ライフサイエンスコーパス: translation termination

1 various fates of ribosomes that pause during translation termination.

2 ex set of molecular functions in addition to translation termination.

3 ents of RF1 and RF2 are critical to accurate translation termination.

4 ular basis for stop codon recognition during translation termination.

5 ATPase activity during both mRNA export and translation termination.

6 ested ribosomes during inhibition of its own translation termination.

7 ctional importance of individual residues in translation termination.

8 Gle1, and IP(6) are also required for proper translation termination.

9 e cleavage of stop codons during inefficient translation termination.

10 n recognition during both tRNA selection and translation termination.

11 as identified that suppresses nonsense codon translation termination.

12 onsense mutations) typically cause premature translation termination.

13 RNA binding site (A-site) during inefficient translation termination.

14 nition and peptide release during eukaryotic translation termination.

15 lowed the established rules for hierarchy of translation termination.

16 haracterized-for example, those required for translation termination.

17 portant role in ester bond hydrolysis during translation termination.

18 t lead to splicing aberrations and premature translation termination.

19 lation elongation or a reduced efficiency of translation termination.

20 pears to be frequent, suggesting inefficient translation termination.

21 ng a critical role in peptide release during translation termination.

22 between the G1093 region and helix 73 during translation termination.

23 ribosome pauses at stop codons during normal translation termination.

24 egion has an adaptive function separate from translation termination.

25 ribosomal proteins and a yeast suppressor of translation termination.

26 reinitiate on AUG codons 5' to the point of translation termination.

27 Hel2 probably interacts with mRNA during translation termination.

28 next downstream AUG, resulting in premature translation termination.

29 A clones) resulted in a frameshift and early translation termination.

30 rotein sequence context and caused premature translation termination.

31 nt whose function is likely to be related to translation termination.

32 eRF3 or eRF1 reduced SFL-mediated premature translation termination.

33 ribosomal particles due to a dysfunction in translation termination.

34 of eRF3a which itself has an active role in translation termination.

35 ystem, we show that PABP directly stimulates translation termination.

36 and suggests involvement of L27 in bacterial translation termination.

37 op codon because of ribosomal pausing during translation termination.

38 on the mechanisms of canonical and premature translation termination.

39 f thousands of genes without manipulation of translation termination.

40 be achievable without general disruption of translation termination.

41 pid ribosome exchange into the cytosol after translation termination.

42 he degradation of mRNAs undergoing premature translation termination.

43 , essential gene in eukaryotes implicated in translation termination.

44 ain translational fidelity by involvement in translation termination.

45 One potential source of DRiPs is premature translation termination.

46 UGA codon as selenocysteine (Sec) instead of translation termination.

47 ear mRNA export, translation initiation, and translation termination.

48 (M-)domain; and a C-terminal domain with the translation termination activity.

49 The C-terminal region provides translation termination activity.

50 eracts with the release factors, (ii) delays translation termination and (iii) dissociates post-termi

51 in a transient increase in the efficiency of translation termination and a loss of the [PSI+] phenoty

52 ndicated that PAIP1 and PAIP2 participate in translation termination and are important regulators of

53 mRNA decay (NMD) pathway monitors premature translation termination and degrades aberrant mRNAs.

54 a nascent peptide motif that interferes with translation termination and elicits tmRNA.SmpB activity.

55 Rat8p also functions in translation termination and has been implicated in funct

56 om complete loss of RFC protein due to early translation termination and increased turnover of a muta

57 ion involved the introduction of overlapping translation termination and initiation codons in-frame i

58 by eRF1, revealing principles of eukaryotic translation termination and laying the foundation for ne

59 [PSI+] is a prion of Sup35p, an essential translation termination and mRNA turnover factor.

60 Here we review both translation termination and NMD, and our subsequent effo

61 cerevisiae orthologue that functions in both translation termination and NMD, has been the only facto

62 itional factors that play roles in premature translation termination and NMD.

63 Among these was eRF1, which regulates translation termination and nonsense-mediated decay (NMD

64 Dlg4) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay

65 slated small ORFs (sORFs) by quantitation of translation termination and peptidic analysis identified

66 rveillance mechanism that monitors premature translation termination and promotes degradation of aber

67 ndings emphasize the importance of efficient translation termination and reveal unexpected link betwe

68 hydrolysis by UPF1 is required for efficient translation termination and ribosome release at a premat

69 Rps3 and eIF3 closely co-operate to control translation termination and stop codon readthrough.

70 is an integral functional unit important for translation termination and that the presence of L11 in

71 natively, the effect of RAC/Ssb mutations on translation termination and the absence of an effect on

72 ve hammerhead ribozyme structure between the translation termination and the polyadenylation signals

73 is conserved rRNA structure in UGA-dependent translation termination and, taken with previous in vitr

74 ithin the ribosomal exit tunnel, can inhibit translation termination and/or peptide elongation.

75 tive amino acid changes, potential premature translation terminations and potential altered splicing.

76 nascent peptide motif (which interferes with translation termination) and quantified the protein chai

77 the pioneer round of translation, premature translation termination, and proteins failing to fold pr

78 llance complex assembles onto the mRNA after translation termination, and scans the mRNA in a 3' to 5

79 ined in mRNA export, translation initiation, translation termination, and stress granule formation.

80 The mechanisms underlying translation termination are key to the understanding of

81 Transcripts harboring premature signals for translation termination are recognized and rapidly degra

82 esults indicate that the Upf1p also enhances translation termination at a nonsense codon.

83 erapy utilizes small molecules that suppress translation termination at a PTC to restore synthesis of

84 RF1 was unable to increase the efficiency of translation termination at any termination signals.

85 represses downstream translation by blocking translation termination at its own stop codon and by cau

86 have been shown to affect the efficiency of translation termination at nonsense codons and/or the pr

87 h as gentamicin have the ability to suppress translation termination at premature stop mutations, lea

88 TP hydrolysis also reduced the efficiency of translation termination at some termination signals but

89 d translating ribosomes and caused premature translation termination at the frameshifting site.

90 nstrated that both PAIP1 and PAIP2 prevented translation termination at the premature termination cod

91 t, the Euplotes hybrid facilitated efficient translation termination at UAA and UAG codons but not at

92 the mRNP can alter the rate of key steps in translation termination; (b) the discrimination between

93 nts that enable the ribosome to overcome the translation termination blockage imposed by an arrest pe

94 (Psi), ref. 4) of nonsense codons suppresses translation termination both in vitro and in vivo.

95 is an epigenetic modifier of the fidelity of translation termination, but its impact on yeast biology

96 er RNA decay (NMD) is triggered by premature translation termination, but the features distinguishing

97 These molecules also inhibit translation termination by an unknown mechanism.

98 ical approaches, we show that PF846 inhibits translation termination by arresting the nascent chain (

99 PABP increases the efficiency of translation termination by recruitment of eRF3a and eRF1

100 ribosome binding, polypeptide elongation, or translation termination, can influence the susceptibilit

101 n a nascent peptide and eRF1 to obstruct the translation termination cascade.

102 Defects in translation termination caused by this mutation have als

103 During translation termination, class II release factor RF3 bin

104 is activated by the presence of a premature translation termination codon (PTC) in an atypical seque

105 Premature translation termination codon (PTC)-mediated effects on

106 rameshift in exon 7 that created a premature translation termination codon (PTC).

107 AAA) was identified 191 bp downstream of the translation termination codon (TGA).

108 ormal open reading frame (ORF) and brought a translation termination codon 33 amino acids downstream.

109 A translation termination codon and a single polyadenylati

110 struction of a gammaHV68 mutant containing a translation termination codon in the LANA ORF (73.STOP).

111 n with a mutant virus containing a premature translation termination codon in the UL83 open reading f

112 ximately 180 bp, located 260 bases 3' to the translation termination codon of p21WAF1/CIP1 cDNA, was

113 on VIII that changes tyrosine codon 426 to a translation termination codon resulting in an EPOR prote

114 an RNA element downstream of the gag natural translation termination codon that prevents degradation

115 exon that replaces an arginine codon with a translation termination codon.

116 ng frame was disrupted by the insertion of a translation termination codon.

117 cated 30 to 70 nucleotides downstream of the translation termination codon.

118 loop, thereby changing the distance from the translation termination codon.

119 t are located at a similar distance from the translation termination codon.

120 That sequence contained a premature translation termination codon.

121 man genetic diseases are caused by premature translation-termination codon (PTC)-generating mutations

122 tron 3, and in the second allele a premature translation-termination codon in exon 1 was identified.

123 mRNAs containing premature translation termination codons (nonsense mRNAs) are targ

124 Eukaryotic mRNAs containing premature translation termination codons (PTCs) are rapidly degrad

125 essenger RNAs (mRNAs) that contain premature translation termination codons (PTCs) are targeted for r

126 How premature translation termination codons (PTCs) mediate effects on

127 apid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect

128 d process that destroys mRNAs with premature translation termination codons (PTCs).

129 es aberrant transcripts containing premature translation termination codons and regulates the levels

130 ox translation initiation codons and partial translation termination codons are absent, the use of TG

131 Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidl

132 Recent results show that mRNAs without translation termination codons are unstable in eukaryoti

133 can suppress the accurate identification of translation termination codons in eukaryotic cells.

134 ative splicing switches introduces premature translation termination codons into selected transcripts

135 68 mutant virus (45STOP) by the insertion of translation termination codons into the portion of the g

136 D) eliminates transcripts carrying premature translation termination codons, but the role of NMD on y

137 .IX (hF.IX), or F.IX variants with premature translation termination codons, or missense mutations, u

138 All three translation termination codons, or nonsense codons, cont

139 pound that promotes readthrough of premature translation termination codons, suggesting that it may h

140 we investigated the efficiency of eukaryotic translation termination codons, to assess codon readthro

141 mRNAs and promotes readthrough of premature translation termination codons.

142 nd degrades transcripts containing premature translation termination codons.

143 bilization of transcripts carrying premature translation termination codons.

144 ate that there are limited interactions with translation termination codons.

145 dation of yeast mRNAs that contain premature translation termination codons.

146 egrade aberrant mRNAs that contain premature translation termination codons.

147 ism that degrades mRNAs containing premature translation termination codons.

148 mechanism that degrades mRNAs with premature translation-termination codons.

149 izes and degrades transcripts with premature translation-termination codons.

150 suggests that they may regulate an aspect of translation termination common to all transcripts.

151 We report the crystal structure of a translation termination complex formed by the Thermus th

152 nstance and facilitating dissociation of the translation termination complex in the other.

153 eRF1 and eRF3 comprise the translation termination complex that recognizes stop cod

154 allographic refinement to a 70S ribosome-RF1 translation termination complex that was recently solved

155 g or looping out of some component(s) of the translation termination complex to the mark.

156 cerevisiae, Sup35p (eRF3), a subunit of the translation termination complex, can take up a prion-lik

157 ike [PSI(+)] variants, where the strength of translation termination corresponds to the level of solu

158 3' untranslated region of mRNAs that affects translation termination, deadenylation, and mRNA decay.

159 visiae Sup35/[PSI(+)] prion, which confers a translation termination defect and expression level-depe

160 re specifically impaired in establishing the translation termination defect that normally accompanies

161 ants recapitulate all of the mRNA export and translation termination defects found in mutants deplete

162 RF1 mutants are quantitatively unlinked with translation termination defects, suggesting that the evo

163 PABP's function in translation termination depends on its C-terminal domain

164 on-prion state that correlate with different translation termination efficiencies.

165 to describe the prion-mediated regulation of translation termination efficiency and discuss its impli

166 -like determinant [PSI+] is able to regulate translation termination efficiency in response to enviro

167 termination and polyadenylation) influences translation termination efficiency, mRNA poly(A) tail le

168 [PSI+] strains exhibit a marked decrease in translation termination efficiency, which permits decodi

169 After translation termination, ER-bound ribosomes are thought

170 ants have previously been shown to exhibit a translation termination error phenotype and the sup44+ a

171 Recognition of translation termination events as premature requires a s

172 ling activities are shared by the homologous translation termination factor complex eRF1:eRF3, sugges

173 cent studies have shown that domain 1 of the translation termination factor eRF1 mediates stop codon

174 Downregulating the translation termination factor eRF1 produces defective v

175 ent premature termination is mediated by the translation termination factor eRF1, which recognizes ri

176 enzyme methylates Gln(185) of the eukaryotic translation termination factor eRF1.

177 e misfolded and self-propagating form of the translation termination factor eRF3 (Sup35), can be cure

178 Translation termination factor eRF3 enhances the activit

179 ics and the prion state of the S. cerevisiae translation termination factor eRF3, Rps23p hydroxylatio

180 PSI+] state is caused by a prion form of the translation termination factor eRF3.

181 e translation elongation factor EF1A and the translation termination factor eRF3.

182 endent ubiquitination and degradation of the translation termination factor GSPT1.

183 3), casein kinase 1alpha (CK1alpha), and the translation termination factor GSPT1] whose ubiquitylati

184 ite effects on [PSI(+)], a prion form of the translation termination factor Sup35 (eRF3).

185 When the translation termination factor Sup35 adopts the prion st

186 otein Lsb2 (Pin3) promotes conversion of the translation termination factor Sup35 into its prion form

187 es derived from the prion domain NM of yeast translation termination factor Sup35 persistently propag

188 pic prion strains, weak and strong, of yeast translation termination factor Sup35 with respect to ang

189 elf-propagating amyloidogenic isoform of the translation termination factor Sup35.

190 self-perpetuating amyloid conformers of the translation termination factor Sup35.

191 y defective self-perpetuating isoform of the translation termination factor Sup35.

192 of the yeast prion [PSI (+)], formed by the translation termination factor Sup35.

193 [PSI(+)] is a prion isoform of the translation termination factor Sup35.

194 The prion [PSI+] forms when the translation termination factor Sup35p adopts a self-prop

195 rpetuating change in the conformation of the translation termination factor Sup35p is the basis for t

196 is a nonfunctional, ordered aggregate of the translation termination factor Sup35p that influences ne

197 ange in the conformation and function of the translation termination factor Sup35p, and is transmitte

198 [PSI(+)] is a prion of the essential translation termination factor Sup35p.

199 The yeast Sup35 protein is a subunit of the translation termination factor, and its conversion to th

200 the Sup35 protein, normally a subunit of the translation termination factor, but impaired in this vit

201 a molecular glue, inducing degradation of a translation termination factor, GSPT1 to achieve its pot

202 When Sup35, a yeast translation termination factor, is aggregated in its [PS

203 ] prion is a self-propagating amyloid of the translation termination factor, Sup35p, of Saccharomyces

204 [PSI+] is a self-propagating amyloid of the translation termination factor, Sup35p.

205 sure as a result of aggregation of the Sup35 translation termination factor, which increases stop cod

206 The yeast prion protein Sup35 is a translation termination factor, whose activity is modula

207 ing amyloid form of Sup35p, a subunit of the translation termination factor.

208 p, a subunit of the Saccharomyces cerevisiae translation termination factor.

209 , which is the prion form of the yeast Sup35 translation termination factor.

210 ich is the altered conformation of the Sup35 translation termination factor.

211 ional change in the prion domain of Sup35, a translation-termination factor.

212 Dom34p and Hbs1p are similar to the translation termination factors eRF1 and eRF3, indicatin

213 ssays revealed that Tpa1p interacts with the translation termination factors eRF1 and eRF3.

214 s of the Upf1p interact with both eukaryotic translation termination factors eRF1 and eRF3.

215 f l-Trp on the function of two known E. coli translation termination factors, RF1 and RF2.

216 tamine residue in the GGQ motif of ribosomal translation termination factors.

217 st [PSI+] prion is an epigenetic modifier of translation termination fidelity that causes nonsense su

218 ation and targets mRNAs undergoing premature translation termination for rapid degradation.

219 d Pyl insertion can effectively compete with translation termination for UAG codons obviating the nee

220 e initiation ternary complex after premature translation termination has occurred nor the elongation

221 (NMD) pathway functions by checking whether translation termination has occurred prematurely and sub

222 ontaining that structure was found to affect translation termination in a codon-specific manner.

223 al ADAR2 protein expression due to premature translation termination in an alternate reading frame.

224 of rluD was recently shown to interfere with translation termination in Escherichia coli.

225 Translation termination in eukaryotes is mediated by two

226 Translation termination in eukaryotes typically requires

227 se results support a direct role for eRF3 in translation termination in higher eukaryotes and also hi

228 th Gle1 and IP(6) are required for efficient translation termination in Saccharomyces cerevisiae and

229 ppression by PAIPs and efficiently activated translation termination in the presence of eRF3a.

230 nding, we quantified the effects of PAIPs on translation termination in the presence or absence of PA

231 Recent studies on translation termination in the yeast Saccharomyces cerev

232 PAIP2 inhibited the activity of free PABP on translation termination in vitro However, after binding

233 ary target of IP(6) for both mRNA export and translation termination in vivo.

234 ribosome positioning and find that premature translation termination in yeast extracts is indeed aber

235 Our results show that eukaryotic translation termination involves a network of interactio

236 w level of readthrough that is enhanced when translation termination is disrupted.

237 Sup35p forms aggregates and its activity in translation termination is downregulated.

238 The results presented here suggest that translation termination is important for assembly of the

239 The role of eRF3 in eukarytotic translation termination is less well understood as its o

240 Eukaryotic translation termination is mediated by two release facto

241 In eukaryotes, translation termination is performed by eRF1, which reco

242 Eukaryotic translation termination is triggered by peptide release

243 Bacterial translation termination is triggered when a stop codon a

244 t to reflect a direct role of NMD factors in translation termination, its mechanism is unknown.

245 Although a UAG codon typically directs translation termination, its presence in Methanosarcina

246 Premature translation termination leads to a reduced mRNA level in

247 genomes, as well as genomes containing an E6 translation termination linker, an E6 frameshift mutatio

248 istic view of how MoMLV manipulates the host translation termination machinery for the synthesis of i

249 interact with each other, the ribosome, the translation termination machinery, and multiple mRNA dec

250 putative surveillance complex that enhances translation termination, monitors whether termination ha

251 e genes (Ofd1, Schizosaccharomyces pombe) to translation termination/mRNA polyadenylation (Tpa1p, Sac

252 ntaining mutant HPV 31 E7 genes, including a translation termination mutant, two Rb-binding site muta

253 HPV type 11 (HPV-11) genomes that contained translation termination mutations in E6 or E7 were const

254 eudouridylation at the PTC can suppress this translation termination (nonsense suppression).

255 Eukaryotic mRNAs where translation termination occurs too soon (nonsense-mediat

256 wnstream sequence information influences how translation termination occurs.

257 rp preferentially blocks RF2 activity during translation termination of the tnaC gene.

258 -containing reporters results from premature translation termination on out of frame stop codons foll

259 gation of [PSI(+)] but are not necessary for translation termination or cell viability.

260 ion factor that fine-tunes the efficiency of translation termination or ribosome recycling.

261 heir release into bulk lipid is triggered by translation termination or, in some cases, by the arriva

262 Additional structural snapshots of the translation termination pathway reveal the conformationa

263 We identify general translation termination pauses in both normal and stress

264 ingle small-molecule drug that modulates the translation termination process at a premature nonsense

265 eRF3 is a GTPase that stimulates the translation termination process by a poorly characterize

266 sitive to the PSI state, indicating either a translation termination process independent of eRF3 or a

267 y pathway, which occurs during the premature translation termination process.

268 h) activity releases tRNA from the premature translation termination product peptidyl-tRNA.

269 a, where it releases tRNA from the premature translation termination product peptidyl-tRNA.

270 d in a general decrease in the efficiency of translation termination rather than a decrease at a subs

271 By modulating the efficiency of translation termination, recognition of long 3'UTRs by U

272 d expression occurred as a result of a novel translation termination/reinitiation event between the n

273 th several ribosomal proteins and eukaryotic translation termination release factor 1.

274 During translation termination, release factor (RF) protein cat

275 e l-Trp-dependent mechanism of inhibition of translation termination remains unclear.

276 sequence-dependent manner to inhibit its own translation termination, resulting in persistence of the

277 Eukaryotic translation termination results from the complex functio

278 Eukaryotic translation termination results from the complex functio

279 Translation termination results in hydrolysis of the fin

280 In contrast to inefficient translation termination, ribosome recycling from truncat

281 coding exons, leading to a frameshift and a translation termination signal 20 codons after the AUG.

282 ight neurofilament (NF-L) mRNA, spanning the translation termination signal, participates in regulati

283 68 nt segment of the transcript spanning the translation termination signal.

284 nation efficiency, which permits decoding of translation termination signals and, presumably, the pro

285 RF3 is required to couple the recognition of translation termination signals by eRF1 to efficient pol

286 One region is just beyond the translation termination site in the 3' region, and the o

287 he cytoplasm when recognized downstream of a translation termination site.

288 of UPF3B during the early and late phases of translation termination suggest that UPF3B is involved i

289 that NMD factors appear to dictate efficient translation termination, suggests that NMD factors do no

290 ng a tetrapeptide and to propose a model for translation termination that accounts for the cooperativ

291 th important roles in ribosome recycling and translation termination that are conserved in eukaryotes

292 This mutation, P70, leads to premature translation termination that deletes a large portion of

293 e nascent polypeptide can affect the rate of translation termination, thereby influencing ribosome pa

294 HCV 3'UTR retains ribosome complexes during translation termination to facilitate efficient initiati

295 A codon is transformed from one that signals translation termination to one specific for Sec.

296 yadenylate-binding protein (PABP) stimulates translation termination via interaction of its C-termina

297 gnal-dependent decrease in the efficiency of translation termination was due to a defect in either eR

298 at the contribution of products of premature translation termination was minimal.

299 he basis of these results and the process of translation termination, we suggest a multistep model fo

300 codon (TGG) at amino acid position 34 into a translation termination (X) codon (TGA).