that translation initiation factor eIF1A directly interacts w

202 phosphorylation of the alpha subunit of the translation initiation factor eIF2 (eIF2alpha) can promo

203 hosphorylates and in end-effect inhibits the translation initiation factor eIF2 (eukaryotic initiatio

204 Phosphorylation of the translation initiation factor eIF2 alpha at a conserved

205 ase (OAS), which respectively inactivate the translation initiation factor eIF2 and stimulate RNA cle

206 The general translation initiation factor eIF2 is a major translatio

207 the synthesis of proteins controlled by the translation initiation factor eIF2(11).

208 mma subunit of the heterotrimeric eukaryotic translation initiation factor eIF2, cause MEHMO syndrome

209 eIF2B GEF activity toward its substrate, the translation initiation factor eIF2, in vitro.

210 orylates the alpha subunit of the eukaryotic translation initiation factor eIF2, leading to global do

211 e or boosting the function of the eukaryotic translation initiation factor eIF2-eIF2B complex, revers

212 actor 4 (ATF4) and phosphorylated eukaryotic translation initiation factor eIF2.

213 is exerted by phosphorylation of the general translation initiation factor eIF2.

214 n of protein synthesis by phosphorylation of translation initiation factor eIF2.

215 gers phosphorylation of the alpha-subunit of translation initiation factor eIF2.

216 tion, DeltaN146 precludes phosphorylation of translation initiation factor eIF2alpha (alpha subunit o

217 nslational control by phosphorylation of the translation initiation factor eIF2alpha (p-eIF2alpha) ac

218 Phosphorylation of the translation initiation factor eIF2alpha anchors a revers

219 gene product, phosphorylates the eukaryotic translation initiation factor eIF2alpha and causes trans

220 induces Perk-mediated phosphorylation of the translation initiation factor eif2alpha causing selectiv

221 PKR activation leads to phosphorylation of translation initiation factor eIF2alpha inhibition of pr

222 host response to virus infection mediated by translation initiation factor eIF2alpha phosphorylation.

223 study, we found that reduced activity of the translation initiation factor eIF2alpha underlies the hy

224 PKR inactivates the translation initiation factor eIF2alpha via phosphorylat

225 at precisely controls phosphorylation of the translation initiation factor eIF2alpha via the unfolded

226 Phosphorylation of the translation initiation factor eIF2alpha within the medio

227 rol nonderepressible 2 (GCN2) phosphorylates translation initiation factor eIF2alpha, initiating the

228 he branch comprising the kinase PERK and the translation initiation factor eIF2alpha, is a pathologic

229 s (MRV) infection induces phosphorylation of translation initiation factor eIF2alpha, which promotes

230 otein translation via phosphorylation of the translation initiation factor eIF2alpha.

231 lar stress responses, by phosphorylating the translation initiation factor eIF2alpha.

232 that are mediated via phosphorylation of the translation initiation factor eIF2alpha.

233 atase activity, dephosphorylating eukaryotic translation initiation factor (eIF2alpha), and derepress

234 s MITF via ATF4 in response to inhibition of translation initiation factor eIF2B.

235 , we show that the mRNAs encoding eukaryotic translation initiation factors eIF2B2 and eIF4G2 are pre

236 ng the local protein synthesis of eukaryotic translation initiation factors eIF2B2 and eIF4G2 in the

237 urs, strongly enhances the dependence on the translation initiation factor eIF2B5.

238 sm involving EIF3C, a subunit of the protein translation initiation factor EIF3, as the direct target

239 By interacting with the translation initiation factor eIF3, Cpeb4 represses the

240 3, earlier shown to interact with eukaryotic translation initiation factor eIF3, in termination.

241 oaded onto capped mRNAs via the multisubunit translation initiation factors eIF3 and eIF4F.

242 Tim Barrel domain protein and the eukaryotic translation initiation factor eIF3b.

243 motif (SBM) in two additional proteins: the translation initiation factor eIF3g and the mRNA-export

244 Moreover, overexpression of translation initiation factor eIF4A, a helicase, enhance

245 was associated with increased expression of translation initiation factors eIF4A and eIF4GI, and red

246 e regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppress

247 Eukaryotic translation initiation factor eIF4AI, the founding membe

248 d activity of mTORC1 and its downstream mRNA translation initiation factors eIF4B and 4EBP1, as well

249 through the phosphorylation of a eukaryotic translation initiation factor, eIF4B.

250 is required for RNAs to bind the eukaryotic translation initiation factor eIF4E and associate with t

251 lation is supported by the localization of a translation initiation factor eIF4E and by ribosome-boun

252 UTR, which is controlled by the oncogene and translation initiation factor eIF4E downstream Myc activ

253 The translation initiation factor eIF4E is an oncogene that

254 Translation initiation factor eIF4E mediates normal cell

255 Here we employ conditional overexpression of translation initiation factor eIF4E to increase protein

256 The interaction of the eukaryotic translation initiation factor eIF4E with the initiation

257 0-fold heterogeneity for interactions of the translation initiation factor eIF4E with the universal m

258 Eukaryotic translation initiation factor eIF4E, an essential compon

259 We show that the eukaryotic translation initiation factor eIF4E, an oncoprotein, dri

260 d the calcineurin regulator Rcn2, the 4E-BP (translation initiation factor eIF4E-binding protein) tra

261 ltiple ribosome biogenesis genes and the key translation initiation factor eIF4E.

262 s its association with and inhibition of the translation initiation factor eIF4E.

263 A translation initiation by sequestering the translation initiation factor eIF4E.

264 s via a direct interaction with the cellular translation initiation factor eIF4E.

265 pha translation by modulating the binding of translation initiation factors eIF4E and eIF4G to p63alp

266 ration of the cap-binding protein eukaryotic translation initiation factor (eIF4E) is enhanced.

267 utcomes and include targeting the eukaryotic translation initiation factor (eIF4E) with its inhibitor

268 phosphate mRNA cap analogues with eukaryotic translation initiation factor (eIF4E).

269 genome that allows the virus to usurp a host translation initiation factor, eIF4E, in a way that diff

270 mulate the activity of the m(7)G cap-binding translation initiation factor, eIF4E, respectively.

271 e based on mutations in the plant eukaryotic translation initiation factors, eIF4E and eIF4G or their

272 The eIF4E translation initiation factors, eIF4E1, eIF4E2, and eIF4

273 Translation initiation factor eIF4F (eukaryotic initiati

274 clude the ability to bind a component of the translation initiation factor eIF4F complex and to engag

275 It relies on its ability to compete with the translation initiation factor eIF4F to specifically reco

276 he ability of infected cells to assemble the translation initiation factor eIF4F, promoting viral pro

277 ciated with the 4F subunit of the eukaryotic translation initiation factor (eIF4F) complex in infecte

278 ated in splicing, interacts with the general translation initiation factor eIF4G and promotes transla

279 untranslated region that interacts with host translation initiation factor eIF4G.

280 carcinoma (PDAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the

281 ch to investigate the role of the eukaryotic translation initiation factor eIF5A in human cervical ca

282 Eukaryotic translation initiation factor eIF5A promotes protein syn

283 The process is mediated by eukaryotic translation initiation factors (eIFs) in conjunction wit

284 osphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation fac

285 ely to the poorly characterized domain II of translation initiation factor IF2 and prevented the bind

286 y studies have implicated aberrant levels of translation initiation factors in cancer etiology and pr

287 s, including therapy resistance, require the translation initiation factor initiation elongation fact

288 Consequently, this essential translation initiation factor is nearly twice as abundan

289 tion of eIF2alpha (P-eIF2alpha), a conserved translation initiation factor, is clock controlled in Ne

290 ity, induced oxidative stress, or stimulated translation initiation factor phosphorylation significan

291 In eukaryotic cells, numerous translation initiation factors prepare ribosomes for pol

292 SPONSE TO DEHYDRATION14, AUXIN RESISTANT1, a translation initiation factor SUI1 family protein, and t

293 report a neuron-specific microexon in eIF4G translation initiation factors that dampens synaptic pro

294 A1 and its highly related isoform eIF5A2 are translation initiation factors that have been implicated

295 which serves as a scaffold to recruit other translation initiation factors that ultimately assemble

296 arrest mediated by the phosphorylation of a translation initiation factor, the alpha subunit of euka

297 he ASOs appear to improve the recruitment of translation initiation factors to the target mRNA.

298 es the eukaryotic initiation factor 2 (eIF2) translation initiation factor upon binding to viral doub

299 s that relies on the interaction of cellular translation initiation factors with the virus genome-enc

300 mechanism that relies on the interaction of translation initiation factors with the virus-encoded VP