ライフサイエンスコーパス: translational

1 Post-translational access to such reactions and chemical grou

2 t for the temporal specificity of sequential translational activation of different axonal mRNAs as se

3 (BONCAT) to visualize and quantify bacterial translational activity in expectorated sputum.

4 h of imaging data in patients further limits translational advances.

5 a source of significant transcriptional and translational alterations, with the number of virus-indu

6 abundant glycans as well as additional post-translational and chemical modifications could also be s

7 ess the potential trajectory of this line of translational and clinical research and address its poss

8 Recent translational and mechanistic studies of samples from pa

9 These lipids slow Ras' translational and orientational diffusion and promote a

10 ing was employed to simultaneously probe the translational and orientational diffusion of four peryle

11 rom the same polypeptide blocks with no post-translational and other modifications, showed predictabl

12 Synonymous codon usage significantly impacts translational and transcriptional efficiency, gene expre

13 autophagy-related interactors and their post-translational and transcriptional regulators.

14 This hypothesis could lead to basic, translational, and clinical studies aimed at reducing CO

15 Our data link transcriptional, translational, and metabolic changes to phenotypes assoc

16 uple gene expression at the transcriptional, translational, and post-translational level using custom

17 ity is a result of genomic, transcriptional, translational, and post-translational molecular features

18 ific metabolites that exert transcriptional, translational, and posttranslational control over the ni

19 this challenge by profiling transcriptional, translational, and posttranslational reporters using CRI

20 reiterative framework, providing the basic, translational, and public health research communities wi

21 neurotrauma research, however, studies using translational animal models are limited.

22 n vitro validation and in vivo evaluation in translational animal models are of general applicability

23 However, before translational applications can be realized, there are a

24 of these properties make AMPs attractive for translational applications.

25 nd and model host-pathogen relationships for translational applications.

26 lize the promise of OoCs for fundamental and translational applications.

27 Taking a reverse translational approach and by combining in situ hybridiz

28 oimaging studies in animals provide a unique translational approach for the identification of the neu

29 Thus, the introduced translational approach identified novel putative biomark

30 emendous amount of progress is still needed, translational approaches to understanding, treating, and

31 gregation in neurons, further supporting the translational aspect of this study.

32 A translational control, and demonstrated co-translational assembly of initiation factor complexes.

33 RAB13 translation leads to a co-translational association of nascent RAB13 with the exch

34 These tools provide an exciting translational avenue to merge omics-based drug discovery

35 independent developmental mechanism for post-translational beta-catenin activation and is required to

36 ia n = 21), data accessed October 2018]; and Translational Biomarkers in Aging and Dementia [TRIAD, n

37 marmosets-as well as in humans, providing a translational bridge between preclinical and clinical st

38 Efficient translational bypassing of a 50-nt non-coding gap in a p

39 d appears to be caused by a reduction in the translational capacity of chloroplasts.

40 pression led to reduction of rRNA levels and translational capacity, whilst induced expression of U3

41 by altering PB composition, ER shape, or ER translational capacity.

42 This review highlights translational challenges between available animal models

43 tatic UPR sets in motion transcriptional and translational changes that promote cell adaption and sur

44 Our findings highlight the power of "post-translational chemical modification" as a tool to study

45 nine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H3 and

46 icular focus on their consequent specialized translational control in stem cells and development.

47 Translational control is a widespread mechanism that all

48 endent translation and is the main target of translational control mechanisms.

49 previously identified specific modes of post-translational control of DHCR7, but it is unknown whethe

50 ndings unveil the previously unreported post-translational control of LGR receptors via NEDD4/NEDD4L

51 horylation is an important mechanism of post-translational control of protein kinases.

52 Post-translational control of these enzymes provides a rapid

53 Translational control targeting the initiation phase is

54 vided novel insights into ATF4 and GCN4 mRNA translational control, and demonstrated co-translational

55 The epitranscriptome, translational control, and protein degradation have emer

56 ulated genes and shown to be responsible for translational control.

57 nvestigated ribosome ubiquitination-mediated translational controls during UPR.

58 at re-initiation is not a major mechanism of translational coupling in E. coli.

59 udies have suggested a role for recycling in translational coupling within operons; if a ribosome rem

60 which can lead to time and cost saving post-translational, covalent conjugation of recombinant prote

61 study provides the proof-of-principle for a translational CRISPR-based approach to treat neurologica

62 The half-life of the translational D. indicum metI RNA-SAM complex is signifi

63 NLs via UPF1/NMD-mediated mRNA stability and translational derepression offers a dynamic mechanism fo

64 d properties that can help drive the further translational development of selective UPR modulators fo

65 ns two parameters, one global related to the translational diffusion coefficient of the paramagnetic

66 etics, and the microviscosity, which governs translational diffusion.

67 otein recruited to collided ribosomes during translational distress.

68 cal representations to visualize and explore translational effects of genetic mutations in cancer gen

69 ower of mouse-based immunology research, the translational efficacy of many new therapies from mouse

70 plimentary to existing methods that focus on translational efficiency analysis.

71 Genes with increased translational efficiency following loss of ARF include m

72 ding frames (ORFs), to the quantification of translational efficiency under various physiological or

73 rocognitive process), and then review extant translational efforts regarding these targets and the ev

74 inocyte differentiation that warrants future translational efforts to repurpose phenformin for the tr

75 f this relationship, limiting the success of translational efforts.

76 conserved Elongator complex, which catalyses translational elongation through tRNA modifications at t

77 ls, strategy for drug selection, and lack of translational endpoints between animals and humans contr

78 dons of a set of mRNAs that are enriched for translational enhancer sequences in the 5' untranslated

79 ed with male infertility as well as emerging translational evidence of genitourinary birth defects an

80 e data demonstrate an essential role for the translational factor eIF4G1 on glucose homeostasis and b

81 ysis predicts that miR-379 targets EIF4G2, a translational factor, which is involved in the control o

82 enerated by cell-autonomous, transcriptional/translational feedback loops (TTFLs), active in all tiss

83 e alternative functions without compromising translational fidelity.

84 bosomal A site is fundamental to maintaining translational fidelity.

85 noise exposure, but new epidemiological and translational field noise studies indicate that nighttim

86 cent chain complexes is key to understand co-translational folding.

87 Translational frameshift errors are often deleterious to

88 In this review, the authors leverage a translational framework to bring together findings from

89 Our findings represent a crucial step toward translational genetics, from highlighting the impact of

90 BipA is a conserved translational GTPase of bacteria recently implicated in

91 These uncover NEMF's role in translational homeostasis in the nervous system and impl

92 molecular insights into how perturbation of translational homeostasis regulates cell fate.

93 ndomized, blinded international study, using translational imaging endpoints, aimed to examine the ne

94 ogical principles of FMT and have a positive translational impact on the rational design of general m

95 sa, the precise pathways and mechanism(s) of translational inhibition are not well understood.

96 e L. plantarum tolerance to rifampin and the translational inhibitor erythromycin.

97 We also identified translational inhibitory elements with G-quadruplexes as

98 regulation is correlated with insertions in translational initiation factors in fidelity-determining

99 tifying disease modifiers is of considerable translational interest, as it could suggest strategies t

100 herefore highlights the need to have optimum translational interventions directed at reactivation due

101 fferences remain unknown due to a paucity of translational investigations taking both development and

102 lcanii, elucidating, for the first time, the translational landscape of a representative of the third

103 the transcriptional, translational, and post-translational level using custom engineered circuits sta

104 implying that most changes occur at the post-translational level.

105 S-Acylation, the reversible post-translational lipid modification of proteins, is an impo

106 S-Palmitoylation is a reversible post-translational lipid modification that dynamically regula

107 aused by the immuno-metabolic interplay in a translational liver cancer model.

108 n using host 5' cap sequences, usurping host translational machinery and evading antiviral surveillan

109 trates remarkable versatility of the E. coli translational machinery for initiation with ncAAs in viv

110 tein kinases (GCN2 and PERK) that act on the translational machinery to slow down protein synthesis v

111 g its proteome allocation toward the protein translational machinery.

112 o form structure in a highly coordinated, co-translational manner.

113 d variable deficiencies in biosynthetic post-translational maturation, membrane sorting, pH homeostas

114 reviously, multiple transcriptional and post-translational mechanisms are reported to control Siah's

115 In Science Translational Medicine, Park et al. develop an oncolytic

116 Translational microbiome science in humans has not yet f

117 ve) anxiety could be used as an intermediate translational model of pathological anxiety to improve d

118 Osteoarthritic (OA) dogs are good translational models, but CPM has not been explored.

119 prehensively analyze cell-type-specific post-translational modification (PTM) signaling networks in o

120 In addition to histone post-translational modification and chromatin remodelling com

121 GF23 regulation in bone: transcription, post-translational modification and peptide cleavage.

122 r signalling networks including various post-translational modification cascades, phosphotransfer and

123 This post-translational modification disrupts the normal functioni

124 O-GlcNAcylation is an abundant post-translational modification in neurons.

125 hat actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking

126 ions, but the enzyme(s) catalyzing this post-translational modification is unknown.

127 In the DNA damage responses, this post-translational modification occurs predominantly on serin

128 des improved localization of a possible post-translational modification of aquaporin Z (AqpZ), and su

129 avior regulation occurs in part through post-translational modification of both the alpha- and beta-s

130 Glycosylation is a common post-translational modification of therapeutic monoclonal ant

131 Despite nitroTyr being an abundant post-translational modification on calmodulin, the mechanisti

132 protein phosphorylation is an essential post-translational modification regulating protein functions

133 Poly(ADP-ribosyl)ation is a reversible post-translational modification synthetized by ADP-ribose tra

134 ergoes lysine acetylation, an important post-translational modification that can regulate protein fun

135 by focal adhesion kinase (FAK), a HDAC5 post-translational modification that controls its subcellular

136 ylation of the Thr-2 residue on EsxA, a post-translational modification that is present in mycobacter

137 ne methylation has been recognized as a post-translational modification with pleiotropic effects that

138 and soluble forms, and a high degree of post-translational modification, notably asparagine-linked gl

139 ulatory significance to this widespread post-translational modification.

140 hown to impart selectivity for specific post-translational modification.

141 s orthologous proteins involved in this post-translational modification.

142 trate function and circuits/networks of post-translational modifications (PTM) are ubiquitous in cell

143 primary sequence and identification of post-translational modifications (PTMs) are key elements in p

144 Post-translational modifications (PTMs) are key events in sig

145 Monitoring of post-translational modifications (PTMs) in therapeutic monocl

146 However, protein regulation by post-translational modifications (PTMs) is not binary, making

147 g conformations and express the correct post-translational modifications (PTMs) to exhibit appropriat

148 y peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its act

149 uding changes in MT network density and post-translational modifications (PTMs), elevated NOX2 expres

150 rization of global proteome and protein post-translational modifications (PTMs).

151 on, removal, and recognition of histone post-translational modifications (PTMs).

152 quantify the quality attributes (e.g., post-translational modifications [PTMs]) of monoclonal antibo

153 of pre-mRNA splicing regulation such as post-translational modifications and changes in the expressio

154 late epigenetic inheritance via histone post-translational modifications and DNA methylation.

155 Protein alterations include post-translational modifications and elimination of individua

156 We also found S. Typhi-induced post-translational modifications in histone methylation and a

157 A variety of post-translational modifications including acetylation, myris

158 y regulates a growing number of diverse post-translational modifications including SUMOylation, phosp

159 e secretory pathway, and for subsequent post-translational modifications including tyrosine sulfation

160 t upon changes in the status of tubulin post-translational modifications indicative of highly dynamic

161 However, the effect of post-translational modifications of ACTN4 on podocyte integri

162 tuin activity is regulated by oxidative post-translational modifications of cysteines during inflamma

163 Post-translational modifications of proteins at DNA damage si

164 protein-protein interaction sites, and post-translational modifications of the two PA2G4 isoforms an

165 Cytoskeletal proteins and post-translational modifications play a role in mood disorder

166 often regulated by ligand binding or by post-translational modifications such as phosphorylation.

167 sms, including DNA methylation, histone post-translational modifications, and chromatin structure reg

168 ry mechanisms including autoregulation, post-translational modifications, and protein compartmentaliz

169 intramolecular repressive interactions, post-translational modifications, and protein-protein interac

170 ify ECM proteins and characterize their post-translational modifications, but ECM proteomics remains

171 uitination is one of the most prevalent post-translational modifications, controlling virtually every

172 role in redox signalling via different post-translational modifications, denoted as 'oxidative eustr

173 taining insight into subunit diversity, post-translational modifications, stoichiometry, structural a

174 3 gene and maintain naturally occurring post-translational modifications.

175 osphorylation are two important protein post-translational modifications.

176 ic, transcriptional, translational, and post-translational molecular features.

177 ing this method, quantitative rotational and translational motion of the cargo in a 3D cell cytoskele

178 Here, we develop a translational mouse model of the dopamine pathophysiolog

179 ilt around a self-sustaining transcriptional-translational negative feedback loop (TTFL) in which the

180 Thus, our study reveals an intricate post-translational network that negatively regulates the abun

181 However, there is tremendous potential for translational neuroscience to advance our understanding

182 The main translational opportunities and challenges for optogenet

183 ifferences might enter the framework and the translational opportunities offered by each.

184 rts in microbial biosensor design, highlight translational opportunities, and discuss challenges for

185 lupus erythematosus (SLE), with the relevant translational opportunities, existing or predicted from

186 This provides a unique translational opportunity to investigate therapeutic del

187 Barttin undergoes post-translational palmitoylation that is essential for its f

188 d subphenotype the disease to accelerate the translational path to new treatments.

189 ready on the market thus having an excellent translational perspective.

190 bled expression of a NifD(Y100Q)-linker-NifK translational polyprotein in plant mitochondria, confirm

191 This nano-construct thus has high translational potential for enabling intra-cartilage del

192 Its translational potential for treating non-genetic patholo

193 pound allows for the first assessment of the translational potential of FMN riboswitch binders agains

194 Underscoring the translational potential of multiscale approaches, the tr

195 The translational potential of our results was evaluated by

196 Harnessing the translational potential of the GLP-1/GLP-1R system in pa

197 iciency of iAs methylation have hindered the translational potential of the laboratory studies.

198 of tumor-expressed antigens and reflects the translational potential of this nanomedicine.

199 te IBMIR for enhanced islet engraftment with translational potential.

200 t of therapeutic interventions with enhanced translational potential.

201 tes that are far removed from the natural co-translational process.

202 t of reduced U3 snoRNA expression on protein translational processes and inflammatory pathways.

203 ingly, we detected only minor changes in the translational profiles of neurons.

204 Chemogenetic manipulations, translational profiling and anterograde tracing identify

205 ional repression as a backup system for post-translational protein degradation which ensures robust d

206 nces revealed that rare codons can impact co-translational protein folding and that positions of some

207 ellular protein homeostasis by regulating co-translational protein folding, localization, and maturat

208 Neddylation is the post-translational protein modification most closely related

209 urinary ELVs and that all three undergo post-translational proteolytic processing.

210 Here, we demonstrate translational read-through across two evolutionarily con

211 These experiments demonstrate that translational read-through drugs are able to suppress th

212 124] in mammals) was found to be involved in translational recovery after starvation from stationary

213 l delivery systems have impeded their use in translational regenerative medicine.

214 atus, but their importance in the process of translational regulation had until recently been greatly

215 eIF2alpha phosphorylation-mediated translational regulation is crucial for global translati

216 A model for translational regulation is presented whereby in the abs

217 irst time that WDR77 is directly involved in translational regulation of E2F1/3 mRNAs through their s

218 n and cancer, little is known about the post-translational regulation of LGR5.

219 However, the post-translational regulation of SNAI2 is less well studied.

220 le methods for assessing the effects of post-translational regulation on enzymatic activity.

221 nections between the UPR(mt) signaling and a translational regulation program called the 'integrated

222 ex, essential networks of small RNA and post-translational regulation to these developmental stages.

223 s been learned from bacteria and yeast about translational regulation, much less is known in metazoan

224 Coupled with eIF4E translational regulation, our study highlights an import

225 thesis, yet little is known about their post-translational regulation.

226 ed the genetic basis to Ssd1, an RNA-binding translational regulator that is functional in wild aneup

227 odimer also has a noncanonical function as a translational regulator.

228 proteasome system (UPS) is an important post-translational regulatory mechanism that controls many ce

229 Improved translational relevance also requires increased focus on

230 gical mechanisms of impulsivity with broader translational relevance for impulsivity-related disorder

231 Translational relevance of DDR1 is supported by its mark

232 ssion in human spinal cord, underscoring the translational relevance of our findings in mice.

233 ed function of the DMN, putatively improving translational relevance of preclinical models of neurops

234 Emphasizing the translational relevance of these findings, the expressio

235 reas in clinical tumor samples, suggesting a translational relevance.

236 Global translational remodeling has emerged as a principal mech

237 calization to P granules is not required for translational repression but is required to enrich mRNAs

238 oli and Salmonella identified a mechanism of translational repression of manY mRNA by the sRNA SgrS t

239 important RNA-binding protein that mediates translational repression through mTOR-dependent signalin

240 and Ded1), indicating a common mechanism of translational repression.

241 n of maternal mRNAs, functioning both as the translational repressor and activator during oocyte matu

242 e having a 5' mRNA extension encoding a Nab1 translational repressor binding site in a CAO knockout l

243 tures are irreplaceable models for basic and translational research but their use can be limited due

244 I (N = 15,301; 1971-1975), and the Stanford Translational Research Integrated Database Environment (

245 iscuss the implications of these results for translational research on the potential use of systemica

246 ry burn victims are warranted and serve as a translational research opportunity for uncovering novel

247 hts comprise the following sections: Basic & Translational Research, Cardiac Failure & Myocarditis, C

248 In translational research, evidence supports the role of WB

249 ve a central and catalytic role in basic and translational research.

250 fear and anxiety, along with the promise of translational research.

251 heir target organ are valuable for basic and translational research.

252 ve proven to be of great value for basic and translational research.

253 d an innovative, cooperative, rapid-response translational-research program that brought together hea

254 nerships with scientists (that is, basic and translational researchers) and academic collaborations.

255 rient concentrations in the cell can lead to translational responses involving mechanisms such as dyn

256 This translational review aims to discuss the interactions be

257 In this translational review, we detail the plausible underlying

258 To address this problem, we adopted a Translational Ribosome Affinity Purification (TRAP)- app

259 This proof of concept study targets the translational rigor of such biomarkers and aims to exami

260 a broad overview of this emerging branch of translational science, summarizing common platforms used

261 ntified priorities directly related to basic/translational science.

262 A50120C00096), National Center for Advancing Translational Sciences (UL1TR002377), National Heart, Lu

263 ers (MSF USA), National Center for Advancing Translational Sciences of the National Institutes of Hea

264 s encoding for antiviral factors bypass this translational shutoff, suggesting the presence of additi

265 ring translation elongation and suggest that translational signaling pathways intricately interact to

266 these proteins initiate transcriptional and translational signaling that functions to alleviate ER s

267 development of Dys(-/-) mice, which may have translational significance in HSP-7 patients, both in te

268 ient rats as a secondary model organism, and translational significance of preventive strategies was

269 Macrophage induces L13a/GAIT-dependent translational silencing of inflammatory genes in respons

270 otherapeutic combination strategy provides a translational solution to the formidable challenges of o

271 s across a surface and through liquids, with translational speeds up to 7 mum s(-1) .

272 ated in the mutant mice, indicating that pre-translational splicing defects may be a critical compone

273 regulate their gene expression at the three translational steps and discuss how translation is used

274 Future translational studies are needed to more fully understan

275 Further, translational studies have found that ILC3 responses are

276 rring T1D risk should sharpen functional and translational studies.

277 slated, leaving ample opportunity for future translational studies.

278 and that losartan is a viable candidate for translational studies.

279 diverse contexts and enables mechanistic and translational studies.

280 Results from our translational study indicate that low level exposure to

281 In this paper, we report a translational study of a new fluorescent agent for use i

282 species and discuss the current state of our translational success in relating findings across specie

283 onflicts with the hypothesis that BC200 is a translational suppressor, we overexpressed BC200 by tran

284 The method does not rely on translational symmetry and can therefore also be applied

285 tudy unravels a new principle of spontaneous translational symmetry breaking, providing a general rou

286 ion of spherical hollow crystals with broken translational symmetry in crystalline molecular bottlebr

287 ntified the DAPIT mitochondrial protein as a translational target of EIF4G2.

288 approaches have led to a growing demand for translational techniques, capable of determining their m

289 While translational theories link neurodevelopmental changes i

290 The 'translational therapeutic index' (TTI) is a drug's ratio

291 These findings seem translational to humans and warrant further study.

292 or measuring NfL in plasma or serum, provide translational tools to make development of axonal protec

293 w ribosome abundance, providing evidence for translational tuning to balance protein synthesis and fo

294 cular emphasis should be put on the clinical translational value of findings.

295 rdiac contractility point to the fundamental translational value of the current preclinical models.

296 The translational value of these findings is signified by th

297 or anxiety-like phenotypes may possess more translational value than common outbred strains for mode

298 ely predict effective drug combinations with translational value.

299 that in photoinducible I307N rhodopsin mice (Translational Vision Research Model 4 [Tvrm4]), a 12k lu

300 rizzled (Fzd) cross-reactivity have hindered translational Wnt applications.